VIDI SYMPOSIUM
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VIDI SYMPOSIUM
Criteria Influencing Potential Impact of HIV Prevention Interventions
January 14, 2008
Thomas Fleming, PhDUniversity of Washington
Fred Hutchinson Cancer Center
1. Percent of HIV transmission risk being addressed
~ Size of the risk group: fraction of the incidence ~ Attributable risk of transmission pathway addressed ~ Potential for reduction in secondary transmission
2. Intervention: Plausible Reduction in Relative Risk
~ Strength of “proof of concept” data ~ Likelihood for effect on secondary transmission
3. Feasible level of coverage of the target population ~ Affordability, Acceptability, Practicality
Criteria Influencing Potential Impact of HIV Prevention Interventions
~ 27% : Black/Hispanic MSM ~ 16% : Black/Hispanic Non-MSM
→ 7% heterosexual ; 9% IDU ~ 24% : White MSM ~ 3% : White Non-MSM Men
→ 1% heterosexual ; 2% IDU
~ 19% : Black/Hispanic Women (Heterosexual) ~ 5% : Black/Hispanic Women (Non-Heterosex)
→ IDU ~ 4% : White Women (Heterosexual) ~ 2% : White Women (Non-Heterosexual)
Size of the Risk Groups Fraction of the US Incidence
1. Percent of HIV transmission risk being addressed
~ Size of the risk group: fraction of the incidence ~ Attributable risk of transmission pathway addressed ~ Potential for reduction in secondary transmission
2. Intervention: Plausible Reduction in Relative Risk
~ Strength of “proof of concept” data ~ Likelihood for effect on secondary transmission
3. Feasible level of coverage of the target population ~ Affordability, Acceptability, Practicality
Criteria Influencing Potential Impact of HIV Prevention Interventions
Hypothetical Example ↓ in Substance Use in MSM
1. % of Tx risk addressed 11.25K (25% US incidence)
~ Size of risk group ~ 22.5K MSM ~ Attributable risk ~ 50% of MSM Tx ~ ↓ in secondary tx ( + )
2. Plausible ↓ in RR 4.5K (10% US incidence)
~ Established POC? ~ Expect 40% ↓ in risk ~ ↓ in secondary tx ( ─ )
3. Feasible coverage 2.25K (5% US Incidence) ~ Practical, Affordable? ~ Expect 50% coverage
Criteria Influencing Potential Impact of HIV Prevention Interventions
1. Percent of HIV transmission risk being addressed
~ Size of the risk group: fraction of the incidence ~ Attributable risk of transmission pathway addressed ~ Potential for reduction in secondary transmission
2. Intervention: Plausible Reduction in Relative Risk
~ Strength of “proof of concept” data ~ Likelihood for effect on secondary transmission
3. Feasible level of coverage of the target population ~ Affordability, Acceptability, Practicality
Criteria Influencing Potential Impact of HIV Prevention Interventions
Hypothetical Example ↓ in Substance Use in MSM
1. % of Tx risk addressed 11.25K (25% US incidence)
~ Size of risk group ~ 22.5K MSM ~ Attributable risk ~ 50% of MSM Tx ~ ↓ in secondary tx ( + )
2. Plausible ↓ in RR 4.5K (10% US incidence)
~ Established POC? ~ Expect 40% ↓ in risk ~ ↓ in secondary tx ( ─ )
3. Feasible coverage 2.25K (5% US Incidence) ~ Practical, Affordable? ~ Expect 50% coverage
Criteria Influencing Potential Impact of HIV Prevention Interventions
1. Percent of HIV transmission risk being addressed
~ Size of the risk group: fraction of the incidence ~ Attributable risk of transmission pathway addressed ~ Potential for reduction in secondary transmission
2. Intervention: Plausible Reduction in Relative Risk
~ Strength of “proof of concept” data ~ Likelihood for effect on secondary transmission
3. Feasible level of coverage of the target population ~ Affordability, Acceptability, Practicality
Criteria Influencing Potential Impact of HIV Prevention Interventions
Hypothetical Example ↓ in Substance Use in MSM
1. % of Tx risk addressed 11.25K (25% US incidence)
~ Size of risk group ~ 22.5K MSM ~ Attributable risk ~ 50% of MSM Tx ~ ↓ in secondary tx ( + )
2. Plausible ↓ in RR 4.5K (10% US incidence)
~ Established POC? ~ Expect 40% ↓ in risk ~ ↓ in secondary tx ( ─ )
3. Feasible coverage 2.25K (5% US Incidence) ~ Practical, Affordable? ~ Expect 50% coverage
Criteria Influencing Potential Impact of HIV Prevention Interventions
1. Percent of HIV transmission risk being addressed
~ Size of the risk group: fraction of the incidence ~ Attributable risk of transmission pathway addressed ~ Potential for reduction in secondary transmission
2. Intervention: Plausible Reduction in Relative Risk
~ Strength of “proof of concept” data ~ Likelihood for effect on secondary transmission
3. Feasible level of coverage of the target population ~ Affordability, Acceptability, Practicality
Criteria Influencing Potential Impact of HIV Prevention Interventions
Hypothetical Example ↓ in Substance Use in MSM
1. % of Tx risk addressed 11.25K (25% US incidence)
~ Size of risk group ~ 22.5K MSM ~ Attributable risk ~ 50% of MSM Tx ~ ↓ in secondary tx ( + )
2. Plausible ↓ in RR 4.5K (10% US incidence)
~ Established POC? ~ Expect 40% ↓ in risk ~ ↓ in secondary tx ( ─ )
3. Feasible coverage 2.25K (5% US Incidence) ~ Practical, Affordable? ~ Expect 50% coverage
Criteria Influencing Potential Impact of HIV Prevention Interventions
Illustrations Vaccine MCT ART 012, 046 052, 060 , Voice
1. % of Tx risk addressed
~ Size of risk group ++ + + ~ Attributable risk ++ ++ ++ ~ ↓ in secondary tx (+/─) ( ─ ) (+/─)
2. Efficacy of intervention
~ Established POC? ? ++ ? ~ ↓ in secondary tx ( ? ) ( ─ ) ( ? )
3. Feasible coverage ~ Practical, Affordable? + +/─ +
Criteria Influencing Potential Impact of HIV Prevention Interventions
~ 27% : Black/Hispanic MSM ~ 16% : Black/Hispanic Non-MSM
→ 7% heterosexual ; 9% IDU ~ 24% : White MSM ~ 3% : White Non-MSM Men
→ 1% heterosexual ; 2% IDU
~ 19% : Black/Hispanic Women: Heterosexual ~ 5% : Black/Hispanic Women: IDU
~ 4% : White Women: Heterosexual ~ 2% : White Women: IDU
Size of the Risk Groups Fraction of the US Incidence
1. Percent of HIV transmission risk being addressed
~ Size of the risk group: fraction of the incidence ~ Attributable risk of transmission pathway addressed ~ Potential for reduction in secondary transmission
2. Intervention: Plausible Reduction in Relative Risk
~ Strength of “proof of concept” data ~ Likelihood for effect on secondary transmission
3. Feasible level of coverage of the target population ~ Affordability, Acceptability, Practicality
Criteria Influencing Potential Impact of HIV Prevention Interventions
VIDI SYMPOSIUM
The Way Forward for
HIV Prevention:
Combination Strategies (HAARP)
Domestic & International
Vaccines Microbicides
ART MCT
STD IDU
Behavioral