Prediction of Restenosis After PCI with Contemporary Drug-Eluting Stents.
Drug-Eluting Stents in AMI (RCTs)
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Clinical Trial Results . org Drug-Eluting Stents in AMI (RCTs) M Leon, TCT 2006 M Leon, TCT 2006 Trial Trial DES DES BMS BMS N N Angio Follow- Angio Follow- Up Up Primary EP Primary EP STRATEGY STRATEGY 1 Cypher Cypher Bx Vel Bx Vel 175 175 Yes Yes 8 mo D, ReMI, 8 mo D, ReMI, CVA, or TVR CVA, or TVR TYPHOON TYPHOON 2 Cypher Cypher Any Any 700 700 Yes Yes 12 mo TVF 12 mo TVF SESAMI SESAMI 3 Cypher Cypher Bx Vel Bx Vel 320 320 Yes Yes 12 mo 12 mo restenosis restenosis PASSION PASSION 4 Taxus Taxus Exp Exp 2 / / Lib Lib 620 620 No No 12 mo D, 12 mo D, ReMI, TVR ReMI, TVR 1. 1. Valgimigli M et al. JAMA 2005; 293:2109-2117. Valgimigli M et al. JAMA 2005; 293:2109-2117. 2. Spaulding C et al. NEJM 2006; 2. Spaulding C et al. NEJM 2006; 355:1093-104. 355:1093-104. 3. Menichelli M. EuroPCR 2006. 3. Menichelli M. EuroPCR 2006. 4. Laarman GJ et al. NEJM 2006; 355:1105-13. 4. Laarman GJ et al. NEJM 2006; 355:1105-13.
description
Drug-Eluting Stents in AMI (RCTs). Valgimigli M et al. JAMA 2005; 293:2109-2117.2. Spaulding C et al. NEJM 2006; 355:1093-104. 3. Menichelli M. EuroPCR 2006. 4. Laarman GJ et al. NEJM 2006; 355:1105-13. M Leon, TCT 2006. Drug-eluting Stents in AMI (RCTs) Mortality. All p=NS. %. - PowerPoint PPT Presentation
Transcript of Drug-Eluting Stents in AMI (RCTs)
Clinical Trial Results . orgClinical Trial Results . org
Drug-Eluting Stents in AMI (RCTs)Drug-Eluting Stents in AMI (RCTs)
M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006
TrialTrial DESDES BMSBMS NN Angio Follow-UpAngio Follow-Up Primary EPPrimary EP
STRATEGYSTRATEGY11 CypherCypher Bx VelBx Vel 175175 YesYes8 mo D, ReMI, 8 mo D, ReMI, CVA, or TVRCVA, or TVR
TYPHOONTYPHOON22 CypherCypher AnyAny 700700 Yes Yes 12 mo TVF12 mo TVF
SESAMISESAMI33 CypherCypher Bx VelBx Vel 320320 Yes Yes 12 mo 12 mo restenosisrestenosis
PASSIONPASSION44 TaxusTaxus ExpExp22/Lib/Lib 620620 NoNo 12 mo D, ReMI, 12 mo D, ReMI, TVRTVR
1.1. Valgimigli M et al. JAMA 2005; 293:2109-2117.Valgimigli M et al. JAMA 2005; 293:2109-2117. 2. Spaulding C et al. NEJM 2006; 355:1093-104.2. Spaulding C et al. NEJM 2006; 355:1093-104.
3. Menichelli M. EuroPCR 2006. 3. Menichelli M. EuroPCR 2006. 4. Laarman GJ et al. NEJM 2006; 355:1105-13.4. Laarman GJ et al. NEJM 2006; 355:1105-13.
1.1. Valgimigli M et al. JAMA 2005; 293:2109-2117.Valgimigli M et al. JAMA 2005; 293:2109-2117. 2. Spaulding C et al. NEJM 2006; 355:1093-104.2. Spaulding C et al. NEJM 2006; 355:1093-104.
3. Menichelli M. EuroPCR 2006. 3. Menichelli M. EuroPCR 2006. 4. Laarman GJ et al. NEJM 2006; 355:1105-13.4. Laarman GJ et al. NEJM 2006; 355:1105-13.
Clinical Trial Results . orgClinical Trial Results . org
2.3 1.9
4.6
9.0
2.2
4.3 4.5
8.0
0.0
4.0
8.0
12.0DES BMS
2.3 1.9
4.6
9.0
2.2
4.3 4.5
8.0
0.0
4.0
8.0
12.0DES BMS
%
%
Drug-eluting Stents in AMI (RCTs) Mortality
Drug-eluting Stents in AMI (RCTs) Mortality
STRATEGY STRATEGY 8 mo8 mo
TYPHOON TYPHOON 12 mo12 mo
SESAMI SESAMI 12 mo12 mo
PASSION PASSION 12 mo12 mo
n=320n=320n=700n=700 n=620n=620n=175n=175
All p=NSAll p=NS
M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006
Clinical Trial Results . orgClinical Trial Results . org
Drug-eluting Stents in AMI (RCTs) Reinfarction
Drug-eluting Stents in AMI (RCTs) Reinfarction
1.11.8 1.7
9.0
1.4 1.8 2.0
7.0
0.0
4.0
8.0
12.0DES BMS
1.11.8 1.7
9.0
1.4 1.8 2.0
7.0
0.0
4.0
8.0
12.0DES BMS
%
%
STRATEGYSTRATEGY 8 mo8 mo
TYPHOON TYPHOON 12 mo12 mo
SESAMI SESAMI 12 mo12 mo
PASSION PASSION 12 mo12 mo
n=320n=320n=700n=700 n=620n=620n=175n=175
All p=NSAll p=NS
M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006
Clinical Trial Results . orgClinical Trial Results . org
Drug-eluting Stents in AMI (RCTs)Stent thrombosis
Drug-eluting Stents in AMI (RCTs)Stent thrombosis
3.4 3.1
1.0
3.03.6 3.7
1.00.0
0.0
4.0
8.0
12.0DES BMS
3.4 3.1
1.0
3.03.6 3.7
1.00.0
0.0
4.0
8.0
12.0DES BMS
%
%
STRATEGY STRATEGY 8 mo8 mo
TYPHOON TYPHOON 12 mo12 mo
SESAMI SESAMI 12 mo12 mo
PASSION PASSION 12 mo12 mo
n=320n=320n=700n=700 n=620n=620n=175n=175
All p=NSAll p=NS
M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006
Clinical Trial Results . orgClinical Trial Results . org
Drug-eluting Stents in AMI (RCTs)Target lesion revascularization
Drug-eluting Stents in AMI (RCTs)Target lesion revascularization
3.7 4.3 5.3
20.0
12.611.2
7.86.0
0.0
6.0
12.0
18.0
24.0DES BMS
3.7 4.3 5.3
20.0
12.611.2
7.86.0
0.0
6.0
12.0
18.0
24.0DES BMS
%
%
STRATEGY STRATEGY 8 mo8 mo
TYPHOON TYPHOON 12 mo12 mo
SESAMI SESAMI 12 mo12 mo
PASSION PASSION 12 mo12 mo
n=320n=320n=700n=700 n=620n=620n=175n=175
p=0.23p=0.23
p<0.001p<0.001p<0.001p<0.001
p=0.006p=0.006
M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006M Leon, TCT 2006
