Celiac disease
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Transcript of Celiac disease
PRESENTED BYPRIYANKA SINGH
Celiac disease
Celiac disease
digestive and autoimmune disorder the lining of the small intestine affected celiac sprue or gluten-sensitive enteropathy
Cause
Prevalence
1% global population affected (Japan south-east Asia exception)
Irish/European or Western disease North Indian population most affected (Punjab, Haryana,
Delhi, Uttar Pradesh, Maharashtra, Rajasthan, Bihar, Uttaranchal, Madhya Pradesh and Gujarat.)
Prevalence rate of celiac disease has been doublingevery 20 years.
The diagnosis rate of celiac disease, only about 5%.
People at risk
RELATIVES OF INDIVIDUALS WITH CELIAC DISEASE (first degree relative more affected)
PEOPLE WITH OTHER AUTOIMMUNE CONDITION (type 1 diabetes , thyroid disorders)
PEOPLE WITH OTHER GENETIC CONDITIONS (down syndrome , tuner syndrome)
Symptom
Multi symptom multi organ disorder More than 200 sign and symptom Children exhibit classical symptom (gastrointestinal) Symptoms are atypical in adults (extra – intestinal)
Symptoms in children and infants
abdominal bloating and pain chronic diarrhea vomiting constipation pale, foul-smelling, or fatty stool weight loss fatigue irritability and behavioral issues dental enamel defects of the permanent teeth delayed growth and puberty short stature failure to thrive Attention Deficit Hyperactivity Disorder (ADHD)
Symptoms in adults
unexplained iron-deficiency anemiafatiguebone or joint painarthritisosteoporosis or osteopenia (bone loss) liver and biliary tract disorders peripheral neuropathy ( tingling, numbness or pain in the
hands and feet)seizures or migrainesmissed menstrual periods infertility or recurrent miscarriagecanker sores inside the mouthdermatitis herpetiformis (itchy skin rash)
Associated medical conditions
Health problems : Osteoporosis Miscarriage or infertility. Birth defects (neural tube defects) Seizures Growth problems Cancer of the intestine (very rare).
Autoimmune diseases: Thyroid disease Type 1 diabetes Lupus Rheumatoid arthritis Sjögren's syndrome
Diagnosis
Blood test * tTG-IgA antibody (tissue transglutaminase
antibody) * total serum IgAt
* Anti-endomysial tests (EMA) * Anti gliadin IgA and Anti- gliadin IgG
antibody tests * Genetic tests – Genetic tests determine the
presence of gene HLADQ2 or HLA DQ8 in an individual Endoscopic biopsy gluten intake 8-12 weeks prior to biopsyConfirmation by positive attitude to gluten free diet
Treatment
No cureNo medicinal treatmentGluten free diet
Treatment and follow up
Treatment Strict gluten free diet Nutrition supplement for deficiencies (6-12 months after
diagnosis)
Follow up Follow up visits at 2 week, 3 month , 6month annually Refer to gluten free health cards Biopsy in special conditions
LIVING GLUTEN FREE
WHAT IS GLUTEN ?
storage protein three grains – wheat, barley and rye maintain shape, acting as a glue that holds food together
Going gluten free
Gluten can be present in a foodproduct in many ways:*As an ingredient *As additives or as a processing aid*Due to cross – contamination
20 parts per million, i.e. 20 mg of gluten per kg of food, is the generally
accepted limit of gluten in ‘gluten free’ labeled food items
In real life terms, approximately 1/10000th of a bread slice contains more gluten than this safe limit
The big three
Wheat is commonly found in: breads baked goods soups pasta
cereals sauces salad dressings
Barley is commonly found in: malt food coloring soups beer Brewer’s Yeast Rye is commonly found in rye bread cereals
Other grains
Triticale breads pasta cereals
Oats
What can they eat?
Fruits Vegetables Meat and poultryFish seafoods Dairy Beans, legumes, and nuts
What about grains?
Rice Cassava Corn (maize) SoyPotato Tapioca Beans Sorghum Quinoa Millet Buckwheat groats Arrowroot Amaranth Teff Flax Chia Yucca Gluten-free oats Nut flours
REFERENCES
www.google.comwww.celiac.orgwww.celiacindia.org.inhttp://www.webmd.com/digestive-disorders/celiac-disease/celiac-disease