Omeneu instant (Asma Saleem Product Manager Neutro Pharma)
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Transcript of Omeneu instant (Asma Saleem Product Manager Neutro Pharma)
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Omeneu Instant(Omeprazole
+Sodiumbicarbonate)
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Digestive System• Esophagus( tube that connects your
mouth and your stomach)• Stomach• Small Intestine• Large Intestine• Gall bladder• Liver• Pancreas
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Stomach• A stretchy bag that holds
your food after you eat.Stomach has 4 major roles in human body.
• To store food• To mix the food with HCl and pepsin• To reduce the size of food particles• To empty the partially digested food
into the small intestine
Esophagus
Stomach
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Stomach Cells• Parietal cells (oxyntic cells) are the stomach epithelium cells
which secrete gastric acid.
• Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors).
• Parietal cells contain an extensive secretary network (canaliculi) from which the HCl is secreted by active transport into the stomach.
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Acid-Related Pathophysiology
The stomach secretes:• Hydrochloric acid (HCl)• Bicarbonates• Pepsinogen• Mucus• Prostaglandins
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Gastroesophageal Reflux Disease (GERD
• Most common disorder of esophagus• Characterized by regurgitation of gastric contents into
esophagus and exposure of esophageal mucous to gastric acid and pepsin.
• Main symptom is heart burn – occurs after eating.
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Complications of GERD
• Esophagitis, stricture or ulcer• Barrett’s Esophagus
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Peptic Ulcer
• Condition characterized by Erosion of GI mucosa resulting from digestiveaction of HCl and pepsin
• Ulcer development– Lower esophagus– Stomach– Duodenum
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Gastric Ulcer
• common in late middle age– incidence increases with age
• Use of NSAIDs - associated with a three- to four-fold increase in risk of gastric ulcer
• Less related to H. pylori than duodenal ulcers – about 80%
• 10 - 20% of patients with a gastric ulcer have a concomitant duodenal ulcer.
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Duodenal Ulcer• Duodenal sites are common as
gastric sites • Most common in middle age • Male to female ratio—4:1 • Associated with increased serum
pepsinogen• H. pylori infection common up to
95%• Smoking is twice as common
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Helicobacter Pylori (H. pylori)
• Helicobacter Pylori (H. pylori) is a spiral shaped bacterium found in the stomach.
• H. pylori damages stomach and duodenal tissue
• Causes 80% of peptic ulcers• Survives the acid environment by
attaching to the sugar molecules that line the stomach wall
• Uses the mucus layer as protection
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Zollinger-Ellison Syndrome
• Zollinger-Ellison Syndrome is a rare disorder that causes one or more tumors to form in the pancreas or
• upper part of the small intestine called the duodenum. • The tumorsare called gastrinomas, and they secrete a large amountof the hormone gastrin. • In this syndrome increased levels of the hormone
gastrin are produced, causing the stomach to produce excess
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Release of Gastric Acid• Histamine stimulates acid release by
interacting with the histamine receptor• Acetylcholine activates the cholinergic
receptors• Gastrin is released when
food is present in the stomach
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Proton Pump Inhibitor
Mode of ActionProton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.
Blocks the enzyme in the wall of the stomach that produces acid.
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Antacids
• Quick but short term• Buffer gastric acid, increasing the pH• Neutralize acid by the following reaction
NaHCO3 + HCl NaCl + H2O + CO2
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Dosage ScheduleIndication Dose Frequency
Short-Term Treatment of Active Duodenal
Ulcer
20mg Once daily for 4 weeks
Benign Gastric Ulcer 40mg Once daily for 4-8 weeks
Gastroesophageal Reflux Disease (GERD)
Symptomatic GERD (with no esophageal
erosions)
20mg Once daily for up to 4 weeks
Erosive Esophagitis 20mg Once daily for 4-8 weeks
Maintenance of Healing of Erosive
Esophagitis
20mg Once daily
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