Relative Contribution of Prepregnancy Overweight and Obesity, Gestational Weight
Gain, and IADPSG-Defined Gestational Diabetes Mellitus to Fetal Overgrowth
The Special Turku Coronary Risk Factor Intervention Project (STRIP) study
Featured Article:
Olli Oranta, P.H.D., Katja Pahkala, P.H.D., Soile Ruottinen, P.H.D.Harri Niikikoski, M.D., P.H.D., Hanna Lagström, P.H.D., Jorma S.A. Viikari, M.D., P.H.D., Antti Jula, M.D., P.H.D., Britt-Marie Loo, P.H.D., Olli Simell, M.D., P.H.D.,
Tapani Rönnemaa, M.D., P.H.D., Olli T. Raitakari, M.D., P.H.D.
Diabetes Care Volume 36: 2952-2959
October, 2013
STUDY OBJECTIVE
• Low-saturated-fat dietary counseling started in infancy improves insulin sensitivity in healthy children 9 years of age
• We aimed to evaluate the effect of lifelong dietary counseling on insulin sensitivity in healthy adolescents between 15 and 20 years of age
• We examined dietary fiber intake and the polyunsaturated fatty acid (PUFA) + monounsaturated (MUFA)-to-saturated fatty acid (SFA) ratio and the association of these dietary factors with homeostasis model of insulin resistance (HOMA-IR)
Oranta O. et al. Diabetes Care 2013;36:2952-2959
STUDY DESIGN AND METHODS
• Adolescents participated in the randomized, controlled STRIP study
• HOMA-IR was assessed annually, as was diet, BMI, pubertal status, serum cotinine concentrations, and physical activity
• Dietary counseling was given biannually during the follow-up
Oranta O. et al. Diabetes Care 2013;36:2952-2959
Oranta O. et al. Diabetes Care 2013;36:2952-2959
RESULTS
• HOMA-IR was lower in the intervention group than in the control group
• Intervention effect was similar in girls and boys
• PUFA+MUFA-to-SFA ratio was higher and the dietary fiber (g/MJ) intake was higher in the intervention group compared with the control group
• There was no association between the PUFA+MUFA-to-SFA ratio and HOMA-IR, whereas dietary fiber intake was associated with HOMA-IR in girls
Oranta O. et al. Diabetes Care 2013;36:2952-2959
Oranta O. et al. Diabetes Care 2013;36:2952-2959
Oranta O. et al. Diabetes Care 2013;36:2952-2959
CONCLUSIONS
• Dietary counseling initiated in infancy and maintained until 20 years of age was associated with improved insulin sensitivity in adolescents
Oranta O. et al. Diabetes Care 2013;36:2952-2959
Oranta O. et al. Diabetes Care 2013;36:2952-2959
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