SDPpred: a method for identification of amino acid residues that determine differences in functional...

Post on 06-Jan-2018

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description

Positions that account for specificity Assignment of specificity to new proteins Experiment Testing on families that include proteins with resolved 3D structure SDPpred Description of specificity groups : Group А: No. 1-10,13… Group В: No.12, 14-16… Group С: No … … Q9KDW MSPFLGEVIGTMILIILGGGVVAGVVLKGTK Q8Y6Z1 ----MIDTSLATQFLGEVIGTAILIILGAGVVAGVSLKRSK Q97JG MTIFFAELVGTLLLILLGDGVVANVVLKNSK GLPF_ECOLI MSQT---STLKGQCIAEFLGTGLLIFFGVGCVA--ALKVAG Q8ZJK5 MSQTA-SSTLKGQCIAEFLGTGLLIFFGAGCVA--ALKLAG GLPF_HAEIN MDKS-----LKANCIGEFLGTALLIFFGVGCVA—-ALKVAG GLPF_PSEAE MTTAAPTPSLFGQCLAEFLGTALLIFFGTGCVA--ALKVAG AQPZ_BRUME MLNKLSAEFFGTFWLVFGGCGSAILAA--AFP Q92NM MFRKLSVEFLGTFWLVLGGCGSAVLAA--AFP Q8UJW MGRKLLAEFFGTFWLVFGGCGSAVFAA--AFP AQPZ_ECOLI MFRKLAAECFGTFWLVFGGCGSAVLAA--GFP Alignment ?