Download - Acne Fagron Advanced Derma · Acne Tailor-made treatment of acne Treatment of acne focusses on the bacterial proliferation, skin inﬂammation and/or follicular hyperproliferation

Fagron Advanced Derma

Indications

Acne

Acne

Acne is one of the most common disorders that dermatologists treat.

Acne can manifest in inflammatory and non-inflammatory forms. Dermatologists assess the severity of a patient’s acne by using a grading scale. Treatment is often adjusted to the grading scale and the inflammatory condition. Acne and inflammation can be treated with active

Acnepharmaceutical ingredients (APIs), whereas moisturisers and dermaceutical ingredients (DCIs) can be used in basic skin care to nourish the skin to a better condition and prevent future inflammation.

To ensure continuous care for the acne skin, the utmost flexibility in terms of treatment combination and dosage is required when prescribing APIs, DCIs and basic skin care.

With Fagron Advanced Derma, patients are guaranteed a total solution for both tailor-made prescription compounding and basic skin care based on:

• Vehicle design according to the latest scientific insights into the safety and tolerance of topically applied ingredients

• • Suitability for vulnerable, sensitive

skin• Optimal compatibility with a broad

range of APIs and DCIs•

formulations for easy prescribing and compounding by indication

Total solutionDiscover Fagron Advanced Derma’s total solution by accessing the various information resources:• Fagron Advanced Derma brochure• Indication brochures• Vehicle brochures• Compatibility table• Quality documents• Compounding Matters formulations

database• Fagron Academy

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Fagron Advanced Derma Leading advanced dermatological care

Acne

Tailor-made treatment of acneTreatment of acne focusses on the bacterial proliferation, skin inflammation and/or follicular hyperproliferation with APIs and DCIs in non-comedogenic vehicles.1. APIs can be selected, based on individual dosing, to meet the patient’s specific treatment needs according to grade of lesion and inflammation.2. DCIs can be added to nourish the skin and prevent inflammation.3. Basic skin care

Recommended APIs and DCIs in the treatment of acne1

API Function Indication specific dosage (range)

Common dose frequency

Azelaic acid Inflammatory acne. 10 to 20% Twice-dailyBenzoyl peroxide Anti-microbial. 2.5 to 10% Twice-daily Clindamycin HCl Anti-microbial. 1% Twice-dailyErythromycin Anti-microbial. 2% Twice-daily Glycolic acid Chemical exfoliating agent, accelerating skin cell turnover. 5 to 10% Once-daily Salicylic acid Keratolytic. 0.5% to 2% Twice-daily Sulphur Keratolytic, anti-fungal and anti-septic. 5 to 10% Twice-dailyTretinoin (vit. A acid) Retinoid, accelerating skin cell turnover. 0.025 to 0.1% Daily before bedtime DCIAloe vera extract Anti-inflammatory and emollient. 0.5 to 5% Twice-dailyAlpha bisabolol Anti-inflammatory. 0.5 to 5% Twice-dailyChamomile extract Anti-inflammatory. 0.5 to 5% Twice-dailyDexpanthenol Anti-inflammatory. 0.5 to 5% Twice-dailyNicotinamide (vit. B3) 2 to 4% Twice-dailyTocopherol (vit. E) Anti-inflammatory and antioxidant. 0.5 to 5% Twice-dailyZinc sulfate Anti-inflammatory and 5-alpha-reductase inhibitor. 5% Twice-daily

Recommended vehicles for compounding and basic skin care in the treatment of acneVehicle Skin type profile Skin types

Fitalite™ Natural gel cream base Oily skin Very dehydrated skin

Nourilite™ Vanishing O/W emulsion base Balanced skin

Seraqua™ Ultra-light O/W serum base Dehydrated skin Specific skin area

Compounding formulations for acneRx/Erythromycin 2%in Nourilite™S. Apply twice-daily

Rx/Tretinoin (vit. A acid) 0.03%in Seraqua™S. Apply daily before bedtime

Rx/Benzoyl peroxide 5%in Fitalite™S. Apply twice-daily

Rx/Clindamycin HCl 1%Nicotinamide (vit. B3) 4%in Fitalite™S. Apply twice-daily

Rx/Glycolic acid 5%in Seraqua™S. Apply once-daily

Rx/Tretinoin (vit. A acid) 0.05%in Nourilite™S. Apply daily before bedtime

Please refer to the Fagron Advanced Derma compatibility table for vehicle and API/DCI combinations.1 Literature references available upon request.

Please refer to the Compounding Matters database at fagron.com for more formulations.

Ageing Skin

Ageing skin

Ageing of the skin is a complex biological process. Dermatologists are treating an increasing number of patients for thiscondition.

The consequence of skin ageing is characterised by degeneration of the skin, wrinkling, thinning, pigmentation, dehydration, increased sensitivity and gradual loss of skin elasticity.

Ageing skinTopical treatment with both active pharmaceutical ingredients (APIs) and dermaceutical ingredients (DCIs) is the moste ective approach.

Treatment and preventive care for ageing skin is usually chronic. The patient must therefore experience maximum comfortduring treatment if compliance is to be forthcoming and optimal results are to be achieved.



• Di erent bases for di erent skin types• Suitability for vulnerable, sensitive


range of APIs and DCIs• A formulary containing di erent




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Ageing skin

Tailor-made treatment of ageing skinAgeing skin is commonly treated by ‘on the spot’ anti-wrinkling, depigmentation and elasticity improving therapy. Preventive and restorative skin care is also used, especially on sun-exposed areas.1. APIs can be selected, based on individual dosing, to meet the patient’s specific treatment needs.2. DCIs can be added to improve and/or recover the skin condition and prevent ageing of the skin.3. Basic skin care is guaranteed with the proper choice of Fagron Advanced Derma vehicles. The vehicles are designed to be suitable for di erent

skin types and serve to nourish the sensitive skin and prevent dehydration.

Recommended APIs and DCIs in the treatment of ageing skin1



Glycolic acid Alpha-hydroxy acid. Useful in ameliorating some of the signs of chronic cutaneous photodamage.

8% Twice-daily

Tretinoin (vit. A acid) Reduces the signs of UV-induced early skin ageing, such as wrinkles, loss of skin elasticity and pigmentation.

0.02 to 0.05% Once-daily before bedtime

DCIAloe vera extract Humectant. Natural e ective ingredient for improving skin hydration. 2 to 10% Twice-dailyArginine HCl Induces significant increase in urea in the stratum corneum and a continuous

increase in skin moisture in ageing skin.2.5% Twice-daily

Ascorbic acid (vit. C) Skin anti-ageing e ect by inducing the production of collagenase-1 and collagenase-3, as well as enzymes important for the production of collagen, and inhibitors of matrix metalloproteinase (MMP).

5 to 15% Once-daily

Lactic acid Useful in ameliorating some of the signs of chronic cutaneous photodamage. 8% Once-daily before bedtimeNicotinamide (vit. B3) Regulates cell metabolism and regeneration, and shows improvement in skin

elasticity, erythema and pigmentation.2 to 5% Once-daily

Retinol (vit. A) Induces the biosynthesis of collagen and reduces the expression of MMP (collagenase-1).

0.4% Once-daily

Tocopherol (vit. E) Acts by smoothing the skin and increasing the ability of the stratum corneum to maintain its humidity and contributes to photoprotection of the skin.

2 to 10% Once-daily

Recommended vehicles for compounding and basic skin care in the treatment of ageing skinVehicle Skin type profile Skin types

Versatile™ Vanishing O/W cream base Oily skin Very dehydrated skin

Fitalite™ Natural gel cream base Balanced skin A ected skin

Nourilite™ Vanishing O/W emulsion base Dehydrated skin Specific skin area

Seraqua™ Ultra-light O/W serum base


Compounding formulations for ageing skinRx/Lactic acid 8%in Nourilite™S. Apply once-daily before bedtime

Rx/Retinol (vit. A) 0.4%in Seraqua™S. Apply once-daily

Rx/Glycolic acid 8%in Versatile™S. Apply twice-daily

Rx/Tretinoin (vit. A acid) 0.05%in Seraqua™S. Apply once-daily before bedtime

Rx/Nicotinamide (vit. B3) 5%Tocopherol (vit. E) 5%in Nourilite™S. Apply once-daily

Rx/Aloe vera extract 5%in Fitalite™S. Apply twice-daily


Alopecia &

E�uvium

Hair loss comes in many forms and is an increasingly common complaint among dermatology patients. While there are manypotential diagnoses, the most frequently encountered are androgenetic alopecia,

Topical treatment is the most common approach and dosages are defined individually. There is a challenge with

disorders: finding a suitable vehicle for application on the skin of the scalp that does not cause greasiness, shininess, dripping and skin irritation after application.

usually chronic. The patient must therefore experience maximum comfort during treatment to ensure compliance and improve the quality of life.









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1



Clobetasol propionate Corticosteroid. 0.05% Twice-dailyKetoconazole Anti-fungal and anti-androgen. 2% Once-dailyLatanoprost Stimulates hair growth and thickening. 0.005% Twice-dailyMelatonin Modulates hair growth. 0.0033 to 0.1% Once-dailyMinoxidil Stimulates hair (re)growth. 2 to 5% Twice-dailyTretinoin (vit. A acid) Increases the percutaneous absorption of minoxidil. 0.01% Once-daily, in combination

with minoxidil 5%DCICa�eine Stimulates hair growth. 1 to 2% Once-daily

Vehicle Skin type profile Skin types

Espumil™ Lipophilic foam base Oily skin Very dehydrated skin

Fitalite™ Natural gel cream base Balanced skin

Seraqua™ Ultra-light O/W serum base Dehydrated skin Specific skin area

1. APIs can be selected, based on individual dosing, to meet the patient’s specific treatment needs.2. DCIs can also be added tailored to the patient’s needs to support the treatment.3. Elegant application is guaranteed with the proper choice of Fagron Advanced Derma vehicles

Rx/Latanoprost 0.005%Minoxidil 5%in Espumil™S. Apply twice-daily

Rx/Ketoconazole 2%in Espumil™S. Apply once-daily

Rx/Latanoprost 0.005%in Seraqua™S. Apply twice-daily

Rx/Minoxidil 5%Tretinoin (vit. A acid) 0.01%in Espumil™S. Apply once-daily

Rx/

in Fitalite™S. Apply once-daily

Rx/Minoxidil 2%in Espumil™S. Apply twice-daily


Please refer to the Fagron Advanced Derma compatibility table for vehicle and API/DCI combinations.1 Literature references available upon request

Atopic D

erm./Ecz.

Atopic dermatitis/eczema

Atopic dermatitis/eczema is one of the most common pathologies that dermatologists treat.

Treatment is focused on the two phases of atopic dermatitis: the exacerbation phase, marked by exacerbation of skin lesions, and the maintenance phase. During the exacerbation phase, active pharmaceutical ingredients (APIs) are required to cure the condition.

Atopic dermatitis/eczemaDuring the maintenance phase, moisturisers and dermaceutical ingredients (DCIs) keep the skin in good condition andprevent future exacerbation.

To ensure continuous care for the skin in each phase, the utmost flexibility in terms of treatment combination and dosage isrequired when prescribing APIs, DCIs and basic skin care.









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Recommended APIs and DCIs in the treatment of atopic dermatitis/eczema1



Betamethasone dipropionate

Corticosteroid, anti-inflammatory. 0.05% Twice-daily

Betamethasone valerate Corticosteroid, anti-inflammatory. 0.05 to 0.1% Twice-dailyClobetasol propionate Corticosteroid, anti-inflammatory. 0.05% Twice-dailyCoal tar solution (liquor carbonis detergens)

Anti-inflammatory, antibacterial and anti-pruritic. 10 to 20% Once or twice-daily

Desonide Corticosteroid, anti-inflammatory. 0.05 to 0.1% Twice-dailyDesoximetasone Corticosteroid, anti-inflammatory. 0.25% Twice-dailyDiflucortolone valerate Corticosteroid, anti-inflammatory. 0.1 to 0.3% Twice-dailyFluocinolone acetonide Corticosteroid, anti-inflammatory. 0.01 to 0.1% Twice-dailyHydrocortisone acetate Corticosteroid, anti-inflammatory. 1% Twice-dailyMometasone furoate Corticosteroid, anti-inflammatory. 0.1% Once-dailyTacrolimus Calcineurin inhibitor, anti-inflammatory. 0.03% to 0.3% Twice-daily Triamcinolone acetonide Corticosteroid, anti-inflammatory. 0.1% Twice-dailyDCIAmmonium lactate Moisturiser. 1 to 10% Once-dailyArginine HCl Moisturiser, precursor in the urea cycle. 2.5% Twice-dailyChamomile extract Anti-inflammatory. 0.5 to 5% Twice-dailyCyanocobalamin (vit. B12) Nitric oxide reducer. 0.07% Twice-daily Dexpanthenol Anti-inflammatory. 5% Twice-dailyGlycerol Moisturiser. 1 to 10% Twice-dailyNicotinamide (vit. B3) Vitamin B3 increases biosynthesis of ceramides. 2% Twice-dailyShea butter Moisturiser and emollient, rich in essential fatty acids. 1 to 10% Twice-daily Urea Moisturiser. 5 to 10% Twice-daily

Atopic dermatitis/eczema

Tailor-made treatment of atopic dermatitis/eczemaPharmacological agents typically used to treat atopic dermatitis/eczema include topical steroids, immunomodulators and moisturisers. 1. APIs can be selected, based on individual dosing, to meet the patient’s specific treatment needs during the exacerbation phase.2. DCIs can be added to improve and/or recover the skin condition and prevent exacerbation.3. Basic skin care

Recommended vehicles for compounding and basic skin care in the treatment of atopic dermatitis/eczemaVehicle Skin type profile Skin types

Occluvan™ Hydrophilic ointment base Oily skin Very dehydrated skin

Emolivan™ Natural W/O cold cream base Balanced skin

Versatile™ Rich Enriched O/W cream base Dehydrated skin Specific skin area

Versatile™ Vanishing O/W cream base Please refer to the Fagron Advanced Derma compatibility table for vehicle and API/DCI combinations.1 Literature references available upon request.

Solydra™ Natural oil base

Compounding formulations for atopic dermatitis/eczemaRx/Hydrocortisone acetate 1%Dexpanthenol 5%in Versatile™ RichS. Apply twice-daily

Rx/Cyanocobalamin (vit. B12) 0.07%in Emolivan™S. Apply twice-daily

Rx/Betamethasone valerate 0.05%in Occluvan™S. Apply twice-daily

Rx/Tacrolimus 0.03%in Versatile™S. Apply twice-daily

Rx/Solydra™ S. Use when bathing or showering

Rx/Triamcinolone acetonide 0.1%Glycerol 5%in Emolivan™S. Apply twice-daily


Hidradenitis

suppurativa

Hidradenitis suppurativa

Hidradenitis suppurativa, or acne inversa, is a chronic, inflammatory skin disorder characterised by abscess and cyst formation localised to apocrine sweat gland-bearing skin, such as the armpits and inner thighs.

Abscesses are present on the skin for days to weeks and are always painful. This pain is considered the most important factor in a patient’s overall assessment of disease severity.

Hidradenitis suppurativaThere is a large unmet medical need for

hidradenitis suppurativa. Treatment of painful nodules with anti-inflammatory, antiseptic and keratolytic active pharmaceutical ingredients (APIs) and dermaceutical ingredients (DCIs) can ease the symptoms and drastically improve a patient’s quality of life.

Success in treating this disease is based on tailored dosing with comfortable, skin-friendly vehicles.









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Hyperpig-

mentation

Hidradenitis suppurativa

Tailor-made treatment of hidradenitis suppurativaHidradenitis suppurativa can be treated with anti-inflammatory, antiseptic and keratolytic APIs and DCIs. 1. APIs can be selected, based on individual dosing, to meet patients’ specific treatment needs according to grade of lesion and inflammation.2. DCIs can be added to improve skin condition and prevent inflammation. 3. Basic skin care is provided with the proper choice of Fagron Advanced Derma vehicles. Each vehicle is specifically designed to suit the needs of

Recommended APIs and DCIs in the treatment of hidradenitis suppurativa1



Clindamycin HCI Antibiotic. 1% Twice-dailyResorcinol Keratolytic, antiseptic. 15% Twice-dailyDCI Alpha bisabolol Anti-inflammatory. 2% Twice-dailyChamomile extract Anti-inflammatory. 0.5 to 5% Twice-daily

Recommended vehicles for compounding and basic skin care in the treatment of hidradenitis suppurativaVehicle Skin type profile Skin types

Nourivan™ Antiox Antioxidant O/W cream base Oily skin Very dehydrated skin

Fitalite™ Natural gel cream base Balanced skin


Dehydrated skin Specific skin area

Compounding formulations for hidradenitis suppurativaRx/Resorcinol 15%in Nourivan™ AntioxS. Apply twice-daily

Rx/Clindamycin HCI 1%in Fitalite™S. Apply twice-daily

Rx/Chamomile extract 2%Resorcinol 15%in Nourivan™ AntioxS. Apply twice-daily

Rx/Alpha bisabolol 2%in Fitalite™S. Apply twice-daily

Rx/Chamomile extract 5%in Fitalite™S. Apply twice-daily

Rx/Clindamycin HCI 1%Alpha bisabolol 2%in Fitalite™S. Apply twice-daily


Hyperpigmentation

Hyperpigmentation is an abnormal accumulation of melanin that leads to dark spots on the skin and may worsen withageing.

This skin disorder may be caused by sun damage, inflammation and other skin injuries, including those related to acne vulgaris. People with darker Asian, Mediterranean or African skin tones are more prone to hyperpigmentation.

HyperpigmentationTopical treatment with both active pharmaceutical ingredients (APIs) and dermaceutical ingredients (DCIs) is the most

individually.

Treatment of hyperpigmentation is usually repetitive. The patient must therefore experience maximum comfort to ensure compliance and achieve optimal results.









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Hyperpigmentation

Tailor-made treatment of hyperpigmentationHyperpigmentation is commonly treated by ‘on the spot’ depigmentation therapy. Preventive and supportive skin care is also used on the skin where the pigmentation usually occurs. 1. APIs can be selected, based on individual dosing, to meet the patient’s specific treatment needs.2. DCIs can be added to improve and/or support the skin condition and prevent hyperpigmentation.3. Basic skin care

Recommended APIs and DCIs in the treatment of hyperpigmentation1



Azelaic acid Keratolytic. 20% Twice-dailyDesonide

hyperpigmentation.0.05% Once-daily

Fluocinolone acetonidetretinoin.

0.01% Once-daily

Glycolic acid Keratolytic. 8% Twice-dailyHydroquinone Despigmentant. 2 to 10% Once-dailyKojic acid Skin whitening agent. Tyrosinase inhibitor. 1 to 4% Twice-dailyMometasone furoate

tretinoin.0.1% Once-daily

Tretinoin (vit. A acid) Keratolytic. 0.05% Once-daily

DCIAlpha bisabolol Despigmentant. Ability to inhibit melanogenesis. 0.5% Once-daily Ascorbic acid (vit. C)

oxidation.5 to 15% Once-daily

Lactic acid Keratolytic. 8% Twice-dailyNicotinamide (vit. B3) Despigmentant. Suppression of melanosome transfer leads to reduction of

cutaneous pigmentation. 4% Once-daily

Tocopherol (vit. E) Despigmentant. Antioxidant that can regulate melanogenesis. 5% Once-daily Zinc sulfate Despigmentant. Acts as vital component of both enzymes and cofactors.

Anti-inflammatory and anti-oxidant.10% Once-daily

Recommended vehicles for compounding and basic skin care in the treatment of hyperpigmentationVehicle Skin type profile Skin types

Versatile™ Vanishing O/W cream base Oily skin Very dehydrated skin

Nourivan™ Antiox Antioxidant O/W cream base Balanced skin

Fitalite™ Natural gel cream base Dehydrated skin Specific skin area

Nourilite™ Vanishing O/W emulsion base Please refer to the Fagron Advanced Derma compatibility table for vehicle and API/DCI combinations.1 Literature references available upon request.

Seraqua™ Ultra-light O/W serum base

Compounding formulations for hyperpigmentationRx/Azelaic acid 20%in Fitalite™S. Apply twice-daily

Rx/Ascorbic acid (vit. C) 10%in Nourivan™ AntioxS. Apply once-daily

Rx/Mometasone furoate 0.1%in Versatile™S. Apply once-daily

Rx/Hydroquinone 4%Fluocinolone acetonide 0.01%in Nourivan™ AntioxS. Apply once-daily

Rx/Glycolic acid 8%Nicotinamide (vit. B3) 4%Alpha bisabolol 0.5%in Seraqua™S. Apply twice-daily

Rx/Ascorbic acid (vit. C) 5%Nicotinamide (vit. B3) 4%in Nourilite™S. Apply once-daily


Hyp. scars

& keloids

Hypertrophic scars and keloids

Wound healing constitutes a perfectly coordinated cascade of cellular and molecular events that interact to promote tissue repair. Scarring is a natural part of the wound healing process, and every wound results in some degree of scarring. Excessive scarring can form as a result of aberrations of physiologic wound healing.

Hypertrophic scars stay within the boundaries of the original lesion, whereas keloids are excessive scars that grow beyond the boundaries of the original wound. Once formed, these are hard to remove without invasive surgery. Excessive scarring can


both physically and psychologically. Treatment of scars and keloids is focused on preventing fibrous tissue overgrowth. Silicones are considered as the gold-standard prophylactic and treatment option for hypertrophic scars and keloids.

demonstrated in many clinical studies. Active pharmaceutical ingredients (APIs) and dermaceutical ingredients (DCIs) provide additional support in the treatment of hypertrophic scars and keloids.









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Tailor-made treatment of hypertrophic scars and keloids

possess protective and hydrating properties that enhance skin tissue repair.1. APIs can be selected, based on individual dosing, to meet patients’ specific treatment needs according to the severity of the closed wound or scar. 2. DCIs can be added to enhance closed wound healing.3. Basic skin care

Recommended APIs and DCIs in the treatment of hypertrophic scars and keloids1



Lidocaine (HCI) Local anaesthetic providing analgesia. 5% Twice-dailyZinc oxide Increases the epithelisation in burn wounds. 20% Once-daily

Treatment of proliferative scars. 40% Once-dailyDCI Aloe vera extract Increases epithelisation and promotes wound healing. Anti-bacterial. 1 to 5% Twice-dailyChamomile extract Increases epithelisation. 0.5 to 5% Twice-dailyDexpanthenol Activates fibroblast proliferation. Increases epithelisation. 1 to 5% Twice-dailyShea butter Moisturiser and emollient rich in essential fatty acids. Inhibits pro-inflammatory

cytokines and promotes wound healing.5 to 20% Twice-daily

Tocopherol (vit. E) Enhances the wound healing process and improves the outcome of scars. 2 to 20% Twice-dailyWhen used before and after surgery improves surgical wound healing and aesthetic results.

2 to 10% Twice-daily, before and after surgery

Recommended vehicles for compounding and basic skin care in the treatment of hypertrophic scars and keloidsVehicle Skin type profile Skin types

Nourisil™ Anhydrous silicone base Oily skin Very dehydrated skin



Fitalite™ Natural gel cream base


Compounding formulations and basic skin care for hypertrophic scars and keloidsRx/Nourisil™S. Apply at least twice-daily

Rx/Dexpanthenol 3%in Nourisil™S. Apply at least twice-daily

Rx/Aloe vera extract 5%in Nourisil™S. Apply at least twice-daily

Rx/Zinc oxide 20%in Emolivan™S. Apply once-daily

Rx/Chamomile extract 5%in Versatile™ RichS. Apply twice-daily

Rx/Shea butter 5%in Fitalite™S. Apply at least twice-daily


Psoriasis

Psoriasis

Psoriasis is a common chronic and recurrent inflammatory skin disease characterised by hyperproliferation of epidermal skin cells.

turnover rate, causing them to build up on the surface of the skin and form scaly plaques.

Psoriasis can have a profound impact

physical, psychological, social, sexual and

Psoriasisoccupational activities. As with many chronic skin diseases, life-long treatment is required.

It is important for patients to experience maximum comfort during treatment to aid compliance and improve their quality of life. The availability of topical preparations that have a pleasant skin feel and produce minimal tackiness and greasiness are of crucial importance to this patient group.









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Psoriasis

Tailor-made treatment of psoriasisIndividual patient disease management is essential in the therapy of psoriasis and focuses on slowing down excessive cell reproduction to reduce skin inflammation and providing hydration with active pharmaceutical ingredients (APIs) and dermaceutical ingredients (DCIs).1. APIs with anti-psoriatic and anti-inflammatory functions can be selected, based on individual dosing, to meet patients’ specific treatment needs.2. DCIs with moisturising and emollient properties can be added to reduce the clinical symptoms of psoriasis. 3. Basic skin care

Recommended APIs and DCIs in the treatment of psoriasis1



Anthralin/dithranol Antipsoriatic. 0.05 to 3% Once or twice-dailyBetamethasone dipropionate

Corticosteroid. Anti-inflammatory. 0.05% Twice-daily

Clobetasol propionate Corticosteroid. Anti-inflammatory. 0.05% Twice-dailyCoal tar solution (liquor carbonis detergens)

Suppression of DNA synthesis and subsequent inhibition of keratinocyte proliferation.

10% Twice-daily

Hydrocortisone acetate Corticosteroid. Anti-inflammatory. 0.25 to 2.5% Twice-dailyMometasone furoate Corticosteroid. Anti-inflammatory. 0.1% Twice-dailySalicylic acid 2 to 6% Twice-dailyTacrolimus Calcineurin inhibitor. 0.1 to 0.5% Twice-dailyDCIAloe vera extract 5% Twice-dailyArginine HCl Moisturiser. 2.5% Twice-dailyCyanocobalamin (vit. B12) Anti-inflammatory. 0.07% Twice-daily Dexpanthenol Moisturiser. Nonsteroidal anti-inflammatory agent. 1 to 5% Twice-dailyGlycerol Moisturiser. 5 to 20% Twice-dailyShea butter Moisturiser and emollient. Rich in essential fatty acids. 20% Twice-daily

Recommended vehicles for compounding and basic skin care in the treatment of psoriasisVehicle Skin type profile Skin types

Occluvan™ Hydrophilic ointment base Oily skin Very dehydrated skin





Compounding formulations and basic skin care for psoriasisRx/Coal tar solution (liquor carbonis detergens) 10%in Occluvan™S. Apply twice-daily

Rx/Tacrolimus 0.5%in Emolivan™S. Apply twice-daily

Rx/Clobetasol propionate 0.05%in Occluvan™S. Apply twice-daily

Rx/Salicylic acid 5%Glycerol 5%in Emolivan™S. Apply twice-daily

Rx/Cyanocobalamin (vit. B12) 0.07%in Versatile™ RichS. Apply twice-daily

Rx/Solydra™S. Use when bathing or showering


Scabies

Scabies

Scabies is an infestation of the skin by the mite Sarcoptes scabiei, which causes intense itching with irritating papular or vesicular eruptions.

The usual sites of infestation are between the fingers and on the wrists, but the face, palms, soles and in some cases the trunk

contagious condition that must be treated with scabicidal medicines. Anyone who has

Scabieshad close contact with the patient requires prophylactic treatment.

Having a range of topical vehicles for compounding allows the prescriber to tailor the treatment to each individual

most medicines are applied before night

preparations are greatly appreciated by patients.









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Scabies

Tailor-made treatment of scabiesScabies is treated by using active pharmaceutical ingredients (APIs) with scabicide and insecticide properties that are applied directly to the site of infestation. 1. APIs can be selected, based on individual dosing, to meet patients’ specific treatment needs according to grade and site of infestation.2. Patient comfort is provided with the proper choice of Fagron Advanced Derma vehicles that are gentle, easy to apply, non-sticky and non-greasy.

Recommended APIs in the treatment of scabies1



Benzyl benzoate Insecticide. It kills lice and scabies mites. 25% Single or multiple application

Permethrin Insecticide. It kills lice and scabies mites. 5% Single or multiple application

Sulphur Sulphur is an antifungal, antibacterial, keratolytic agent. Also shows scabicide activity.

8 to 10% Single or multiple application

Recommended vehicles for compounding in the treatment of scabiesVehicle Skin type profile Skin types

Fitalite™ Natural gel cream base Oily skin Very dehydrated skin

Nourilite™ Vanishing O/W emulsion base Balanced skin


Dehydrated skin Specific skin area

Compounding formulations for scabiesRx/Benzyl benzoate 25%in Nourilite™S. Single or multiple application

Rx/Permethrin 5%in Fitalite™S. Single or multiple application

Rx/Permethrin 5%in Nourilite™S. Single or multiple application

Rx/Sulphur 8%in Nourilite™S. Single or multiple application


Xerosis

Xerosis

Xerosis, also called dry skin, is a condition that the majority of people will experience at some stage in their lives.

Dry skin can be chronic or may arise acutely in response to changes in the environment,

exogenous and endogenous factors. Three key skin-related deficiencies play an important role in xerosis: a deficiency in natural moisturising factor (NMF), a deficiency in ceramides, the skin barrier

Xerosislipids, and a deficiency of the skin’s own moisture network.

all three deficiencies to restore skin condition using both active pharmaceutical ingredients (APIs) and dermaceutical ingredients (DCIs). A very comfortable and hydrating topical base is the key to patient compliance in restoring and maintaining a good skin condition.









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Xerosis

Tailor-made treatment of xerosisXerosis treatment is focused on restoring hydration of the skin and retaining skin barrier function. 1. APIs can be selected, based on individual dosing, to meet patients’ specific treatment needs according to grade of dehydration and

loss of barrier function.2. DCIs can be added to restore or maintain the skin condition and prevent exacerbation.3. Basic skin care is provided by choosing Fagron Advanced Derma vehicles that nourish sensitive skin and prevent skin dehydration.

Recommended API and DCIs in the treatment of xerosis1



Salicylic acid Keratolytic. Reduces the severity of xerosis. 5 to 10% Twice-dailyDCI Ammonium lactate Moisturiser. Improves barrier function and symptoms of xerosis. 12% Twice-dailyArginine HCl Moisturiser. Improves the clinical symptoms of dry skin. 2.5% Twice-dailyDexpanthenol Moisturiser. Nonsteroidal anti-inflammatory agent. 1 to 5% Twice-dailyGlycerol Moisturiser. Improves barrier function and symptoms of xerosis. 2.5 to 20% Twice-dailyLactic acid Moisturiser. Improves barrier function and symptoms of xerosis. 10% Twice-dailyMenthol 1 to 3% Twice-dailyNicotinamide (vit. B3) Increases biosynthesis of ceramides. 2 to 5% Twice-dailyShea butter Moisturiser and emollient. Rich in essential fatty acids. 1 to 20% Twice-dailyUrea Moisturiser. Improves barrier function and symptoms of xerosis. 5 to 40% Twice-daily

Recommended vehicles for compounding and basic skin care in the treatment of xerosisVehicle Skin type profile Skin types

Emolivan™ Natural W/O cold cream base Oily skin Very dehydrated skin

Versatile™ Rich Enriched O/W cream base Balanced skin

Versatile™ Vanishing O/W cream base Dehydrated skin Specific skin area

Nourilite™ Vanishing O/W emulsion base


Compounding formulations and basic skin care for xerosisRx/Salicylic acid 5%Urea 10%in Emolivan™S. Apply twice-daily

Rx/Lactic acid 10%Nicotinamide (vit. B3) 4%in Versatile™ RichS. Apply twice-daily

Rx/Ammonium lactate 12%in Emolivan™S. Apply twice-daily

Rx/Urea 20%Dexpanthenol 1%Nicotinamide (vit. B3) 4%in Nourilite™S. Apply twice-daily

Rx/Arginine HCI 2.5%Glycerol 20%in Versatile™S. Apply twice-daily

Rx/Solydra™S. Use when bathing or showering



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or opinion. Medical professionals, doctors and compounding pharmacists using this information are advised to do so solely if appropriate in their own professional opinion and judgement. Fagron does not accept and cannot be held responsible or liable in any case for the formulations or information contained herein.