Acne Fagron Advanced Acne Tailor-made treatment of acne Treatment of acne focusses on the bacterial

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Transcript of Acne Fagron Advanced Acne Tailor-made treatment of acne Treatment of acne focusses on the bacterial

  • Fagron Advanced Derma

    Indications

    Acne

  • Acne

    Acne is one of the most common disorders that dermatologists treat.

    Acne can manifest in inflammatory and non-inflammatory forms. Dermatologists assess the severity of a patient’s acne by using a grading scale. Treatment is often adjusted to the grading scale and the inflammatory condition. Acne and inflammation can be treated with active

    Acne pharmaceutical ingredients (APIs), whereas moisturisers and dermaceutical ingredients (DCIs) can be used in basic skin care to nourish the skin to a better condition and prevent future inflammation.

    To ensure continuous care for the acne skin, the utmost flexibility in terms of treatment combination and dosage is required when prescribing APIs, DCIs and basic skin care.

    With Fagron Advanced Derma, patients are guaranteed a total solution for both tailor-made prescription compounding and basic skin care based on:

    • Vehicle design according to the latest scientific insights into the safety and tolerance of topically applied ingredients

    • • Suitability for vulnerable, sensitive

    skin • Optimal compatibility with a broad

    range of APIs and DCIs •

    formulations for easy prescribing and compounding by indication

    Total solution Discover Fagron Advanced Derma’s total solution by accessing the various information resources: • Fagron Advanced Derma brochure • Indication brochures • Vehicle brochures • Compatibility table • Quality documents • Compounding Matters formulations

    database • Fagron Academy

    fagron.com

    Fagron Advanced Derma Leading advanced dermatological care

  • Acne

    Tailor-made treatment of acne Treatment of acne focusses on the bacterial proliferation, skin inflammation and/or follicular hyperproliferation with APIs and DCIs in non-comedogenic vehicles. 1. APIs can be selected, based on individual dosing, to meet the patient’s specific treatment needs according to grade of lesion and inflammation. 2. DCIs can be added to nourish the skin and prevent inflammation. 3. Basic skin care

    Recommended APIs and DCIs in the treatment of acne1 API Function Indication specific

    dosage (range) Common dose frequency

    Azelaic acid Inflammatory acne. 10 to 20% Twice-daily Benzoyl peroxide Anti-microbial. 2.5 to 10% Twice-daily Clindamycin HCl Anti-microbial. 1% Twice-daily Erythromycin Anti-microbial. 2% Twice-daily Glycolic acid Chemical exfoliating agent, accelerating skin cell turnover. 5 to 10% Once-daily Salicylic acid Keratolytic. 0.5% to 2% Twice-daily Sulphur Keratolytic, anti-fungal and anti-septic. 5 to 10% Twice-daily Tretinoin (vit. A acid) Retinoid, accelerating skin cell turnover. 0.025 to 0.1% Daily before bedtime DCI Aloe vera extract Anti-inflammatory and emollient. 0.5 to 5% Twice-daily Alpha bisabolol Anti-inflammatory. 0.5 to 5% Twice-daily Chamomile extract Anti-inflammatory. 0.5 to 5% Twice-daily Dexpanthenol Anti-inflammatory. 0.5 to 5% Twice-daily Nicotinamide (vit. B3) 2 to 4% Twice-daily Tocopherol (vit. E) Anti-inflammatory and antioxidant. 0.5 to 5% Twice-daily Zinc sulfate Anti-inflammatory and 5-alpha-reductase inhibitor. 5% Twice-daily

    Recommended vehicles for compounding and basic skin care in the treatment of acne Vehicle Skin type profile Skin types

    Fitalite™ Natural gel cream base Oily skin Very dehydrated skin

    Nourilite™ Vanishing O/W emulsion base Balanced skin Seraqua™ Ultra-light O/W serum base Dehydrated skin Specific skin area

    Compounding formulations for acne Rx/ Erythromycin 2% in Nourilite™ S. Apply twice-daily

    Rx/ Tretinoin (vit. A acid) 0.03% in Seraqua™ S. Apply daily before bedtime

    Rx/ Benzoyl peroxide 5% in Fitalite™ S. Apply twice-daily

    Rx/ Clindamycin HCl 1% Nicotinamide (vit. B3) 4% in Fitalite™ S. Apply twice-daily

    Rx/ Glycolic acid 5% in Seraqua™ S. Apply once-daily

    Rx/ Tretinoin (vit. A acid) 0.05% in Nourilite™ S. Apply daily before bedtime

    Please refer to the Fagron Advanced Derma compatibility table for vehicle and API/DCI combinations. 1 Literature references available upon request.

    Please refer to the Compounding Matters database at fagron.com for more formulations.

    Ageing Skin

  • Ageing skin

    Ageing of the skin is a complex biological process. Dermatologists are treating an increasing number of patients for this condition.

    The consequence of skin ageing is characterised by degeneration of the skin, wrinkling, thinning, pigmentation, dehydration, increased sensitivity and gradual loss of skin elasticity.

    Ageing skin Topical treatment with both active pharmaceutical ingredients (APIs) and dermaceutical ingredients (DCIs) is the most e ective approach.

    Treatment and preventive care for ageing skin is usually chronic. The patient must therefore experience maximum comfort during treatment if compliance is to be forthcoming and optimal results are to be achieved.

    With Fagron Advanced Derma, patients are guaranteed a total solution for both tailor-made prescription compounding and basic skin care based on:

    • Vehicle design according to the latest scientific insights into the safety and tolerance of topically applied ingredients

    • Di erent bases for di erent skin types • Suitability for vulnerable, sensitive

    skin • Optimal compatibility with a broad

    range of APIs and DCIs • A formulary containing di erent

    formulations for easy prescribing and compounding by indication

    Total solution Discover Fagron Advanced Derma’s total solution by accessing the various information resources: • Fagron Advanced Derma brochure • Indication brochures • Vehicle brochures • Compatibility table • Quality documents • Compounding Matters formulations

    database • Fagron Academy

    fagron.com

    Fagron Advanced Derma Leading advanced dermatological care

  • Ageing skin

    Tailor-made treatment of ageing skin Ageing skin is commonly treated by ‘on the spot’ anti-wrinkling, depigmentation and elasticity improving therapy. Preventive and restorative skin care is also used, especially on sun-exposed areas. 1. APIs can be selected, based on individual dosing, to meet the patient’s specific treatment needs. 2. DCIs can be added to improve and/or recover the skin condition and prevent ageing of the skin. 3. Basic skin care is guaranteed with the proper choice of Fagron Advanced Derma vehicles. The vehicles are designed to be suitable for di erent

    skin types and serve to nourish the sensitive skin and prevent dehydration.

    Recommended APIs and DCIs in the treatment of ageing skin1 API Function Indication specific

    dosage (range) Common dose frequency

    Glycolic acid Alpha-hydroxy acid. Useful in ameliorating some of the signs of chronic cutaneous photodamage.

    8% Twice-daily

    Tretinoin (vit. A acid) Reduces the signs of UV-induced early skin ageing, such as wrinkles, loss of skin elasticity and pigmentation.

    0.02 to 0.05% Once-daily before bedtime

    DCI Aloe vera extract Humectant. Natural e ective ingredient for improving skin hydration. 2 to 10% Twice-daily Arginine HCl Induces significant increase in urea in the stratum corneum and a continuous

    increase in skin moisture in ageing skin. 2.5% Twice-daily

    Ascorbic acid (vit. C) Skin anti-ageing e ect by inducing the production of collagenase-1 and collagenase-3, as well as enzymes important for the production of collagen, and inhibitors of matrix metalloproteinase (MMP).

    5 to 15% Once-daily

    Lactic acid Useful in ameliorating some of the signs of chronic cutaneous photodamage. 8% Once-daily before bedtime Nicotinamide (vit. B3) Regulates cell metabolism and regeneration, and shows improvement in skin

    elasticity, erythema and pigmentation. 2 to 5% Once-daily

    Retinol (vit. A) Induces the biosynthesis of collagen and reduces the expression of MMP (collagenase-1).

    0.4% Once-daily

    Tocopherol (vit. E) Acts by smoothing the skin and increasing the ability of the stratum corneum to maintain its humidity and contributes to photoprotection of the skin.

    2 to 10% Once-daily

    Recommended vehicles for compounding and basic skin care in the treatment of ageing skin Vehicle Skin type profile Skin types

    Versatile™ Vanishing O/W cream base Oily skin Very dehydrated skin

    Fitalite™ Natural gel cream base Balanced skin A ected skin

    Nourilite™ Vanishing O/W emulsion base Dehydrated skin Specific skin area

    Seraqua™ Ultra-light O/W serum base Please refer to the Fagron Advanced Derma compatibility table for vehicle and API/DCI combinations. 1 Literature references available upon request.

    Compounding formulations for ageing skin Rx/ Lactic acid 8% in Nourilite™ S. Apply once-daily before bedtime

    Rx/ Retinol (vit. A) 0.4% in Seraqua™ S. Apply once-daily

    Rx/ Glycolic acid 8% in Versatile™ S. Apply twice-daily

    Rx/ Tretinoin (vit. A acid) 0.05% in Seraqua™ S. Apply once-daily before bedtime

    Rx/ Nicotinamide (vit. B3) 5% Tocopherol (vit. E) 5% in Nourilite™ S. Apply once-daily

    Rx/ Aloe vera extract 5% in Fitalite™ S. Apply twice-daily

    Please refer to the Compounding Matters database at fagron.com for more formulations.

    Alopecia &

    E� uvium

  • Hair loss comes in many forms and is an increasingly common complaint among dermato