Omeneu Instant(Omeprazole
+Sodiumbicarbonate)
Digestive System• Esophagus( tube that connects your
mouth and your stomach)• Stomach• Small Intestine• Large Intestine• Gall bladder• Liver• Pancreas
Stomach• A stretchy bag that holds
your food after you eat.Stomach has 4 major roles in human body.
• To store food• To mix the food with HCl and pepsin• To reduce the size of food particles• To empty the partially digested food
into the small intestine
Esophagus
Stomach
Stomach Cells• Parietal cells (oxyntic cells) are the stomach epithelium cells
which secrete gastric acid.
• Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors).
• Parietal cells contain an extensive secretary network (canaliculi) from which the HCl is secreted by active transport into the stomach.
Acid-Related Pathophysiology
The stomach secretes:• Hydrochloric acid (HCl)• Bicarbonates• Pepsinogen• Mucus• Prostaglandins
Gastroesophageal Reflux Disease (GERD
• Most common disorder of esophagus• Characterized by regurgitation of gastric contents into
esophagus and exposure of esophageal mucous to gastric acid and pepsin.
• Main symptom is heart burn – occurs after eating.
Complications of GERD
• Esophagitis, stricture or ulcer• Barrett’s Esophagus
Peptic Ulcer
• Condition characterized by Erosion of GI mucosa resulting from digestiveaction of HCl and pepsin
• Ulcer development– Lower esophagus– Stomach– Duodenum
Gastric Ulcer
• common in late middle age– incidence increases with age
• Use of NSAIDs - associated with a three- to four-fold increase in risk of gastric ulcer
• Less related to H. pylori than duodenal ulcers – about 80%
• 10 - 20% of patients with a gastric ulcer have a concomitant duodenal ulcer.
Duodenal Ulcer• Duodenal sites are common as
gastric sites • Most common in middle age • Male to female ratio—4:1 • Associated with increased serum
pepsinogen• H. pylori infection common up to
95%• Smoking is twice as common
Helicobacter Pylori (H. pylori)
• Helicobacter Pylori (H. pylori) is a spiral shaped bacterium found in the stomach.
• H. pylori damages stomach and duodenal tissue
• Causes 80% of peptic ulcers• Survives the acid environment by
attaching to the sugar molecules that line the stomach wall
• Uses the mucus layer as protection
Zollinger-Ellison Syndrome
• Zollinger-Ellison Syndrome is a rare disorder that causes one or more tumors to form in the pancreas or
• upper part of the small intestine called the duodenum. • The tumorsare called gastrinomas, and they secrete a large amountof the hormone gastrin. • In this syndrome increased levels of the hormone
gastrin are produced, causing the stomach to produce excess
Release of Gastric Acid• Histamine stimulates acid release by
interacting with the histamine receptor• Acetylcholine activates the cholinergic
receptors• Gastrin is released when
food is present in the stomach
Proton Pump Inhibitor
Mode of ActionProton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.
Blocks the enzyme in the wall of the stomach that produces acid.
Antacids
• Quick but short term• Buffer gastric acid, increasing the pH• Neutralize acid by the following reaction
NaHCO3 + HCl NaCl + H2O + CO2
Dosage ScheduleIndication Dose Frequency
Short-Term Treatment of Active Duodenal
Ulcer
20mg Once daily for 4 weeks
Benign Gastric Ulcer 40mg Once daily for 4-8 weeks
Gastroesophageal Reflux Disease (GERD)
Symptomatic GERD (with no esophageal
erosions)
20mg Once daily for up to 4 weeks
Erosive Esophagitis 20mg Once daily for 4-8 weeks
Maintenance of Healing of Erosive
Esophagitis
20mg Once daily
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