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Assoc. Prof. Dr. Halil Murat AYDIN

BSc & MSc, Chemical Engineering PhD, Bioengineering

ADDRESS: Hacettepe University, Department of Environmental Engineering & Bioengineering Division and Center for Bioengineering Beytepe, 06800, Ankara, TURKEY Phone: 90 312 2977800/131 Mobile: 90 533 5515830 Fax: 90 312 2992053 E-mail: hmaydin@hacettepe.edu.tr NATIONALITY: Turkish LANGUAGE: English (fluent), Italian (beginner) EDUCATION AND PROFESSIONAL CAREER Ph.D. BIOENGINEERING. 2002-2008 Hacettepe University, Ankara, Turkey. Project Title: Preparation of Biodegradable Polymeric Materials and/or Calcium Phosphate Composites and Their Use in Hard Tissue Repair (funded by Turkish Ministry of Industry and Trade, SANTEZ: 00020.STV.2006-1.) This cross-disciplinary study includes polymer synthesis and characterization, preparation of scaffolds containing ceramics, tailoring surface and bulk properties, cell culture studies with stem cells and other cell lines for cranial defects and endodontics applications, and in vivo animal experiments (e.g. Sprague Dawley rats). Characterization techniques such as FTIR, GPC, NMR, DSC, mechanical tests, µ-CT, SEM, confocal microscopy, cell staining techniques applied for evaluation. Other Projects: “TissueBiomed 105T509” (funded by Turkish Academy of

Sciences) and “NoE Expertissues” (funded by EU) “Tissue Engineering in Biomedical Technology” 01.03.2006-

01.12.2008 (funded by Turkish Academy of Sciences).

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Integrated Ph.D. Expertissues (European Network of Excellence, NMP 3-CT- 2004-500283) 2005-2011. Project Title: Biodegradable Cranium Repair Materials from Poly(L-lactide),

Poly(e-caprolactone) and Calcium Phosphate Blends This EU-funded project integrated into my PhD programme in order to enhance knowledge transfer within the Expertissues network. During this project, I have been working in collaboration with Keele University (UK) and University of Trento (Italy) for cell culture & matrix development studies. Visiting Scholar MEDICAL SCHOOL 2005-2006 ISTM Keele University, Staffordshire, UK Project title: Investigating cell response to synthetic bone substitutes prepared by using dual porogen A new technique has been developed for enhancing the interconnectivity of the synthetic tissue constructs for gas and nutrient delivery. The research foundings were published in Journal of Biomaterials Applications and CRC Biomaterials Fabrication and Processing Handbook, and presented at 20th European Conference on Biomaterials, France. M.Sc. CHEMICAL ENG. 2000-2002 Hacettepe University, Ankara, Turkey, Date: 06/09/2002 Project title [Poly-L-Lactide/Poly-e-Caprolactone and Their HA/TCP Composites]

From biodegradable polymers and biocompatible ceramics, composite structures for tissue engineering were developed during my MSc project. I have acquired experience in plastic processing techniques such as injection, compression moulding and solvent casting. I also worked on super critical fluid systems for pore generation.

B.SC. CHEMICAL ENG. 1992-1999 Ankara University, Ankara, Turkey, Date: 25/06/1999 TOPICS (MODULES): Fluid dynamics, thermodynamics, reaction engineering, heat

transfer, chemical engineering design, transport phenomena.

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PRESENT POSITION - Associate Professor at Faculty of Engineering, Department

of Environmental Engineering

OTHER AFFILIATIONS

- Deputy Manager at Hacettepe University Institute for Science and Engineering (2016-)

- Manager at Hacettepe University Center for Bioengineering

(2014-)

- Vice Chairman of Bioengineering Division, Hacettepe University Institute of Science (2014-2015)

- Member of Animal Studies Board, Hacettepe University

Institute of Science (2015-)

- Chief Scientific Officer at BMT Calsis Health Technologies Co. (2013-)

Duty and responsibility: BMT Calsis is the first Class-III Orthobiologics manufacturer in Turkey. I have been working in BMT Calsis’s R&D Facility Located in Hacettepe Teknokent as Design Director and as Advisor at the project named Production of Composite Screws for the Repair of Osteochondral Defects.

I work as a PI for TÜBİTAK 1507 and 1511 R&D Projects. I am responsible of all design, scale up and registration duties regarding to products, i.e. from benchtop testing to clinical practice. In my supervision, BMT Calsis Co has commercialized several medical devices for ortopeadics. I am holding one Turkish Patent, one WO patent and two Turkish Patent Application and one Eurpoean Patent Application in the field of hard tissue repair.

Finalized products and ongoing projects include: - Suprabone Granules & Powder Ceramic Bone

Substitutes - Suprabone Putty Polymer/Ceramic Composite Paste - Suprachon Cartilage Repair Plug - Supramatrix Polymeric Cranium Repair Matrix - Supraflex Collagen-Ceramic Composite - Medical Device Expert at KIWA-Meyer Certification

Services Inc.

Duty and responsibility: Product Expert for audits. Orthopedics and biomaterials (lenses, stents, grafts, etc.)

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FORMER POSITIONS Post Doctoral Fellow at Hacettepe University Bioengineering

Division

Assistant PI: I served as a researcher in Erhan Pişkin’s group in two of the group’s projects entitled: Developments of Portable, Real-Time and Non-Labelled Biosensors for Biomolecular Diagnostics (00367.STZ.2006-1) (Founded by Turkish Ministry of Industry and Trade). Cranirare, An integrated clinical and scientific approach for craniofacial malformations” (funded by EU).

Marie Curie Post Doctoral Fellow (IEF: Intra European Fellowship), Keele University ISTM, UK

Duty and responsibility: This Highly Prestigious Marie Curie fellowship for carier development within the scheme called FP7-IEF. Project name is “Development of New Strategies for Osteochondral Regeneration, PIEF-GA-2009-237762). Outcomes: Several peer rewieved papers and conference presentations; British Patent Application.

Research Assistant: Chemical Engineering Department & Bioengineering Division, Hacettepe University

Duty and responsibility: I served as a Laboratory Instructor for the Instrumental Analysis Laboratory and the Basic Chemistry Laboratory and as a teaching assistant to Professor Erhan Pişkin in Polymer Science and Technology subject.

Engineer: TUBITAK – BIYOMEDTEK: Center for Biomedical Technologies

Duty and responsibility: My major duties were to research on several projects mainly based on biomaterials and to run the test and analysis services.

Patent translator: Dilta Translation Office, Istanbul, Turkey, 2002-2006

Duty and responsibility: My main duties were to translate patents from English to Turkish, especially in the fields of pharmaceutics, engineering, materials, and chemistry for Turkey’s biggest patent office, Deriş Patent Ofisi.To date, I have translated over 300 patents into Turkish.

Trade Manager: CIM Engineering, Ankara, Turkey, 1999-2000

Duty and responsibility: I was responsible for sales and customer relations for the leading vulcanization press manufacturer in the Middle East, CIM Engineering.

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Technical Skills - Clean room design, Medical Device Directives, Design and Production

- Polymer synthesis and modification

- Plastics testing and characterisation

- Material characterization: GPC, UV-VIS, FTIR, DSC, SEM, contact angle, mechanical

testing (i.e. tensile, compression tests)

- Supercritical carbon dioxide extraction & reaction systems (Tharr Instruments)

- Cell culture and characterization techniques

- Authorized Radiation Worker, registered at Keele University (Micro Computerized

Tomography, µCT)

- Animal experiments

- Design and fabrication of control release of drugs/macromolecules

- Fabrication and charaterisation of scaffolds for tissue engineering

-Decellularization of aorta, tendon and cornea

Research Experience - Biomaterials: Synthesis, modification and characterization of polymeric & ceramic

biomaterials, tailoring tissue engineering scaffolds from synthesis step (including

biodegradable polymers, e.g. poly-L/DL-lactides, polyglycolides and poly-e-

caprolactone and ceramics, mainly hydroxyapatites and tricalcium phosphate),

biodegradable polymeric plates and screws, membranes, stents, xenografts etc.

Involvement in the production of Turkey’s first orthobiological products (Suprabone

TCP granules, Suprabone Injectable Putty, SupraFelt cartilage repair material etc).

- Tissue engineering applications: Production of tissue engineering scaffolds from

natural and/or synthetic materials for in vitro cell differentiation or in vivo tissue repair.

Reconstitution of such constructs with stem cells and development of controlled

delivery systems for hard tissue regeneration.

- Preparation of Carbon Aerogels: Carbon aerogels for tissue engineering, energy, and

carbon capture applications.

- Supercritical CO2 applications: Porosity generation and residue removal in polymeric

matrices. Production of porous bone and cartilage repair composites consisted of

polymeric, ceramic and animal origin materials. Production and sterilization thereof.

-µCT: Registred user for micro computerized tomography imaging and analysis (Keele

University, UK).

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-Cell culture: Cell culture applications including static and dynamic bioreactors, related

skills such as confocal microscopy, staining, histological evaluations, FTIR/TGA/XRD

ossification analyses etc.

-Medical Device Regulations: Thanks to the work has beend done with BMT Calsis

Co, I have gained enourmous experience in Medical Device directives, regulations and

verification including Medical Device Directive 93/42/EEC, Tissues of Animal Origin

Directive (2003/32/EC), MEDDEV, etc.

Awards 1. FP7 EU Framework Program Marie Curie IEF Fellowsip – 2009.

2. 61st Lindau Nobel Laureate Meeting Dedicated to Physiology/Medicine, Lindau,

Germany, Selected Young Scientist Participant Award, 2011.

3. ‘Damak Yarıklarının in situ Doku Mühendisliği ile Onarımı: Alveolar Hayvan Modeli

Oluşturulması ve Farklı Rejimlerde Biyobozunur Doku İskeleleri ile Onarımı’ titled

abstract for the 2nd Presentation Award in Turkish Plastic and Reconstructive Surgery

Congress, 2014.

4. National Patent Registraton Award with a Turkish Patent: ‘Osteokondral

Defektlerin Onarımı’, 2015.

5. International Patent Registraton Award with a European Patent: ‘A Biomaterial’,

2015.

6. International Association of Advanced Materials Young Scientist Award, 2015.

7. METU Prof. Dr. Mustafa N. Parlar Foundation Technology Award, 2015.

Patents and Patent Applications 1A. Turkish Patent No:TR 2009/04029 B. “Bir Biyomalzeme”, Aydin HM, Ozgurbuz LM.

1B. World Patent No: WO/2010/144065, “A Biomaterial”, HM Aydin HM, Ozgurbuz LM.

1C. European Patent EP2512377, “A Biomaterial”, HM Aydin HM, Ozgurbuz LM.

2.Turkish Patent No: TR 2010/11221. ”Osteokondral Defektlerin Onarımı İçin Bir Doku

İskelesi” (31.12.2010). Aydin HM, Ozgurbuz LM.

3. Turkish Patent No: TR 2012/10367. “Biyobozunur Elastomer ve Üretim Yöntemi”

(21.03.2014). Aydin HM, Ozgurbuz LM.

4. Turkish Patent Application No: TR 2016/08970. “A Heat Malleable Biodegradable

Composite” (28.06.2016). Aydin HM.

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Grants & Other Projects 1. Tissue Engineering in Biomedical Technology (TUBITAK-National): Researcher.

2. “TissueBiomed 105T509” (TUBITAK and NoE Expertissues/EU-International:

Researcher.

3. "CRANIRARE": Clinical and Scientific Approaches to Craniofacial Malformations

(EU-International): Researcher.

4. Expertissues (European Network of Excellence, NMP 3-CT 2004-500283-EU-

International): Researcher.

5. SanTez: 00367.STZ.2006-1 Development and Characterization of Portable, Real

Time and Lable-Free Biosensors for Biomolecular Recognition Systems (Ministry of

Industry-National): Researcher.

6. SanTez: 00020.STV.2006-1. Preparation of Biodegradable Polymeric Materials and

Their Composites with Calcium Phosphates and the Use Thereof in Hard Tissue

Repair (Ministry of Industry-National): Fellow.

7. AB Marie Curie IEF Fellowship, Development of New Strategies for Osteochondral

Regeneration, (PIEF-GA-2009-237762-Keele University-International): Post Doctoral

Fellow.

8. TUBITAK Teknogirişim (Project No. 8070098- National), Development of Drug

Releasing Biodegradable Polymeric Ventilation Tubes: PI.

9. KOSGEB, Hacettepe University Technology Incubation Center R&D Project

No:2009-04-National): PI.

10. Hacettepe University Technopolis R&D Project: Production of Composite Screws

for the Repair of Osteochondral Joint Defects (National): Advisor.

11. SME R&D Fund of TEYDEB 1507 Programme, Composite Matrix for Cartilage

Repair, No: 7110730 (TUBITAK-National): PI.

12. SME R&D Fund of TEYDEB 1507 Programme, Development of Collagen/Beta-TCP

Synthetic Bone Grafts, No: 7120905 (TUBITAK-National): PI.

13. SME R&D Fund of TEYDEB 1507 Programme, Development of Polyurethane

Based Bone Grafts, No: 7131048 (TUBITAK-National): PI.

14. TC0101 Ministry of Health-TUBITAK 1003: Development of Foecal Occult Blood

Test Kits. Researcher.

15. COST-EU MP1301 Action, Development of Growth Factor Releasing

Elastomer/Ceramic Composite Materials and Investigation of Their Potential Use as an

ATMP (Advanced Therapy Medicinal Produc) for Bone Tissue Engineering, Project No:

213M184, (International): PI.

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16. TUBITAK TEYDEB 1511 Research and Technology Development and Innovation

Programme with Priority Fields, Production of Arthroscopic Hard Tissue Regeneration

Implants, No:1130005 (TUBITAK-National): PI.

17. Hacettepe University Research Project No: 1860, Preparation of Decellulerized

Cornea via Supercritical Carbon Dioxide for Corneal Tissue Engineering (National): PI.

18. Hacettepe University Research Project No: 6021, Production of Oriented Cell

Sheets by Using Patterned Surfaces (National): PI.

19. Ministry of Science, Industry and Technology Teknoyatirim Grant Project No:

0153.TYD.2014.01, SupraChon (National): Advisor.

20. Hacettepe University Research Project No: THD-2015-8859, Production of PGS-

Acellular Aorta Composite Vascular Grafts (National): PI.

21. Hacettepe University Research Project No: FHD-2016-11817, Preparation of Waste

Paper Derived Carbon Aerogel-Elastomer Matrices (National): PI.

22. COST-EU BM1302 Action, Preparation of Novel and Decellularized Matrices for

Cornea Tissue Engineering, Project No: 215M071, (International): PI.

23. TUBITAK 1003 (103.SAB.KLNK.2015.2 Call) 3D Production of Laser Assisted

Bioglass-HAP Biomaterials and Its Application as Metal Implant Coating (No: 1130005,

PI: Prof. Dr. M. Erdem Ereyen, TUBITAK-National): Researcher.

24. TUBITAK 1005 New Ideas and Products Call: Development of Urethane Ceramic

Composite Orbital Implants (No: 215S835, TUBITAK-National): PI.

Book Chapter 1. Yang Y, Cunha-Reis C, Bagnaninchi PO, Aydin HM, Control and Monitoring of

Scaffold Architecture for Tissue Engineering. In Biomaterials Fabrication and

Processing Handbook, Chapter 3, 2008, CRC Press, USA.

2. Ozgurbuz LM, Kutlu HN, Aydin HM, Biomaterials in Musculoskeletal Conditions:

Classification, Design, and Regulatory Aspects. Sports Injuries Handbook, Springer,

Germany, pp 1-11, 2014.

3. Yang Y, Aydin HM, Wimpenny I, Liu C, Chapter 2: Biocompatibility, Bioactivity and

Bioresorbability. In Inorganic Biomaterials: Structure, Properties and Applications, in

press, Chapter 2, pages 19-44, 2014.

4. Ozdil D, Aydin HM, Stem Cell Based Medicinal Products: Regulatory Perspectives.

In Advanced Surfacess in Stem Cell Research, Wiley-Scrivener Publishing LLC, USA,

Chapter 11, page 321-340, 2016.

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Publications 1. Aydin HM, Calimli A, Pişkin E, Microporous scaffolds from poly(lactide-co-ε-

caprolactone) composites with hydroxyapatite and tricalcium phosphate using

supercritical CO2 for bone tissue engineering, J. Bioactive and Compatible Polymers,

2004; 19: 383-394.

2. Aydin HM, Turk M, Calimli A, Pişkin E, Attachment and growth of fibroblasts on

poly(L-lactide/epsilon-caprolactone) scaffolds prepared in supercritical CO2 and

modified by polyethylene imine grafting with ethylene diamine-plasma in a glow-

discharge apparatus, The Journal Of Artificial Organs, 2006; 29: 873-880.

3. Yang Y, Bagnaninchi PO, Cunha-Reis C, Aydin HM, Pişkin E, El Haj AJ,

Characterisation of scaffold architecture by optical coherence tomography. Optics in

Tissue Engineering and Regenerative Medicine, Progress in Biomedical Optics and

Imaging, 2007; 8 (16): 64390G.1-9.

4. Aydin HM, Pişkin E, Cathepsin K/TRAP: Can they be used to induce osteogenesis,

Medical Hypotheses, 2009; 72(4):464-465.

5. Yang Y, Aydin HM, Pişkin E, El Haj AJ, Assesment of a new biomimetic scaffold and

its effects on bone formation by OCT, Proceedings of SPIE (Society of Photo-optical

Instrumentation Engineers), 2009; Vol. 7166: 71660L-71660L-6.

6. Aydin HM, El Haj AJ, Pişkin E, Yang Y, Improving pore interconnectivity in polymeric

scaffolds for tissue engineering, Journal of Tissue Engineering and Regenerative

Medicine, 2009; 3(6):470-476.

7. Aydin HM, Yang Y, Kohler T, El Haj A, Müller R, Pişkin E, Interaction of osteoblasts

with macroporous scaffolds made of PLLA/PCL blends modified with collagen and

hydroxyapatite, Advanced Engineering Materials, 2009; 11(8): B83-B88.

8. Aydin HM, HU B, Sule-Suso J, El Haj A, Yang Y, Study of Tissue Engineered Bone

Nodules by Fourier Transform Infrared Spectroscopy, Analyst, 2011; 136: 775-780.

9. Aydin HM and Yang Y, Rapid production of highly interconnedted porous scaffolds

by spheroidized sugar particles for tissue engineering. Journal of Hacettepe Biology

and Chemistry, 2011; 39(1):23-28.

10. Aydin HM, Korkusuz P, Vargel I, Uckan D, Guzel E, Cavusoglu T, Kilic E, Pişkin E,

Investigation of polymer/mesenchymal stem cell constructs for cranial defects: 6

months in vivo study, J. Bioactive and Compatible Polymers, 2011; 26(2): 207-221.

11. Aydin HM, A three-layered osteochondral plug: structural, mechanical, and in vitro

compatibility analysis, Advanced Engineering Materials, 2011; 13(12): B511-B517.

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12. Aydin HM, Kourush S, Rzayev Z, Piskin E, Microwave-assisted Rapid Synthesis of

Poly(glycerol-sebacate) Elastomers, Biomat. Sci., 2013;1:503-509.

13. Ozdil D & Aydin HM, Polymers for Tissue Engineering Applications, Review, 2014,

Journal of Chemical Technology and Biotechnology, 2014; 89(12):1793-1810.

14. Deegan A, Aydin HM, Bin H, Konduru S, Kuiper JH, Yang Y, A Facile in vitro Model

to Study Rapid Mineralization in Bone Tissues, Biomedical Engineering Online –

2014;13:136.

15. Sarikaya B & Aydin HM, Development of collagen/ beta-tricalcium phosphate based

synthetic bone grafts via Dehydrothermal Processing, BioMed Research International,

2015, DOI:10.1155/2015/576532.

16. Namli H et al., Vertical Bone Augmentation Using Bone Marrow Stem Cells: An in

vivo Study in the Rabbit Calvaria, Implant Dentistry, 2016;25(1):54-62.

17. Ekin O, et al., Poly(L-Lactide)/Poly(ε-Caprolactone) and Collagen/β-Tricalcium

Phosphate Scaffolds for the Treatment of Critical-Sized Rat Alveolar Defects: A

Microtomographic, Molecular-Biological, and Histological Study, The Cleft Palate

Craniofacial Journal, 2016;53(4):453-63.

18. Salimi K, Topuzogullari M, Dincer S, Aydin HM, Piskin E, Microwave Assisted

Green Approach for Graft Copolymerization of L-Lactic Acid onto Starch, Journal of

Applied Polymer Science, 2016; 133: 42937.

19. Aydin HM, Kourush S, Yilmaz M, Turk M, Rzayev Z, Piskin E, Synthesis and

Characterization of Poly(glycerol-co-sebacate-co-e-caprolactone) Elastomers, Journal

of Tissue Engineering and Regenerative Medicine, 2016;10(1): E14-22.

20. Erdogan H, Yilmaz M, Babur E, Duman M, Aydin HM, Demirel G, Plasmonic

Nanorod-Embedded Dipeptide Microspheres via the Freeze-Quenching Method for

Near-Infrared Laser-Triggered Drug-Delivery Applications, Biomacromolecules, 2016;

17 (5): 1788–1794. 21. Sahan S et al., Polyurethane/Tricalcium Phosphate Bone Adhesives and

Substitutes for Load Bearing Applications, 2017, Journal of Biomaterials and Tissue

Engineering, DOI: 10.1166/jbt.2017.1585.

22. Guler S, Hosseinian P, Aydin HM, Hybrid Aorta Constructs via in-situ Crosslinking

of Poly(glycerol-sebacate) within a Decellularized Matrix, 2017, Tissue Engineering

Part C, DOI: 10.1089/ten.TEC.2016.0375.

23. Tevlek A, Hosseinian P, Ogutcu C, Turk M, Aydin HM, Bi-layered Constructs of

Poly(glycerol-sebacate)-b-tricalcium Phosphate for Bone-Soft Tissue Interface

Applications, Journal of Materials Science and Engineering Part C, 2017; 72: 316–324.

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24. Yucekul A et al., Tri-Layered Composite Plug for the Repair of Osteochondral

Defects, 2017, Journal of Tissue Engineering, in press.

25. Guler S et al., Decellularization by Supercritical Carbon Dioxide (sc-CO2)-A Review,

2017, Tissue Engineering Part B, in press.

26. Sahan S et al., Polyurethane-Ceramic Matrices as Orbital Implants, 2017,

International Journal of Artificial Organs, submitted.

27. Garipcan A et al., Alveolar Defect Treatment in Rat Model with TGF-B3 and BMP-2

Releaseing Scaffolds, 2017, Tissue Engineering and Regenerative Medicine,

submitted.

28. Can GD et al., Biomechanical and Morphological Properties of a Completely

Autologous Tissue Engineering Product: Advanced Platelet Rich Fibrin (A-PRF), 2017,

Journal of Oral Implantology, submitted.

29. Guler S et al., Improvement of Decellularization Efficiency of Porcine Aorta by

Using Dimethyl Sulfoxide as Penetration Enhancer, 2017, Biomaterials Science,

submitted.

30. Sneddon G et al., Aminated Poly(vinyl chloride) Solid State Adsorbents with

Hydrophobic Function for Postcombustion CO2 Capture, 2017, Journal of Materials

Chemistry C, submitted.

Articles in Edited Collections 1. Aydin HM and Pişkin E, Microcellular Plastics, Plastics Journal, PAGEV, June 2002.

2. Aydin HM, Porous Structure Preparation from P(LLA/CL)-HA/TCP Composites in

Supercritical Carbon Dioxide, Proceedings of POLSEM, p. 232-237, 2004.

3. Pişkin, E., N. Bölgen ve H.M. Aydın, “Novel Methods for Preparation of

Biodegradable Scaffolds,” XXIII SICOT/SIROT Triennial World Congress, 31, İstanbul,

2005.

4. Aydin HM, Yang Y, Pişkin E, El Haj A, Optimizing Degradable Scaffolds for Cranium

Tissue Repair, Eur. Cell. Mater., 2006; 11 (Supl. 3), 69. 5. Aydin HM, Egri S, Bolgen N, Pişkin E, Biodegradable Biomaterials for Soft and Hard

Tissue Repair, 4967, World Congress on Medical Physics and Biomedical Engineering,

August 27- September 1, 2006, COEX Seoul, Korea.

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6. Aydin HM, Yang Y, Pişkin E, El Haj AJ, A New Scaffold Preparation Technique,

Plastic Reconstructive and Aesthetic Surgery Stem Cell and Tissue Engineering

Symposium, Samsun, 2007. 7. Pişkin, E., N. Bölgen, S. Eğri, H.M., Aydın and İ.A. İşoğlu, “Novel Scaffolds for

Tissue Engineering,” Trento Innovation Conferences in Materials Engineering: 1st

Meeting Advances in Polymers, Composites and Biomaterials, 35, Trento, 2007. 8. Pişkin, E., N. Bölgen, İ. Vargel, P. Korkusuz, H.M. Aydın, S. Eğri, K. Tuzlakoğlu, A.

İşoğlu, X. Kaitian, K. Kesenci, G. Köktürk, A. Kozluca, E. Ural, D. Uzunok, C. Babaç, T.

Şirin, S. Dinçer, M. Türk, G. Güven, S. Odabaş, F. Sayar, M. Türkoğlu, H. Yavuz-

Ersan, A. Şenköylü, Z.M.O. Rzaev and T. Kutsal, “Biodegradable Polymers and Novel

Scaffolds for Tissue Engineering: Experience of Hacettepe University Group,” Plastic

Reconstructive and Aesthetic Surgery Stem Cell and Tissue Engineering Symposium,

Samsun, 2007.

9. Aydin HM, Vargel I, Cavusoglu T, Korkusuz P, Guzel E, Pişkin E, Filling Cranial

Defects in Rats: 6 Months Animal Study, Tissue Engineering Part A, P177, 2008; 14(5):

855. 10. Aydin HM, Yang Y, Kohler T, Pişkin E, Novel Technique for HA Particle Coating

within 3D Polymeric Structures, Tissue Engineering Part A, P291, 2008; 14(5): 890.

11. D.A. Korpe et al., TERMIS EU 2013 Tissue Engineering and Regenerative

Medicine İstanbul congress: "Optimization Process of Alginate Coated Chitosan

Nanoparticles" at TERMIS EU 2013 Tissue Engineering and Regenerative Medicine

Abstract Book, 637 pp., Istanbul, 2013.

12. H.M. Aydın et al., Regeneration of Osteochondral Defects Using a Multilayered

Scaffold: A Novel Design, in vitro Performance, and in vivo Healing in Ovine Model in

25th European Conference on Biomaterials Abstract Book, P209, Madrid, 2013.

13. C. Öğütçü & H.M. Aydın, R&D Strategies in Biomaterial Production in 19th

International Biomedical Science and Technology Symposium Abstract Book, 58 pp.,

Kuşadası, 2013.

14. S. Guler, et al., Supercritical Carbon Dioxide (scCO2) Assisted Decellularization of

Aorta in 27th European Conference on Biomaterials Abstract Book" pp 3402, Liverpool,

UK, 2014.

15. B. Aslan, S. Guler, H.M. Aydin, 4th TERMIS World Congress 2015, Boston, USA:

“Corneal Collagen Matrix Coated with Poly(p-xylylene) (PPX) for Keratocyte

Orientation” in Tissue Engineering Part A, Volume 21, S191 pp., 2015.

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16. S. Guler, L. Lee, H.M. Aydin, Y. Yang, 4th TERMIS World Congress 2015, Boston,

USA: “Improvement of Decellularization Efficiency of Porcine Aorta by using Dimethyl

Sulfoxide as Penetration Enhancer” in Tissue Engineering Part A, Volume 21, S190

pp., 2015.

17. B. Sarikaya et al., 4th TERMIS World Congress 2015, Boston, USA:

“ImproveEffects of Dehydrothermal Treatment of Collagen/beta-TCP Scaffold on Bone

Regeneration in Critical Size Bone Defects” in Tissue Engineering Part A, Volume 21,

S58 pp., 2015.

18. S. Guler, P. Hosseinian, H.M. Aydin, XXV International Materials Research

Congress: "Preparation of Poly(glycerol-sebacate) (PGS)-Decellularized Aorta

Composites" In MRS Abstract Book, Cancun, Mexico, 2016.

19. Guler S, Hosseinian P, Aydin HM, Enhancing Mechanical Properties of

Decellularized Aortae via in situ Polymerization, 8th National Biomechanics Congress

Abstract Book, page 113, 19-23 October 2016, Ankara, Turkey.

Invited Lectures and Seminars 1. Aydin HM, A morphological Study of Cell Aggregations on Mineralisation, 8th

International Conference on Cell Engineering (ICCE), June 11-12, 2010, Trinity

College, Dublin, Ireland (Keynote).

2. Aydin HM, Strategic Perspectives in Regenerative Medicine R&D, 18th International

Biomedical Science and Technology Symposium, September 10-13, 2012, Tokat,

Turkey.

3. Aydin HM, Patent Nedir? Bilimesl Araştırmalarda Patent, TMMOB Chamber of

Chemical Engineers, Ankara Branch, December 2012, Ankara, Turkey.

4. Aydin HM, Benchtop to Patient: Synthetic Grafts. Boğaziçi University 1st

Biomaterials Day, February 2013, İstanbul, Turkey.

5. Aydin HM, Hard Tissue Repair Materials. Bioengineering Student Congress, 29

April-1 May, 2013, Tokat, Turkey.

6. Aydin HM, Biomaterials for Tissue Engineering, Hacettepe University 2nd

Biomaterials Day, April 2014, Ankara, Turkey.

7. Aydin HM, University-Industry Collaboration Projects, Project Proposal Preparation

Workshop, June 4-5, 2014, Sinop, Turkey.

8. Aydin HM, BEC 2015 VII. Bioengineering Congress, ‘CE Approval Process and

Design Dossiers for Hard Tissue Repair Materials’19-21 November 2015, İzmir,

Turkey.

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Oral Presentations 1. Aydin HM, Calimli A, Pişkin E, Preparation of Microporous Scaffolds From

poly(LLA/CL) and Their HA and TCP Blends in Supercritical Carbon Dioxide Media,

30th Annual Congress of the European Society for Artificial Organs, September 3-6,

2003, Aachen, Germany.

2. Aydin HM, Porous Structure Preparation from P(LLA/CL)-HA/TCP Composites in

Supercritical Carbon Dioxide, POLSEM 2004, April 28-30, 2004, Mersin, Turkey

3. Aydin HM, Turk M, Calimli A, Pişkin E, Engineering with Membranes: Medical and

Biological Applications, May 15-18, 2005, Camogli, Italy.

4. Aydin HM, Optimizing Degradable Scaffolds for Cranium Repair, 20th European

Conference on Biomaterials, September 27 - October 1, 2006, Nantes, France.

5. Sayin TC, Aydin HM, Murray PE, Namerow K, An Ultrastructural Investigation of

Tissue-Engineered Pulp Constructs, AAE Annual Meeting, April 29 – May 2, 2009,

Orlando, USA.

6. Aydin HM, El Haj AJ, Yang Y, Investigation of Tissue Formation Within 3-Phasic

Scaffolds in vitro, TERMIS 2010, June 13-17, Galway, Ireland.

7. Aydin HM, Investigation of Composite Matrices for Bone and Cartilage Repair,

Kanghui Medical EuroSummit 2011, April 25-29, 2011, Barcelona, Spain.

8. H.M. Aydın et al., Regeneration of Osteochondral Defects Using a Multilayered

Scaffold: A Novel Design, in vitro Performance, and in vivo Healing in Ovine Model,

25th European Conference on Biomaterials, Madrid, 2013.

9. S. Guler, P. Hosseinian, E. Akbay, M.A. Onur, H.M. Aydin, Supercritical Carbon

dioxide (sc-CO2) Asssted Decellularisation of Aorta, 26th European Conference on

Biomaterials, Liverpool, 2014.

10. Aydin HM, Clinical Translation of Biodegradable Composites for Hard Tissue

Repair, TERMIS AP 2014, September 24-27, Daegu, Korea.

11. Sahan S, et al., ‘PU/TCP Bone Adhesives and Substitutes for Load Bearing

Applications’, Advanced Materials World Congress 2015, August 23-26, Stockholm,

Sweden.

12. Aydin HM, ‘Polyurethane-Ceramic Matrices as Orbital Implants, 27th European

Congress on Biomaterials, August 30- September 3, Krakow, Poland. 13. Sarikaya B, et al., Effects of Dehydrothermal Treatment of Collagen/b-TCP Scaffold

on Bone Regeneration in Critical Size Bone Defects, IV. TERMIS World Congress,

September 8-11, Boston, USA.

15

14. Sarikaya B, et al., Collagen/Beta-tricalcium Phosphate Based Synthetic Bone

Grafts via Dehydrothermal (DHT) Processing, 21st International Biomedical Science

and Technology Symposium, October 22-24, Antalya, Turkey.

15. Tevlek A & Aydin HM, Waste Paper to Bone Graft, 7th Bioengineering Congress,

BEC2015, 19-21 November, 2015, Izmir, Turkey.

16. Guler S, Hosseinian P, Aydin HM, Enhancing Mechanical Properties of

Decellularized Aortae via in situ Polymerization, 8th National Biomechanics Congress,

19-23 October 2016, Ankara, Turkey.

Poster Presentations 1. Uzunok D, Ozgoz D, Tuzlakoglu K, Ural E, Kesenci K, Kokturk G, Aydin HM, Ayhan

H, Pişkin E, Applications of Biodegradable Biomaterials, BIOMED IXth International

Symposium on Biomedical Science and Technology, September 19-22, 2002, Kemer-

Antalya, Turkey.

2. Uzunok D, Ozgoz D, Tuzlakoglu K, Babac C, Garipcan B, Gurpinar A, Ural E,

Kesenci K, Kokturk G, Aydin HM, Ayhan A, Kazimoglu C, Bolukbasi S, Senkoylu A,

Vargel I, Erdem A, Erk Y, Tuysuz M, Yamurlu M, Akpinar H, Saber R, Kocum C, Mutlu

S, Ozguven A, Duman M, Applications of Biodegradable Polymers, EMCC-3, May 13-

15, 2003, Thessaloniki, Greece.

3. Aydin HM, Calimli A, Pişkin E, Microporous Scaffolds, 11th International Science and

Technology Days, Biomed 2004, September 6-10, 2004, Ankara, Turkey.

4. Aydin HM, Salgin U, Yang Y, Pişkin E, El Haj AJ, Optimizing Degradable Scaffolds

for Cranium Repair, Tissue and Cell Engineering Society (TCES) Meeting, July 3-4,

2006, University of Sheffield, Sheffield, UK.

5. Aydin HM, Yang Y, Pişkin E, El Haj AJ, A new scaffold preparation technique,

Plastic, Reconstructive and Aesthetic Surgery Stem Cell and Tissue Engineering

Symposium, May 10-12, 2007, Samsun Turkey.

6. Aydin HM, Yang Y, Kohler T, Pişkin E, A triphasic scaffold: Preparation and in vitro

evaluation, Biomed 2008, 14th Biomedical Science & Technology Symposium &

International Workshop on Networking/Platforming in Biomedical Technologies Focus

on Nanomedicine, May 4-7, 2008, Marmaris, Turkey.

7. Aydin HM, Yang Y, Kohler T, Müller R, Pişkin E, Novel Technique for HA Particle

Coating within 3D Polymeric Structures, TERMIS EU 2008, June 22-26, Porto,

Portugal.

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8. Aydin HM, Vargel I, Cavusoglu T, Korkusuz P, Guzel E, Pişkin E, Scaffolds + MSCs

for Cranial Defect Repair: 6 months in vivo study, 6th Marie Curie Cutting-Edge

Conference, October 27-31, 2008, Algarve, Portugal.

9. Aydin HM, Korkusuz P, Güzel E, Uçkan D, Kılıç, Vargel I, Çavuşoğlu T, Pişkin E,

Polimer-Mezenkimal Kök Hücre Kompozitlerinin Kraniyal Defektlerde Uygulanması: Altı

Aylık İn Vivo İzlem Uluslararası Katılımlı 19. Ulusal Elektron Mikroskopi Kongresi, June

22-25, 2009, Trabzon, Turkey.

10. Aydin HM, Vargel I, Cavusoglu T, Korkusuz P, Guzel E, Pişkin E, Stem cells

seeded scaffolds for cranium repair, Porous Hydrogels for biomedical applications –

from cytapheresis to tissue engineering, Summer School September 29-October 2,

2009, Antalya, Turkey.

11. Aydin HM, Pişkin E, Investigation of Tissue Engineering Scaffolds/Stem Cells in

Cranial Defects, TERMIS 2010, June 13-17, Galway, Ireland.

12. Aydin HM, First Orthobiologic Product In Turkey: Suprabone, Marie Curie

Conference, July 1-2, 2010, Turin, Italy.

13. Aydin HM, Sule-Suso J, Hu B, El Haj AJ, Yang Y, FTIR Study of Tissue Engineered

Bone Nodules, SPEC 2010 – 6th International Spec Conference, June 26th – July 1st,

2010, Manchester, UK.

14. Aydin HM et al., Investigation of polymer/ mesenchymal stem cell constructs for

cranial defects, 16th International Biomedical Science and Technology Symposium,

September 28 – October 2, 2010, Istanbul, Turkey.

15. Aydin HM, Hu B, El Haj AJ, Yang Y, Mimicking Intramembranous Ossification, 16th

International Biomedical Science and Technology Symposium, September 28 –

October 2, 2010, Istanbul, Turkey.

16. Aydin HM, Hu, B, El Haj AJ, Yang Y, Enhancement of Calcium Nodule Production,

by Osteoblasts, ESB 2010 – 23rd European Conference on Biomaterials, September

11-15, 2010, Tampere, Finland.

17. Aydin HM, Yang Y, An Ultrastructural and in vitro Analyses of a Three-Layered

Osteochondral Plug, ESB 2011 - 24th European Conference on Biomaterials,

September 4-8, 2011, Dublin, Ireland.

18. Arslan O, Sener G, Aydin HM et al., Biodegradable Nanofibers for Neural Tissue

Applications, 18th International Biomedical Science and Technology Symposium,

September 10-13, 2012, Tokat, Turkey.

19. B. Sarikaya & H.M. Aydın, Development of Collagen/b-TCP Based Synthetic Bone

Grafts at TERMIS EU, Genova, 2014.

17

20. Guler S, et al., Improvement of Decellularization Efficiency of Porcine Aorta by

using Dimethyl Sulfoxide as Penetration Enhancer, IV. TERMIS World Congress,

September 8-11, Boston, USA.

21. Aslan B, Guler S & Aydin HM, Corneal Collagen Matrix Coated with Poly(p-

xylylene) (PPX) for Keratocyte Orientation, IV. TERMIS World Congress, September 8-

11, Boston, USA.

22. Körpe DA, Hosseinian P, Guler S, Duman M, Aydin HM, Synthesis of Gelatine-

Methacrylate Hydrogels as Cell Carriers, 9. Meeting of Scandinavian Society of

Biomaterials, 30 May-4 June 2016, Reykjavik, Iceland.

Conference Chairing 1. Session 6: Cell Network at 8th International Conference on Cell Engineering (ICCE),

June 11-12, 2010, Trinity College, Dublin, Ireland.

2. 18th International Biomedical Science and Technology Symposium, September 10-

13, 2012, Tokat, Turkey.

Certificates 1. ISO 13485:2003 and 93/42/EEC Medical Devices Directive Basic Training

Certificate, MEYER, Certificate No. GKA-1446, November 14, 2008. 2. Computer Literacy Certificate, Hacettepe University Training Centre, Document No:

BOSB04, Certificate No: 0754, February 13, 2009.

3. 2007/47/EC Medical Devices Directive Basic Training Certificate,MEYER, Certificate

No. MYR-256, March 22, 2009. 4. ISO 9001:2008, ISO 13485:2003, and 93/42 EEC Internal Auditing certificates,

MEYER, Certificate No. GKA-2085, March 28, 2009.

5. Cleanroom Automation Training Certificate, Nasyonel Teknoloji, June 17, 2009.

6. 93/42/AT Denetçi Belgesi (Sertifika No: 2219, Kiwa-Meyer, 10.03.2015).

7. ISO 13485:2003 Denetçi Belgesi (Sertifika No: 2219, Kiwa-Meyer, 10.03.2015).

Organizing and Management Skills 1. The Design and Building of Quartz Crystal Microbalance (QCM) Biosensors,

Advance Practical Course, June 20-27, 2004, Ankara, Turkey – Group leader

2. Biomed 2004, 11th International Biomedical Science and Technology Days,

September 6-10, 2004, Ankara, Turkey – Organizing team member

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3. ExperTissues Annual Progress Meeting and AleaJacta Est/Expertissues Tutorial

Course, 15-17 October, 2005, Antalya, Turkey – Organizing team member

4. StemCell 2007: Plastic, Reconstuctive and Aesthetic Surgery Stem Cell and Tissue

Engineering Symposium, 10-12 May, 2007, Samsun, Turkey

5. BIOMED 2008: 14th International Biomedical Science and Technology Symposium,

Marmaris, Turkey

6. FEBS Advance Practical Course: QCM, SPR/Elipsometer & AFM as novel

Biosensors & Imaging Systems, June 22-29, 2008, Ankara, Turkey – Group leader

7. COST Action B28, Array Technologies for BSL3 and BSL4 Pathogens, Workshop on

Array Technologies, May 3-6, 2010, Istanbul, Turkey – Organizing commity member

8. Expertissues Trainig Course on Cranio-Maxillofacial Animal Models, July 28-31,

2010, Ankara, Turkey – Organizing team member

9. Biomed 2010 – 16th International Biomedical Science and Technology Symposium,

September 29 – October 2, 2010, Besiktas, Istanbul, Turkey – National Advisory Board

Member

10. 18th International Biomedical Science and Technology Symposium, September 10-

13, 2012, Tokat, Turkey – National Advisory Board Member

11. TERMIS EU Chapter 2013 Congress, June, 2013, Istanbul, Turkey (National

Organizing Committee).

12. 2nd Biomaterials Day, Hacettepe University, April 2014, Ankara, Turkey (Sc

Entific Committee)

13. 20th International Biomedical Science and Technology Symposium, August 24-27,

2014, Köyceğiz, Muğla, Turkey – National Advisory Board Member.

14. KOMPEGE III, International Participation III. Ege Composite Materials Symposium,

Kuşadası, Aydın, Turkey – Scientific Board Member.

Theses Completed 1. Burcu Sarıkaya: “Development of Collagen/Beta-Tricalcium Phosphate Based

Synthetic Bone Grafts”. 2. Selcen Güler: “ Development of Extracellular Matrix Preparation Protocols Using

Supercritical Fluid Supported Decellularization Method for Aorta Tissue Repair”.

3. Bahar Aslan: “Preparation of Polymeric and Decellularized Matrices for Cornea

Tissue Engineering”.

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Journal Referee Duties 1. Journal of Tissue Engineering and Regenerative Medicine

2. Acta Biomaterialia

3. Journal of Materials Science and Engineering

4. Physiological Research

5. Journal of Microencapsulation 6. Advanced Materials Letters

7. Turkish Journal of Biochemistry

8. Kara Harp Okulu Bilim Dergisi

9. Pamukkale University Journal of Engineering Sciences

Professional Membership 1. Founding member of the National Society of Biomedical Sciences.

2. Member of Biomaterials and Tissue Engineering Society.

3. Member of European Society for Artificial Organs (ESAO).

Courses, Workshops & Meetings 1. Advanced Practical Course on the Design and Building of Quartz Crystal

Microbalance (QCM) Biosensors, June 20-27, 2004, Ankara, Turkey

2. 2nd Alea Jacta Est/2nd EXPERTISSUES TUTORIAL COURSE – “Tissue Engineering

of Bone and Cartilage: Current Trends and Future Perspectives”, October 17-19, 2005,

Antalya, Turkey.

3. Bone and Cartilage Tissue Engineering, Satellite Workshop, May 12, 2007, Samsun,

Turkey.

4. NanoTR-3 Nanoscience and Nanotechnology Conference, June 11-14, 2007,

Ankara, Turkey.

5. Expertissues 36th Month Meeting, October 5-6, 2007, Kusadasi, Turkey.

6. 6th Marie Curie Cutting-Edge Conference, October 27-31, 2008, Algarve, Portugal.

7. Hacettepe University Continuous Training Centre, Biomaterial-Tissue Compatibility

in Tissue Engineering Applications, March 27, 2009, Ankara, Turkey

8. FP7 Marie Curie Actions/ Industry-Academia Partnerships and Pathways IAPP

Summer School: Porous Hydrogels for biomedical applications –from cytapheresis to

tissue engineering, Summer School September 29-October 2, 2009, Antalya, Turkey.

20

10. European Society for Artificial Organs & American Society for Artificial Internal

Organs Joint Winter School: Bioartificial Organs & Cell Therapy 2010, January 21-23,

2010, Semmering, Austria.

11. Monaco Extra Summer School, September 29 – October 2, 2010, Antalya, Turkey.

12. COST Action B28, Workshop on Array Technologies, May 5-6, 2010, Istanbul,

Turkey.

13. 24th Annual Scientific Congress of Turkish Neurosurgical Society, May 14-18, 2010,

Antalya, Turkey.

14. Marie Curie Conference, July 1-2, Turin, Italy.

15. EuroScience Open Forum, July 2-7, Turin, Italy.

16. MIT Professional Education – Short Programs: Controlled Release Technology:

Polymeric Delivery Systems For Pharmaceuticals, Proteins and Other Agents, July 19-

23, 2010, Boston, USA.

17. 5th Workshop on Biopolymeric Systems, March 4, 2011, Industrial Experience in

Biomaterial Production, Ankara, Turkey.

18. 7th Symposium on Controlled Releaase Systems, 2 June 2011, Istanbul, Turkey.

19. 61st Nobel Laureates Meeting, 26 June – 1 July 2011, Lindau, Germany.

20. 8th Nanoscience – Nanotechnology Congress & IANM 3rd World Congress, June

25-29, 2012, Ankara, Turkey.

21. Advances in Tissue Engineering, 20th Annual Short Course, August 8-11, 2012,

Rice University, Houston, Texas, USA.

22. 18th International Biomedical Science and Technology Symposium, September 10-

13, 2012, Gaziosmanpaşa Üniversitesi, Tokat, Turkey.

23. BIOMATEN Workshop on “Use of Biomaterials in Medical Field”, March 19, 2013,

Ankara, Turkey.

24. Universita Degli Studi Di Trento Summer School on Biomaterials and Regenerative

Medicine, July 8-12, 2013, Riva del Garda, Italy.

25. International Cartilage Repair Society ICRS 2013 Congress, September 15-18,

2013, İzmir, Rurkey.

26. COST Action MP1301 First MC and WG Meeting, March 13-14, 2014 Turin, Italy.

27. British Council’s Researchers Link Programme, New Horizons in Biocatalysis for

Biomaterials Workshop, April 8-12, 2014, İzmir, Turkey.

28. International Conference on Tissue Engineering, 20-25 June 2014, Kos, Greece.

29. The International Bioprinting Congress, 24-25 July, 2014, Singapore.

21

30. The International Seminar on Lab on A Chip, 7-11 September, 2014, Kuşadası,

Turkey.

31. HUNITEK Advanced Technologies on Health Sciences Symposium, 15-16

September, 2014, Ankara, Turkey.

32. 21st International Biomedical Science and Technology Symposium, October 22-24,

2015, Antalya, Turkey.

33. Turkish Ministry of Health, Turkish Pharmacopea Workshop, December 9-12, 2015,

Kizilcahamam, Turkey.