Electrolyte Disturbances Hypercalcemia, Hyponatremia, Hypernatremia, Hyperkalemia.
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Transcript of Electrolyte Disturbances Hypercalcemia, Hyponatremia, Hypernatremia, Hyperkalemia.
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Electrolyte Electrolyte DisturbancesDisturbances
Hypercalcemia, Hyponatremia, Hypercalcemia, Hyponatremia, Hypernatremia, Hyperkalemia Hypernatremia, Hyperkalemia
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HypercalcemiaHypercalcemia
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EtiologyEtiology
Hypercalcemia results when the Hypercalcemia results when the entry of calcium into the circulation entry of calcium into the circulation exceeds the excretion of calcium into exceeds the excretion of calcium into the urine or deposition in bone. the urine or deposition in bone.
Sources of calcium are most Sources of calcium are most commonly the bone or the commonly the bone or the gastrointestinal tract gastrointestinal tract
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EtiologyEtiology
Hypercalcemia is a relatively common Hypercalcemia is a relatively common clinical problem. clinical problem.
Elevation in the physiologically Elevation in the physiologically important ionized (or free) calcium important ionized (or free) calcium concentration. concentration.
However, However, 40 to 45 percent of the 40 to 45 percent of the calcium in serum is bound to calcium in serum is bound to proteinprotein, principally albumin; , , principally albumin; , increased protein binding causes increased protein binding causes elevation in the serum total calcium. elevation in the serum total calcium.
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Increased Increased bonebone resorption resorption
Primary and secondary Primary and secondary hyperparathyroidism hyperparathyroidism
Malignancy Malignancy Hyperthyroidism Hyperthyroidism Other - Paget's disease, estrogens or Other - Paget's disease, estrogens or
antiestrogens in metastatic breast antiestrogens in metastatic breast cancer, hypervitaminosis A, retinoic cancer, hypervitaminosis A, retinoic acid acid
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Increased Increased intestinalintestinal calcium calcium absorptionabsorption
Increased calcium intake Increased calcium intake Renal failure (often with vitamin D Renal failure (often with vitamin D
supplementation) supplementation) Milk-alkali syndrome Milk-alkali syndrome Hypervitaminosis D Hypervitaminosis D Enhanced intake of vitamin D or Enhanced intake of vitamin D or
metabolites metabolites Chronic granulomatous diseases (eg, Chronic granulomatous diseases (eg,
sarcoidosis) sarcoidosis) Malignant lymphoma Malignant lymphoma Acromegaly Acromegaly
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EtiologyEtiology
Hyperalbuminemia Hyperalbuminemia 1) severe dehydration 1) severe dehydration
2) multiple myeloma who have a 2) multiple myeloma who have a calcium-binding paraprotein. calcium-binding paraprotein.
This phenomenon is called This phenomenon is called pseudohypercalcemia (or factitious pseudohypercalcemia (or factitious hypercalcemia)hypercalcemia)
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Other causesOther causes
Chronic lithium intake Chronic lithium intake Thiazide diuretics Thiazide diuretics Pheochromocytoma Pheochromocytoma Adrenal insufficiency Adrenal insufficiency Rhabdomyolysis and acute renal failure Rhabdomyolysis and acute renal failure Theophylline toxicity Theophylline toxicity Familial hypocalciuric hypercalcemia Familial hypocalciuric hypercalcemia Immobilization Immobilization Total parenteral nutritionTotal parenteral nutrition
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Primary Primary hyperparathyroidismhyperparathyroidism
Activation of osteoclasts leading to Activation of osteoclasts leading to increased bone resorption in primary increased bone resorption in primary hyperparathyroidism (also cancer).hyperparathyroidism (also cancer).
Adenoma (80%)Adenoma (80%) Hyperplasia (15-20%)Hyperplasia (15-20%) Carcinoma (<1%)Carcinoma (<1%)
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Secondary Secondary hyperparathyroidismhyperparathyroidism
Due to increased PTH in response to Due to increased PTH in response to decreased calciumdecreased calcium
ESRDESRD
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Tertiary Tertiary hyperparathyroidismhyperparathyroidism
An autonomous nodule develops An autonomous nodule develops after longstanding secondary after longstanding secondary hyperparathyroidism hyperparathyroidism
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Familial hypocalciuric Familial hypocalciuric hypercalcemia (FHH)hypercalcemia (FHH)
Mutation in the Ca-sensing receptor Mutation in the Ca-sensing receptor in parathyroid and kidney which in parathyroid and kidney which increases the Ca set pointincreases the Ca set point
May also increase the PTH May also increase the PTH ( parathyroid isn’t sensing Calcium)( parathyroid isn’t sensing Calcium)
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MalignancyMalignancy
PTHrP- PTH related peptide PTHrP- PTH related peptide (squamous cell lung cancer, renal, (squamous cell lung cancer, renal, breast, bladder)breast, bladder)
Cytokines (TNF, INTERLEUKIN-1)Cytokines (TNF, INTERLEUKIN-1) OAF: Local osteolysis (breast cancer, OAF: Local osteolysis (breast cancer,
multiple myeloma)multiple myeloma) Tumoral effect (Hogkins / NHL)Tumoral effect (Hogkins / NHL)
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Vitamin D ExcessVitamin D Excess
Granulomas (sarcoid, TB, histo)Granulomas (sarcoid, TB, histo) Vitamin D IntoxicationVitamin D Intoxication
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Increased bone turnoverIncreased bone turnover
HyperthyroidismHyperthyroidism ImmobilizationImmobilization Paget’s diseasePaget’s disease Vitamin AVitamin A
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MiscellaneousMiscellaneous
Thiazides (increase resorption in Thiazides (increase resorption in kidney)kidney)
Ca-based antacids (Milk-Alkali Ca-based antacids (Milk-Alkali Syndrome)Syndrome)
Adrenal insufficiencyAdrenal insufficiency
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Clinical ManifestationsClinical Manifestations
BonesBones
stonesstones
abdominal groansabdominal groans
psychic moanspsychic moans
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BonesBones
OsteopeniaOsteopenia Osteitis fibrosa cystica (seen in Osteitis fibrosa cystica (seen in
severe hyperparathyroidism only)severe hyperparathyroidism only)
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Osteitis Fibrosa Cystica
Cysts, fibrous nodules, salt and pepper appearance on X-ray
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StonesStones
NephrolithiasisNephrolithiasis NephrocalcinosisNephrocalcinosis Nephrogenic Diabetes InsipidusNephrogenic Diabetes Insipidus
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Abdominal GroansAbdominal Groans
AnorexiaAnorexia NauseaNausea VomitingVomiting ConstipationConstipation PancreatitisPancreatitis Peptic ulcer diseasePeptic ulcer disease
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Psychic MoansPsychic Moans
FatigueFatigue
DepressionDepression
ConfusionConfusion
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LabsLabs
Free Calcium Measured or Free Calcium Measured or Calculated( Measured Ca+(0.8x(4.0-Calculated( Measured Ca+(0.8x(4.0-
alb) or use med-math?alb) or use med-math? PTH (irma assay)PTH (irma assay) PTH rpPTH rp VIT D , VIT AVIT D , VIT A PO4PO4 URINE CALCIUM- 24 HRSURINE CALCIUM- 24 HRS
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TreatmentTreatment
Normal Saline (4-6L per day)Normal Saline (4-6L per day)
FILL THE TANKFILL THE TANK Furosemide-CALCIURESIS Furosemide-CALCIURESIS
Start after patient is intravascularly repletedStart after patient is intravascularly repleted Bisphosphonates- Inhibits osteoclast Bisphosphonates- Inhibits osteoclast
activity(reducing bone resorption and activity(reducing bone resorption and turnover) malignancy and ?Immobilizationturnover) malignancy and ?Immobilization
28 hrs half-life( zolendronate, pamidronate)28 hrs half-life( zolendronate, pamidronate)
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TreatmentTreatment
SQ/IM( not nasal spray)Calcitonin 4 SQ/IM( not nasal spray)Calcitonin 4 u/kg q12 hrsu/kg q12 hrs
increase to 8 units q 12 hrsincrease to 8 units q 12 hrs
Onset 6-8 hours,duration 2-3 daysOnset 6-8 hours,duration 2-3 days
Steroids( targets OAF, 5-A Steroids( targets OAF, 5-A Hydroxylase)Hydroxylase)
Onset 24-48 hrs daysOnset 24-48 hrs days
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Primary Hyperparathyroid
Surgery (JCEM 2009)Age <50 yrs, GFR <60ml/min, Cal 1
mg/dl above normal, DEXA <-2.5
MedicalBisphonates,Calcitonin,estrogen,sermEarly DEXA scans
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Hypercalcemia QuizHypercalcemia Quiz
PTH IncreasedPTH Increased Cal IncreasedCal Increased PO4 decreasedPO4 decreased
What do I have?What do I have?
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quizquiz
PTH DECREASEDPTH DECREASED CAL INCREASEDCAL INCREASED PO4 DECREASED/ INCREASED- PO4 DECREASED/ INCREASED-
EITHEREITHER
WHAT IS IT?WHAT IS IT?
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QUIZQUIZ
PTH DECREASEDPTH DECREASED CAL INCREASEDCAL INCREASED PO4 INCREASEDPO4 INCREASED
WHAT IS IT?WHAT IS IT?
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QUIZQUIZ
PTH NORMALPTH NORMAL CAL INCREASEDCAL INCREASED PO4 DECREASEDPO4 DECREASED
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QUIZQUIZ
PTH INCREASEDPTH INCREASED CAL DECREASEDCAL DECREASED PO4 INCREASEDPO4 INCREASED
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QUIZQUIZ
PTH INCREASEDPTH INCREASED CAL DECREASEDCAL DECREASED PO4 DECREASEDPO4 DECREASED
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HyponatremiaHyponatremia
Santosh Reddy MDSantosh Reddy MD
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DEFINITIONDEFINITION
Defined as Serum Sodium less than Defined as Serum Sodium less than 136 meq/lt136 meq/lt
4 % of hospitalized patients4 % of hospitalized patients
NEJM 2000:342:1581-NEJM 2000:342:1581-9( Adrogue,Madias)9( Adrogue,Madias)
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HyponatremiaHyponatremia
Disorders of sodium are generally Disorders of sodium are generally due to changes in total body water, due to changes in total body water, not sodiumnot sodium
Hyper- or Hypo- osmolality Hyper- or Hypo- osmolality watershifts watershifts
changes in brain cell volumechanges in brain cell volume changes in mental status, seizureschanges in mental status, seizures
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Hyponatremia: Hyponatremia: pathophysiologypathophysiology
Excess water compared to sodium, Excess water compared to sodium, almost always due to almost always due to increased increased ADHADH
The increased ADH may be:The increased ADH may be: Appropriate (e.g. hypovolemia or Appropriate (e.g. hypovolemia or
hypervolemia with too little effective hypervolemia with too little effective arterial volume)EAV.arterial volume)EAV.
Inappropriate (e.g. SIADH)Inappropriate (e.g. SIADH)
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WorkupWorkup
Measure Measure plasma osmolality plasma osmolality to to determine if hypo, hyper, or isotonic determine if hypo, hyper, or isotonic hyponatremiahyponatremia
Urine OsmolalityUrine Osmolality Serum NASerum NA Urine NAUrine NA
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Hypertonic HyponatremiaHypertonic Hyponatremia
Excess of another effective osmoles, Excess of another effective osmoles, such as mannitol, glucosesuch as mannitol, glucose
Each 100mg/dL of glucose above 100 Each 100mg/dL of glucose above 100 causes a decrease in Na by 1.8 causes a decrease in Na by 1.8 mEq/LmEq/L
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Isotonic HyponatremiaIsotonic Hyponatremia
Lab artifact from Lab artifact from hyperlipidemia hyperlipidemia
or hyperproteinemiaor hyperproteinemia
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Hypotonic HyponatremiaHypotonic Hyponatremia
Most common scenarioMost common scenario True excess of water compared to NaTrue excess of water compared to Na
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Hypotonic HyponatremiaHypotonic Hyponatremia
hypovolemichypovolemic euvolemiceuvolemichypervolemichypervolemic
UNa>20 UNa<10
FeNa>1% FeNa<1%
Pt’s clinical history
Uosm>100 Uosm<100 Uosm var.
UNa<10 UNa>20FeNa<1% FeNa>1%
SIADH,
adrenal insuff,
hypothyroidism
Primary polydipsia,
low solute
Reset osmostat
Renal losses
Extrarenal losses
CHF, cirrhosis, nephrosis
Renal failure
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Hypovolemic Hypotonic Hypovolemic Hypotonic HyponatremiaHyponatremia
Renal losses: Thiazides or other Renal losses: Thiazides or other diuretics, salt-wasting nephropathy, diuretics, salt-wasting nephropathy, adrenal insufficiencyadrenal insufficiency
Extra-renal losses: GI losses Extra-renal losses: GI losses (diarrhea), third-spacing (pancreatitis), (diarrhea), third-spacing (pancreatitis), inadequate intake, insensible lossesinadequate intake, insensible losses
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Euvolemic Hypotonic Euvolemic Hypotonic HyponatremiaHyponatremia
SIADHSIADH
pulmonarypulmonary-pneumonia, asthma, COPD, PTX, -pneumonia, asthma, COPD, PTX, +pressure ventilation, small cell lung cancer+pressure ventilation, small cell lung cancerintracranialintracranial-trauma, stroke, hemorrhage, -trauma, stroke, hemorrhage, tumors, infection, hydrocephalustumors, infection, hydrocephalusdrugs-drugs-antipsychotics, antidepressants, thaizidesantipsychotics, antidepressants, thaizidesmisc-misc-pain, nausea, post-op statepain, nausea, post-op state
EndocrinopathiesEndocrinopathies (adrenal insuff, (adrenal insuff, hypothyroidism)hypothyroidism)
Reset osmostat ( exercise, seizures)Reset osmostat ( exercise, seizures)
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Low soluteLow solute
““tea & toast”, “beer potomania” – tea & toast”, “beer potomania” – increased free water intake with increased free water intake with greatly decreased solute loadgreatly decreased solute load
Maximum rate of water excretion on Maximum rate of water excretion on a normal diet is 10-12 L per day – a normal diet is 10-12 L per day – more than this you overwhelm the more than this you overwhelm the excretory capacity of the kidneyexcretory capacity of the kidney
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Hypervolemic Hypotonic Hypervolemic Hypotonic HyponatremiaHyponatremia
CHF: CHF: low effective arterial volume (EAV) low effective arterial volume (EAV) ADH ADH
Cirrhosis: Cirrhosis: ascites causes low EAVascites causes low EAV ADH ADH
Nephrotic syndrome: Nephrotic syndrome: hypoalbuminemia hypoalbuminemia causes low EAV causes low EAV ADH ADH
Advanced renal failureAdvanced renal failure
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Methods to increase NaMethods to increase Na
Restrict free water range 800-1.2 lt Restrict free water range 800-1.2 lt per dayper day
Remove stimulus for ADH Remove stimulus for ADH (volume (volume replete, increase EAV, treat pulmonary replete, increase EAV, treat pulmonary pathology, etc)pathology, etc)
DemeclocyclineDemeclocycline (ADH antagonist) (ADH antagonist) 300MG BID TO QID300MG BID TO QID
Normal salineNormal saline after NA deficit is after NA deficit is calculatedcalculated
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TreatmentTreatment
NA deficitNA deficit: HYPOTONIC EUVOLEMIA: HYPOTONIC EUVOLEMIA
TBW ( 60 % MEN : 50% WOMEN) x TBW ( 60 % MEN : 50% WOMEN) x
(DESIRED NA----MEASURED NA )(DESIRED NA----MEASURED NA ) Ex: 100 kg Man, MEASURED NA 120Ex: 100 kg Man, MEASURED NA 120
TBW 60 MEQ x 12( D--- M sodium)TBW 60 MEQ x 12( D--- M sodium)
720 MEQ PER 24 HOURS720 MEQ PER 24 HOURS
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TreatmentTreatment
0.9 % : 154 meq/ LT0.9 % : 154 meq/ LT 3% : 514 meq / LT3% : 514 meq / LT
GIVE : 4. 6 LT OF 0.9 % NACLGIVE : 4. 6 LT OF 0.9 % NACL
1.4 LT OF 3 % NACL1.4 LT OF 3 % NACL
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Treatment of Euvolemic Treatment of Euvolemic HyponatremiaHyponatremia
Asymptomatic: Asymptomatic: correct at rate of correct at rate of < < 0.5 0.5 mEq/L/hrmEq/L/hr
Symptomatic:Symptomatic: initital initital rapid correction of Na rapid correction of Na (2 mEq/L/hr) until symptoms resolve(2 mEq/L/hr) until symptoms resolve
Rate of correction should NOT exceed 12mEq in a Rate of correction should NOT exceed 12mEq in a 24 hour period, or 18mEq in a 48 hour period to 24 hour period, or 18mEq in a 48 hour period to avoid avoid Central pontine myelinosis Central pontine myelinosis (CNS (CNS demyelination demyelination changes in mental status, changes in mental status, paralysis, pseudobulbar palsy)paralysis, pseudobulbar palsy)
NEPHROLOGY 1994;4:1522-30NEPHROLOGY 1994;4:1522-30
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TreatmentTreatment
Conivaptan( vaprisol): Conivaptan( vaprisol): AquaresisAquaresis:blocks :blocks the activity of AVP ,free water the activity of AVP ,free water excretion,without losses of NA/Kexcretion,without losses of NA/K
EVEREST trial for CHFEVEREST trial for CHF
Tolvaptan( Salt 1 and 2 trials) V2 Tolvaptan( Salt 1 and 2 trials) V2 receptor antagonist( hypervolemic or receptor antagonist( hypervolemic or Euvolemic)Euvolemic)
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HypernatremiaHypernatremia
Santosh ReddySantosh Reddy
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DefinitionDefinition
Increase in the serum sodium Increase in the serum sodium concentration greater than 145 concentration greater than 145 meq /L meq /L
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HypernatremiaHypernatremia
Usually loss of hypotonic fluid, can Usually loss of hypotonic fluid, can also be infusion of too much also be infusion of too much hypertonic fluidhypertonic fluid
Hypernatremia is a strong thirst Hypernatremia is a strong thirst stimulus, so usually only affects pts stimulus, so usually only affects pts w/o access to water (intubated, w/o access to water (intubated, altered mental status,insensible altered mental status,insensible losses nursing home patient)losses nursing home patient)
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HypernatremiaHypernatremia
By definition, all pts are hypertonicBy definition, all pts are hypertonic Can be HypovolemicCan be Hypovolemic
HypervolemicHypervolemic
EuvolemicEuvolemic
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Workup: HypernatremiaWorkup: Hypernatremia
Check volume status Check volume status (vitals, orthostatics, (vitals, orthostatics, JVP, skin turgor, mucous membranes, BUN, Cr)JVP, skin turgor, mucous membranes, BUN, Cr)
If hypovolemic, check UIf hypovolemic, check Uosmosm and U and UNaNa to to determine whether free water loss is determine whether free water loss is renal or extra-renalrenal or extra-renal
If euvolemic, check UIf euvolemic, check Uosm osm to evaluate to evaluate for complete or partial DIfor complete or partial DI
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HypernatremiaHypernatremia
hypovolemichypovolemic euvolemiceuvolemichypervolemichypervolemic
UOsm300-600 UOsm>600
UNa>20 UNa<20
Uosm<300 Uosm 300-600 Uosm >600
Complete DI Partial DI, reset osmostat
Intracellular osmole
generation
Renal losses
Extrarenal losses
Exogenous hypertonic saline, Mineralocorticoid excess
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Hypovolemic HypernatremiaHypovolemic Hypernatremia
Renal water losses: osmotic diuresis Renal water losses: osmotic diuresis from glucose/mannitolfrom glucose/mannitol
Extra-renal water losses: diarrhea, Extra-renal water losses: diarrhea, insensible (fever, exercise)insensible (fever, exercise)
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Euvolemic HypernatremiaEuvolemic Hypernatremia
Diabetes Insipidus: central or Diabetes Insipidus: central or nephrogenicnephrogenic
Seizures, exercise: intracellular Seizures, exercise: intracellular osmole generation osmole generation water shifts water shifts transient increase in Natransient increase in Na
Reset osmostat( I,I,I)Reset osmostat( I,I,I)
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Hypervolemic Hypervolemic hypernatremiahypernatremia
Hypertonic saline administrationHypertonic saline administration
Mineralocorticoid excess: causes Mineralocorticoid excess: causes ADH suppressionADH suppression
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TreatmentTreatment
Replete free water deficitReplete free water deficit
Free water deficit = TBW x (Free water deficit = TBW x (SerumSerumNaNa--140140))
140140 D5 W replacementD5 W replacement Restore access to waterRestore access to water Correct volume status Correct volume status
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TreatmentTreatment
Must replete free water deficit via IVF Must replete free water deficit via IVF or enteral feedsor enteral feeds
Correct at rate < 0.5 mEq/L/hr to Correct at rate < 0.5 mEq/L/hr to avoid cerebral edemaavoid cerebral edema
Must consume > 1L HMust consume > 1L H22O/dayO/day
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TreatmentTreatment
For hypovolemia hypernatremia For hypovolemia hypernatremia – Correct with ¼ or ½ NSCorrect with ¼ or ½ NS
For Hypervolemic hypernatremiaFor Hypervolemic hypernatremia– Correct with DCorrect with D55W and a loop diureticW and a loop diuretic
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TreatmentTreatment
DI: Central: desmopressin DI: Central: desmopressin
Nephrogenic : Salt restriction + Nephrogenic : Salt restriction + Thiazides Amiloride, Nsaids.Thiazides Amiloride, Nsaids.
V 1 A AND V2 receptor blockage V 1 A AND V2 receptor blockage trialstrials
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HyperkalemiaHyperkalemia
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HyperkalemiaHyperkalemia
Transcellular shiftsTranscellular shifts
Decreased excretion by kidneysDecreased excretion by kidneys
Normal GFR Normal GFR
a)Normal aldosterone (CHF,Cirrhosis)a)Normal aldosterone (CHF,Cirrhosis)
b)Hypoaldosterone(Diabetes etc)b)Hypoaldosterone(Diabetes etc)
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Hyperkalemia: Transcellular Hyperkalemia: Transcellular shiftsshifts
Acidosis, Acidosis, Beta-blockersBeta-blockers insulin deficiencyinsulin deficiency dig intoxicationdig intoxication massive cellular necrosismassive cellular necrosis hyperkalemic periodic paralysishyperkalemic periodic paralysis
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Hyperkalemia: decreased Hyperkalemia: decreased excretionexcretion
Decreased GFR (AKI)Decreased GFR (AKI)
Hypoaldosteronism with a normal Hypoaldosteronism with a normal GFR (due to low renin, low GFR (due to low renin, low aldosterone, or decreased response aldosterone, or decreased response to aldosterone)to aldosterone)
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Hyperkalemia: symptomsHyperkalemia: symptoms
WeaknessWeakness ParesthesiasParesthesias PalpitationsPalpitations Peaked T waves on EKG Peaked T waves on EKG (look like they (look like they
might hurt to sit on)might hurt to sit on)
Other EKG findings: Other EKG findings: increased PR interval, increased PR interval, widened QRS, sine wave pattern, PEAwidened QRS, sine wave pattern, PEA
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Peaked T wavesPeaked T waves
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Sine wave
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WorkupWorkup
Rule out pseudohyperkalemia (IVF + Rule out pseudohyperkalemia (IVF + KCl, hemolysis due to venipuncture, KCl, hemolysis due to venipuncture, increased plt or WBC)increased plt or WBC)
Rule out transcellular shiftRule out transcellular shift Assess GFRAssess GFR If normal GFR, calculate TTKGIf normal GFR, calculate TTKG
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TTKG: TTKG: Trans-Tubular Potassium Trans-Tubular Potassium GradientGradient
(Urine(UrineKK/Plasma/PlasmaKK)/(Urine)/(UrineOsmOsm/Plasma/PlasmaOsmOsm)) TTKG tells you how well aldosterone TTKG tells you how well aldosterone
is workingis working TTKG<7 TTKG<7 decreased effective decreased effective
aldosterone functionaldosterone function TTKG>7 TTKG>7 normal aldosterone normal aldosterone
functionfunction
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TreatmentTreatment Calcium Gluconate/Calcium Chloride: Calcium Gluconate/Calcium Chloride:
stabilizes cell membranesstabilizes cell membranes 1-2 amps I.V 1-2 amps I.V 1-3 mins onset lasts 20-30mins1-3 mins onset lasts 20-30mins Insulin:drives K into cells Insulin:drives K into cells regular Insulin 10 units IV with 1-2 regular Insulin 10 units IV with 1-2
amps of D50amps of D50 Beta-2 agonists: Beta-2 agonists: drives K into cells;drives K into cells;Albuterol 10-20mcg inh or IV 0.5mg Albuterol 10-20mcg inh or IV 0.5mg Onset 30-60 minsOnset 30-60 mins
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Treatment
Bicarbonate: Bicarbonate: drives K into cells in exchange for Hdrives K into cells in exchange for H
1-3 amps 1-3 amps
Onset 15-30 mins last 60 minsOnset 15-30 mins last 60 mins
Kayexalate: Kayexalate: exchanges Na for K in gutexchanges Na for K in gut
30-90 mg PO/PR 30-90 mg PO/PR
Onset 1-2 hrsOnset 1-2 hrs
Diuretics;decreases total body K; IV Diuretics;decreases total body K; IV lasixlasix
hemodialysis: hemodialysis: decreases total body K decreases total body K