AUTHOR INDEX FOR VOLUME 19

529

A

Aarbakke, Jarle, and Ueland, Per M. Interaction of s-Adenosylho-

mocysteine with Isolated Rat Hepatocytes, 463

Albuquerque, E. X., Warnick, J. E., Maleque, M. A., Kauffman,F. C., Tamburini, R., Nimit, Y., and Daly, J. W. The Pharma-

cology of Pumiiotoxin-B. I. Interaction with Calcium Sites in the

Sarcoplasmic Reticulum of Skeletal Muscle, 411

Alonso, Angel. See Kuhn and Heinrich, 103

Appu Rao, A. G., and Cairn, John R. A Comparative Study of the

Interaction of Chiorpromazine, Trifluoperazine, and Promethazine

with Mouse Brain Tubulin, 295

Arduengo, A. J. See Kilbourn, Park, and Katzenellenbogen, 388

Ashley, Patricia L., and Griffin, Brenda Walker. Involvement of

Radical Species in the Oxidation of Aminopyrine and 4-Aminoan-

tipyrine by Cumene Hydroperoxide in Rat Liver Microsomes, 146

B

Bachur, Nicholas R. See Pan and Pedersen, 184

Baker, Peter F. See Honerjdger and Reiter, 68

Baizarini, J. See De Clercq, Torrence, Mertes, Schmidt, Shugar,

Barr, Jones, Verhelst, and Walker, 321

Bannon, Michael J., Michaud, Richard L., and Roth, Robert H.Mesocortical Dopamine Neurons: Lack of Autoreceptors Modulat-

ing Dopamine Synthesis, 270

Barber, Roger, and Butcher, Reginald W. The Quantitative Rela-

tionship between Intracellular Concentration and Egress of Cyclic

AMP from Cultured Cells, 38

Barr, P. J. See De Clercq, Baizarini, Torrence, Mertes, Schmidt,

Shugar, Jones, Verhelst, and Walker, 321

Beaulleu, Denise. See Rosenblatt, Whitehead, Vuchich, Pottier, and

Matiaszuk, 87

Belvedere, G. See Gozukara, Robinson, Deutsch, Coon, Guengerich,

and Gelboin, 153

Bergman, Mark 0. See Olsen, Van Ness, Lummis, Watkins, Napias,

and Greenlee, 217

Bertino, Joseph R. See Scanlon, Cashmore, Moroson, and Dreyer,

481

Billiau, Alfons. See De Clercq, Heremans, Descamps, Verhelst, and

De Ley, 122

Bourne, Henry R. See Salomon, 109

Brennan, M. J. W., Cantrill, R. C., Oldfield, M., and Krogsgaard-

Larsen, P. Inhibition of ‘y-Aminobutyric Acid Agonist Drugs:

Pharmacology of the ‘y-Aminobutyric Acid Receptor, 27

Brown, Kenneth B. See Pringle and Miller, 49

Burgisser, Ernst, Hancock, Arthur A., Lefkowitz, Robert J., and

De Lean, Andre. Anomalous Equilibrium Binding Properties of

High-Affinity Racemic Radioligands, 205

Burgisser, Ernst, Lefkowitz, Robert J., and De Lean, Andre.

Alternative Explanation for the Apparent “Two-Step” Binding

Kinetics of High-Affinity Racemic Antagonist Radioligands, 509

Butcher, Reginald W. See Barber, 38

Byrne, John R. See Milne, 276

C

Camerman, Arthur. See Camerman, 517

Camerman, Norman, and Camerman, Arthur. On the Stereochem-

istry of Dopaminergic Ergoline Derivatives, 517

Cann, John R. See Appu Rao, 295

Cantor, Elinor H., Greenberg, Louise H., and Weiss, Benjamin.

Effect of Long-Term Changes in Sympathetic Nervous Activity on

the Beta-Adrenergic Receptor-Adenylate Cyclase Complex of Rat

Pineal Gland, 21

Cantrill, R. C. See Brennan, Oldfield, and Krogsgaard.Larsen, 27

Cascales, Maria. See Cerddn and Santos-Ruiz, 451

Cashmore, Arlene R. See Scanlon, Moroson, Dreyer, and Bertino,

481

Catterall, William A., and Risk, Martin. Toxin T.,, from Ptychod.

iscus brevis (Formerly Gymnodinium breve) Enhances Activation

of Voltage-Sensitive Sodium Channels by Veratridine, 345

Catterall, William A. See Tamkun, 78

Cerd#{225}n, Sebastian, Cascales, Maria, and Santos-Ruiz, Angel.

Effect of Thioacetamide on the Pentose Phosphate Pathway and

Other NADP-Linked Enzymes of Rat Liver Cytosol: Chronology

of the Perturbations and Metabolic Significance, 451

Chang, Jaw Kang. See Vvu, Lee, Ling, Loh, and Yang, 302

Chin, J. H., and Goldstein, D. B. Membrane-Disordering Action of

Ethanol: Variation with Membrane Cholesterol Content and

Depth of the Spin Label Probe, 425

Christopherson, Rose. See Wartell, Watkins, and Rannels, 520

Cimino, Mauro. See Prozialeck and Weiss, 264

Cole, Susan P. C., Zelt, David T., and Marks, Gerald S. Comparison

of the Effects of Griseofulvin and 3,5-Diethoxycarbonyl-1,4-dihy-

dro-2,4,6-trimethylpyridine on Ferrochelatase Activity in Chick

Embryo Liver, 477

Conn, P. Michael. See Marian and Cooper, 399

Conney, A. H. See Nordqvist, Thakker, Vyas, Yagi, Levin, Ryan,

Thomas, and Jerina, 168

Coon, J. J. See Gozukara, Belvedere, Robinson, Deutsch, Guengerich,

and Gelboin, 153

Cooper, Ralph L. See Marian and Conn, 399

Cox, David. See Kaslow, Groppi, and Bourne, 406

Cusi, D., and Garay, R. P. The Effect ofTieniic Acid on Na� and K�

Transport in Human Red Cells, 438

D

Daly, J. W. See Albuquerque, Warnick, Maleque, Kauffman, Tam.

burini, and Nimit, 411

De Clercq, E., Baizarini, J., Torrence, P. F., Mertes, M. P.,

Schmidt, C. L., Shugar, D., Barr, P. J., Jones, A. S., Verhelst,

G., and Walker, R. T. Thymidylate Synthetase as Target Enzyme

for the Inhibitory Activity of 5-Substituted 2’-Deoxyuridines on

Mouse Leukemia L1210 Cell Growth, 321

De Clercq, Erik, Heremans, Hubertine, Descamps, Johan, Ver-

helst, Gabriel, De Ley, Marc, and Billiau, Alfons. Effects of

E-5-(2-Bromovinyl)-2’-Deoxyuridine and Other Selective Anti-

Herpes Compounds on the Induction of Retrovirus Particles in

Mouse BALB/3T3 Cells, 122

De Lean, Andre. See Burgisser, Hancock, and Lefkowitz, 205

De Lean, Andre. See B#{252}rgisser and Lefkowitz, 509

De Ley, Marc. See De Clercq, Heremans, Descamps, Verheist, and

Billiau, 122

Descamps, Johan. See De Clercq, Herermans, Verheist, De Lev, and

Billiau, 122

Deutsch, J. See Gozukara, Belvedere, Robinson, Coon, Guengerich,

and Gelboin, 153

Dickinson, K., Richardson, A., and Nahorski, S. R. Homogeneity

of Beta�-Athenoceptors on Rat Erythrocytes and Reticulocytes: A

Comparison with Heterogeneous Rat Lung Beta-Adrenoceptors,

194

Dreyer, Robert N. See Scanlon, Cashmore, Moroson, and Bertino,

481

Duffell, Michael W., Graham, J. Michael, and Ziegler, D. M.

Changes in Dimethylaniine N-Oxidase Activity of Mouse Liver

and Kidney Induced by Steroid Sex Hormones, 134

Dunn, Deborah A. See Sufrmn and Marshall, 307

530 AUTHOR INDEX

E

Ehlert, Frederick J., Roeske, Wiffiam R., and Yamamura, Henry

I. Mathematical Analysis of the Kinetics of Competitive Inhibition

in Neurotransmitter Receptor Binding Assays, 367

Eisen, Judith S. See Lingle and Marder, 349

El-Fakahany, Esam, and Richelson, Elliott. Effects of Lanthanides

on Muscarinic Acetylcholine Receptor Function, 282

Erickson, Leonard C. See Ramonas, Kiesse, Kohn, and Zaharko,

331

F

Firnau, Gunter, Sood, Sudesh, Pantel, Richard, and Garnett,Stephen. Phenol Ionization in Dopa Determines the Site of Meth-

ylation by Catechol-O-Methyltransferase, 130

Forte, Anthony J. See Nelson, Vaishnav, Mitchell, Gillette, and

Hinson, 140

Frazer, Alan. See Moyer, Greenberg, and Weiss, 187

Freer, Richard J. See Rubin and Sink, 31

Friedman, Stanley. The Inhibition of DNA(Cytosine-5)Methylases

by 5-Azacytidine: The Effect of Azacytosine-Contnining DNA, 314

Frigon, Ronald P., O’Connor, Daniel T., and Levine, Gail L

Human Dopamine-fl-Hydroxylase: Comparison of the Enzyme

from Plasma, Adrenal Medulla, and Pheochromocytoma by Ha-

dioimmunoassay, 444

G

Galivan, John. See Whiteley and Nimec, 505

Galla, H. J., and Trudell, J. R. Perturbation of Peptide-Induced

Lateral Phase Separations in Phosphatidic Acid Bilayers by the

Inhalation Anesthetic Methoxyflurane, 432

Garay, R. P. See Cusi, 438

Garnett, Stephen. See Firnau, Sood, and Pantel, 130

Gelboin, H. V. See Gozukara, Belvedere, Robinson, Coon, and Guen-

gerich, 153

Gillette, James R. See Nelson, Forte, Vaishnav, Mitchell, and Hin-son, 140

Glazer, Robert I., and Hartman, Kathleen D. Analysis of the Effect

of 5-Fluorouracil on the Synthesis and Translation of Polysomal

Poly(A)RNA from Ehrlich Ascites Cells, 117

Gnegy, M., and Treismann, G. Effect of Calmodulin on Dopamine-

Sensitive Adenylate Cyclase Activity in Rat Striatal Membranes,

256

Goldstein, D. B. See Chin, 425

Gozukara, E. M., Belvedere, G., Robinson, R. C., Deutsch, J.,Coon, M. J., Guengerich, F. P., and Gelboin, H. V. The Effect

of Opoxide Hydratase on Benzo[alpyrene Diol Epoxide Hydrolysis

and Binding to DNA and Mixed-Function Oxidase Proteins, 153

Graham, J. Michael. See Duffel and Ziegler, 134

Greenberg, Louise H. See Cantor and Weiss, 21

Greenberg, Louise H. See Moyer, Frazer, and Weiss, 187

Greenlee, Donald V. See Olsen, Bergman, Van Ness, Lummi.s, Wat.

kins, and Napias, 217

Griffin, Brenda Walker. See Ashley, 146

Groppi, Vincent E. See Kaslow, Cox, and Bourne, 406

Guengerich, F. P. See Gozukara, Belvedere, Robinson, Deutsch,

Coon, and Gelboin, 153

H

Hamrell, Michael R., Laszlo, John, and Sedwick, W. David.

Transient Induction of Phenotypic Resistance in Human Lympho-

blastoid Cells following Sequential Use of Two Antifolates, 491

Hancock, Arthur A. See B#{252}rgisser, Lefkowitz, and De Lean, 205

Hanson, Mats. Effects of Mitosis Inhibitors on Respiration and Fast

Axonal Transport in Frog Sciatic Nerves, 291

Hartman, Kathleen D. See Glazer, 117

Heidenreich, Kim A. See Zahniser and Molinoff, 372

Heinrich, Peter C. See Kuhn and Alonso, 103

Heremans, Hubertine. See De Clercq, Descamps, Verheist, De Ley,and Billiau, 122

Hill, S. J., and Young, J. M. Characterization of [3H]Mepyramine

Binding to the Longitudinal Muscle of Guinea Pig Small Intestine,

379

Hinson, Jack A. See Nelson, Forte, Vaishnav, Mitchell, and Gillette,

140

Honerj#{225}ger, Peter, Reiter, Melchior, and Baker, Peter F. Effect

of the Cardioactive Drug AR-L 57 on Free Intracellular Calcium

and Ouabain-Insensitive Ion Fluxes in the Squid Giant Axon, 68

I

Iba, Michael M. See Nerland and Mannering, 162

Insel, Paul A. See Shattil, McDonough, and Turnbull, 179

J

Jacoby, Richard. See Levin and Wein, 525

Jerina, D. M. See Nordqvist, Thakker, Vyas, Yagi, Levin, Ryan,

Thomas, and Conney, 168

Ji, Sungchul, Lemasters, John J., and Thurman, Ronald G. A

Fluorometric Method To Measure Sublobular Rates of Mixed-

Function Oxidation in the Hemoglobin-Free Perfused Rat Liver,

513

Jones, A. S. See De Clercq, Balzarini, Torrence, Mertes, Schmidt,

Shugar, Barr, Verhelst, and Walker, 321

K

Kaslow, Harvey R., Cox, David, Groppi, Vincent E., and Bourne,

Henry R. An Mr 52,000 Peptide Can Mediate Effects of Cholera

Toxin on Adenylate Cylase in Intact Cells, 406

Katzenellenbogen, John A. See Kilbourn, Arduengo, and Park, 388

Kauffman, F. C. See Albuquerque, Warnick, Maleque, Tamburini,

Nimit, and Daly, 411

Kilbourn, Michael R., Arduengo, A. J., Park, Joon T., and Katz-

enellenbogen, John A. Conformational Analysis of Nonsteroidal

Estrogens: The Effect of Conformer Populations on the Binding

Affinity of meso- and dl-Hexestrol to the Estrogen Receptor, 388

Kitano, Takafuini. See Vaught and Takemori, 236

Klesse, Wolfgang. See Ramonas, Erickson, Kohn, and Zaharko, 331

Kohn, Kurt W. See Ramonas, Erickson, Klesse, and Zaharko, 331

Konopa, Jerry. See Woynarowski, 97

Krogsgaard-Larsen, P. See Brennan, Cantrill, and Oldfield, 27

KUhn, Barbara, Alonso, Angel, and Heinrich, Peter C. The Effectof D-Galactosamine and Actinomycin D on Polysomes and Mes-

senger RNA Levels in Rat Liver, 103

L

Laszlo, John. See Hamrell and Sedwick, 491

Law, P. Y., Ostwald, T. J., Way, E. L, and Loh, H. H. Interaction

of Diazosulfaniic Acid and the Opiate Receptor: Inhibition of

Specific Binding to Synaptic Membranes and Labeling of a Mem-

brane Lipid Stereospecifically Protected by Opiods, 355

LeDuc, Louise E., Wyche, Angela A., Sprecher, Howard, San-

karappe, S. K., and Needleman, Philip. Analogues of Arachi-

donic Acid Used To Evaluate Structural Determinants of Prosta-

glandin Receptor and Enzyme Specificities, 242

Lee, Nancy M. See Wu, Ling, Chang, Loh, and Yang, 302

Lefkowitz, Robert J. See B#{252}rgisser and De Lean, 509

Lefl(owitz, Robert J. See Bzirgisser, Hancock, and De Lean, 205

Lemasters, John J. See Ji and Thurman, 513

Levin, Robert M., Jacoby, Richard, and Wein, Alan J. Effect of

Adenosine Triphosphate on Contractility and Adenosine Triphos-

phatase Activity of the Rabbit Urinary Bladder, 525Levin, W. See Nordqvist, Thakker, Vyas, Yagi, Ryan, Thomas, Con-

ney, and Jerina, 168

Levine, Gail L. See Frigon and O’Connor, 444

lAng, Nicholas. See Wu, Lee, C/tang, Loh, and Yang, 302

Lingle, Chris, Eisen, Judith S., and Marder, Eve. Block of Gluts-

matergic Excitatory Synaptic Channels by Chlorisondamine, 349

Loh, H. H. See Law, Ostwald, and Way, 355

AUTHOR INDEX 531

Loh, Horace H. See Wu, Lee, Ling, Chang, and Yang, 302

Lopez, J. Raphael. See Wastek and Richelson, 15

Lummis, Sarah C. See Olsen, Bergman, Van Ness, Watkins, Napias,

and Greenlee, 217

M

Macfarlane, Donald E. The Effects of Methyl Mercury on Platelets.

Induction of Aggregation and Release via Activation of the Pros-

taglandin Synthesis Pathway, 470

Maleque, M. A. See Albuquerque, Warnick, Kauffman, Tamburini,

Nimit, and Daly, 411

Mannering, Gilbert J. See Nerland and Iba, 162

Marder, Eve. See Lingle and Eisen, 349

Marian, Jan, Cooper, Ralph L., and Conn, P. Michael. Regulation

of the Rat Pituitary Gonadotropin-Releasing Hormone Receptor,

399

Marks, Gerald S. See Cole and Zelt, 477

Marshall, Garland R. See Sufrmn and Dunn, 307

Matiaszuk, N. Vera. See Rosenblatt, Whitehead, Vuchich, Pottier,

and Beaulieu, 87

Maynert, E. W. See Moon and Pai, 44

McDonough, Margaret. See Shattil, Turnbull, and Insel, 179

McMahon, Kathryn K. See Schimmel and Serio, 248

Mertes, M. P. See De Clercq, Balzarini, Torrence, Schmidt, Shugar,

Barr, Jones, Verhelst, and Walker, 321

Michaud, Richard L. See Bannon and Roth, 270

Miller, Keith W. See Pringle and Brown, 49

Milne, Richard J., and Byrne, John R. Effects of Hexamethonium

and Decamethonium on End-Plate Current Parameters, 276

Minton, Allen P. The Bivalent Ligand Hypothesis: A Quantitative

Model for Hormone Action, 1

Mitchell, Jerry R. See Nelson, Forte, Vaishnav, Gillette, and Hinson,

140

Molinoff, Perry B. See Zahniser and Heidenreich, 372

Moon, B. H., Pai, V. S., and Maynert, E. W. Ring Stacking in

Solutions of Norepinephrine and the 4:1 Norepinephrine .ATP

Complex, 44

Moroson, Barbara A. See Scanlon, Cashmore, Dreyer, and Bertino,

481

Moyer, John A., Greenberg, Louise H., Frazer, Alan, and Weiss,

Benjamin. Subsensitivity of the Beta-Adrenergic Receptor-

Linked Adenylate Cyclase System of Rat Pineal Gland following

Repeated Treatment with Desmethylimipramine and Nialamide,

187

N

Nahorski, S. R. See Dickinson and Ricardson, 194

Napias, Christian. See Olsen, Bergman, Van Ness, Lummis, Wat-

kins, and Greenlee, 217

Needleman, Philip. See LeDuc, Wyche, Sprecher, and Sankarappe,

242

Nelson, Sidney D., Forte, Anthony J., Vaishnav, Yashesh, Mitch-

ell, Jerry H., Gillette, James R., and Hinson, Jack A. TheFormation of Arylating and Alkylating Metabolites of Phenacetin

in Hamsters and Hamster Liver Microsomes, 140

Nerland, Donald E., Iba, Michael M., and Mannering, Gilbert J.

Use of Linoleic Acid Hydroperoxide in the Determination of Ab-

solute Spectra of Membrane-Bound Cytochrome P-450, 162

Nimec, Zenia. See Whiteley and Galivan, 505

Nimit, Y. See Albuquerque, Warnick, Maleque, Kauffman, Tambu-

rini, and Daly, 411

Nordqvist, M., Thakker, D. R., Vyas, K. P., Yagi, H., Lavin, W.,Ryan, D. E., Thomas, P. E., Conney, A. H., and Jerina, D. M.

Metabolism of Chrysene and Phenanthrene to Bay-Region Diol

Epoxides by Rat Liver Enzymes, 168

0

O’Connor, Daniel T. See Frigon and Levine, 444Ohuchi, Kazuo. See Yamazaki, Sasaki, and Sakai, 456

Oldfield, M. See Brennan, Cantrill, and Krogsgaard-Larsen, 27

Olsen, Richard W., Bergman, Mark 0., Van Ness, Paul C., Lum-

mis, Sarah C., Watkins, Andrew E., Napias, Christian, andGreenlee, Donald V. y-Aminobutyric Acid Receptor Binding in

Mammalian Brain: Heterogeneity of Binding Sites, 217

Ostwald, T. J. See Law, Way, and Loh, 355

P

Pal, V. S. See Moon and Maynert, 44

Pan, Su-Shu, Pedersen, Leslie, and Bachur, Nicholas R. Compar-

ative Flavoprotein Catalysis of Anthracycline Antibiotic: Reduc-

tive Cleavage and Oxygen Consumption, 184

Pantel, Richard. See Firnau, Sood, and Garnett, 130

Park, Joon T. See Kilbourn, Arudengo, and Katzenellenbogen, 388Pedersen, Leslie. See Pan and Bachur, 184

Pottier, A. See Rosenblatt, Whitehead, Vuchich, Matiaszuk, and

Beaulieu, 87

Pringle, Michael J., Brown, Kenneth B., and Miller, Keith W.

Can the Lipid Theories of Anesthesia Account for the Cutoff in

Anesthetic Potency in Homologous Series of Alcohols?, 49

Prozialeck, Walter C., Cimino, Mauro, and Weiss, Benjamin.

Photoaffinity Labeling of Calmodulin by Phenothiazine Antipsy-

chotics, 264

R

Ramonas, Lori M., Erickson, Leonard C., Kiesse, Wolfgang,

Kohn, Kurt W., and Zaharko, Daniel S. Differential Cytotox-

icity and DNA Cross-Linking Produced by Polymeric and Mono-

meric Activated Analogues of Cyclophosphamide in Mouse L1210

Leukemia Cells, 331

Rannels, D. Eugene. See Wartell, Christopherson, and Watkins, 520

Reiter, Melchior. See Honerjdger and Baker, 68Richardson, A. See Dickinson and Nahorski, 194

Richelson, Elliott. See El-Fakahany, 282

Richelson, Elliott. See Wastek and Lopez, 15

Risk, Martin. See Catterall, 345

Robinson, R. C. See Gozukara, Belvedere, Deutsch, Coon, Guenger-

ich, and Gelboin, 153

Roeske, William R. See Ehlert and Yamamura, 367

Rosenblatt, D. S., Whitehead, V. M., Vuchich, M.-J., Pottier, A.,

Matiaszuk, N. Vera, and Beaulieu, Denise. Inhibition of Meth-

otrexate Polyglutamate Accumulation in Cultured Human Cells,

87

Roth, Robert H. See Bannon and Michaud, 270

Rubin, Ronald P., Sink, Lynn E., and Freer, Richard J. On the

Relationship between Formylinethionyl-Leucyl-Phenylalanine

Stimulation of Arachidonyl Phosphatidylinositol Turnover and

Lysosomal Enzyme Secretion by Rabbit Neutrophils, 31

Ryan, D. E. See Nordqvist, Thakker, Vyas, Yagi, Thomas, Conney,

and Jerina, 168

S

Sakai, Kiyoshi. See Yamazaki, Ohuchi, and Sasaki, 456

Salomon, Michael R., and Bourne, Henry R Novel 549 Lymphoma

Variants with Aberrant Cyclic AMP Metabolism, 109

Sankarappe, S. K. See LeDuc, Wyche, Sprecher, and Needleman,

242

Santos-Ruiz, Angel. See Cerdcmn and Ca-scales, 451

Sasaki, Masaaki. See Yamazaki, Ohuchi, and Sakai, 456

Scanlon, Kevin J., Cashmore, Arlene R., Moroson, Barbara A.,

Dreyer, Robert N., and Bertino, Joseph R. Inhibition of Serine

Metabolism by Tetrahydrohomofolate in L1210 Mouse Leukemia

Cells, 481

Schimniel, Richard J., McMahon, Kathryn K., and Serb, Rosa!-

md. Interactions between Alpha-Adrenergic Agents, Prostaglan-

din E1, Nicotinic Acid, and Adenosine in Regulation of Lipolysis in

Hamster Epididymal Adipocytes, 248

Schmidt, C. L. See De Clercq, Balzarini, Torrence, Mertes, Shugar,

Barr, Jones, Verhelst, and Walker, 321

532 AUTHOR INDEX

The Subject Index for Volume 19 will appear in the November 1981 issue as part of a cumulative index for the year 1981.

Schuette, Barbara P. See Vistica, 92

Schwabe, Ulrich. See Trost, 228

Sedwick, W. David See Hamrell and Laszlo, 491

Serio, Rosalind. See Schimmel and McMahon, 248

Shattil, Sanford J., McDonough, Margaret, Turnbull, Judy, andInsel, Paul A. Characterization ofAlpha-Adrenergic Receptors in

Human Platelets Using [3H]Clonidine, 179

Shiah, Shii-Pying. See Stern, 56Shugar, D. See De Clercq, Balzarini, Torrence, Mertes, Schmidt,

Barr, Jones, Verhelst, and Walker, 321

Sink, Lynn E. See Rubin and Freer, 31

Sood, Suresh. See Firnau, Pantel, and Garnett, 130

Spears, C. Paul. Nucleophilic Selectivity Ratios of Model and Clinical

Alkylating Agents by 4-(4’-Nitrobenzyl)pyridine Competition, 496

Sprecher, Howard. See LeDuc, Wyche, Sankarappe, and Needle-

man, 242

Stern, S. Alexander, and Shiah, Shii-Pying. Solubiity of Inhalation

Anesthetics in Various Media: A New Correlation, 56

Sufrmn, Janice R., Dunn, Deborah A., and Marshall, Garland R.Stenc Mapping of the L-Methiomne Binding Site of ATP: L-

Methionine S-Adenosyltransferase, 307

T

Takemori, A. E. See Vaught and Kitano, 236

Tamburini, R. See Albuquerque, Warnick, Maleque, Kauffman,Nimit, and Daly, 411

Tamkun, Michael M., and Catterall, William A. Ion Flux Studies

of Voltage-Sensitive Sodium Channels in Synaptic Nerve-Ending

Particles, 78

Thakker, D. R. See Nordqvist, Vyas, Yogi, Levin, Ryan, Thomas,

Conney, and Jerina, 168

Thomas, P. E. See Nordqvist, Thakker, Vyas, Yogi, Ryan, Conney,

andJerina, 168

Thorgeirsson, Snorri S. See Wirthe, 337

Thurman, Ronald G. See Ji and Lemasters, 513

Torrence, P. F. See De Clercq, Balzarini, Mertes, Schmidt, Shugar,

Barr, Jones, Verhelst, and Walker, 321

Treismann, G. See Gnegy, 256

Trost, Thomas, and Schwabe, Ulrich. Adenosine Receptors in Fat

Cells: Identification by (-)-N6-[3H]Phenylisopropyladensoine

Binding, 228

Trudell, J. R. See Galla, 432Turnbull, Judy. See Shattil, McDonough, and Insel, 179

U

Ueland, Per M. See Aarbakke, 463

V

Vaishnav, Yashesh. See Nelson, Forte, Mitchell, Gillette, and Hin-

son, 140

Van Ness, Paul C. See Olsen, Bergman, Lummis, Watkins, Napias,

and Greenlee, 217

Vaught, Jeifry L, Kitano, TakafUmi, and Takemori, A. E. Inter-

actions of Leucine Enkephalin and Narcotics with Opioid Recep-

tom, 236

Verhelst, G. See De Clercq, Balzarini, Torrence, Mertes, Schmidt,Shugar, Barr, Jones, and Walker, 321

Verheist, Gabriel. See De Clercq, Heremans, Descamps, De Ley, and

Billiau, 122

Vistica, David T., and Sehuette, Barbara P. Carrier Mechanism

and Specificity Accounting for the Increase in Intracellular Mel-

phalan by the Basic Amino Acids, 92

Vuchich, M.-J. See Rosenblatt, Whitehead, Pottier, Matiaszuk, and

Beaulieu, 87

Vyas, K. P. See Nordqvist, Thakker, Yagi, Levin, Ryan, Thomas,

Conney, and Jerina, 168

W

Walker, R. T. See De Clercq, Balzarini, Torrence, Mertes, Schmidt,S/sugar, Barr, Jones, and Verhelst, 321

Warnick, J. E. See Albuquerque, Maleque, Kauffman, Tamburini,Nimit, and Daly, 411

Wartell, Sue A., Christopherson, Rose, Watkins, Clyde A., and

Rannels, D. Eugene. Inhibition of Synthesis of Lung Proteins by

Halothane, 520

Wastek, Gregory J., Lope; J. Raphael, and Richelson, Elliott.Demonstration of a Muscarmnic Receptor-Mediated Cyclic GMP-

Dependent Hyperpolarization of the Membrane Potential of

Mouse Neuroblastoma Cells Using [3H]Tetraphenylphosphonium,

15

Watkins, Andrew E. See Olsen, Bergman, Van Ness, Lummis, Na-

pias, and Greenlee, 217

Watkins, Clyde A. See Wartell, Christopherson, and Rannels, 520

Way, E. L. See Law, Ostwald, and Loh, 355

Wein, Alan J. See Levin and Jacoby, 525

Weiss, Benjamin. See Cantor and Greenberg, 21

Weiss, Benjamin. See Moyer, Greenberg, and Frazer, 187

Weiss, Benjamin. See Prozialeck and Cimino, 264

Whitehead, V. M. See Rosenblatt, Vuchich, Pottier, Matiaszuk, and

Beaulieu, 87

Whiteley, John M., Nimec, Zenia, and Gailvan, John. Treatment

of Reuber H35 Hepatoma Cells with Carrier-Bound Methotrexate,

505

Wirthe, Peter J., and Thorgeirsson, Snorri S. Mechanism of N-

Hydroxy-2-Acetylaminofluorene Mutagenicity in the Salmonella

Test System: Role of N-O Acyltransferase and Sulfotransferase

from Rat Liver, 337

Woynarowski, Jan M., and Konopa, Jerry. Inhibition of DNA

Biosynthesis in HeLa Cells by Cytotoxic and Antitumor Sesquiter-

pene Lactones, 97

Wu, Chuen-Shang C., Lee, Nancy M., Ling, Nicholas, Chang, Jaw

Kang, Loh, Horace H., and Yang, Jen Tsi. Conformation of

$-Endorphin Analogues in Cerebroside Sulfate Solution, 302

Wyche, Angela A. See LeDuc, Sprecher, Sankarappe, and Needle-

man, 242

Y

Yagi, H. See Nordqvist, Thakker, Vyas, Levin, Ryan, Thomas, Con.

ney, and Jerina, 168

Yamamura, Henry I. See Ehlert and Roeske, 367

Yamazaki, Mitsuo, Ohuchi, Kazuo, Sasaki, Masaaki, and Sakai,

Kiyoshi. Inhibition of 15-Hydroxyprostaglandin Dehydrogenase

by 9,1 1-Deoxyprostaglandins in Vitro and in Vivo, 456

Yang, Jen Tsi. See Wu, Lee, Ling, Chang, and Loh, 302

Yoda, Atsunobu, and Yoda, Shizuko. The Interation of Ouabagenin

and (Na� + Ki-ATPase in the Presence of Na�, Mg2�, and ATP,

62

Yoda, Shizuko. See Yoda, 62

Young, J. M. See Hill, 379

Z

Zaharko, Daniel S. See Ramonas, Erickson, Klesse, and Kohn, 331

Zahniser, Nancy R., Heidenreich, Kim A., and Molinoff, Perry B.

Binding of [:�H]Amino67dihythoxy4234tetrahydronaphthal

ene to Rat Striatal Membranes: Effects of Purine Nucleotides and

Ultraviolet Irradition, 372

Zelt, David T. See Cole and Marks, 477

Ziegler, D. M. See Duffel and Graham, 134

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MOLECULAR PHARMACOLOGY

An International Journal

VOLUME 19, 1981

EDITOR: NORMAN KIRSHNER

ASSOCIATE EDITOR: T. A. SLOTKIN

EDITORIAL AND ADVISORY BOARD

EARL BARIL HERBERT D. LANDAHL

R. B. BARLOW ROBERT J. LEFKOWITZ

L. L. BENNETT, JR. ANTHONY Y. H. Lu

N. J. M. BIRDSALL KARL MAGLEBY

JOEL BOCKAERT GILBERT J. MANNERING

BRUCE BRECKENRIDGE RONALD M. MCELHANEY

THEODORE M. BRODY KEITH W. MILLER

ERNEST BUEDING PERRY B. MOLINOFF

A. S. V. BURGEN DANIEL W. NEBERT

WILLIAM CATTERALL CHARLES A. NICHOL

COLLIN F. CHIGNELL JOHN P. PERKINS

RONALD CHUANG RICHARD M. PHILPOT

DoMINICK L. CINTI BERNARD PULLMAN

P. MICHAEL CONN K. V. RAJAGOPALAN

BRIAN Cox H. P. RANG

JOHN W. DALY ELLIOTT RICHELSON

JAMES N. DAVIS MARTIN RODBELL

GEORGE I. DRUMMOND GERALD ROSEN

MOHYEE E. ELDEFRAWI JOHN B. SCHENKMAN

ROBERT F. FURCHGOTF ARNOLD SCHWARTZ

ALFRED G. GILMAN DAVID SILVERMAN

ROBERT I. GLAZER IAN C. P. SMITH

DAVID V. G0DIN SOLOMON H. SNYDER

AVRAM GOLDSTEIN SNORRI S. THORGEIRSSON

H. JOSEPH GOREN JAMES R. TRUDELL

CHARLES HEIDELBERGER PAUL 0. P. Ts’o

GEORGE H. HITCHINGS DAVID C. U’PRICHARD

DONALD JERINA WYLIE W. VALE

ARTHUR KARLIN ELLIOT S. VESELL

JOYCE J. KAUFMAN 0. H. VIVEROS

SEYMOUR KAUFMAN MICHAEL J. WARING

LEMONT B. KIER HAREL WEINSTEIN

ERNEST KUN

CONTENTS OF VOLUME 19

NUMBER 1, JANUARY 1981

ALLEN P. MINTON. The Bivalent Ligand Hypothesis: A Quantitative Model for HormoneAction 1

GREGORY J. WASTEK, J. RAPHAEL LOPEZ, AND ELLIOTT RICHELSON. Demonstration of aMuscarinic Receptor-Medicated Cyclic GMP-Dependent Hyperpolarization of the Mem-brane Potential of Mouse Neuroblastoma Cells Using [3H]Tetraphenylosphonium 15

ELINOR H. CANTOR, LOUISE H. GREENBERG, AND BENJAMIN WEISS. Effect of Long-TermChanges in Sympathetic Nervous Activity on the Beta-Adrenergic Receptor-AdenylateCyclase Complex of Rat Pineal Gland 21

M. J. W. BRENNAN, R. C. CANTRILL, M. OLDFIELD, AND P. KROGSGAARD-LARSEN. Inhibitionof -y-Aminobutyric Acid Release by -y-Aminobutyric Acid Agonist Drugs: Pharmacology ofthe -y-Aminobutyric Acid Receptor 27

RONALD P. RUBIN, LYNN E. SINK, AND RICHARD J. FREER. On the Relationship betweenFormylmethionyl-Leucyl-Phenylalanine Stimulation of Arachidonyl PhosphatidylinositolTurnover and Lysosomal Enzyme Secretion by Rabbit Neutrophils 31

ROGER BARBER AND REGINALD W. BUTCHER. The Quantitative Relationship between Intra-cellular Concentration and Egress of Cyclic AMP from Cultured Cells 38

B. H. MooN, V. S. PAl, AND E. W. MAYNERT. Ring Stacking in Solutions of Norepmephrineand the 4:1 Norepinephrine . ATP Complex 44

MICHAEL J. PRINGLE, KENNETH B. BROWN, AND KEITH W. MILLER. Can the Lipid Theoriesof Anesthesia Account for the Cutoff in Anesthetic Potency in Homologous Series ofAlcohols? 49

S. ALEXANDER STERN AND SHII-PYNG SHIAH. Solubiity of Inhalation Anesthetics in VariousMedia: A New Correlation 56

ATSUNOBU YODA AND SHIZUKO YODA. The Interaction of Ouabagenin and (Na� + K�)-ATPase in the Presence of Na�, Mg2�, and ATP 62

PETER HONERJAGER, MELCHIOR REITER, AND PETER F. BAKER. Effect of the CardioactiveDrug AR-L 57 on Free Intracellular Calcium and Ouabain-Insensitive Ion Fluxes in theSquid Giant Axon 68

MICHAEL M. TAMKUN AND WILLIAM A. CATTERALL. Ion Flux Studies of Voltage-SensitiveSodium Channels in Synaptic Nerve-Ending Particles 78

D. S. ROSENBLATT, V. M. WHITEHEAD, M.-J. VUCHICH, A. POTTIER, N. VERA MATIASZUK,

AND DENISE BEAULIEU. Inhibition of Methotrexate Polyglutamate Accumulation inCultured Human Cells 87

DAVID T. VISTICA AND BARBARA P. SCHUETTE. Carrier Mechanism and Specificity Account-ing for the Increase in Intracellular Melphalan by the Basic Amino Acids 92

JAN M. WOYNAROWSKI AND JERZY KONOPA. Inhibition of DNA Biosynthesis in HeLa Cellsby Cytotoxic and Antitumor Sesquiterpene Lactones 97

BARBARA KUHN, ANGEL ALONSO, AND PETER C. HEINRICH. The Effect of D-Galactosamineand Actinomycin D on Polysomes and Messenger RNA Levels in Rat Liver 103

MICHAEL R. SALOMON AND HENRY R. BOURNE. Novel 549 Lymphoma Variants withAberrant Cyclic AMP Metabolism 109

ROBERT I. GLAZER AND KATHLEEN D. HARTMAN. Analysis of the Effect of 5-Fluorouradil onthe Synthesis and Translation of Polysomal Poly(A)RNA from Ehrlich Ascites Cells . . . 117

ERIK DE CLERCQ, HUBERTINE HEREMANS, JOHAN DESCAMPS, GABRIEL VERHELST, MARC DE

LEY, AND ALFONS BILLIAU. Effects of E-5-(2-Bromovinyl)-2’-Deoxyuridine and OtherSelective Anti-Herpes Compounds on the Induction of Retrovirus Particles in Mouse 122BALB/3T3 Cells

GUNTER FIRNAU, SUDESH SooD, RICHARD PANTEL, AND STEPHEN GARNETT. Phenol loni-zation in Dopa Determines the Site of Methylation by Catechol-O-Methyltransferase . . . 130

MICHAEL W. DUFFEL, J. MICHAEL GRAHAM, AND D. M. ZIEGLER. Changes in DimethylanilineN-Oxidase Activity of Mouse Liver and Kidney Induced by Steroid Sex Hormones 134

SIDNEY D. NELSON, ANTHONY J. FORTE, YASHESH VAISHNAV, JERRY R. MITCHELL, JAMES R.GILLETTE, AND JACK A. HINSON. The Formation of Arylating and Alkylating Metabo-lites of Phenacetin in Hamsters and Hamster Liver Microsomes 140

PATRICIA L. ASHLEY AND BRENDA WALKER GRIFFIN. Involvement of Radical Species in theOxidation of Aminopyrine and 4-Aminoantipyrine by Cumene Hydroperoxide in RatLiver Microsomes 146

E. M. GOZUKARA, G. BELVEDERE, R. C. ROBINSON, J. DEUTSCH, M. J. CooN, F. P. GUENGER-

ICH, AND H. V. GELBOIN. The Effect of Epoxide Hydratase on Benzo[a]-pyrene DiolEpoxide Hydrolysis and Binding to DNA and Mixed-Function Oxidase Proteins 153

DONALD E. NERLAND, MICHAEL M. IBA, AND GILBERT J. MANNERING. Use of Linoleic AcidHydroperoxide in the Determination of Absolute Spectra of Membrane-Bound Cyto-chrome P-450 162

M. NORDQVIST, D. R. THAKKER, K. P. VYAS, H. YAGI, W. LEVIN, D. E. RYAN, P. E. THOMAS,A. H. CONNEY, AND D. M. JERINA. Metabolism of Chrysene and Phenanthrene to Bay-Region Diol Epoxides by Rat Liver Enzymes 168

SHORT COMMUNICATIONS

SANFORD J. SHArFIL, MARGARET MCDONOUGH, JUDY TURNBULL, AND PAUL A.INSEL. Characterization of Alpha-Adrenergic Receptors in Human Platelets Using[3HjClonidine 179

SU-SHU PAN, LESLIE PEDERSEN, AND NICHOLAS R. BACHUR. Comparative FlavoproteinCatalysis of Anthracycine Antibiotic: Reductive Cleavage and Oxygen Consumption . . . 184

NUMBER 2, MARCH 1981

JOHN A. MOYER, LOUISE H. GREENBERG, ALAN FRAZER, AND BENJAMIN

WEISS. Subsensitivity of the Beta-Adrenergic Receptor-Linked Adenylate Cyclase Sys-tern of Rat Pineal Gland following Repeated Treatment with Desmethylimipramineand Nialamide 187

K. DICKINSON, A. RICHARDSON, AND S. R. NAHORSKI. Homogeneity of Beta 2-Adrenoceptorson Rat Erythrocytes and Reticulocytes: A Comparison with Heterogenous RatLung Beta-Adrenoceptors 194

ERNST BURGISSER, ARTHUR A. HANCOCK, ROBERT J. LEFKOWITZ, AND ANDRE DE

LEAN. Anomalous Equilibrium Binding Properties of High-Affinity Racemic Radioli-gands 205

RICHARD W. OLSEN, MARK 0. BERGMAN, PAUL C. VAN NESS, SARAH C. LUMMIS, ANDREW E.WATKINS, CHRISTIAN NAPIAS, AND DONALD V. GREENLEE. -y-Aminobutyric Acid Recep-tor Binding in Mammalian Brain: Heterogeneity of Binding Sites 217

THOMAS TR05T AND ULRICH SCHWABE. Adenosine Receptors in Fat Cells: Identification by(-)-N6-[’3H]Phenylisopropyladenosine Binding 228

JEFFRY L. VAUGHT, TAKAFUMI KITANO, AND A. E. TAKEMORI. Interactions of LeucineEnkephalin and Narcotics with Opioid Receptors 236

LOUISE E. LEDUC, ANGELA A. WYCHE, HOWARD SPRECHER, S. K. SANKARAPPE, AND PHILIP

NEEDLEMAN. Analogues ofArachidonic Acid Used To Evaluate Structural Determinantsof Prostaglandin Receptor and Enzyme Specificities 242

RICHARD J. SCHIMMEL, KATHRYN K. MCMAHON, AND ROSALIND SERb. Interactions betweenAlpha-Adrenergic Agents, Prostaglandin E1, Nicotinic Acid, and Adenosine in Regulationof Lipolysis in Hamster Epididymal Adipocytes 248

M. GNEGY AND G. TREISMANN. Effect of Calmodulin on Dopamine-Sensitive AdenylateCyclase Activity in Rat Striatal Membranes 256

WALTER C. PROZIALECK, MAURO CIMIN0, AND BENJAMIN WEISS. Photoaffinity Labeling of

Calmodulin by Phenothiazine Antipsychotics 264

MICHAEL J. BANNON, RICHARD L. MICHAUD, AND ROBERT H. ROTH. Mesocortical DopamineNeurons: Lack of Autoreceptors Modulating Dopamine Synthesis 270

RICHARD J. MILNE AND JOHN H. BYRNE. Effects of Hexamethonium and Decamethoniumon End-Plate Current Parameters 276

ESAM EL-FAKAHANY AND ELLIOTT RICHELSON. Effects of Lanthanides on Muscarinic Ace-tyicholine Receptor Function 282

MATS HANSON. Effects of Mitosis Inhibitors on Respiration and Fast Axonal Transport inFrog Sciatic Nerves 291

A. G. APPU RAO AND JOHN R. CANN. A Comparative Study of the Interaction of Chiorpro-mazine, Tnfiuoperazine, and Promethazine with Mouse Brain Tubulin 295

CHUEN-SHANG, C. WU, NANCY M. LEE, NICHOLAS LING, JAW KANG CHANG, HORACE H. LOH,AND JEN TsI YANG. Conformation of /3-Endorphin Analogues in Cerebroside Sul-fate Solution . 302

JANICE R. SUFRIN, DEBORAH A. DUNN, AND GARLAND R. MARSHALL. Steric Mapping of theL-Methionine Binding Site of ATP:L-Methionine S-Adenosyltransferase 307

STANLEY FRIEDMAN. The Inhibition of DNA(Cytosine-5)Methylases by 5-Azacytidine: TheEffect of Azacytosine-Containing DNA 314

E. DE CLERCQ, J. BALZARINI, P. F. TORRENCE, M. P. MERTES, C. L. SCHMIDT, D. SHUGAR P.J. BARR, A. S. JONES, G. VERHELST, AND R. T. WALKER. Thymidylate Synthetase asTarget Enzyme for the Inhibitory Activity of 5-Substituted 2’-Deoxyuridines on MouseLeukemia L 1210 Cell Growth 321

LORI M. RAMONAS, LEONARD C. ERICKSON, WOLFGANG KLESSE, KURT W. KOHN, AND DANIEL

S. ZAHARKO. Differential Cytotoxicity and DNA Cross-Linking Produced by Polymericand Monomeric Activated Analogues of Cyclophosphamide in Mouse L1210 Leu-kemia Cells . . 331

PETER J. WIRTH AND SNORRI S. THORGEIRSSON. Mechanism of N-Hydroxy-2-Acetylamino-

fluorene Mutagenicity in the Salmonella Test System: Role of N-O Acyltransferase andSulfotransferase from Rat Liver . . . . 337

SHORT COMMUNICATIONS

WILLIAM A. CATTERALL AND MARTIN RISK. Toxin T4 . from Ptychodiscus brevis (FormerlyGymnodinium breve) Enhances Activation of �Voltage-Sensitive Sodium Channelsby Veratridine 345

CHRIS LINGLE, JUDITH S. EISEN, AND EVE MARDER. Block of Glutamatergic ExcitatorySynaptic Channels by Chlorisondamine 349

ERRATUM 354

NUMBER 3, MAY 1981

P. Y. LAW, T. J. OSTWALD, E. L. WAY, AND H. H. LOH. Interaction of Diazosulfanilic Acidand the Opiate Receptor: Inhibition of Specific Binding to Synaptic Membranes andLabeling of a Membrane Lipid Sterospecifically Protected by Opioids . . 355

FREDERICK J. EHLERT, WILLIAM R. ROESKE, AND HENRY I. YAMAMURA. MathematicalAnalysis of the Kinetics of Competitive Inhibition in Neurotransmitter Receptor BindingAssays 367

NANCY R. ZAHNISER, KIM A. HEIDENREICH, AND PERRY B. MOLINOFF. Binding of [3H]-Amino-6,7-dihydroxy- 1,2,3,4-tetrahydronaphthalene to Stnatal Membranes: Effects of Pu-rine Nucleotides and Ultraviolet Irradiation . . 372

S. J. HILL AND J. M. YOUNG. Characterization of [3HjMepyramine Binding to the Longitu-dinal Muscle of Guinea Pig Small Intestine 379

MICHAEL R. KILBOURN, A. J. ARDUENGO, JooN T. PARK, AND JOHN A. KATZENELLENBO-

GEN. Conformational Analysis of Nonsteroidal Estrogens: The Effect of ConformerPopulations on the Binding Affinity of meso- and dl-Hexestrol to the Estrogen Receptor 388

JAN MARIAN, RALPH L. COOPER, AND P. MICHAEL CONN. Regulation of the Rat PituitaryGonadotropin-Releasing Hormone Receptor . . 399

HARVEY R. KASLOW, DAVID Cox, VINCENT E. GROPPI, AND HENRY R. BOURNE. An Mr

52,000 Peptide Can Mediate Effects of Cholera Toxin on Adenylate Cyclase in In-tact Cells . 406

E. X. ALBUQUERQUE, J. E. WARNICK, M. A. MALEQUE, F. C. KAUFFMAN, R. TAMBURINI, Y.NIMIT, AND J. W. DALY. The Pharmacology of Pumiiotoxin-B. I. Interaction withCalcium Sites in the Reticulum of Skeletal Muscle 411

J. H. CHIN AND D. B. GOLDSTEIN. Membrane-Disordering Action of Ethanol: Variation withMembrane Cholesterol Content and Depth of the Spin Label Probe . . . . . . 425

H. J. GALLA AND J. R. TRUDELL. Perturbation of Peptide-Induced Lateral Phase Separationsin Phosphatidic Acid Bilayers by the Inhalation Anesthetic Methoxyfiurane . . . 432

DANIELE CU5I AND RICARDO GARAY. The Effect of Tieniic Acid on Na� and K� SodiumTransport in Human Red Cells 438

RONALD P. FRIGON, DANIEL T. O’CONNOR, AND GAIL L. LEVINE. Human Dopamine-f3-Hydroxylase: Comparison of the Enzyme from Plasma, Adrenal Medulla, and Pheochro-rnocytoma by Radioimmunoassay 444

SEBASTIAN CERDAN, MARIA CASCALES, AND ANGEL SANTOS-RUIZ. Effect of Thioacetamideon the Pentose Phosphate Pathway and Other NADP-Linked Enzymes of Rat LiverCytosol: Chronology of the Perturbations and Metabolic Significance 451

MITSUO YAMAZAKI, KAZUO OHUCHI, MASAAKI SASAKI, AND KIYOSHI SAKAI. Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by 9,11-Deoxyprostaglandins in Vitro and in Vivo 456

JARLE AARBAKKE AND PER M. UELAND. Interaction of S-Adenosylhomocysteine with Iso-lated Rat Hepatocytes 463

DONALD E. MACFARLANE. The Effects of Methyl Mercury on Platelets: Induction of Aggre-gation and Release via Activation of the Prostaglandin Synthesis Pathway 470

SUSAN P. C. COLE, DAVID T. ZELT, AND GERALD S. MARKS. Comparison of the Effects ofGriseofulvin and 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on Ferroche-latase Activity in Chick Embryo Liver 477

KEVIN J. SCANLON, ARLENE R. CASHMORE, BARBARA A. MoRosoN, ROBERT N. DREYER, AND

JOSEPH R. BERTINO. Inhibition ofSerine Metabolism by Tetrahydrohomofolate in L1210Mouse Leukemia Cells 481

MICHAEL R. HAMRELL, JOHN LASZLO, AND W. DAVID SEDWICK. Transient Induction ofPhenotypic Resistance in Human Lymphoblastoid Cells following Sequential Use ofTwo Antifolates 491

C. PAUL SPEARS. Nucleophiic Selectivity Ratios of Model and Clinical Alkylating Agents by4-(4’-Nitrobenzyl)pyridine Competition 496

SHORT COMMUNICATIONS

JOHN M. WHITELEY, ZENIA NIMEC, AND JOHN GALIVAN. Treatment of Reuber H35 Hepa-toma CbIIS with Carrier-Bound Methotrexate 505

ERNST BURGHISSER, ROBERT J. LEFKOWITZ, AND ANDRE DELEAN. Alternative Explanationfor the Apparent “Two-Step” Binding Kinetics of High-Affinity Racemic AntagonistRadioligands 509

SUNGCHUL Ji, JOHN J. LEMASTERS, AND RONALD G. THURMAN. A Fluorometric Method ToMeasure Sublobular Rates of Mixed-Function Oxidation in the Hemoglobin-Free PerfusedRat Liver 513

NORMAN CAMERMAN AND ARTHUR CAMERMAN. On the Stereochemistry of DopaminergicErgoline Derivatives 517

SUE A. WARTELL, ROSE CHRISTOPHERSON, CLYDE A. WATKINS, AND D. EUGENE

RANNELS. Inhibition of Synthdsis of Lung Proteins by Halothane 520

ROBERT M. LEVIN, RICHARD JACOBY, AND ALAN J. WEIN. Effect of Adenosine Triphosphateon Contractility and Adenosine Triphosphatase Activity of the Rabbit Urinary Bladder 525

AUTHOR INDEX FOR VOLUME 19 529The Subject Index for Volume 19 will appear in the November 1981 issue as part of a

cumulative index for the year 1981.