Relative Contribution of Prepregnancy Overweight and Obesity, Gestational Weight

Gain, and IADPSG-Defined Gestational Diabetes Mellitus to Fetal Overgrowth

The Special Turku Coronary Risk Factor Intervention Project (STRIP) study

Featured Article:

Olli Oranta, P.H.D., Katja Pahkala, P.H.D., Soile Ruottinen, P.H.D.Harri Niikikoski, M.D., P.H.D., Hanna Lagström, P.H.D., Jorma S.A. Viikari, M.D., P.H.D., Antti Jula, M.D., P.H.D., Britt-Marie Loo, P.H.D., Olli Simell, M.D., P.H.D.,

Tapani Rönnemaa, M.D., P.H.D., Olli T. Raitakari, M.D., P.H.D.

Diabetes Care Volume 36: 2952-2959

October, 2013

STUDY OBJECTIVE 

• Low-saturated-fat dietary counseling started in infancy improves insulin sensitivity in healthy children 9 years of age

• We aimed to evaluate the effect of lifelong dietary counseling on insulin sensitivity in healthy adolescents between 15 and 20 years of age

• We examined dietary fiber intake and the polyunsaturated fatty acid (PUFA) + monounsaturated (MUFA)-to-saturated fatty acid (SFA) ratio and the association of these dietary factors with homeostasis model of insulin resistance (HOMA-IR)

Oranta O. et al. Diabetes Care 2013;36:2952-2959

STUDY DESIGN AND METHODS

• Adolescents participated in the randomized, controlled STRIP study

• HOMA-IR was assessed annually, as was diet, BMI, pubertal status, serum cotinine concentrations, and physical activity

• Dietary counseling was given biannually during the follow-up

Oranta O. et al. Diabetes Care 2013;36:2952-2959

Oranta O. et al. Diabetes Care 2013;36:2952-2959

RESULTS

• HOMA-IR was lower in the intervention group than in the control group

• Intervention effect was similar in girls and boys

• PUFA+MUFA-to-SFA ratio was higher and the dietary fiber (g/MJ) intake was higher in the intervention group compared with the control group

• There was no association between the PUFA+MUFA-to-SFA ratio and HOMA-IR, whereas dietary fiber intake was associated with HOMA-IR in girls

Oranta O. et al. Diabetes Care 2013;36:2952-2959

Oranta O. et al. Diabetes Care 2013;36:2952-2959

Oranta O. et al. Diabetes Care 2013;36:2952-2959

CONCLUSIONS

• Dietary counseling initiated in infancy and maintained until 20 years of age was associated with improved insulin sensitivity in adolescents

Oranta O. et al. Diabetes Care 2013;36:2952-2959

Oranta O. et al. Diabetes Care 2013;36:2952-2959