Animal Procurement, Animal Procurement, Transport, Quarantine
and Health SurveillanceSurveillance
D. HarrisonSupervisor QA LabImport/Export
Laboratory Animal Care and Use Program and Facilities
Import/Export
Animal ProcurementAnimal Procurement
Ho do e get How do we get them in ?them in ?
A d h d And how do we keep them keep them
clean?Laboratory Animal Care and Use Program and Facilities
clean?
Animal ProcurementAnimal Procurement
TOPICSTOPICSTOPICSTOPICS
•• Animal ProcurementAnimal Procurement•• Animal ProcurementAnimal Procurement•• Transporting Lab AnimalsTransporting Lab Animals•• Receiving Quarantine & Receiving Quarantine & •• Receiving, Quarantine & Receiving, Quarantine &
ConditioningConditioning•• Microbiological StatusMicrobiological Status•• Microbiological StatusMicrobiological Status•• Animal Health MaintenanceAnimal Health Maintenance
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
Sooner or later, PI’s will want to order in animals for their studies.
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
Facilities should have aFacilities should have acentralized system in place fort ki d d i ttracking orders and receipts.
We call our system GRANITE
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
Procurement Sources
• Approved Commercial • Approved Commercial Vendors/ SuppliersOth U i iti / • Other Universities/ Collaborators
• Unknown Commercial Vendors
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
An animal order must be placed An animal order must be placed with the Supervisor of the facility that will be receiving the animalsthat will be receiving the animals
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
• Reviewed for space available Reviewed for space available in vivarium
• And checked against the current Commercial Vendor current Commercial Vendor listing for approval into the ULAR vivariums
Laboratory Animal Care and Use Program and Facilities
ULAR vivariums
Animal ProcurementAnimal Procurement
A d h k d i t th And checked against the current Commercial Vendor listing for approval into the ULAR vivariums
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
Orders are then sent to the Orders are then sent to the ULAR Animal Desk
• Checked against protocols • Checked against protocols and accounts and entered into Graniteinto Granite.
• Forwarded to purchasing at th R h F d tithe Research Foundation.
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
Non Approved Rodent Orders t t th QAare sent to the QA
Import/Export deskfor quarantine processing.
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
A h lth tA health reportis requestedfrom the facilityfor a yearsworth of testingdata on theanimal facility/room
Laboratory Animal Care and Use Program and Facilities
Animal ProcurementAnimal Procurement
We also checkWe also checkthe type oftransportationto be usedto be used
Laboratory Animal Care and Use Program and Facilities
Transporting Lab AnimalsTransporting Lab Animals
Regulations that Govern Animal Regulations that Govern Animal Transport1. Animal Welfare Act (AWA) 1. Animal Welfare Act (AWA) 2. Public Health Service (PHS) Policy3. The Guide4. CDC5. FDA6. US Dept of Transportation7. US Fish and Wildlife Service8 Oth C t R i t
Laboratory Animal Care and Use Program and Facilities
8. Other Country Requirements
Transporting Lab AnimalsTransporting Lab Animals
AWA Governs-AWA Governs1. Shipping Containers
– SizeSize– Material– # Animals per Container– Food/Water– Temperature Range- Ventilation– Cleanliness
Laboratory Animal Care and Use Program and Facilities
Transporting Lab AnimalsTransporting Lab Animals
AWA Governs – (cont.)AWA Governs (cont.)2. Cargo/Terminal area
Temperature Range Ventilation– Temperature Range- Ventilation– Cleanliness
3 Delivery Vehicles3. Delivery Vehicles– Climate controlled– Cleanliness– Cleanliness
Laboratory Animal Care and Use Program and Facilities
Transporting Lab AnimalsTransporting Lab Animals
Transportation TypesTransportation- Types• Trucking firms
C i l i i• Commercial air carriers• Special equipped
vehiclesvehicles
Laboratory Animal Care and Use Program and Facilities
Receiving AnimalsReceiving Animals
Receipt at the InstitutionReceipt at the Institution• Receiving Room- clean• Check Vehicle shipping animalsCheck Vehicle shipping animals
Laboratory Animal Care and Use Program and Facilities
Receiving AnimalsReceiving Animals
• Disenfect exterior surfaces Disenfect exterior surfaces before entering facility
• Check shipping box condition pp gand verify shipment vs. Granite
Laboratory Animal Care and Use Program and Facilities
Receiving Animalsg
Receipt at the VivariumReceipt at the Vivarium• Pull up Granite, print cage cards • Verify receipt vs animal order• Verify receipt vs. animal orderReceipt at the Room
V if i l b• Verify animal numbers• Examine animals (sex, sick, dead)
Laboratory Animal Care and Use Program and Facilities
Receiving AnimalsReceiving Animals• Transfer Transfer
information to records/cage cards
• Report any problems to the Supervisor
Laboratory Animal Care and Use Program and Facilities
Quarantine of Incoming A i lAnimals
• All animals come into OSU are clean???? • Isolation• Observation, testing, conditioning , g, g• Quarantine Period is dependent on facility
and species.– Rodents 6-8 wks– Non Human Primates 1- 2 months– Others vary by testing and previous health reportsOthers vary by testing and previous health reports
• No experimental procedures (generally)• Animals in quarantine should be handled
Laboratory Animal Care and Use Program and Facilities
Animals in quarantine should be handled after animals of known health status
Quarantine of Incoming A i lAnimals
• Animal TreatmentAnimal Treatment– Health Exams
Diagnostic procedures– Diagnostic procedures• TB tests• Parasitology, bloodwork,Parasitology, bloodwork,microbiology
– Prophylaxis - pinworm op y a s p oFenbendazole feed
– Treatment for existing
Laboratory Animal Care and Use Program and Facilities
gpathogens- found on diagnostics
Quarantine of Incoming A i lAnimals
• Facility DesignFacility Design– Separate from
colony (Isolation)
– Negative pressure pressure environment
WHY??WHY??
Laboratory Animal Care and Use Program and Facilities
Conditioning PeriodConditioning Period
• Allows for acclimatization Allows for acclimatization before study begins
• Can be run at same time as • Can be run at same time as QuarantineSt d i l • Stressed animals hormones (adrenal) which can effect experimental data
Laboratory Animal Care and Use Program and Facilities
Microbiological StatusMicrobiological Status• What does this refer to?What does this refer to?
The types of organisms the animal is carryingy g
Laboratory Animal Care and Use Program and Facilities
Microbiological StatusMicrobiological Status
• Axenic– Means “germ-free”– Born by C-section (sterile)y ( )
• Gnotobiotic (no-toe-by-ah-tic)– Carefully defined microbial floray– All microbes present are known,
usually given to the animal by y g ymouth
Laboratory Animal Care and Use Program and Facilities
Microbiological StatusMicrobiological Status
• Specific Pathogen Free (SPF)– Certain disease (pathogen) Certain disease (pathogen)
eliminated
• Barrier ―Different meanings to facilitiesDifferent meanings to facilities―Known disease status―Sterile or non sterile equipment
Laboratory Animal Care and Use Program and Facilities
q p
Microbiological StatusMicrobiological StatusTrexler ®Trexler ®Systems are used forare used forboth
Laboratory Animal Care and Use Program and Facilities
Microbiological StatusMicrobiological Status• ConventionalConventional
– Raised in normal environment– Number and type of microbes – Number and type of microbes
unknown
Laboratory Animal Care and Use Program and Facilities
Health Surveillance & M i tMaintenance
• Animal Technician is the first line Animal Technician is the first line of defense
• Quality Assurance & Health Monitoring Programg g―Sentinel Program ―Environmental Program―Large Animal Program
• Vaccines/Physicals/ Updated testing• TB Testing
Laboratory Animal Care and Use Program and Facilities
• TB Testing
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