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BODY CAVITIES Slidelearn Team. FORMATION OF BODY CAVITY END OF 3 RD WEEK At the end of third week...
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Transcript of BODY CAVITIES Slidelearn Team. FORMATION OF BODY CAVITY END OF 3 RD WEEK At the end of third week...
![Page 1: BODY CAVITIES Slidelearn Team. FORMATION OF BODY CAVITY END OF 3 RD WEEK At the end of third week there is differentiation of Intraembryonic mesoderm.](https://reader034.fdocuments.net/reader034/viewer/2022042822/5697c0251a28abf838cd51a3/html5/thumbnails/1.jpg)
BODY CAVITIES
Slidelearn Team
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FORMATION OF BODY CAVITY END OF 3RD WEEK At the end of third week
there is differentiation of Intraembryonic mesoderm changes into Paraxial mesoderm Intermediate
mesoderm Lateral plate
mesoderm
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FORMATION OF BODY CAVITY Lateral plate mesoderm Intracellular clefts appears in the
lateral plate mesoderm at 3rd week and divides it into Parietal/somatic layer Visceral/splanchnic layer Primitive body cavity
Somatic mesoderm later forms the parietal layer of serous membrane lining outside the pericardial, peritoneal and pleural cavities
Splanchnic mesoderm form the viseral layer that cover the lungs, abdominal organs and the heart
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FORMATION OF (intraembryonic coelom) BODY CAVITY
Intraembryonic mesoderm give rise to three cavities
Pericardial cavity Large Peritoneal cavity Two pericardioperitoneal
cavities
Lateral body folds: Parietal layer of LPM Overlying ectoderm Cells of adjacent somites
Endoderm: folds & closes Gut tube
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End of 4th week Closure of gut tube
Midgut connection to yolk sac Vitelline duct Incorporate in umbilical cord Degenerate in 2nd - 3rd
months
Closure of ventral body wall Head and tail folds Embryo curve in fetal position Gap in area of connecting
stalk
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SEROUS MEMBRANES
Parietal layer Serous layer of serous membranes Lining peritoneal, pleural &
pericardial cavities Visceral layer
Visceral layer of serous membrane Covering abdominal organs, heart
and lungs
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SEROUS MEMBRANES
Parietal and visceral layers Become mesothelial continuous at junction of gut
& posterior abdominal wall Form Dorsal mesentery Extent; foregut to hind gut
Ventral mesentary Caudal foregut to upper
duodenum Thinning of septum
transversum
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CLINICAL APPLICATIONS
Ventral body defectsThorax, abdomen, pelvisFailure of closure of ventral body wallMainly involve lateral body folds
Ectopic cordis Gastroschisis Bladder & cloacal exstrophy
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Ectopic cordis
Failure in thoracic region Heart outside body cavity Cantrell Pentalogy
Secondary to body wall closure defect
Defect from sternum to upper abdomen
Ectopia cordis Defect in diaphragm Absence of diaphragm Omphalocele Gastroschisis
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Gastroscisis Defect in abdominal region Intestinal loop herniate in
amniotic cavity Incidence increasing Common in mothers; lean &
below 20yrs Detected by
Ultrasound Alpha fetoprotein Affected loops; ulcerate,
volvulus, compromised blood supply
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Bladder & cloacal exstrophy
Pelvic region defect Minor defect: only
bladder involved Major defect :bladder
and rectum exposed
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Omphalocele
Failure of gut tube to return to abdominal cavity
Loops of intestine and liver outside
Covered by amnion 2-5/10,000 15% cases have chromosomal
abnormality Elevated alpha fetoprotein
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THORACIC CAVITY
Septum Transversum Thick plate of
mesoderm B/w thoracic cavity
and yolk sac stalk Incomplete “Pericardioperitoneal
canals” on each side of gut
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Lung bud
grow within pericardioperitoneal canals
Expand dorsally, ventrally and laterally
Canals become small Lungs grow in
mesenchyme of body wall
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THORACIC CAVITY
Pleuropericardial folds Small ridges Projecting in primitive thoracic
cavity Become membranes Contain
Common cardinal veins Phrenic nerves
Fuse with each other & lung root
Dividing thoracic cavity Adult “fibrous pericardium”
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DIAPHRAGM
Pleural cavity communicate with peritoneal by pericardioperitoneal canals
Crescent shaped pleuroperitoneal folds Extends medially and ventrally 7th week fuse with
Mesentary of esophagus Septum transversum
Addition of peripheral rim Myoblasts from somites C3-5
penetrate membrane
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DIAPHRAGM
Derived from Septum transversum –
central tendon Pleuroperitoneal
membranes—membranous part
Somites C3-5 -- Muscular component
Mesentary of esophagus -- crura
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DESCENT OF DIAPHRAGM
Initially septum transversum---opposite cervical somites Nerve supply from C-3,4,5 Forming phrenic nerves (sensory and motor) Pass through pleuropericardial folds Sensory fibers from thoracic intercostal nerves as most
peripheral part derived from thoracic wall mesenchyme
6th week – level of thoracic somites 3rd month - Lower thoracic & first lumbar vertebra
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CLINICAL APPLICATIONS
Congenital diaphragmatic hernia 1/2000 Failure of pleuroperitoneal
membranes Pleural and peritoneal
cavities communicate Abdominal viscera enter
pleural cavity 85-90 % left side heart pushed anteriorly Lungs hypoplastic 75% death
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Clinical Anomalies
Parasternal herniaMuscular fibers failureDiscover at several years of ageSmall peritoneal sac with intestinal loop
Esophageal herniaShortness of esophagusUpper part of stomach in thoraxStomach constricted at diaphragm
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