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What is Evidence-Based Medicine? Payam Kabiri, MD. PhD. Clinical Epidemiologist Tehran University of...
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![Page 1: What is Evidence-Based Medicine? Payam Kabiri, MD. PhD. Clinical Epidemiologist Tehran University of Medical Sciences.](https://reader036.fdocuments.net/reader036/viewer/2022062423/56649e915503460f94b95bf2/html5/thumbnails/1.jpg)
What is Evidence-Based
Medicine?
Payam Kabiri, MD. PhD.Clinical EpidemiologistTehran University of Medical Sciences
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Volume of new information a major barrier
0
500000
1000000
1500000
2000000
2500000
Trials MEDLINE BioMedical
Med
ical
Art
icle
s pe
r Y
ear
5,000?per day
1,360 per day
55 per day
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The Problem
The Knowledge Gap
Time to meet information needs
decreasing
Amount of Information is rising
Knowledge Gap
Time
Amount of Information
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Half-time or Half-life of Clinical Medical Science is
now
about 6 Month
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Doubling time of biomedical science was
about 19 years in 1991
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about 20 months in 2001
Doubling time of biomedical science was
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So you work in a job which:
Its half-time (half-life) is 6 months, & Its doubling-time is 20 month
You works in a ever-changing & ever-growing profession !
So you should keep updating !
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The Slippery Slope
Years since Med School graduation
Knowledgeof best current HTNcare
r = -0.54r = -0.54p<0.001p<0.001. ... ..
. . .... . . . .... . ............ ........
........
......
....
......
Shin,et al: CMAJ;1993: 969-976
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For General Physicians to keep current:
Read 19 new articles per day which appear in medical journals
19 x 2 hrs (Critical Appraisal) = 38 hrs per day
Davidoff F et al. (1995)
EBM; A new journal to help doctors identify
the information they need. BMJ 310:1085-86.
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"Kill as Few Patients as Possible" - Oscar London Rule 31- Review the world literature fortnightly
A Year of MEDLINEindexed journals
WashingtonMonument
555 feet
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Can’t I trust the editors?
Percent of articles meeting quality criteria
NEJM 12.6%
Ann Int Med 7.6%
JAMA 7.2%
Lancet 6.2%
BMJ 4.4%
Arch Int Med 2.4%
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Random Medical News
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Medical Publishing
Annually: 20,000 journals 17,000 new books
MEDLINE: 4,000 journals 6 Million references 400,000 new entries yearly
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Types of Medical articles
Original Article Review Article Case Reports
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Hierarchy of studies
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EBM History
G. Guyatt from McMaster University in 90s Sackett in 1995 defined EBM
“Our clinical decesion malking should be based on the best scientific avaiabe evidence”
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What is Evidence? Evidence is anything used to determine or
demonstrate the truth of an assertion. Scientific evidence is evidence which
serves to either support or counter a scientific theory or hypothesis.
In scientific research evidence is accumulated through observations of phenomena occur in the natural world, or created as experiments in a laboratory
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What is ‘level of evidence’?
The extent to which one can be confident that an estimate of effect or association is correct (unbiased).
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Levels of EvidenceLevel of
EvidenceType of Study
1a Systematic reviews of randomized clinical trials (RCTs)
1b Individual RCTs
2a Systematic reviews of cohort studies
2b Individual cohort studies and low-quality RCTs
3a Systematic reviews of case-controlled studies
3b Individual case-controlled studies
4 Case series and poor-quality cohort and case-control studies
5 Expert opinion based on clinical experience
Adapted from: Sackett DL et al. Evidence-Based Medicine: How to Practice and Teach EBM. 2nd ed. Churchill Livingstone; 2000.
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What is Evidence-Based Medicine?
“Evidence-based medicine is the integration of best research evidence with clinical expertise and patient values”
- Sackett & Straus
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EBM - What is it?
Clinical Expertise
Research Evidence
Patient Preferences
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Traditional medicine
Experiences Pathophysiology,
references,…
Patient value
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By best research evidence
clinically relevant research Unbiased research Reproducible research often from the basic sciences of medicine especially from patient centered clinical
research
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By clinical expertise
We mean the ability to use our clinical skills and past experience to rapidly identify each patient’s unique health state and diagnosis, their individual risks and benefits of potential interventions, and their personal values and expectations.
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By patient values
We mean the unique preferences, concerns and expectations each patient brings to a clinical encounter and which must be integrated into clinical decisions if they are to serve the patient.
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When these three elements are integrated, clinicians and patients form a diagnostic and therapeutic alliance which optimizes clinical outcomes and quality of life
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EBM Steps
1. Ask your clinical question
2. Search your literature for answer
3. Appraise the retrieved documents
4. Apply your findings
5. Evaluate the performance
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The five-step process for using an evidence-based approach in general practice
(1) define the problem
(2) track down the information sources you need
(3) critically appraise the information
(4) apply the information with your patients
(5) evaluate how effective this application of information is.
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How do we actually practice EBM? The full-blown practice of EBM comprises 5 steps, and this book takes
them up in turn: • Step 1: Converting the need for information (about prevention, diagnosis,
prognosis, therapy, causation, etc) into an answerable question (Chapter 1).
• Step 2: Tracking down the best evidence with which to answer that question (Chapter 2).
• Step 3: Critically appraising that evidence for its validity (closeness to the truth), impact (size of the effect), and applicability (usefulness in our clinical practice) (the first halves of Chapters 3-7).
• Step 4: Integrating the critical appraisal with our clinical expertise and with our patient’s unique biology, values and circumstances (the second halves of Chapters 3-7).
• Step 5: Evaluating our effectiveness and efficiency in executing Steps 1-4 and seeking ways to improve them both for next time (Chapter 9).
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Acquire the best evidence
Appraise the evidence
Applyevidence to patient care
Assess your patient
Ask clinical questions
EBM Method
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What are the limitations of EBM?
First, the need to develop new skills in searching and critical appraisal can be daunting, although (as we pointed out above) evidence-based care can still be applied if only the former has been mastered and directed toward pre-appraised resources
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Second, busy clinicians have limited time to master and apply these new skills, and the resources required for instant access to evidence are often woefully inadequate in clinical settings.
Finally, evidence that EBM “works” has been late and slow to come.
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The usefulness of EBM
1. Treatments & diganistic test are being used at a time when their effectiveness is approved
2. EBM prevent using ineffective tratment methods, so it will probabaly decrease charges
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The usefulness of EBM
3. It help us updateing our knowledge continously instead of reading lots of irrleavany & unreliabae litraure, so time saving.
4. It helps policy makesrs through development of clinical guidlines, providing them with enough documntsm& evidence
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The usefulness of EBM
5. Instead of teaching stdents current standard treatmnet methode, it teach them how to find the best current therapy for their disease
6. EBM promote evidence instead of persons authority
7. It decreases medical errors
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Seven alternatives to evidence based medicine Eminence based medicine Vehemence based medicine Eloquence based medicine Providence based medicine Nervousness based medicine Diffidence based medicine Confidence based medicine
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Eminence based medicine
The eminent physician's white hair and balding pate are called the "halo" effect. The more senior the colleague, the less importance he or she placed on the need for anything as mundane as evidence. Experience, it seems, is worth any amount of evidence.
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Vehemence based medicine
The substitution of volume for evidence is an effective technique for brow beating your more timorous colleagues and for convincing relatives of your ability.
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Eloquence based medicine
The year round suntan, carnation in the button hole, silk tie, Armani suit, and tongue should all be equally smooth. Sartorial elegance and verbal eloquence are powerful substitutes for evidence.
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Providence based medicine
If the caring practitioner has no idea of what to do next, the decision may be best left in the hands of the Almighty. Too many clinicians, unfortunately, are unable to resist giving God a hand with the decision
making.
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Nervousness based medicine
Fear of litigation is a powerful stimulus to overinvestigation and overtreatment. In an atmosphere of litigation phobia, the only bad test is the test you didn't think of
ordering.
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Diffidence based medicine
Some doctors see a problem and look for an answer. Others merely see a problem. The diffident doctor may do nothing from a sense of despair. This, of course, may be
better than doing something merely because it hurts the doctor's pride to do nothing.
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Confidence based medicine
This is restricted to surgeons
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Was it clear enough !