Dau Nanh Va Kha Nang Ngan Ngua Benh Tim Mach - Hong Le Tho

8/3/2019 Dau Nanh Va Kha Nang Ngan Ngua Benh Tim Mach - Hong Le Tho

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U NNH - NATTOKINASEV KH NNG NGN NGA CC BNH V TIM MCH

Hng L Th---o0o---Ngun

http://thuvienhoasen.orgChuyn sang ebook 8-8-2009

Ngi thc hin : Nam Thin [email protected] Audio Ti Website http://www.phatphaponline.org

Mc LcLi dnPhn 1 - Cc bin chng tim mch

Cholesterol - th phm gy tai binCc loi Bnh tim mch ph bin nht

Cc chng bnh khng ly lan v vai tr ca dinh dngPhn 2 - Natto l g ?Phn 3 - Pht hin c o ca GS Sumi Hiroyuki

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Li dn

Trc khi i vo ch chnh ca bi vit: u nnhNattokinase v kh

nng ngn nga cc bnh v tim mch, tc gi xin gii thiu tht s lcmt s nt c trng v cc chng bnh ny trong t trng tm vonhng hot cht c trong u nnh hay u nnh ln men (Natto) gi vai trkh c o qua pht hin ca cc nh khoa hc, chuyn gia nghin cu ykhoa trn th gii cng b trong hn 20 nm qua. Thnh qu nghin cuv enzym Nattokinase--t ht u nnh nu chn c ln men-- rt tnhc ca GS Sumi Hiroyuki (Nht bn) l mt pht hin k th mang li ktqu tt p cho bit bao ngi ang ng trc nguy c t qu, tai binmch mu no cng nh dn mu c tim, co tht ng mch vnhTc gi

ngh rng khng th l gii mt cch khoa hc v mt hn th v trong khitm hiu tc dng ca Nattokinase nu khng c trang b mt kin thcti thiu v ngnh y, c bit l b mn Tim Mch hin i. V l xin mi

bn c chu khlm quen vi nhng kin thc c bn di y nht lch n s tc ng v chuyn ha ni sinh ca nhng Enzym lm ngmu do lng m trong mu qu cao gy nn, v Enzym (Plasmin) duy nhtlm ph tan nhng vn (cc)mu tn ng bm cht ni mc-- cn tr
http://phatphaponline.org/kinh/Audio/Sach%20Noi/Quoc%20Te/An%20Chay%20Mot%20Triet%20Ly%20Song%20-%20Avadhutika%20Anandamitra%20Acarya%20-%20Bs%20Lien%20Huong%20Dich/http://phatphaponline.org/kinh/Audio/Sach%20Noi/Quoc%20Te/An%20Chay%20Mot%20Triet%20Ly%20Song%20-%20Avadhutika%20Anandamitra%20Acarya%20-%20Bs%20Lien%20Huong%20Dich/


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dng mu a dng kh tr v tim, ln no b duy tr mi hot ngbnh thng ca c th duy tr s sng .

Nu nhng con vn chuyn lun lu tun hon ny trc trc thtaibin s n vi chng ta, c th s phn ng kch lit t triu chng tim pmnh, hi hp, kh th n au tht ngc, t qu, bi lit v cui cng ldn n iu au bun nht khi tri tim ngng p hay t bo no b hoi tdo thiu mu hoc dng kh. Trong qu trnh , Nattokinase s phi lm gkhi c np vo c th qua b my tiu ha, liu n c ch tht s hay chl s tng tng t v qung co ? Li gii ny s bt u t y

Mt khc, iu quan trng nht m tc gi xin mn php nhc li Thcphm chc nng khng phi l thuc tr bnh trc tip v thng c thiphng tip th, a phn mang tnh cht la gt nht l qua cc chiu thc

thng mi truyn tiu a cp nh chng ta thy. Hai l y khng phimt bi bo hc thut (Academic paper) m l mt bi chuyn kho vvy tc gi trnh ghi ch rm r tng chi tit trch dn m ch chung vo

phn t liu tham kho cui bi cho d c, mong cc tc gi lin quanthng cm v lng th.

Ngi vit s khng vui khi bi bo v Nattokinase ny b li dng tuyntruyn, qung co cho mt loi thc phm chc nng i t Nattokinase mcht lng ca chng khng thng qua kim nh cht lng ca c quan yt c trch nhim ca nc s ti v khng c s ng ca tc gi.

Li khuyn m chng ti mun gi n bn c l hy tr v vi thinnhin, c cuc sng lnh mnh v an vui vi nhng ht u nnh ng nhqu bu m to ha ban cho gn gn sc khe, trong ngn nga ccc chng tim mch, t qu m chi ph cha tr v cng tn km, khng k

bao nhiu iu au kh khc khi gp tai bin

Ni dung gm c 3 chng:

(1) V cc bin chng tim mch

(2) Natto l g ?(3) Pht hin c o ca GS Sumi Hiroyuki (Nht bn)

Ngoi ra chng ti cn nh km mt bi phng vn GS Sumi Hiroyuki bn c tham kho.


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Phn 1 - Cc bin chng tim mch

Theo bo co ca T chc Y t th gii (WHO), t qu (tai bin mch mu

no) l tnh trng ri lon chc nng thn kinh gm hai loi chnh l nhimu no v xut huyt no. Trong , 80% t qu l do nhi mu no. Tnthng ny lm gim t ngt hoc ngng hon ton vic cung cp mu n

no.

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Cholesterol - th phm gy tai bin

n tui 50 khi khm sc khe nh k, chng ta thng yu cu cc bc s

lm hng lot xt nghim c bn nh th nc tiu, phn, musau khi onhp tim, huyt p. Ti sao chng ta thng thy bc s t ng nghe vongc ngay khi bt u khm, g nh vo khp gi, nhn vo sc din vtrong qu trnh trao i, v bc s kh knh tm hiu sinh hot thng nhtnh ch n ung, vn ng, gic ng, ngh ngi v c chu k kinh nguytca n gii lm g ? c bit l bn cnh in tm v in no ,vic chp X-quang, Siu m hay Chp ct lp in ton (CT.Scanner), Nisoi, Sinh thit (Biopsy) v hng lot xt nghim chuyn su bt buckhi c yu t no b nghi ng c vn mc d nhng ch s v hmlng m (Cholesterol v Triglyceride) trong mu, huyt p, mch p

thng c xem xt u tin, cho bit c th ni chung v qu tim niring bnh thng hoc c g trc trc m mt thng khng th thyc. T tui 49 tr i, nh cu ni 49 cha qua 53 ti, chu k sinhhc ca con ngi bt u xy ra nhiu xo trn, bc vo lp ngi trithin mnh v vy vic khm ph ra mt chng bnh nan y no trong cth l iu bnh thng. Vn quan trng l pht hin sm ngn ngav cha tr trc khi qu mun nh bnh i tho ng, tim mch, ung


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thdn n cc bin chng khc nh thn kinh, tun hon, tiu ha, hhp, vn ng (xng khp) hay tai mt gy ic hoc m la (cc binchng nghim trng ca bnh i tho ng).

M, hng nm c khong 6 triu ngi b suy tim, trong s ny khong1,5 triu b bnh tim mch v 1/3 ca con s b t vong. Khong 1/5trong s cc trng hp b bnh tim mch khng h c triu chng hay cnh

bo trc. T sut n ng ngi M cht v bnh tim l khong200/100,000 dn s trong khi ngi Scotland l 320/100,000 ; Anh l250/100,000 cao gp hai ln so vi cc nc nh Ha Lan, Php. Ring

Nht bn t sut n ng cht v bnh tim ch l 20/100,000 dn s, mcthp nht trong cc nc pht trin. Vo nm 1970 nhiu nghin cu chothy t sut t vong v bnh tim lin quan mt thit vi lng tiu th cht

bo ng vt. Hai ln thc nghim lm sng ln Hoa k vi 360,000 ngi

tham gia cng a n kt lun rng nhng ngi n nhiu cht bo ngvt c nguy c bnh tim rt cao so vi nhng ngi n chay, khng n hayn t cht bo ng vt. Cng l ngi Nht nhng ngi Nht trong ncvn c t sut cht v bnh tim thp hn ngi sng ti M l mt so snhth v.

Tuy nhin quan h gia Cholesterol v ch n ung, mc hp thu chtbo ng vt vn cn nhiu b n, v c khi ngc li, khng theo cng thct l thun k trn, khng phi n nhiu cht bo ng vt l hm lngcholesterol trong mu cao, c th c chc nng t n iu chnh sn lng

cholesterol cn thit cho bn thn n duy tr s n nh, tc l nu lngcholesterol t thc n gim (hay thiu) th c th s tng cng sn xutcholesterol; ngc li nu cholesterol t thc n tng th c th s gim vicsn xut v c khong 20 gen dnh dng n qu trnh iu chnh v chuynha ny. V d mt gen c tn Neuropeptide (NPY) ng vai tr iu chnhmc cn thit v c nhng ngi vi mt bn ca gen c mc cholesterol cao hn nhng ngi khng c bn gen . V vy cng cn c kin nghi ng rngNhng bng chng khoa hc ng sau mi lin h giach n ung, cholesterol v bnh tim rt mong manh (TS Nguyn vn

Tun).Cholesterol l mt loi m (lipid) rt quan trng i vi hot ng sng cac th, gi vai tr trung tm xy dng mng t bo, cc hormon sinh dc, tito Vitamin D v thc y qu trnh tiu ha, tuy nhin nu hm lngCholesterol trong mu tng qu mc s lm tng nguy c b x va ng


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mch, km theo l bnh tng huyt p, bnh mch vnh vi cc binchng nguy him nh nhi mu c tim, t qu.

V phng din ha hc, Cholesterol l mt cht bo, da vo cu trc phnt, cht bo trong thc phm di ba dng chnh:

-khng bo ha dng a phn (poly-unsaturated)-khng bo ha dng n phn (mono-unsaturated)-bo ha (saturated)

Cht bo bo ha l nhng cht bo c ngun gc t ng vt (k c sa,ph- mai) trong nhit trung bnh (25 C) chng l mt khi c trong khicht bo khng bo ha dng n thng tm thy trong tri olives, u

phng, tri b cn cht bo khng bo ha dng a phn thng thy

trong ng (bp), m, rau ci trong quan trng nht l Cholesterol didng bo ha trong ng vt v mt s thc vt nh du da. Cholesterolc ch bin trong Gan .Cholesterol LDL c chuyn t Gan n ni (b

phn) no trong c th cn, cn HDL th c ch vo Gan sn xut raHormon hay thi ra ngoi qua ti mt. H thng ch bin v vn chuynCholesterol lm vic mt cch nhp nhng trong c th khe mnh, singnng c mt khp c th con ngi nhng khi c th b au tim (nhi muheart attack) th cc phn t Cholesterol n tp trung dn cc lm ri lon,tc nghn ng mchv vy cc nh khoa hc cho rng Cholesterol l th

phm gy huyt p (HA) cao gy tai bin tim mch.

Ni c nhiu nht trong c th l no v h thng thn kinh v Cholesterollm bc tng ngn phn bn trong v bn ngoi thn kinh t bo khngthm nc v chnh v c tnh khng tan (trong nc v trong mu) nn gyra hiu ng ngc li l to cn tr tun hon hay lu thng mu huyt trongc th khi vn thnh cc. Trong c th, Cholesterol c chuyn ch trongcc ht phn t hnh cu (sperical particles) gm c nhiu cht Lipoprotein.

Nhng phn t hnh cu ny chuyn ch Cholesterol i khp c th, miphn t c th chuyn ch 1500 phn t (molecules) v hnh trnh cachng thng ko di 24 gi. Nhng c nhiu loi phn t mang trchnhim vn chuyn khc nhau:

*Loi lipoprotein c t trng cao (High density lipoprotein:HDL)tt, phitrn >35 mg/dl

*Loi lipoprotein c trng lng thp (Low density lipoprotein:LDL)xu,phi di < 160 mg/dl


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Ngi ta c bit 60%-80% Cholesterol trong mu c chuyn ch bngLDL v khong 15-20% c chuyn ch bng HDL. Phn cn li, di25% c cc phn t khc vn chuyn. Cholesterol b kh t cc t bovn chuyn, a vo Gan x l trc khi thi ra ngoi l loi HDL (tt)v loi t Gan i vo cc t bo l loi xu (LDL). Thng thng hm lngHDL t hn LDL theo t l 1/3 hay 1/5 v LDL l hm lng biu kin nh bnh m trong mu ca bnh nhn theo kt qu xt nghim .Cholesterol l mt trong nhng nguyn nhn nghn tim, Cholesterol cngnhiu th mc nguy him cng cao.Tnh trng tc nghn tim cn gi l xva ng mch (Arteriosclerosis) tc cc mch tim b gim kh nng nhi (co bp) v khi ng mch khng cn n hi th mu v oxy khng thn cung cp cho c tim, tim s khng vn hnh bnh thng, to ra tnhtrng kh th. Chng x cng ng mch thng thng l X va ngmch (atherosclerosis) nh hng n cc ng mch chuyn mu vo tim,

no, thn v chi vi triu chng d thy l khi cholesterol bt u lng ng(tch t) thnh nhng vt bo trn lp ngoi ca ng mch. Nhng vt bony l nhng tiu thc bo (microphages), l mt t bo mu trng m chcnng ca chng l n (th tiu) nhng t bo b h hi hay cht. Theothi gian, cc tiu thc bo ny bm vo vch ca ng mch v lm cho slun chuyn ca ng mch tr nn bt bnh thng. Calcium cng tch t vvy ngi b bnh au tim thng b vi ha ng mch. Tiu cu (Platelet),nhng t bo mu c nhim v lm nhng vn cc mu (Clot), tch t phatrn mng thnh mt khi cng bao quanh vnh ng mch, gy ra chnghuyt khi (Thrombus), huyt khi tch t lu ngy s dy lm bt ngknh ca ng mch v lm tt nghn hon ton. ng mch c th b vhay mt huyt khi c th b tch ri (bung) ra lm bt cc ng mch nh.Thnh phn ca huyt khi l nhng cht bo, chng rt d v v t nhinngn cn lu thng , lm cho tim mt ngun cung cp mu. S kin ny xyra khi mu chy qua nhng ng mch v thnh nhng mnh nh, thinhng cht bo ra ngoi, hnh thnh nhng cc mu (vn), mi lc mt lndn lm nghn hon ton ng mch. Hin tng ny ch xy ra trong vngvi pht v hu qu cui cng l chng huyt khi ng mch vnh(Coronary Thrombosis), bnh nhn cm thy au ngc khng chu ng ni.

Nu ng mch b nghn ko di, c tim s hoi t v cui cng l bnhnhn t vong v b nhi mu c tim (MyoCardial Infarction). Ni tm lihuyt khi l cht si (Fibre), chnh cht si ny lm cho ng knh cang mch b hp dn gy au tht ngc (Angina) khi ng mch b tht li,lm cho mu khng lu thng vo tim theo mt tc cn thit v n chnhl th phm a n ci cht bi chng nhi mu c tim .


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Huyt khi gy nhi mu c tim

Huyt khi gy nghn mch phi

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Cc loi Bnh tim mch ph bin nht

-bnh ng mch vnh (Coronary Artery Disease)-bnh nhi mu c tim(Myocardial Infarction)-bnh tng huyt p(Hypertension)-Bnh c tim dn khng r nguyn do(Idiopathic Dileated Cardiomyopathy)-Vim c tim(Myocarditis)Bnh C tim(Cardiomyopathies)-Bnh hp van tim(Valvular Heart Disease)-Bnh c tim ph ln(Hypertropic Cardiomyopathy)-Bnh c tim hn ch(Restrictive Cardiomyopathy)-Bnh mng tim(Percardial Disease)-Bnh tim bm sinh(Congetinal Heart Disease)


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-Ri lon nhp tim(Arythmias)-Chng thiu mu(Ischaemia)bnh thiu mu(Ischaemic Heart Disease)

C th tm lc li nh sau:

(1) Cht bo bo ha c khuynh hng kch thch gan sn xut thmcholesterol v lm tng hm lng ca m trong mu ln cao. Hu qu llm x cng ng mch, lm nghn mch vnh ca tim, gy au tht ngc,tng nguy c t qu tim, tng huyt p ng mch c th dn n tai binmch mo no.

(2) Nm 1998, nghin cu ca nhm Cherl-Ho-Lee ( S.J. Cho, M.A Juilleratv C.H Lee) pht hin c ch ca hiu qu lm gim Cholesterol trong gannh protein u nnh tc ng thy phn (hydrolysate) lm tan-- cc loi

m (cht bo) c trong gan khi c th hp th nhng loi cht bo bo haqua thc phm, gim lng th th LHL-R (Low Density LipoproteinReceptor) nh vy C quan qun l thuc v thc phm Hoa K (FDA) cng nhn protein ca u nnh l mt hot cht lm gim (hn ch) bnhtim mch (Cardiovascular Disease) vo nm 1999. 50 % bnh nhn c hmlng m trong mu cao chu u cht v cc chng tim mch v chi phtr liu ln n 200 t USD/nm. Chnh Protein ca u nnh (SPI) chkhng phi Isoflavones (u nnh) kt hp lm gim m trong mu thpi (The American Journal of Clinical Nutrition Vol. 83) do tc ng sinh hctch cc ca Peptides ca u nnh khi thm thu vo t bo gan (Hepatic

cells) .

(3) H thng phn hy si Fibrin t Fibrinogen* (nt huyt khi l trunggian xy ra nhi mu c tim cp (AMI)l mt h enzym ni sinh trong huyttng c tn l Plasmin (TS Sumi Hiroyuki chng minh Nattokinase mnhgp 4 ln so vi Plasmin) c kh nng tiu tn (phn gii) Fibrin, bnhthng ha hot ng lu thng trong ng mch, mu huyt tr li trngthi lun chuyn t nhin sau khi cm c mu nh nhng si Fibrin hmli, lm ng mu (vt thng) gip c th khng mt mu qu nhiu (bnghuyt).

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*Si Fibrin

Fibrinogen l mt cht c trong huyt tng (yu t ng mu) chu tcng ca Enzym thrombin sinh ra mt loi protein khng ha tan gi l


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Fibrin trong giai on cui ca qu trnh ng mu. Mc Fibrinogen bnhthng trong huyt tng l 2-4 g/l

Hot tnh phn hy Fibrin c duy tr bnh thng trong cn bng ni mbi mt s cht c ch tun hon. S dng thuc tan huyt khi ngoi sinhlm hot ha h thng th tiu Fibrin bnh thng qua nhiu con ng khcnhau, tt c nhng con ng cui cng dn ti vic bin Plasminogenthnh Plasmin, c tc dng phn gii huyt khi trong vng 24-48 gi saukhi tr liu.

C 5 loi thuc tan huyt khi (FDA Hoa k):

-Alteplase (t-PA) c ngun gc t ti tng hp DNAngn nga AMI(Nhi mu c tim cp) l thuc tan huyt khi c hiu, khng gy hiu ng

phn hy ton thn m ch tp trung vo v tr hnh thnh huyt khi (nghal chng kt hp chn lc vi Plasminogen gn vi Fibrin) nhng ch ltng i, vi liu cao vn c th gy hiu ng khng mong mun.

-Streptokinase c ngun gc t cu khun tan mu Betangn nga AMI.

-Urokinase (UK) c ngun gc t cht tit t bo thn ngi (nc tiu)tr huyt khi tnh mch su, nghn mch phi

-Tng hp hot ha Streptokinase Plasminogen Anisoylat ha (APSAC)

ngn nga AMI.-Tenecteplase, mt dng bin i Plasminogen thnh plasmin c hiu quhn t-PA v Alteplase l d dng v dng vin tim tnh mch thuc quanhanh qua 5 giy c th lm tng hiu lc ca vic iu tr sm nhi mu ctim cp.

Trong Streptokinase l mt hot cht Plasminogen ph bin nhng gyphn ng ph l c kh nng phn hy h thng (ton thn), tim tng cmng lm tng t huyt khi thng qua vic tng gii phng Thrombin ( t

huyt) c gi l hiu ng tr ng tr li lm chm tc tan huyt sm.Urokinase v Streptokinase thuc cng loi thuc nhng Urokinase t hnrt nhiu v vy Streptoninase thng l thuc hng u dng iu trAMI.

iu ng lu Chy mu lin tc l bin chng nguy him nht ca tr liulm tan huyt khi, gi l hin tng bng huyt (khng cm mu). Chy


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mu do tr liu lm tan huyt khi c th gy chy mu ni tng nh hocnng. Chy mu t pht t nghim trng bao gm cc hin tng nh t mu

b mt, i ra mu, chy mu rng li v ho ra mu. Chy mu t pht nngbao gm chy mu no, sau mng bng, sinh dc tit niu v ng tiuha. Chy mu thng xy ra nht ti cc v tr lun ng thng (Catheter)

bm thuc hay rt dch hoc v tr chc tnh mch.

Hin nay Wafarin (mt cht dn xut Coumarin) l thuc chng ngng ung c s dng rng ri nht v l liu php l tng iu trhuyt khi tnh mch su cp v tc mch phi cp. Wafarin c xem lloi thuc l tng phng nga t qu cho bnh nhn rung nh, ri lonchc nng tht nng v bnh van tim.Tuy nhin cc bc s chuyn khoa ti

Nht bn khuyn co l khi s dng Wafarin cha bnh, chng ng mu(huyt khi) th trnh n Natto v Vitamin K s cn tr tc dng ca thuc

nht l nhng bnh nhn c huyt khi tnh mch.

Qu trnh ng mu l s tng tc v chuyn ha phc tp ca cc t bo,protein v cc hormon ti ch. Ri lon ng mu v ngng kt tiu cu lmtng nguy c huyt khi v cc bin c tc mch, ti tc mch sau iu tr tithng mch vnh. u tin thnh mch vnh (ni mc) b tn thng gii

phng Thromboxan kch thch kt tp tiu cu. S hnh thnh nt tiu cul giai on u tin trong hai giai on ring bit ca qu trnh hnh thnhcc mu ng v c l l giai on ch yu lm ngng chy mu. Giai onhai bao gm mt chui phn ng phi hp sn sinh Thrombin, Thrombin

xc tc chuyn Fibrinogen thnh Fibrin. Cc t bo hng cu dnh vo lisi Fibrin cui cng hnh thnh cc mu ng thc s. Ni chung, huytkhi tnh mch gm c si Fibrin v cc t bo hng cu, trong khi huytkhi ng mch c hnh thnh t s kt tp tiu cu. V vy cc thucchng kt tp tiu cu c dng ngn nga huyt khi ng mch cncc thuc chng ng c s dng ngn nga huyt khi tnh mch.Aspirin l cht chng tiu cu (huyt khi ng mch) hu hiu tuy nhinc nhiu phn ng khng mong mun nh lm long mu, xut huyt nimc bao tnu dng trong mt thi gian di. V vy Bc s chuyn khoa

thng cho bnh nhn ung Aspirin liu thp (81 mg) nga bnh huytkhi tch t trong mch mu, tng cng lu thng mu huyt cho nhngngi c huyt p cao. i vi ngi khng dung np c Aspirin th thay

bng Clopidogel . Kt qu lm gim t l t vong, nhi mu c tim, tai binmch mu notng t nh Aspirin.


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Cc tc dng ph ch yu ca cc thuc lm tan huyt khi l chy mu, dng ( nh Streptokinase lm tt huyt p, lon nhp tim, nhi mu c tim ti

pht) v au tht ngc. i vi thuc chng tiu cu, c Aspirin vTiclopidin u gy nhim c mu nhng gim bch cu trung tnh l mi longi ln nht khi dng Ticlopidin.

(4) Bnh ng mch vnh dng ch tnh trng bnh l khi ng mch(M) b hp li (hoc tc nghn) tnh trng hp hay tc nghn lng M v lx va M. Khi lng M vnh b hp li n mt mc no th dngmu n nui tim s khng dn n tnh trng thiu mu c tim. Huht cc trng hp bnh M vnh l do x va M gy nn. Nguyn nhn

bnh l th cha r v vy ngi ta dng khi nim l yu t nguy c ca bnh M vnh: HA cao, ri lon lipid mu (LDL cao, HDL thp,Triglyceride cao). Hp lng M vnh s gy ra tnh trng thiu mu c tim,

bnh nhn b au ngc, suy tim, ri lon nhp tim v nguy c b nhi mu ctim cp. Khi mng x va ng mch trong lng M vnh v ra th s lmbt tc hon ton M vnh v gy ra thiu mu c tim trm trng cp tnh,hoi t c timcn c gi l nhi mu c tim cp v t l a n tvong rt cao. Chng trnh iu tra ca i hc Harvard vo nm 1989 trn20,000 Bc s Hoa k, kt lun rng vi 1 vin Aspirin liu thp c th gim

bnh tim mch n 44% nh tc dng lm long mu (tan vn mu trongng mch) v vy thuc tr nhc u nh Aspirin 81, Clopidogel hay Plavix(hn hp gia Aspirin v Clopidogel gi rt t, gp nhiu ln) u cs dng cho ngi c nguy c tim mch hay huyt p cao, trc khi canthip bng cch bng cch nng mch vnh qua da hay phu thut bt cumch vnh (by-pass), t Stent.

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Cc chng bnh khng ly lan v vai tr ca dinh dng

*Tim mch v tai bin git 12 triu ngi/nm* c lng c 177 triu ngi b Tiu ng tp 2(Trong 2/3 l ngi mc bnh l cc nc ang pht trin)* Hn 1 t ngi tha trng lng (bo ph)* Cao huyt p (CHA) khong 600 triu ngi trn ton th gii,13% b t vong v 4.4% b tt nguyn 2/3 s ngi b tai bin ldo huyt p cao, thng nh hng n tim mch, suy thn vtai bin mch mu no* M trong mu cao tng nguy him cho bnh suy tim.18% ngi


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b tai bin v 56% b suy tim , 7.9% ngi b t vong v m trongmu cao.*n t tri cy, thiu rau xanh s lm tng nguy c b ung th, suytim v tai bin.

Ngun: WHO, s liu v cc chng bnh mn tnh v chin lc ton cu(2005)

Bng 1. Nng cao sc khe gim t l tai bin mch mu no.Ngun: Tai bin Mch mu No PGS.TS Nguyn vn ng theo DennisM. Warlox C.P Strategy for Stroke 1991 (Medical Jounal 1991)

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Phn 2 - Natto l g ?

Natto l nhng ht u nnh luc chn c vi Enzim (Bacillusnatto) mt mi trng 40C trong vng 14-18 gi ln men thnh nhnght u c mu nu, nhn nht cao v bn (cha nhiu Acid Glutamic),c mi nng nc (ca nc tiu) rt kh chu vi ngi khng quen. Theokinh nghim ca nh sn xut cho bit khi nht cng cao th cht lng

Natto cng tt v v cng ngt. L mt mn n dn d rt ph bin nng


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thn Nht bn, h thng n cm sng vi Natto, nc tng vi rong binphi kh (Nori) v trng g sng. Ngy nay Natto cn c ch bin trongcc mn n xo nu vi tht, lm sandwich kp natto hay bnh m gi l

Natto-burger (!) .

Natto l mt c sn thin nhin, khng qua ch bin (nu, xo, hp ) vvy nhng t cht b dng cho sc khe u c gi nguyn vn trong enzym Nattokinase l mt hot cht sn sinh trong qu trnh ln men tnhin c xem l hot cht c hiu qu trong vic ngn nga cc chng

bnh tim mch--mt pht hin v cng l th bi nh nghin cu sinh l hcNht bn ni ting, GS Sumi Hiroyuki vo nm 1980 (xem phn 3).

T trc n nay, c nhiu thc n t u nnh ln men nh cc loi Tng(miso), Chao.. bng nhng con men nh Aspergillus, Rhozipus hay

Actinomucos nhng ch c Natto l ln men t vi khun (active proteaseenzymes) Bacillus Subtilis c trong rm r v c gi ph bin l BacillusNatto.

Natto l ch ghp ca Nat (np) v To (u) vi ngha l u nnh lnmen ngy nay, xut hin Nht vo nm 1068 . u nnh ngoi lmthc n, l loi u dng cng dng c Pht (nasshonp vo cha)trong nh cha v a vo bp ch bin thc n cho tng l, ni s . Ngynay vo ngy lp xun (tt c truyn theo m lch) ti Nht bn, cc chathng qung ri nhng ht u trc cng chnh cho khch hnh hng

n ving, hay cc c ln tui vn gi tc l nm ht u nnh trc ca tr t ( ma qu), rc hn (may mn) vo nh.

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Pht hin ra Natto

C 5 truyn thuyt ch yu c lu truyn cho n ngy nay:

1) Du nhp t Trung Hoa:

Vo nm 754 nh s Ganji ca Nht bn sang Trung Hoa hnh o v khitr v mang theo khong 5.5 tn bnh u nnh ln men (khng pmui) v t pht trin thnh mt mn n trong nh cha di tn

Natto. Ngi ta c bit hn 2000 nm trc ngi TQ ch bin ra mnu h ln men c tn l TAN-SHIH (bnh tu hmm mu sng) hay KAN-SHIH (bnh tu h ngt) m ngy nay vn cn lu li qua dng tng bng


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u en. Qui trnh lm ra Tan-Shih c ghi li trong sch v Nng nghip Trung quc Chi-Min Yao-shu u tin vo nm 535 trong thut lirng u nnh c nu chn, phi trong phng m ri gi trong rm v ln men t nhin thnh Koji, sau ra li bng nc sch, ly xc quncht bng vi trong nhiu ngy, cui cng phi kh hay sy kh lmthnh bnh. Trong rm hay r c cha loi enzim Bacillus Subtilis v d lnmen trong iu kin nhit cao (40C) v to ra cht nhn, mi hi nh k.

2) Thuyt Thi Yayoi Nht bn:

Thi i Yayoi (300 BC-200 AD) l thi k nn nng nghip ca Nht bnc nhng bin chuyn quan trng. Ngi ta pht hin ht u nnh nhng a im khai qut kho c thi i ny mt s a phng (tnh

Akita ng bc, Yamaguchi hay Shizuoka pha Nam) cho thy ngiNht bit trng v n u nnh t rt sm. Bn yu t lm thnh Nattoxa kia t thi Yayoi hi : u nnh, rm r t vic trng la, vi khunln men v thi tit nng m vng ng bc Nht bn. S ngu nhin giavic nu chn u nnh ri qun vo rm r trong iu kin nng m ( lnmen) c th c gii thch bng

(1) thi Yayoi ngi Nht xy nh c l si gia nh (tate-ana) v c thiquen nu n trn l si (amado) gia nh ri phi trn trn nh thc n dtha chung quanh bp v nh vy ch qua mt m l nhng ht u c

nu chn gi ct trong rm tr thnh Natto

(2) nhng ht Natto c mi kh chu ny trc tin l c dng lm thcn cho nga trong chung

(3) nhng ht u chn sch s th c em vo nh cha cng dng n Shinto nhng v tnh khi chuyn ch bng rm c qun cht dy bn

bng tranh (kamidana) to xc tc ln men cho nhng ht u nnh bntrong v bin chng thnh Natto. Nhng nhng huyn thoiny cng chac ti liu no chng minhtr ch Natto trong Nat l cng np(hay cng dng) cn To l ht u.

3)Thuyt Thi t Shotoku tnh Shiga (vng trung b NB, pha ng thnhph Kyoto)

Tng truyn rng thi t Shotoku vo u th k th by i nga qua ngni Omi v gh li qua m ti lng Warado, vng trng nhiu u nnh.


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ng ta cho nga n nhng ht u ( nu chn) d tha, gi trong rm vtreo cnh cy. Ngy hm sau nhng ht u ln men thnh Natto v khing cho thm mui nm th th thy ngon ngt v dn lng bt chc snxut ra mn Natto c o ny. T i tn lng thnh lng gi bngrm (Warazuto Mura) v thc t l lng ny l ni sn xut Natto chon nhng nm 1920. GS Ota Teruo cho rng Thi t Shotoku hc cchln men t mt v s ngi Triu tin, bn thn ca ng ta tn l Keiji, kthut len men u nnh trong khi Thi t theo ng hc o pht. Tt c cctruyn thuyt khc v Natto u ni rng Natto xut pht t cc tnh minBc NB.

3) Thuyt Hachiman Taro Yoshiie (ph bin nht)

Hachiman Taro Yoshiie l tn gi thn mt ca Minamoto Yoshiie, mt

Samurai ni ting con ca lnh cha Minamoto no Yoriyashi thi Heian caNht bn. Yoshiie l v tng anh hng trong cuc chin ko di 9 nmZenkunen (1051) v trn chin 3 nm Gosanen (1083) trong nhng cuc dplon cc s qun min Bc. Nng dn vng ny ng ln v ngho i,chng li su thu, tht ma v nn gi rt v vy triu nh Kyoto vic tng Yoshiie, cha ng ln min Bc khng ch. Trn ng t Kyotoln Edo (Vng Tokyo v ph cn) ngon ngho dc theo nhiu tnh ngho(Oshukaido). Tng truyn khi on qun ngng li nu u nnh cho ngan th b tn cng bt ng nh vi v qun u trong gi rm ct cht volng nga. Ngy hm sau hay sau na, thy gi u m hn (v thn nhit

ca Nga) v bc mi khng khip do ln men nhng n nga n rt ngon.Binh lnh t m nm th th pht hin y l mn n b dng, mau tiu vnhun trng khng b snh trng hay to bn.

Mt giai thoi khc k rng khi tng Yoshiie n thnh ph Iwadeyama Miyagi (tnh vng ng bc) thng trn Zenkunen (Trc chn nm) thtng qun cho rng nh n Natto ca dn lng dng ln m thng trn v t Natto tr thnh c sn ni ting ca lng Iwadeyama t thi k giaEdo. 32 nm sau Yoshiie tht trn Gosannen, b bt ti Sankanbu tnh Akita.

Trong thi gian chin u ti y Yoshiie nu u cho nhng nng dnngho i v vi vng gi vo l tranh, nng dn ngc nhin v my ngysau u bc mi hng v nhn nht nhng v i nn n ngon lnh v t Natto tr thnh mn n b dng ca ngi Nht bn n ngy nay.Cui cng chin thng tr v Kyoto mang theo k thut ch bin Natto vvy con ng v ca ng c gi l con ng Natto pht xut t lngYokote tnh Akita min ng bc sang cc tnh Yamagata, Sendai,


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Fukushima, Haizu,Mito, Urawa (Saitama),Tokyo, Kofuv cui cng lTanba (gn Kyoto), ni ni u c ph bin k thut sn xut Natto v trthnh c sn ni ting sau ny Cu chuyn huyn thoi v tng qunHachiman Taro Yoshiie tr nn mt tc phm truyn khu bt h cho nngy nay.

Ngoi giai thoi va k, chung quanh Natto cn c nhiu giai thoi nhHong tr thnh nh s Natto khi nh vua Kogen (1331-1333) b ngaivng ln ni i tu v ch bin u nnh thnh Natto (u nnh nu chn givo rm ln men) nh vy cc cha vng Yamaguni hay Kyoto cng cho ra i nhng c sn Natto ni ting nh Tanba Natto hayYamaguni Natto.

Vo thi i Muromachi (1338-1573) ngi Nht bn bit cch ch bin

Tng (miso) v cc loi nc tng (shoyu)mt loi nc chm-- t htu nnh hay en nh vy cch lm Natto cng thay i t nhiu bngcch gia v thm tng thay v mui, c bit trong nh n thin hc, cc vs s dng rt nhiu loi tng, u h v Natto trong ba n (ShojinRyori) nh vy Natto cng tr nn ph bin trong gii Samurai, s si haytng lp qu tc. T th k th 17 (thi Tokugawa) Natto tr nn ph

bin rng khp, Mito (tnh Ibaraki) l ni sn xut ra nhiu loi Natto niting lu truyn cho n ngy nay. Ngay Tokyo vo nhng nm 1970,ngi ta cn thy cnh bn do Natto v u h bng xe p trong cc khu

ph ngho, tr thnh mn n sng ca gii bnh dn, rt tin li v ch cn

natto vi cm nng v nc tng l c th xong ba cm sng hay thmmt t tng (miso) cho vo Natto thnh bt canh nng (natto-jiru) cho bacm ti.

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Gii m nhng b n chung quanh Natto

Nh khoa hc u tin nghin cu v s b n ca Natto l tin s K.Yabe,mt chuyn gia v vi sinh hc cng b nhng kt qu tm ti ca ng v sln men ca Natto vo nm 1894, ghi li rng Natto, mt loi pho-maithc vt gii thiu vi cc nc phng ty vn rt quen thuc vi ccloi ph-mai t sa b hay sa d. Trc Abe, cha c mt ai tm hiunguyn nhn ti sao Natto c th ln men t rm r bc quanh, qu l mtiu k b. Vi kin thc v vi sinh vt, TS Abe cho rng u nnh nu chnchc chn c ln men bng mt loi vi sinh vt no v vi phng


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php trch ly, Abe tm thy 4 loi vi khun (ba loi thuc h Micrococciv mt loi Bacillus) gip cho u nnh ln men d dng (ng ta phthin Bacillus subtilis l loi men gip cho u nnh nu chn ln men(nhng khng xc nh l mt loi enzym c trong rm r bc quanh

Natto). Nhng khm ph ny v mt khoa hc ca Abe gy c tingvang v nh gii chuyn mn xc nh c tnh cht c bit v dinhdng ca Natto v phng din vi sinh.

Qun i Nht bn trong thi chin tranh Nht-Nga (1904-05) phi nngy 3 ba bng Natto vi cm nh vy binh lnh gn gi c sc khekhng b au bng, tiu chy hay to bn trn ng hnh qun.

Vo nm 1905 TS Shin Sawamura (i hc Tokyo) thnh cng trong victch 2 loi vi khun Natto t u nnh nu chn, trong vi khun gy ra

mi hng c bit lm ht u ln men (Bacillus natto) cng nh vi khunto cht nhn rt do dai (Bacillus mesentericus vulgarus) to v ngt. T, khng nh c loi enzym---qua nhiu kim chng trn cc loi nattokhc nhau--- Bacillus Natto do TS Sawamura tm thy l chnh xc. Bacillus

Natto ng ngha vi Bacillus Subtilis trong thut ng ngy nay. Nhiunghin cu cho thy ngi ta dng nhiu loi men tng t sn xut

Natto nhng tt c u tht bi, sn phm Natto ny khng c mi v donh Natto sn xut bng loi men t rm r, iu gip cc nh khoahc Nht bn xc nhn c rng con men to ra Natto phi l mt loi mencc c tnh khc vi loi men Bacillus Subtilis tuy rng cng h.

S d cc nh khoa hc NB ct cng nghin cu v thc phm c ony v cho rng y l mt thc n gip con ngi sng lu, gi gn csc khe trong c 4 nh nghin cu n hng ngy natto, sng n 80.4tui vo nhng nm 1900 l bng chng c th. Nhng kt qu nghin cusau ca GS Muramatsu Shisuke (trng Nng nghip Morioka) trch lyc 3 loi Bacillus c trong Natto to ra mi v hng v cho Natto nhngng xc nh nhng enzym Natto ny giu protein v cht tinh bt gip chotiu ha d dng cng nh hp thu c dng cht t thc n khc nh vi

khun natto c trypsin v diastase (enzyme). Vic tm ti sn xut theoli cng nghip sn phm Natto c nghin cu lin tc cc trng ihc Nht bn (nh GS Hazawa Jun H Hokkaido) ng dng cc loienzym c tnh nng tng t vi enzym t rm r phc v qun i vinchinh Nht bn Mn chu, Trung quct nm 1919. T , Natto trthnh thc phm ch yu cho qun i vin chinh trong th chin th hai vngy cng ph cp n nhn dn. Qua thng k chng ta c th thy t mc


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tiu th Natto 39,000 tn nm 1958 tng vt ln n 170,000 tn/nm 1982chng t Natto tr thnh lng thc dinh dng m bnh qun ngi

Nht s dng 1.42 kg/nm (v hin nay l khong 2 kgs/nm).

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Hiu qu dinh dng ca Natto--thc phm chc nng

Khuynh hng ngy cng tiu th sn phm Natto v tin rng Natto khngnhng l thc n r tin d tiu, nhiu protein v khng gy hi nh cc loithc phm ch bin cng nghip (n lin) mc d mi hng (do vi khunPyrazine gy ra) ca Natto vn gy kh chu, cc k kh ngi . Bn thnngi vit bi ny Nht trn 40 nm nhng cng khng th lm quenvi mi c bit ca Natto mc d vn bit y l mt thc n bnh dn c

dinh dng cao. Nhiu anh em Vit nam phi b chy lnh xa khingi bn Nht (trong c x) bn cnh m np gi Natto ra n. iu khcthng l nhng ai quen hay chu c th ngy cng nghinmn nymt cch l lng nh ngi Php ghin ph-mai ln men xanhRoquefort nng mi vy.

y cng l im yu m cc nh sn xut thc phm ra sc khc phc bngcch (1)Pha trn vi ht d (2) hun khi, sy kh vi cm la mch (3) thmCalci (4)Natto vi loi rong to giu Vitamin B-12 hay (5) Pha trn Natto vgo lcv c nhng pht biu nh gi kh tch cc ca gii chuyn

mn vo nhng nm cui v thp k 1970 nh nghin cu ca GS Kameda(H Y khoa Kanazawa) v hiu qu ngn nga nhim c, t bo ung th,kim loi nng ca Natto trn c th chut hay nh tng kt ca GS Ohtathuc vin nghin cu Thc phm quc gia (NB) rng c nhiu chng cqua nghin cu c bn cho thy hiu qu ca Natto nh ngn nga bnh kitl, tiu chy v nhim c ng rut hay gim bogia cc nh chuynmn mc d cho dn nay vn cn nhiu tranh ci nhng r rng l ngi n

Natto khng b y hi, trng bng nh khi n cc loi u khc, c nghal enzyme natto c kh nng l mt hot cht c ch khng th ph nhn.

Trc khi i vo chi tit dinh dng c bit v kh nng ngn nga ccchng bnh tim mch ca Nattokinase, chng ta hy lt qua nhng ctrng tng qut ca u nnh.

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c trng ca u nnh


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u nnh l loi u c xem l ttnht trong cc loi ng cc nhnhng c tnh dinh dng sau:

- Protein (35-45%) gm cc loi Acid amin c bn (Isoleucine, Leucine,Lysin, Methionine, Phenylamin, Tryptophan, Valin)

Isoflavones (cht Genistein) l mt estrogen thc vt ngn ng mu trongng mch, chng xp xng, gip cho hot ng ca no b cho Nam lnn di 4 dng: Aglycone, Daizein, Genistein v Glycitein. Mi ngy c thcn 50 mg Isoflavones (tng ng vi ming u ph hay 30 gr unnh rang) l cht khng b tiu hy trong qu trnh ch bin, nu nngthc n . Isoflavones c l gii nh mt hot cht chng Oxy ha, ngncn cc gc t do (free radical) tn cng LDL, gip c th gim Cholesterolxu (LDL), tng o thi chng ra ngoi v lm gim nguy c suy tim mch.

- Cht bo (15-20%) trong acid bo bo ha thp (13%), khng ccholesterol (acid bo khng bo ha 30%). Lng acid bo khng no cnthit nh acid Linoleic 50% v 7% Alpha Linoleic acid l ngun cung cpacid bo chui mch di Omega 3 (pht trin no tr em) quan trng cho cth nh DHA ( Docosa Hexanoic Acid) v EPA (Eicossa Pentaenoic Acid)c hiu qu trong vic tr cc chng bnh v tim mch, ung th v nhiu

bnh khc.

- Glucose (15-25%)

- Cht v c, mui khong nh Ca, Fe, Mg, P, K, Na, S (5%)- Nc (8%)- Vitamin: A, B1, B2, D, E, F. Globulin, cellulose

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Nhng hiu qu tng qut t u nnh

Trong bi Thc phm chc nngC m mi (1) chng ti ni qua v

u nnh, mt trong nhng ng cc c Vua Thn Nng (nm 2838 BC) Trung quc xp vo loi dinh dng c bn v gi tr ca u nnh qua kinhnghim hn 4000 nm ca cuc sng con ngi c chng minh tuynhin mi n nm 1970 th hng lot nghin cu khoa hc v u nnhtrong vic ngn nga cc chng bnh trong y khoa mi c tp trung quanhiu kha cnh. Kh nng phn tch nh tnh cng nh nh lng ccthnh phn ha hc, bnh l v chc nng khc phc ca u nnh dn c


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sng t khi iu kin phn tch ha l, cn lm sng v lm sng trong kthut nghin cu y khoa v ha sinh c nhng bc pht trin vt bc.Trong ng y, u nnh c v ngt, bi, khng c (lnh tnh) gii nhit,iu ha ng tng, b nguyn kh, thng li 12 kinh mch. Trong tn gio (

Nht bn), u nnh c dng xua t kh v vy nh cha thng tungu nnh vo ngy 1 thng 2 hng nm (tt m lchgi l Xun phn--Setsubun) trc cng vo dp l (mamemaki) nh mt php l lm schchn thanh tnh. Cc v cao nin thng tung nhng ht u nnh ra khica, h to Oni wa sto, Fuku wa uchi (Qu ma ra ngoi, phc lc vo nh).

-Ci thin xng

Sn phm i t u nnh nh sa u nnh khng c nhiu hm lng calcinhng Isoflavones c th ngn nga chng long xng hoc xp xng.

Nhiu nghin cu cho thy Isoflavones trong u nnh c kh nng nh mthormon n tnh (estrogen) thc vt c hiu qu duy tr nhng t bo xngthm vng chc. Cc nh nghin cu i n mt kt lun kh chcchn rng Estrogen thc vt (Isoflavones) c tc dng tch cc n xngtrong ph n thi k mn kinh, lm cho xng chc hn, trnh b xp vnh vy m gim nguy c gy xng. y l cch iu tr an ton, r tin vc hiu qu nht.

-Gim cc chng tin mn kinh

Thng k cho thy ph n chu b thng hnh nh bc ha, m hi trm(khi ng) hn ph n chu u trong thi k mn kinh. Nhng chng tinmn kinh hin r trong thi k hormon n tnh gim bt giai on tinmn kinh. Khi mn kinh c th khng cn sn xut ra hormon n tnh(Estrogen) gy ra mt lot bin i tm sinh l trong c th ngi ph ndn n mt s bin chng nh long xng, tiu ng hay ung th (vhoc t cung). Hormon n tnh gi vai tr iu ha hot ng sinh hc (kc hot ng tnh dc ca n gii) trong c thn nhit v vy nhngIsoflavone ca u nnhtng t nh Estrogen do non so sn sinh cnthit pht trin c quan sinh dc n-- c kh nng khng ch cc chngtin mn kinh. V vy, u nnh c xem l phng php tr liu an tongip ph n vt qua thi k ny thay v dng cc phng php tr liu bngHormon thay th (Hormone Replacement Therapy) c nguy c gy ung thcao. Qua kho st ngi ta pht hin rng ngi ph n Nht bn b tcng ca cc chng tin mn kinh (4% phi dng HRT tr liu) thp hn

ph n ngi M (phi tr liu bng HRT l 30%), t b nng bng (bc ha)


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nh i sng n ung nhiu sn phm u nnh . Mt nghin cu khc trn22,000 ngi ph n Nht bn thc hin vo nm 2003 chng minh rngch n giu Isoflavone c trong Miso (sp tng Nht) hay Natto s gimdn 50% nguy c b ung th v.

-Gim nguy c suy tim

Cc nh khoa hc Nga kho st cht m c trong u nnh lm gimCholesterol v Triglyceride trong mu t u th k 20. Lames W.Anderson, chuyn gia v ni tit cho bit n 30 gr/ngy u nnh s lmgim 13% LDL (xu) trong khi HDL (tt) khng i nh tc dng ca acidamin, c bit l 2 cht Glycine v Arginine. V vy ngi dn cc nc tiuth nhiu u nnh c t l suy tim thp hn cc nc khc v u nnhngn nga c cc bnh tim mch do lm gim cht m (Cholesterol)--loi

Lipoprotein nng thp hay cn gi l Cholesterol xutrong mu, lnguyn nhn gy nn chng huyt khi, x cng ng mch hay nguy himhn l chng x va ng mch gy nn t vong. Cc Isoflavones ca unnh gip cho ng mch c n hi, tim co tht nhp nhng v u nhn. Mc d t l t vong v suy tim, xut huyt hay t qu ca ngi Nhtthp hn ngi u m nhng thng k cho thy 60% b t vong Nht ldo nhi mu v xut huyt no v vy nn n nhiu Natto l iu thngc cc bc s khuyn bnh nhn. Cng ln tui th hin tng b ng mucng cao khi lng plasmin gim enzym duy nht trong c th c kh nngtrc tip tiu hy si fibrin-- lm tan mu vn cc trong ng mch.

-Ngn nga mt s bnh ung th

Nhiu nghin cu cho thy n nhiu sn phm i t u nnh s ngn ngac cc loi bnh ung th do hormon gy ra nh Ung th v (Ph n), ungth tin lit tuyn (nam) hay ung th ng rut. Nht bn ngi n ngn u khun (tu h) 5 ln/tun c t l b ung th tin lit tuyn (prostatecancer) thp hn khong 50% so vi n ng n u khun 1 ln /tun hay thn v ngi dng sp Miso (canh tng) t b ung th d dy hn nhngngi khng dng u nnh. Tng t Trung quc ph n dng thc

phm u nnh (di 1 ln/ tun ) c t l b ung th phi v ung th v caogp 2 n 3,5 ln so vi ph n dng hng ngy. Nhng kt qu nghin cuv tc dng ca u nnh v cc chng ung th u i n kt lun t l cangi dng thc phm c cha Estrogen thc vt c t l ung th thp hndn tc hp thu nhiu cht bo cao, nhiu m ng vt v t tiu th cccht si (fibre).


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amin ca nhng ng cc khc. u nnh cn l ngun ca Lecithin vVitamin E l nhng hot cht chng oxy- ha thin nhin ngn chn tc hica Cholesterol nng thp (LDL) mt khc u nnh li giu Magnesiumgi vai tr quan trng cho xng, tim mch v chng x va ng mch.Hn th na u nnh cn c tc dng rt tt cho Thn thc hin chc nngca mnh (ph thi cht b do chuyn ha ca m, ph thi nc, khongcht d tha trong c th, c t trong thc phm). m thc vt c trongu nnh thay th m ng vt (t tht) lm cho Thn lm vic t hn,lng protein trong nc tiu gim, ngn nga nguy c sn thn. Ti hingh quc t v dinh dng t chc ti New Zealand (30/4-3/5/2006) GSMasafumi Kitakaze khng nh Natto c tc dng lm gim r rt ccchng M (Triglyceride v Cholesterols) trong mu cao qua nghin cuchung ca 4 c quan y t Nht Bn, ku gi cng ng th gii ci thin npsinh hot (Lifestyle) v tiu th Natto thin nhin trc nguy c bo ph do

tha dinh dng v cc chng bnh him ngho, nan y (tiu ng, ungth) ngy cng tng khp ni trn th gii.

Tuy nhin gn y, mt s nh nghin cu ti hi ngh o cho hayEstrogen c trong u nnh c nguy c lm suy yu tinh trng ca nam gii,kh c th gip non so th tinh trong c th ph n (BS Chris Barratt, ihc Birmingham) v tinh trng rt nhy cm i vi Estrogen nhn to trongqu trnh th tinh. Nhng y l kt qu so snh gia Estrogen thin nhinv Estrogen nhn to i t mi trng vi ch s tinh trng ngy cng gimtrn c th v vy s khng nh v tc hi ca nhng IsoflavonesEstrogenthc vttrn tinh trng mi dng li mc cnh bo, gii hc thut chtha nhn Isoflavones c tc dng ngn nga chng ung th tin lit tuyn nam gii. Tuy nhin iu ny khng phi l khng c l khi nhng nh tuhnh (Pht gio) s dng u nnh lm thc n ph bin, xem l mt bin

php dit dc c t nghn nm nay, l ngun thc phm ch binnhiu mn n chay hay gim m hin nay. Ngoi ra cn c kin cnh bomt tri ca u nnh l cht Hemaglutinin trong u nnh c kh nng lmcho hng cu b vn, gim hp thu dng kh hay tc hi n chc nng catuyn gip nu n thng xuyn trong nhiu nm tuy nhin nhng pht biu

ny cha c gii chuyn mn tn thnh, cho rng cc phng php chbin u nnh thnh thc phm mi l nguyn nhn ch yu chng hn nhlng kim cn st khi ngm u nnh, to ra Lysinealine gy ung th trongkhi un si (luc), gy trng chng bng, ng thi kh i cc tc nhntch cc nh Genistein hay Daizein.


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Bc s Nguyn Vit Tin, Gim c Bnh vin ph sn Trung ng (VitNam) khuyn Ph n chun b c thai khng nn n nhiu thc n ch bint u nnh. Hp cht Genistein trong u nnh c tc dng tiu dit tinh

binh trc khi chng kt hp vi trng (non so) da theo kt qu camt nghin cu trng y t cng cng Johns Hopkins (Maryland M)nhng FDA (M) hay WHO vn cha ln ting xc nhn chnh thc nhngthng tin ny.

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Phn 3 - Pht hin c o ca GS Sumi Hiroyuki

Natto tr thnh mt ti nng hi khi TS Sumi Hiroyuki tung ra nhngkt qa bt ng v hiu qu ca natto trong vic lm tan cc huyt khitrong ng mch--mt trong nhng nguyn nhn suy tim v t vong ca

bnh nhn b cc chng x va ng mch vnh hay t qu v nghn hayxut huyt novo nm 1980. Trong ba cm tra ti nh n ca i hcY khoa Chicago, Sumi ly mt mu Nattomn n quen thuc ca ng--tvo khay thy tinh c cc mu ng th 18 gi sau cc mu ng ny tan rd dng, iu gi rng trong Natto c th c mt (hay nhiu ?)hot cht(fibrinolytic enzyme) c th phn hy huyt khi nh thy phn si Fibrin--l mt enzym ni sinh hnh si-- c kh nng lm ng mu (t mu) ngn chng xut huyt ni. Sumi bt u lu ti vai tr ca nattokinasev Vitamin K2 c trong Natto chng minh n l hot cht gip cho ngi

Nht bn sng lu, lm tng kh nng to ra Plasmin ni sinh gip cho cth trnh c tai bin hay t qu bi huyt khi hay cc chng x vang mch, suy tim bin chng gy nn.Theo kt qu nghin cu ca 3 cquan y t--i hc bang Oklahoma (M), JCR Pharmaceuticals (NB) vTrng Y khoa Miyazaki-- phi hp th nghim trn c th ngi (in vivo)

bng cch cho n Natto 200 gr/ngy v kim chng c nhng hiu ngk trn, c bit pht hin lng Plasmin ni sinh gim st ngi cao tuikhng lm tan huyt khi, vn cc trong ng mch th hiu qu cngr rt. Cc Bc s M thng s dng cc loi thuc cha hot cht lm

tan si fibrin nh Urokinase (t nc tiu con ngi), TPA ( tisueplasminogen activators) t t bo ung th gi l Melanoma (sn sinh enzymplasmin) cn Bc s Chu u li dng Streptokinase l loi protein i t vikhun cha tr bnh huyt khi trong thi k bnh mi pht... nhng hiung ca cc loi thuc ny rt ngn, ch ko di trong vng 20 pht khngth ko di khi bnh nhn ln cn t qu hay tai bin cp. l cha k


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nhng phn ng ph gy, xut huyt, d ng, nn ma, lon nhp tim khidng TPA.

TS Sumi Hiroyuki sinh ti tnh Nara (bn cnh Kyoto) vo nm 1945. Ttnghip Vi khun hc i hc Tokushima, nghin cu Vin MichealRees Chicago vo nm 1980 vi t cch l chuyn gia ca B GD-KH

Nht bn. Sau khi lm ph GS H Y Miyazaki v bnh l hc tr thnhGS Bnh l hc H Kurashiki v l gim c c quan nghin cu xuynquc gia v vi sinh hc. ng cn c gi l Tin s Natto (Dr Natto) ca

Nht bn.

Nm 1986, TS Sumi Hiroyuki cng b ton b kt qu nghin cu v tcdng ca Nattokinase sau khi th nghim gn 200 loi thc phm khc nhau so snh, xc nh Nattokinase l mt loi enzym mang kh nng phnhy huyt khi mt cch hu hiu v mnh nht trong cc loi enzym, gp 4ln Plasminenzym ni sinh lm tan mu ng--ng thi tuyt i an ton

cho c th khi hp th qua ng n ung. Vn l mt nh nghin cu visinh hc, Sumi bc sang lnh vc y khoa nghin cu v Enzymes vy l mt lnh vc pht trin ni tri ca Nht bn. C nhiu loi u (uen, u xanh, ht hng dng) c th ch bin thnh Natto thay chou nnh nhng ch c Bacillus Natto l hiu qu hn c tuy nhin enzymny ch xut hin khi c rm r l iu ng lu . Ngi ta trng unnh t 150 nm trc ti Hoa k nhng khng pht hin ra vi khun lnmen tng t v khng c loi vi khun Bacillus Natto tn ti . Mt khc, tnghn xa ngi ta cho rng Natto rt hu hiu trong vic phng chng bnhcm cm, ng c thc n (kit l, tiu chy cp), lm chc xng., tiu

dit vi trng gy bnh cng nh gip cho ph n mang thai sinh con khekhon. Da trn nhng bi thuc c truyn ny Sumi tm cch chngminh bng khoa hc cho bit Natto c cha Di-Picolinic Acid c th khngch vi khun O-157 nh hiu ng dit khun, hn ch s sinh si ca cc vikhun c hi ng thi thc y loi vi khun c li cho sc khe tngtrng nh vi khun Lactobacillus c trong Natto hay mt enzym ni tinglm tan vn mu ng trong mch mu nh Nattokinase cp trn.


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Kt qu cho thy chng mu ng (huyt khi) trong tim v no gy tai binnh nhi mu c tim hay t qu cao hn c cc chng ung th v vy Nattoc xem l thc phm chc nng tch cc c tc dng lu di vo c thcon ngi nhm ngn nga cc chng tim mch tch cc v r tin nht,thng qua i sng hng ngy hn l tim chch cc loi thuc tr liu trctip c nhiu tc dng ph khng mong mun. Ngoi ra vi hm lngvitamin K2 trong Natto ( c hm lng rt cao 870 micro gr/100 gr ) gipcho xng ca ph n mn kinh chc hn, khng b xp do long xng(Osteoporosis) m 60% ph n tui ny u vng phi. Hin nay ngita cn khm ph ra tc dng ca Vitamin K2 (Menaquinone 7) gip cho vicsn sinh ra mt loi protein c tn Osteocalcin hot ng nh mt cht keokt hp vi Calci trong xng trong khi hm lng Vitamin K2 ca c thngy cng gim theo lo ha. B Y t NB cng nhn tc dng (dc l)chng long xng ca Vitamin K2 v xem Natto l ngun cung cp b

sung Vitamin ny cho c th t Nattokinase. Theo phn tch trong 100 gNatto c cha 1,000 Micro gram Menaquinone 7, ngi bnh thng tiu th1 micro gram/1kg trng lng c th. C ngha l ngi nng 60 kgs cn 60micro-gram vitamin K2 hay 10 g Natto l cho 1 ngy. Hn th na, trong

Natto cn c Isoflavone l mt hp cht c kh nng chng oxy-ha tngt estrogen n gii v FDA Hoa k khuyn co ngi dn nn dng ti thiu50 mg /ngy ngn nga ung th, ngha l mt gi Natto n trong ngy lva . Bnh ung th tin lit tuyn M cao gp 15 ln Nht cho thyi sng n nhiu Natto vn c li cho cc chng ung th V (ph n) hayTin lit tuyn (nam) hu hiu.V hiu qu ca hot ng chng oxy-ha thu nnh ln men c sc mnh gp 4 ln u nnh bnh thng nh enzym

bacillus c trong Natto, tuy nhin c ch phn ng ny cha c khngnh. Trong 1 gr Natto c khong 1 triu-1 t vi khun Bacillus v thc nny c b y t Nht bn xem l thc phm c tc dng cha bnh tiuha t nhiu nm trc. Hin nay thc n i t Natto ph cp kh rngri trn nhiu nc ty phng, c bit l Hoa K, h cho rng y lmt trong nhng nguyn nhn gip cho ngi Nht c tui th bnh quncao nht trn th gii. Tuy nhin nhc im ca Nattokinase l b phn hytrong mi trng 70C v vy vic ch bin bng cch nu chn Natto l iu

nn trnh, tt nht l n sng bng cch pha trn vo cm thm x du nhngi Nht bn thng dng. ngt c trong Natto l nhng AcidGlutamic thin nhin trong cht nhn khi ln men v vy khng nhng gipcho c th hp thu mt lng ng thin nhin m cn gip cho rut tipnhn calci d dng. Trong 100 gr Natto cn c 7 gr cht si v vy y lyu t nhun trng tt, gip cho tiu ha khng b snh hi (trng), tc

bng nh khi n cc sn phm u nnh khc. Ngoi ra enzym Protease c


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trong Natto s gip phn gii cc protein thnh cc loi acid amin nhAmilase bin cc cht tinh bt thnh ng, Lipase phn gii cht bo trungtnh thnh Glycerin v acid bogip cho c th hp th cc dng chtcn thit ngoi hiu qu khc nh gip cho ph n c ln da p, gim cnv cc chng bnh do tui cao nh ni trn nh Lecithin.

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Ngn nga chng tim mch bng Natto: an ton v r nht

Gi 1 liu Urokinase, thuc lm tan vn mu rt t tin, khong 1,500USD/liu v ch hu hiu trong vng 30 pht hay s dng thuc t-PA chiu qu trong 3-6 gi v c gi ln n 2,200 USD/liu , r nht cng l200USD/liu nu dng Streptokinase hiu qu trong vng 12 ting trong khi

100 gr Natto ch l 1 USD c cng hiu qu tng ng ko di 8-12 tingng h v an ton v Natto t c phn ng ph nh Urokinase. Con s thngk mi nht cho bit lng Natto tiu th trn u ngi NB ngy nay l 2kgs/nm v cho ti nay cha c pht hin no cnh bo tc dng ph cngnh Natto l ngun gy d ng. S d nh vy l v Vitamin K c trong

Natto cn c chc nng lm ng mu trong khi Pyrazine v Nattokinase ctc dng ngc li, ph tan mu vn cc v vy c th chng ta c th chnla s dng cc cht ny tng h cn bng lu thng mu huyt mkhng gy ra mt tc dng ph no v gii thch c l do ti sao Nattokhng gy ra s chy mu (xut huyt ni) khng kim sot c nh

trng hp Aspirin. Nhiu bc s tim mch Nht bn cho bnh nhn sdng Natto, n 2 ln/tun thay v Wafarin trong khi ngn chn xut huyt vng mc v kt qu rt kh quan. GS Sumi Hiroyuki khuyn co l bnhnhn tim mch nn n Natto vo ba cm ti ch nht ngn nga mtcch hiu qu nht cc bnh xut huyt no hay ri lon nhp tim thng ckhuynh hng xy ra vo sng th hai. Vi Lecithin v Linoleic acid ctrong u nnhhay sn phm ca n l Nattoth ng mch c co dn(flexible), mu c lm sch gip cho c th ngn c chng x vang mch vnh hay xut huyt no khi HA ln cao thay cho vic s dng

cc loi thuc nh Aspirin (d gy xut huyt bao t) hay Plavix. Nhngthnh qu ca TS Sumi Hiroyuki cng c hai v chuyn gia hai khuvc khc nhau phi hp nghin cu, l BS Martin Milner Trung tm Ykhoa t nhin Portland, bang Oregon (Hoa k) v TS Kouhei Makise thuc

bnh vin Makise Kyoto, cng cng b kt qu qua bi vit trn tp chchuyn mn kt lun rngl chuyn gia lu nm v tim mch v h hpchng ti nht tr khng nh rng Nattokinase l mt pht hin y phn


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chn trong vic ngn nga v iu tr cc chng bnh lin quan n timmch, v chng ti xc nh Nattokinase l mt hot cht thin nhin cth lm tan cc huyt khi hu hiu, khng gy d ng v c an ton caohn c ti, nhn sm Triu tin hay Bromelain (t qu da) thin nhin thcy sn sinh ra Plasmin trong qu trnh thy phn si Fibrin .

Bng 2. Hiu ng ca Nattokinase ln Fibrin

Ngun: Natto and Its active Ingredient Nattokinase (Martin Milner andKouhei Makise)

---o0o---Thay li kt

Theo thng k, thnh ph HCM mi nm c khong 17,500 b t qu do taibin mch mu no) trong 9,000 ngi b t vong, a s cn li l sngkiu thc vt hay mt kh nng lao ng gy bit bao au kh cho thnquyn. Nc ta li l mt nc c truyn thng s dng u nnh trong nung t lu i, sn xut cc loi nc tng v nc chm t u nnhni ting nh Tng lng bn Hng Yn:

Anh i anh nh qu nhNh canh rau mung, nh c dm tng

V hn cn nhiu ngi vn cha qun Tng C H ng, xemtng c l gia bn nh nhng nng dn t x ng bc b. Ngyxa tng truyn tng bn c dng tin Vua v ni ting l ngon,


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hng thm du ngt v nhiu cht dinh dng, c th ch bin ra nhiu loinc chm n km.

Vo nhng nm 1930-40 lng bn c c Thn th Lu kho tay lm tngly thng hiu C Lm m mn cho tng lng Bn rn rp, hi nhp thtrng c nc, cnh tranh vi tng C ( H ng). c bit khc vi

Natto ca Nht bn l tng lng bn ln men t xi (np go ngon nuchn) trong hai ngy vi u nnh rang, nghin thnh bt ri ngm bngnc ma v Cha thiu (xi) m thi (nc ngm u) th lm tng mingon. Bn cnh , nhiu loi nc chm nh x du hay tng chm trongcc mn tht nng, tht xo trn vi cc loi rauphong ph v cn bng

b dng tht tuyt diu. Ngoi tng bn, cn c tng Dc M (Lmthao-Vit Tr), tng Nam n (Ngh An) l mt loi nc chm kh co, dng ht Ng (bp) hay np lm mc c s dng ph bin cc

a phng pha bc nh cc loi mm min nam. Tuy nhin ng tic lnhng lng ngh truyn thng ch bin Tng hay nc tng dn d b maimt v li lm n chp git, tranh dnh ln nhau, khng gn gi tnh chtngon c o hnh thnh t trm nm nay v ln sng thc phm ch

bin n lin nh m, bn v cc mn sp kh chim u th trn th trngtrong np sng ngy cng th ha ln t. Hn th na vic nghin cunhng yu t tch cc cho sc khe t nhng thc phm truyn thng i tu nnh hin nay vn cn b trng, cha thy c nghin cu khoa hc nov mt Ha sinh v bnh l ni v hiu qu tch cc ca cc loi tng nc ta, v vy ngi tiu dng hay nhn dn ni chung vn cn m m,hiu qua li n hay qung co mt cch nh tnh. Hn th na, cc chng

bnh hin i nh cc bnh nh bo ph, tiu ng, tiu ha, ng rut,ung th cc loi ngy cng tng cao, ngi tiu dng ngy cng hng vngun thc phm thin nhin, trong u nnh c xem l ngun mv cht bo thc vt tt nht nh cp trn. Mong rng cc nhnghin cu thc phm, dinh dngca nc ta s tm ti v khm ph tnhng mn n truyn thng ny vi nhng li gii thch tha ng v khoahc gip ngi dn ci thin cht lng cuc sng mt cch hiu qu,gp phn tch cc khng nhng vo vic lnh mnh ha x hi m cn ng

gp vo i sng dinh dng an ton t c sn t ngun thc vt, thy hisn ca Vit nam. Chc hn nhiu ngi ang ch i cc nh khoa hc nc ta khai ph, vi nhng nhng thnh qu nghin cu c o tng tnh GS Sumi Hiroyuki thc hin 20 nm trc y, ngi bin Nattothnh mt ngun thc phm chc nng c gi tr kinh t v sc khe cao vr tin mc d hnh th v hng v ca Natto khng hp dn nh tng bnca Hng Yn . Hng lot sn phm Nattokinase di dng vin, con nhng,


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bt hay ph gia trong thc nc a vo sn xut v rao bn khp ni,m ra mt th trng rng ln trn th gii c hng triu triu ngi angng trc nhng chng bnh nan y v him ngho vi chi ph cha bnh,chm sc ngy cng ln cao khng khip.

Khng l tng bn ca Vit nam ch m thm nm trong x gc tnh l,cn li trong nhng hi k vn hc, l hoi nim (nostalgy) ca nhngngi Vit xa x ?

Thng 6/2008

T liu s dng cho lot bi ny & ti liu tham kho ch yu:

(1) Journal of Agricultural and Food chemistry Vol. 55, No. 26.(2) History of Soybeans and Soyfoods: 1100 B.C to the 1980sWilliamsShurtleff and Akiko AoyagiSoyinfo LaFayette, California(3) TS Nguyn vn Tun: Phytoestrogen v sc khe con ngi (Y dcngy nay)Cholesterol v bnh tim (Y dc ngy nay)u nnh v Sc khe: u l thc v u l gihttp://vietsciences.free.fr/timhieu/khoahoc/ykhoa/soja-phytoestrogen.htm )(4) BS Nguyn thng Chnh: u nnh, Tofu, Phytoestrogen (Y dcngy nay)

(5) BS Nguyn c: u nnh Gi tr dinh dng, tr liu (Y dc ngynay)(6) Tm hiu & phng tr bnh Mch mu noBS V Hi Long/Nguynkim Dn (NXB Ph n)(7) Special Report Nattokinase & Cardiovascular Health Ralph E.

Holworth, Jr., D.O (www.needs.com/Catalog/Cardio1.pdf)(8) Soy, Isoflavones and Breast Cancer risk in JapanYamamoto et al.

Japan Cancer Institute 2003,95 (12)906-13(9) Khoa hc v i sng 28/4/2008(10) The World is paying attention to Natto, which contributes to

Japanese longevityThe department of Physiological Chemistry, Kurashiki University (Japan)

Dr Hiroyuki Sumi(11) NattokinaseRon Kenedy M.D (California)(12) Journal of Agricultural and Food chemistry Vol 55, No. 26.(13) Tai bin mch mu noPGS.TS Nguyn vn ng (NXB Y Hc)


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(14) Bnh tim mchBS Micheal Petch (Hong Minh Hng dch, GS.BSTrn Phng Hnh hiu nh (NXB TPHCM)(15) Bo tng Natto v nh my ch bin c th tham quan: Takano Foods

Factory Tour and Museum in Japan1542 Aza Noda, Onuma-Gashira, Ogawa (phone:0299-58-5101)website: http://www.takanofooods.co.jp/(C th tham quan min ph)(16) Ngh lm tng lng BnNguyn hu ThcVn ha Nghthut(17) n chay khng th thiu u nnhn chay s dit dc Tin tc online(18) Examining the efects of Natto consumption on Lifestyle-relateddiseasesEstablishing Nattos Effectiveness in Lifestyle-related disease

prevention

National Cardiovascular Center (Suita, Osaka, Japan) et al.(19) Natto and Its active ingredient NattokinaseA potent and SafeThrombolytic AgentMartin Milner, N.D and Kouhei Makise, M.D.Center for Natural Medecine, Portland Oregon (Hoa K) v Kyoto

Imadegawa Makise (Kyoto)(20) Bo Sc Khe & i sng (nhiu bi lin quan n tim mch)(21) Lot bi Thc phm chc nngC m mi (ba bi) ca Hng lTh trn trang web Vietsciences hay Ha Hc Vit Nam hoc boSc khe & i sng nm 2007 (B Y t Vit Nam)

nh km theo bi:

1) Nattokinase enzym


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2) Natto

3) Si Fibrin

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Ht

Dau Nanh Va Kha Nang Ngan Ngua Benh Tim Mach - Hong Le Tho

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