Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.
-
Upload
brianna-norman -
Category
Documents
-
view
237 -
download
0
Transcript of Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.
![Page 1: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/1.jpg)
Wendy Chen, MD, PhD: PGY-3Charleen T. Chu, MD, PhD:
Neuropathology
![Page 2: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/2.jpg)
50 yo Caucasian male presenting with right lower eyelid erythema and thickening.
Itchy Erythema fluctuates, worse after sun
exposure No change in vision Some AM eyelid matting/crusting
![Page 3: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/3.jpg)
Seen by dermatologist in 2006 -- bilateral periorbital rash, erythematous and itchy, scaling plaques, worsened by sun exposure.
? Rosacea ---> treated with Akne-mycin (erythromycin 2%) without improvement.
Punch biopsy of LEFT lower eyelid
![Page 4: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/4.jpg)
Dermatopathology report:“lichenoid dermatitis with deep perivascular extension of the infiltrate . . . lupus erythematosis vs. lichenoid photodermatitis”
Subsequently, PAS stain: thickened basement membrane Colloidal iron: focal increase in dermal mucin Favoring discoid lupus erythematosis
![Page 5: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/5.jpg)
Treated with Protopic (tacrolimus 0.1%) – bilateral periorbital rash improved.
Serologic testing: ANA, RF, Anti-DNA, Anti-histone, Anti-SS
A/B negative. C3, C4 WNL CBC, LFTs, BMP WNL RPR non-reactive
![Page 6: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/6.jpg)
Over the next 3 years, pt continued to have intermittent flares of periorbital, facial, and scalp rashes ---> continued Protopic.
In 2009, presented to dermatology again with persistent RLL erythema and thickening accompanied by erythematous pustules of the face ---> acne rosacea
To ophthalmology for second opinion
![Page 7: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/7.jpg)
Past Medical/Surgical History• Acne rosacea• Lupus erythematosis, DISCOID, not systemic• Anxiety, Depression• S/P hernia repair
Past Ocular History• S/P left periorbital skin bx• Hyperopia• Astigmatism
Social History• Tob – none• EtOH – social use• Drugs – none• Excessive sun exposure and multiple severe sunburns prior to age 18
MedicationsTopical tacrolimus 0.1% prnLexaproAtivan
![Page 8: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/8.jpg)
Va CC: 20/20 OUPupils: No APDIOP: 14 OUEOM: Full OUCVF: Full OU
![Page 9: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/9.jpg)
![Page 10: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/10.jpg)
OD OSExternal Acne rosacea Acne rosacea
Lids/Lashes LL with MGD, telangiectasia, diffuse erythema and thickening, no distortion of lash line or madarosis
Normal
Conj/Sclera White and quiet White and quiet
Cornea Clear Clear
AC Deep and quiet Deep and quiet
Iris Round and reactive Round and reactive
Lens Clear Clear
Vitreous Normal Normal
![Page 11: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/11.jpg)
Ocular rosacea – typically bilateral, but can be asymmetric.
Discoid lupus without systemic involvement.
Infectious – viral, bacterial, fungal.
Malignancy – basal cell carcinoma, squamous cell carcinoma, sebaceous adenocarcinoma.
![Page 12: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/12.jpg)
Rosacea-associated blepharitis ---> Blephamide BID with resolution of symptoms.
Returned 5 months later with RLL recurrence (slow return of symptoms).
Referred to oculoplastics for biopsy.
![Page 13: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/13.jpg)
Wedge resection of lateral portion of the RLL lesion in Oct 2009.
Conjunctival cultures taken: Fungus culture negative Virus culture negative Bacterial culture with light coag neg
Staph Adenovirus PCR negative HSV1/2 PCR negative
![Page 14: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/14.jpg)
HyperkeratosisAcanthosisSquamous cell nests and strands infiltrating the dermis
![Page 15: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/15.jpg)
Infiltrative border
![Page 16: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/16.jpg)
Suggestion of early keratin pearl formation
![Page 17: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/17.jpg)
Mitotic figures
![Page 18: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/18.jpg)
Interface dermatitis with vacuolar degeneration
![Page 19: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/19.jpg)
EYELID RIGHT LOWER, WEDGE BIOPSY A. SUPERFICIALLY INVASIVE SQUAMOUS
CELL CARCINOMA (0.2 CM, 0.1 CMTHICK), WELL DIFFERENTIATED
NO ANGIOLYMPHATIC OR PERINEURAL INVASION PRESENT.
MARGINS FREE OF TUMOR.
![Page 20: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/20.jpg)
Pt continued to have persistent RLL erythema and thickening.
Re-excision of adjacent area performed Nov. 2009, given prior diagnosis ---> suture with foreign body giant cell reaction, acute and chronic inflammation and fibrosis.
![Page 21: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/21.jpg)
Started po Doxycycline 100mg daily for further treatment of ocular rosacea.
Patient was followed q4 months for 1 yr with waxing and waning progression of RLL lesion.
Most recent visit revealed a change in appearance of RLL.
![Page 22: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/22.jpg)
![Page 23: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/23.jpg)
Prior biopsy site Vertical extension of the lesion with minor distortion of lid architecture
![Page 24: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/24.jpg)
Given the recent change in the appearance of the lesion and prior diagnosis of carcinoma, a repeat wedge resection was performed in January 2011 on the medial portion of the RLL lesion.
![Page 25: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/25.jpg)
Dense interface dermatitis, architectural distortion.
Keratin pearl
![Page 26: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/26.jpg)
Maturation & narrow strand-like extensions suggest pseudocarcinomatous hyperplasia
Thick basement membrane
![Page 27: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/27.jpg)
Review of initial wedge excision revealed that the diagnosis of carcinoma may have been incorrect. Prolonged clinical history of rashes, chronic
inflammation and suspicion of DLE were not known to the original pathologist.
Both excisions showed: SQUAMOPROLIFERATIVE LESIONS WITH
PSEUDOEPITHELIOMATOUS HYPERPLASIA.
![Page 28: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/28.jpg)
10-40X less common than basal cell carcinoma.
Typically arise from actinic keratoses. Lower eyelid most common ocular site. Histologic characteristics:
Hyperkeratosis, acanthosis Interface dermatitis, infiltrative nests and strands Keratinocyte nuclear hyperchromasia and
maturational ayptia, mitotic figures Keratin pearls, dyskeratotic cells
![Page 29: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/29.jpg)
Chronic inflammation can result in histologic changes that mimic invasive squamous carcinoma.
Features that can help differentiate PCH/PEH from SCC: Narrow, strand-like infiltration of epithelium
▪ Tangential section can result in isolation from surface
Lack of dysplastic hyperchromatic nuclei, lack of maturational atypia▪ Reactive atypia – pale nuclei with uniform
nucleoli
![Page 30: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/30.jpg)
Systemic lupus more commonly causes corneal lesions, retinal vasculopathy keratoconjunctivitis sicca, peripheral
ulcerative keratitis, interstitial keratitis Very rarely can give isolated lid lesions
that mimic malignancy CCL variants
Discoid lupus erythematosis – plaque lesions Lupus erythematosis profundus (panniculitis) Systemic disease - idiopathic orbital edema
![Page 31: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/31.jpg)
Unlike regular pseudoepitheliomatous hyperplasia, significant cytologic atypia (N/C ratio, hyperchromasia, mitoses) can occur.
Features that help differentiate DLE from SCC: History of chronicity, rashes
▪ SCC shows rapid onset/growth (< 6 mo), nodular or ulcerative changes.
Intradermal mucin (colloidal iron) Thickened basement membrane (PAS)
Papalas et al. “Cutaneous Lupus Erythematosus of the Eyelid as a Mimic of Squamous Epithelial Malignancies” Ophthal Plast Reconstr Surg 2010.
![Page 32: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/32.jpg)
Features that help differentiate CCL from SCC: Perifollicular and acrosyringeal inflammation Follicular plugging Vacuolar interface change Compact orthokeratosis
The “helpful” features may not be present or may not be recognized without a high index of suspicion 37% of cutaneous LE cases incorrectly interpreted initially
even by Board certified dermatopathologists
Zedek et al. “Cutaneous Lupus Erythematosis simulating squamous neoplasia: The clinicopathologic conundrum and histopathologic pitfalls” J Am Acad Dermatol 2007; 56: 1013-20.
![Page 33: Wendy Chen, MD, PhD: PGY-3 Charleen T. Chu, MD, PhD: Neuropathology.](https://reader034.fdocuments.net/reader034/viewer/2022051215/56649e9f5503460f94ba1345/html5/thumbnails/33.jpg)
Persistent unilateral lower lid erythema/thickening despite treatment of discoid lupus and ocular rosacea warrants biopsy. SCC can develop in lesions of discoid LE
The histologic DDx includes actinic keratosis/SCC, lichen planus-like keratosis & PCH/PEH
▪ Combination of cytologic atypia from lupus and PCH/PEH (which normally lacks atypia) is a diagnostic pitfall
▪ Chronic history and suspicion of lupus would raise the awareness threshold to prevent overcalling the lesion
Providing clinical history is key to avoiding misdiagnosis >> rare mimics of a common neoplasm