Unlocking the Power of the Genome - The Howell Foundation · 2019-05-28 · 2014 MIT Technology...
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© 2016 Illumina, Inc. All rights reserved. Illumina, 24sure, BaseSpace, BeadArray, BlueFish, BlueFuse, BlueGnome, cBot, CSPro, CytoChip, DesignStudio, Epicentre, ForenSeq, Genetic Energy, GenomeStudio, GoldenGate, HiScan, HiSeq, HiSeq X, Infinium, iScan, iSelect, MiniSeq, MiSeq, MiSeqDx, MiSeq FGx, NeoPrep, NextBio, Nextera, NextSeq, Powered by Illumina, SureMDA, TruGenome, TruSeq, TruSight, Understand Your Genome, UYG, VeraCode, verifi, VeriSeq, the pumpkin orange color, and the streaming bases design are trademarks of Illumina, Inc. and/or its affiliate(s) in the US and/or other countries. All other names, logos, and other trademarks are the property of their respective owners. Unlocking the Power of the Genome Karen Possemato Chief of Staff, Illumina| 08/25/2016
Transcript of Unlocking the Power of the Genome - The Howell Foundation · 2019-05-28 · 2014 MIT Technology...
© 2016 Illumina, Inc. All rights reserved.Illumina, 24sure, BaseSpace, BeadArray, BlueFish, BlueFuse, BlueGnome, cBot, CSPro, CytoChip, DesignStudio, Epicentre, ForenSeq, Genetic Energy, GenomeStudio, GoldenGate, HiScan, HiSeq, HiSeq X, Infinium, iScan, iSelect, MiniSeq, MiSeq, MiSeqDx, MiSeq FGx, NeoPrep, NextBio, Nextera, NextSeq, Powered by Illumina, SureMDA, TruGenome, TruSeq, TruSight, Understand Your Genome, UYG, VeraCode, verifi, VeriSeq, the pumpkin orange color, and the streaming bases design are trademarks of Illumina, Inc. and/or its affiliate(s) in the US and/or other countries. All other names, logos, and other trademarks are the property of their respective owners.
Unlocking the Power of the Genome Karen PossematoChief of Staff, Illumina| 08/25/2016
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Technology Has Changed
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Technology Has Changed Our Lives
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Technology Adoption is Accelerating
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● Immune engineering● Precise gene-editing in plants● Conversational interfaces● Reusable rockets
● Robots that teach each other● DNA App Store● Solarcity’s Gigafactory● Slack● Tesla autopilot● Power from the air
Breakthrough Technologies 2016MIT Technology Review
http://www.technologyreview.com/lists/technologies/2016/
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ge·no·micsjēˈnōmiks,-ˈnäm-/noun
The branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Genome:thecompletesetofgenesorgeneticmaterialpresentinacellororganism
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Thehumangenomeiscomposedof3.2billionletters
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The Genome is the Software Program of Life
11Photo credit:: David Hallet/The Press
Within That Code Is Our “Blueprint”
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Genetic Bugs
Source: Nature Reviews | Genetics
ATTGGCCTTAACCCGATCCGATTATCAGGATATTGGCCTTAACCC CCGATTATCAGGATInsertion-deletion Variant
ATTGGCCTTAACCCCCGATTATCAGGATATTGGCCTTAACAGTGGATTATCAGGATBlock Substitution
ATTGGCCTTAACCCCCGATTATCAGGATATTGGCCTTCGGGGGTTATTATCAGGATInversion Variant
ATTGGCCTTAGGCCTTAACCCCCGATTATCAGGATATTGGCCTTA ACCCCCGATTATCAGGATCopy Number Variant
ATTGGCCTTAACCCCCGATTATCAGGATATTGGCCTTAACCTCCGATTATCAGGATSingle Nucleotide Variant
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Genotyping vs. Sequencing
AGCTACCCTGCATCGATTACGGATCCCAGTAATGCATCGAAGCTACCCTGCATCGATTACGGATCCCAGTAATGCATCGAAGCTACCCTGCATCGATTACGGATCCCAGTAATGCATCG
AGCTACCCTGCATCGATTACGGATCCCAGTAATGCATCGAAGCTACCCTGCATCGATTACGGATCCCAGTAATGCATCGAAGCTACCCTGCATCGATTACGGATCCCAGTAATGCATCG
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Illumina is Unlocking the Power of the Genome
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Illumina is Unlocking the Power of the Genome
SMARTEST COMPANY,2014 MIT Technology Review
10 BREAKTHROUGH TECHNOLOGIES,2013 MIT Technology Review
THE12 MOST DISRUPTIVENAMES IN BUSINESS,
2013 Forbes
TOP 10 INNOVATIONS,2012 The Scientist Magazine
FASTEST GROWING TECH COMPANIES,2010 Forbes
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$100 million
$10 million
$1 million
$100,000
$10,000
$1,000
$100
‘01 ‘02 ‘03 ‘04 ‘05 ‘06 ‘07 ‘08 ‘09 ‘10 ‘11 ‘12 ‘13 ‘14
In 2001 Sequencing One Human Genome Took About a Year and Cost $100 Million
Moore’s Law
$1,000
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>90% of the world’s sequencing data have been generated using Illumina sequencers.
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Genomics has Many ApplicationsAgriculture
BioPharm
Cancer
Complex Disease
Consumer
ForensicsGenetic Health
Infectious Disease
Population Genetics
Reproductive Health
Research
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2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
A Decade of ProgressTowards our Vision
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2005 2006 2007 2008 2009 2010 2011 2012 20132004
A Decade of ProgressThe genomics transformation in society
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2005 2006 2007 2008 2009 2010 2011 2012 20132004
A Decade of ProgressThe genomics transformation in society
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2005 2006 2007 2008 2009 2010 2011 2012 20132004
A Decade of ProgressThe genomics transformation in society
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2005 2006 2008 2009 2010 2011 2012 20132004 2007
A Decade of ProgressThe genomics transformation in society
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2005 2006 2007 2008 2009 2010 2011 2012 20132004
A Decade of ProgressThe genomics transformation in society
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Changing Human HealthNext-generation sequencing moving rapidly into the clinic
Cancer PanelsWhole GenomeWhole ExomeTargeted
SequencingNon-Invasive
Prenatal Testing
