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Curcumin (Curcuminoid) as

Hepatoprotective Active

Ingredient of Curcuma species(C. Xanthoriza, C. Longa, etc)

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Curcumin memberikanefek positif terhadap

genotoksisitas liver olehrifampicin dan juga

berefek menekan efekstres oksidatif. Sehingga

curcumin tidak hanyaberefek terapi tetapi

 juga bekerja sebagaiprolaksis kerusakan

liver.

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Mechanism of Actioncurcumi

n

Sharma &A. Phase ' Clinical Trial of oral curcumin biomarkers ofsystemic activity and compliance. Clinical Cancer &es. #(()* +(

&if,'%2,

P3A

A!T

AST

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Curcuma

•CCl0) use as mimicryagent of hepatoto4in invitro

• Curcuma e5ectivelyprotected against CCl)0induced hepaticdestruction

• may prevent thepero4idation of lipids by

CCl). 6ollo7ing theinhibition of lipidpero4idation orupregulation of theantio4idant en8ymesactivity, %609#0relatedfactor # :%rf#; plays animportant role 7hich ishighly e4pressed in

deto4ication organs,such as liver andkidney

  :

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u!ash C, et a". #$%&. 'herapeutic o"es of Curcumin Lessons Learned from C"inica"'ria"s. 'he AA* +ourna", o". %-. American Association of *harmaceutica" cientists

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osage

u!ash C, et a". #$%&. 'herapeutic o"es of Curcumin Lessons Learned from C"inica"'ria"s. 'he AA* +ourna", o". %-. American Association of *harmaceutica" cientists

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'arget 'erapi

u!ash C, et a". #$%&. 'herapeutic o"es of Curcumin Lessons Learned from C"inica"

'ria"s. 'he AA* +ourna", o". %-. American Association of *harmaceutica" cientists

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u!ash C, et a". #$%&. 'herapeutic o"es of Curcumin Lessons Learned from C"inica"'ria"s. 'he AA* +ourna", o". %-. American Association of *harmaceutica" cientists

Hasi" 'erapi

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Penggunaan bersamaan

Curcumin denganAsetilsistein bersifat sinergis

hepatoprotektor danrenoprotektor. =ombinasi ini

 juga dapat mengurangi 9S>Asetilsistein.

/om!inasi Curcumin 0

 Aseti"sistein

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ediaan pada pasien

  osis 1ang diterima pasien 2 & 3a"i sehari, % sendo3 ta3ar

Curcumin 1ang diterima pasien 2 & X # mg 4 hari 2 5 mg 4 hari

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 Ana"isa osis

osis e6asa Curcumin se!agai hepatoprotector 2 % gram 4hari

osis Ana3 2 (77458) X osis e6asa

(C"ar3e9s !od1 6eight ru"es) 2 &:458 X % gram4hari

2 -;$ mg4hari

osis 1ang diterima pasien 2 5 mg4hari

/esimpu"an 2 underdose

e3omendasi 2 /om!inasi dengan hepatoprote3tor "ain di3arena3an dosis

1ang diterima tida3 ade3uat untu3 prote3si, dan !e"um ada sediaan 1g pra3tis

tersedia sesuai dosis hepatoprote3tor.

'inda3 Lan

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*usta3a• utha evara