Cardiovascular Outcomes in Patients with Drug Eluting Stents ...
Drug-eluting Stents Versus Bare-metal Stents in Taiwanese Patients with Acute Coronary Syndrome in a...
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Drug-Eluting and Bare Metal Stent Studies Thursday, April 25, 2013 8:30 AM w 12:30 PM (Abstract nos. AS-062, AS-064, AS-156, AS-157, AS-158) - AS-062 Drug-eluting Stents Versus Bare-metal Stents in Taiwanese Patients with Acute Coronary Syndrome in a Real-world Registry: In- hospital and 12-month Cardiovascular Outcome. Wen-yee Chen. Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Background: DES is widely used including for patients with ACS. However, large studies comparing outcomes of DES and BMS implanted in ACS patients are limited. Methods: Characteristics and 1-year cardiovascular outcomes were compared between ACS participants receiving either BMS or DES implantations. Results: Characteristics were markedly different between groups. Dyslipidemia, known coronary artery disease, family history of vascular disease, or non-ST-segment elevation ACS was more common in the DES group (n ¼ 650). Cigarette smoking, history of cerebrovascular disease, ST-segment myocardial infarction, or Killip IV classification was more common in the BMS group (n ¼ 1672) (all, p < 0.05). Compared with the BMS group, the DES group was associated with significantly lower cumulative 1-year incidence of all-cause mortality (3.4% vs. 5.8%; p ¼ 0.008), target vessel revascularization (TVR) (5.2% vs. 7.4%; p ¼ 0.035), or major adverse cardiac events (MACE) (10.2% vs. 15.6%; p < 0.001). The BMS group had significantly higher risk-adjusted total mortality (HR ¼ 1.85; p ¼ 0.026), TVR (HR ¼ 1.59; p ¼ 0.035), MACE (HR ¼ 1.68; p ¼ 0.001), referenced as the DES group. Conclusion: The study suggests use of DES over BMS in patients with ACS is beneficial in terms of lower mortality, TVR, and MACE in a real-world setting. - AS-064 Zotarolimus-eluting Versus Everolimus-eluting Stents for Treatment of Unprotected Left Main Coronary Artery Stenosis: 2- year Follow-up of Single-center Registry. Sung Il Im, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Sun Won Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh. Korea University Guro Hospital, Seoul, Korea (Republic of). Background: Percutaneous coronary intervention (PCI) is an increas- ingly popular alternative to bypass surgery for the management of left main (LM) coronary artery disease. One restrospective study demon- strated that ZES for the treatment of unprotected left main (ULM) stenosis resulted in the excellent angiographic and clinical outcomes. We compared the mid-to long-term clinical outcomes between ZES and EES in an all-comer analysis that included all patients with ULM stenosis who underwent PCI with ZES or EES. Methods: From October 2006 and February 2012, a total 88 patients underwent PCI with ZES or EES for ULM stenosis. ZES was implanted in 38 patients and EES in 50 patients. Six months angiographic outcomes and major clinical outcomes up to 24 months were compared between the two groups. Results: The baseline clinical and procedural characteristics were mostly similar between the ZES and EES group. At 6 months, major angiographic outcomes were similar between the two groups. After 2 years of clinical follow-up, there were no differences in the rate of cardiac death (5.2% vs. 8.0%) and all major adverse cardiac events (MACEs, 13.1% vs. 14.0%) between the two groups. The risk of repeat revascularization was also similar between the two group [TLR, 2.6% vs. 0% (p¼0.432); TVR, 7.9% vs. 4% (p¼0.648)]. Conclusion: In all-comers undergoing second generation DES implantation for ULM stenosis, ZES and EES showed comparable 6- month angiographic outcomes and 2-year major clinical outcomes in real world Asian population. - AS-156 Everolimus Eluting Stent Shows Better Patency with Reduced ISR Development for a Period of 2.4 years in Bangladeshi Stent Era: Our Experiences in Apollo Hospitals Dhaka. Ahm Waliul Islam, Shams Munwar, Shahab Uddin Talukder, Aqm Reza, Tamzeed Ahmed, Azfar Hossain Bhuiyan, Atique Bin Siddique, Aparajita Karim, Rowsan Masud, Atikullah Miah, Md. Shamsul Alam, Shaifur Rahman Shohel. Apollo Hospitals, Dhaka, Bangladesh. Background: Nature of Coronary artery disease (CAD) in Bangladeshi population is diffuse with small caliber arteries. Now a day, these are treated, by PCI with stent deployment. However, long term data on In- stent re-stenosis (ISR) in these patients is not yet available. Therefore, the aim of our present study was to assess long-term outcome of stent patency or the development of ISR of varieties stent in single vessel territory. Methods: Patients were selected retrospectively, whom PCI done at our hospital and relook coronary angiogram (CAG) was done to assess for further evaluation of their previous PTCA from 2005 to 2012. Total Table Six months Angiographic and 24 months clinical outcomes Variables, n(%) ZES (n[38) EES (n[50) P-value 6-month angiographic outcomes FU MLD 2.840.87 2.441.34 0.458 DS% LM 19.119.8 22.331.9 0.787 LAD 19.611.7 18.95.5 0.941 LCX 62.348.2 20.422.4 0.243 Late loss (LM) 0.7390.847 0.591.07 0.718 Binary ISR 3(7.8) 1(2) 0.604 24 month clinical outcomes Mortality 2(5.2) 5(10) 0.694 Cardiac death 2(5.2) 4(8) 0.695 Non Cardiac death 0(0) 1(2) 1.000 Myocardiac infraction 0(0) 1(2) 1.000 Revascularization 3(7.9) 3(6) 1.000 TLR 1(2.6) 0(0) 0.432 TVR 3(7.9) 2(4) 0.648 Non TVR 0(0) 1(2) 1.000 All MACE 5(13.1) 7(14) 1.000 TLR MACE 3(7.8) 4(8) 1.000 The American Journal of Cardiology â APRIL 23e26, 2013 ANGIOPLASTY SUMMIT ABSTRACTS/Poster 77B P O S T E R A B S T R A C T S APRIL 23e26, 2013
Transcript of Drug-eluting Stents Versus Bare-metal Stents in Taiwanese Patients with Acute Coronary Syndrome in a...
TableSix months Angiographic and 24 months clinical outcomes
Variables, n(%) ZES(n[38)
EES(n[50)
P-value
6-month angiographic outcomesFU MLD 2.84�0.87 2.44�1.34 0.458DS%LM 19.1�19.8 22.3�31.9 0.787LAD 19.6�11.7 18.9�5.5 0.941LCX 62.3�48.2 20.4�22.4 0.243Late loss (LM) 0.739�0.847 0.59�1.07 0.718Binary ISR 3(7.8) 1(2) 0.60424 month clinical outcomesMortality 2(5.2) 5(10) 0.694Cardiac death 2(5.2) 4(8) 0.695Non Cardiac death 0(0) 1(2) 1.000Myocardiac infraction 0(0) 1(2) 1.000Revascularization 3(7.9) 3(6) 1.000TLR 1(2.6) 0(0) 0.432TVR 3(7.9) 2(4) 0.648Non TVR 0(0) 1(2) 1.000All MACE 5(13.1) 7(14) 1.000TLR MACE 3(7.8) 4(8) 1.000
POSTER
ABSTRACTS
APRIL 23e26, 2013
Drug-Eluting and Bare Metal StentStudies
Thursday, April 25, 2013
8:30 AM w 12:30 PM
(Abstract nos. AS-062, AS-064,AS-156, AS-157, AS-158)
- AS-062
Drug-eluting Stents Versus Bare-metal Stents in Taiwanese Patientswith Acute Coronary Syndrome in a Real-world Registry: In-hospital and 12-month Cardiovascular Outcome. Wen-yee Chen.Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Background: DES is widely used including for patients with ACS.However, large studies comparing outcomes of DES and BMSimplanted in ACS patients are limited.
Methods: Characteristics and 1-year cardiovascular outcomes werecompared between ACS participants receiving either BMS or DESimplantations.
Results: Characteristics were markedly different between groups.Dyslipidemia, known coronary artery disease, family history of vasculardisease, or non-ST-segment elevation ACS was more common in theDES group (n ¼ 650). Cigarette smoking, history of cerebrovasculardisease, ST-segment myocardial infarction, or Killip IV classificationwas more common in the BMS group (n ¼ 1672) (all, p < 0.05).Compared with the BMS group, the DES group was associated withsignificantly lower cumulative 1-year incidence of all-cause mortality(3.4% vs. 5.8%; p ¼ 0.008), target vessel revascularization (TVR)(5.2% vs. 7.4%; p ¼ 0.035), or major adverse cardiac events (MACE)(10.2% vs. 15.6%; p < 0.001). The BMS group had significantly higherrisk-adjusted total mortality (HR ¼ 1.85; p ¼ 0.026), TVR (HR ¼ 1.59;p ¼ 0.035), MACE (HR ¼ 1.68; p ¼ 0.001), referenced as the DESgroup.
Conclusion: The study suggests use of DES over BMS in patientswith ACS is beneficial in terms of lower mortality, TVR, and MACE ina real-world setting.
- AS-064
Zotarolimus-eluting Versus Everolimus-eluting Stents forTreatment of Unprotected Left Main Coronary Artery Stenosis: 2-year Follow-up of Single-center Registry. Sung Il Im,Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Sun Won Kim,Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim,Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh. KoreaUniversity Guro Hospital, Seoul, Korea (Republic of).
Background: Percutaneous coronary intervention (PCI) is an increas-ingly popular alternative to bypass surgery for the management of leftmain (LM) coronary artery disease. One restrospective study demon-strated that ZES for the treatment of unprotected left main (ULM)stenosis resulted in the excellent angiographic and clinical outcomes.We compared the mid-to long-term clinical outcomes between ZES and
The American Journal of Cardiology� APRIL 23e26, 2013 AN
EES in an all-comer analysis that included all patients with ULMstenosis who underwent PCI with ZES or EES.
Methods: From October 2006 and February 2012, a total 88 patientsunderwent PCI with ZES or EES for ULM stenosis. ZES was implantedin 38 patients and EES in 50 patients. Six months angiographicoutcomes and major clinical outcomes up to 24 months were comparedbetween the two groups.
Results: The baseline clinical and procedural characteristics weremostly similar between the ZES and EES group. At 6 months, majorangiographic outcomes were similar between the two groups. After 2years of clinical follow-up, there were no differences in the rate ofcardiac death (5.2% vs. 8.0%) and all major adverse cardiac events(MACEs, 13.1% vs. 14.0%) between the two groups. The risk of repeatrevascularization was also similar between the two group [TLR, 2.6%vs. 0% (p¼0.432); TVR, 7.9% vs. 4% (p¼0.648)].
Conclusion: In all-comers undergoing second generation DESimplantation for ULM stenosis, ZES and EES showed comparable 6-month angiographic outcomes and 2-year major clinical outcomes inreal world Asian population.
- AS-156
Everolimus Eluting Stent Shows Better Patency with Reduced ISRDevelopment for a Period of 2.4 years in Bangladeshi Stent Era:Our Experiences in Apollo Hospitals Dhaka. Ahm Waliul Islam,Shams Munwar, Shahab Uddin Talukder, Aqm Reza, Tamzeed Ahmed,Azfar Hossain Bhuiyan, Atique Bin Siddique, Aparajita Karim,Rowsan Masud, Atikullah Miah, Md. Shamsul Alam,Shaifur Rahman Shohel. Apollo Hospitals, Dhaka, Bangladesh.
Background: Nature of Coronary artery disease (CAD) in Bangladeshipopulation is diffuse with small caliber arteries. Now a day, these aretreated, by PCI with stent deployment. However, long term data on In-stent re-stenosis (ISR) in these patients is not yet available. Therefore, theaim of our present studywas to assess long-term outcome of stent patencyor the development of ISR of varieties stent in single vessel territory.
Methods: Patients were selected retrospectively, whom PCI done atour hospital and relook coronary angiogram (CAG) was done to assessfor further evaluation of their previous PTCA from 2005 to 2012. Total
GIOPLASTY SUMMIT ABSTRACTS/Poster 77B
