Detect New infections of HIV, Hepatitis C, syphilis and Hepatitis B Feasibility of conduct

TUPDD0101:WILL A MULTIPLEX ASSAY DETECT NEW INFECTIONS OF HIV, SYP, HEP C AND B IN URBAN INDIA?

1. Detect New infections of HIV, Hepatitis C, syphilis and Hepatitis B

2. Feasibility of conduct3. Diagnostic accuracy4. Client preference

POPULATION

INTERVENTION SETTING

Hinduja National Hospital and Medical Research Center, and Sion Hospitals Mumbai, India

Point of care + combined counselling+

confirmatory testing STD Clinic attendees

Sion Hospital, Mumbai

OBJECTIVE

Mumbai Urban Poor

MiriadTM test on fingerstick blood

FLOW OF PARTICIPANTS

CATEGORY

SENSITIVITY

SPECIFICITY

REFERENCE STANDARDIndex test statusPRELIMINARY

POSITIVE

Index test statusPRELIMINARY

NEGATIVE

HIV 100% [95%, CI: 94.8,

100]

99.7% [95%, CI: 98.3,

99.9]

ELISA (antigen+antibody) +

Western BlotELISA

HBV 13.3% [95%, CI: 6.6, 23.2]

99.3% [95%, CI: 97.6,

99.9]

HBsAg + Total anti HBc + HBV DNA HBsAg + anti-HBc

HCV 50% [95%, CI: 1.26,

98.74]

99.7% [95%, CI: 98.5,

99.9]

HCV antibody + HCV RNA

Anti HCV screening test (EIA based)

Syphilis 86.1% [95%, CI: 70.5,

95.3]

85.2% [95%, CI: 80.9,

88.8]TRUST + TPHA TPHA

RESULTSDemographics

Gender 83% males

Age (mean) 31.2 years

Sample size375 STD Clinic

attendees

NITIKA PANT PAI, MD, MPH, PhDAssistant professor

McGill University, MontrealEmail: [email protected];

Co-investigators: Dr Anjali Shetty Hinduja Dr Rachita Dhurat, Sion

Detect New infections of HIV, Hepatitis C, syphilis and Hepatitis B Feasibility of conduct

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