1

1. --- Brilinta 2. --- 3. --- 4. ---103 Q&A

(()) 0077--88003366778833 33332255 http://www.kmhk.kmu.edu.tw/affairs/index.asp?deptcode=4600

aspirin

( ST

ST )

1. clopidogrel

2.

3. aspirin aspirin

100 mg

ticagrelor 90mg/tab

1. (loading dose)180

mg 2 90 mg

2. aspirin aspirin

( 325 mg)aspirin

75-100 mg

3. clopidogrel

ticagrelor

4.

Ticagrelor

P2Y12 ADP-

Ticagrelor

(ICH)

()

ticagrelor

C

1. ticagrelor(

)

2.

1. P2Y12 ADP-

clopidogrel

(6.9hrs v.s. 6hrs)

(30mins v.s. 2hrs)

clopidogrel

2. aspirin (75-100mg/day)

Brilinta

Kaohsiung Municipal Hsiao-Kang Hospital Drug Bulletin

65

--- --- ---

2

clopidogrel (9.8% vs.11.7% at 12

months; HR 0.84; 95% CI 0.77 to 0.92;

P

3

Tiotropium

/

Fenoterol/Ipratropium

Salbutamol/Ipratropium

Combivent

(Salbutamol 2.5 + Ipratropium 0.5mg,

2.5mL/UDV)

(methylxanthines)

/

Aminophylline

Theophylline (SR)

Phyllocontin

(Aminophylline 225mg/Tab)

(inhaled corticosteroids)

/

Beclomethasone

Budesonide

Fluticasone

Flixotide evohaler

(Fluticasone 50mcg/dose)

Flixotide Nebules

(Fluticasone 2mg/2ml )

/

Formoterol/Budesonide

Salmeterol/Fluticasone

Seretide evohaler

(Salmeterol 25+Fluticasone 50g/dose)

(Salmeterol 25+Fluticasone 250g/dose)

Symbicort Turbuhaler

(Budesonide 160g+ formoterol 4.5g)

(systemic corticosteroids)

/

Prednisolone

Methyl-prednisone

Donison

(Prednisolone 5mg/Tab)

4

(phosphodiesterase-4)

/

Roflumilast

COPD

(1)(2)

()

(3)(4)(

)

COPD

1. Chronic obstructive pulmonary disease:

Definition, clinical manifestations,

diagnosis, and staging. 2014 UpToDate

2. Management of stable chronic obstructive

pulmonary disease. 2014 UpToDate

3. 2012

4.

4

//

: http://adr.doh.gov.tw/default.asp Butin /

Bromocriptine

2.5 mg/Tab

Bromocriptine

bromocriptine

() (

)(

(EMA) bromocriptine

(1) 2.5 mg bromocriptine

HIV

(2) bromocriptine

(3)

bromocriptine

bromocriptine

1. 2.5 mg bromocriptine

HIV

2. bromocriptine

(

)

3. bromocriptine

-Eclampsia-Pre-eclampsia

pregnancy-induced hypertension

4. bromocriptine

Zithromax /

Azithromycin/

250 mg/Tab

azithromycin-

1 azithromycin

(drug reaction/rash with eosinophilia

and systemic symptoms, DRESS)

azithromycin DRESS

DRESS azithromycin

-(Stevens-Johnson syndrome,SJS)

5

Zithromax

syrup/

Azithromycin/

40mg/ml,15ml/Bot

(toxic epidermal necrolysis, TEN) DRESS SJS/TEN

azithromycin

1. azithromycin

2. azithromycin

Immunoglobulin

6%

/

Human immune

globulin

3g/50mL/Bot

Human immune globulin

non-hyperimmune human immune globulin

FDA human immune globulin

()

()()()()

FDA human immune globulin

(1) human immune globulin

(2)

(3)

(4)

human immune globulin

(5)

(6)

1. human immune globulin

2. human immune globulin

3.

1. human immune globulin

2. human immune globulin

6

3. human immune globulin

(1) ()/

(2)

(3)

(4)

(5)

(6)

(7)

:Acetazolamide:Acetazolamax(250mg/Tab)Acetazolamax

500~1000mg/day BID~ QID24~48

48

Harnalidge

OACS

Harnalidge

OCAS

MMR

MMR 4

:

Cubicin

1. Cubicin 0.9% N/SCubicin

12 48

2. Cubicin0.9% N/SLactated Ringers injection

Peg-Intron 1. 2-8

2. 2-8 24

Lanoxin(digoxin)

1. Micromedex, hemodialysis digoxin

2. digoxin

digoxin

influ-A

(positive) Tamiflu

HD

1. UpToDate: High-flux hemodialysis:75mg(1#) after each dialysis

session for 5 days.

2. : Hemodialysis:30mg(0.5#) non-dialysis day.

103 Q&A

7

(Dynastat)

1.

2. Dynastat(Parecoxib 40mg/Vial) Lactated ringer

()()

3. 0.9%NaCl 5%Dextrose

0.45%NaCl/5%Dextrose

Cervarix

Cervarix

1. 016

2. Cervarix Cervarix 3

Cervarix

MSD

Varivax, Live, 0.5mL/Vial 30

60

(Ref: MSD)

Solu-medrol

Tazocin Midatin

1. Solu-medrol Tazocin Y-site Midatin

Y-site

2. Solu-medrol Midatin Tazocin 0.9% N/S

Premarin

Premarin

Ref: UpToDate

Anxicam (2mg/mL/amp)

?

Anxicam 4

()

Radi-K

Slow-K

Radi-K 2.54mEq/tabSlow-K 8mEq/tab

Radi-K Slow-K

Botox

Botox 2~8 C

B-Complex

(

)

1. B-Complex 1mL/Amp ample

2. B()

3. B

Zovirax inj

1. Zovirax

2. 15-25 12

Takepron OD Dexilant

Dexilant(Dexlansoprazole,60mg/Cap) TakepronOD (Lansoprazole,

30mg/Cap)

8

Relenza

1. Relenza

(1)

(2)

(3)

(4) Relenza

(5)

(6)

(7)

(8)

(9)

2. : 5

(1) 5 2 2

(2) 10 2 (10

1 )

Ccr=20mL/min

liver cirrhosis child pugh c

tygacil

1. tygacil liver cirrhosis child pugh

c

2. UpToDateloading dose: 100 mg single dose; maintenance

dose: 25 mg every 12 hours

Klaricid XL

Klaricid XL (homogeneous matrix)

Colimycin loading dose

IV

?

Colimycin (MicromedexUpToDate...)

loading dose

40 Kg 3 vial50 Kg 3.5 vial60 Kg 4.5 vial (Maxmium dose)

Maintenance dose

ClCr 70 ml/min2.5 vial Q12H

ClCr 50 ml/min2.0 vial Q12H

ClCr 20 ml/min1.0 vial Q12H

ClCr