Download - The Eindhoven Diabetes Education Simulator (e-DES) - incorporating different food products and composite meals

Incorporating different food products and composite meals in the Eindhoven Diabetes Education Simulator (E-DES)

Anne Maas, MSc ([email protected])

Researcher at Máxima Medical Center, Eindhoven

The problem…

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Eindhoven Diabetes Educational Simulator (E-DES)

Objective:Practice safely, independently at home!

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Simplified physiological model

• Gut, plasma and remote compartments

• In- and outflow of glucose and insulin

In equations

Glucose in gut

Glucose in plasma

Insulin in plasma

Insulin in remote compartment

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pl

meal1

11

meal

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Model calculates glucose and insulin

Fit model on data

Fit model on data

time

con

cen

trati

on

magnitudeerror

peak (simulation)

peak (data)

data

original model

error

optimal model

Predicting OGTT data for healthy people

Plasma glucose Plasma insulin

From clinical to home setting: food inclusion

• Hypothesis: capture differences in dynamic profile by adjusting mathematical model

Graph from Sadler 2011, ILSI Europe Concise Monograph Series

Meal ingestion data from literature

• Literature search glucose + insulin data• 18 publications• 57 meals, 220 subjects total

• 35 meals included, … subjects total

Resulting model fits for different meals

Plasma glucose

Adjustments in the model

Conclusion & outlook

• Conclusion:– 35 different food products/meals included– Wide variety of meals– Only food intake part of model adjusted

• Outlook:– Dinner data largely missing measure 6

dinners in new research– Method & food profiles transferable to

model for diabetes type 1 and 2

• Y Rozendaal• N van Riel• P Hilbers• W Cottaar

• C van Pul• H Haak

Sponsored by Novo Nordisk

The team