University of Groningen

Immunotherapy based on influenza virosomes and recombinant Semliki Forest virusde Mare, Arjan

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Publication date:2007

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Citation for published version (APA):de Mare, A. (2007). Immunotherapy based on influenza virosomes and recombinant Semliki Forest virus:novel strategies for the treatment of cervical cancer. s.n.

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Immunotherapy based on influenza virosomes and recombinant Semliki Forest

virus

novel strategies for the treatment of cervical cancer

Copyright 2007 Arjan de Mare, The Netherlands

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without written permission of the author and, when appropriate, the publisher holding the copyrights of the published articles.

ISBN:

978-90-367-3066-2 (hardcopy) 978-90-367-3067-9 (digital)

Cover:

During the Trojan War, Talthybios and Eurybates, heralds of King Agamemnon, have reluctantly come to the tent and ships of Achilles to claim the slave girl Briseis for their monarch. Fearful and reverent of the Achaean hero and his host of Myrmidons, they deliver their message and are allowed to take away the girl unopposed [Homer, The Iliad, Book I]. Original Illustration by Mariette Oude Munnink.

Layout and design:

Evelien Heuvel and Arjan de Mare

Printed by PrintPartners Ipskamp B.V., Enschede, The Netherlands

RIJKSUNIVERSITEIT GRONINGEN

Immunotherapy based on influenza virosomes and recombinant Semliki Forest

virus

novel strategies for the treatment of cervical cancer

Proefschrift

ter verkrijging van het doctoraat in de Medische Wetenschappen

aan de Rijksuniversiteit Groningen op gezag van de

Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op

woensdag 13 juni 2007 om 16.15 uur

door

Arjan de Mare

geboren op 4 maart 1979 te Hengelo

Promotores: Prof. dr. J.C. Wilschut Prof. dr. A.G.J. van der Zee

Copromotor: Dr. C.A.H.H. Daemen

Beoordelingscommissie: Prof. dr. C.J.M. Melief Prof. dr. L.F.M.H. de Leij Prof. dr. A.J.M. van Oosterhout

Paranimfen: Dr. Jørgen M. de Jonge Drs. Annechien J.A. Lambeck

The research described in this thesis was performed at the Department of Medical Microbiology, Molecular Virology Section of the University Medical Center Groningen, in collaboration with the Department of Obstetrics and Gynaecology within the Institute for Transplantation, Immunology, and Inflammation (TRIO) of the Graduate School for Drug Exploration GUIDE.

The research described in this thesis was funded by the Dutch Cancer Society (KWF Kanker-bestrijding), Project grant RuG-2001-2361.

The printing of this thesis was financially supported by:

Dutch Cancer Society, Amsterdam, The Netherlands

Medisch Spectrum Twente Hospital Group, Enschede, The Netherlands

University of Groningen, Groningen, The Netherlands

Graduate School for Drug Exploration GUIDE, Groningen, The Netherlands

Solvay Pharmaceuticals B.V., Weesp, The Netherlands

Avanti Polar Lipids, Inc., Alabaster, AL, USA

Part I: Introduction

Chapter 1 General introduction Chapter 2 Virosomes for antigen and DNA delivery Adv Drug Deliv Rev. 2005 Jan;57(3):451-63. Chapter 3 Recombinant alphaviruses as vectors for anti- tumour and anti-microbial immunotherapy J Clin Virol. 2006 Mar;35(3):233-43.

Part II: Research articles

Chapter 4 Virosome-mediated delivery of protein antigens in vivo: efficient induction of class I MHC-restricted cytotoxic T lymphocyte activity Vaccine. 2005 Jan;23(10):1232-41. Chapter 5 The effect of pre-existing immunity on the capacity of influenza virosomes to induce cytotoxic T lymphocyte activity Manuscript in preparation.

Chapter 6 A virosomal immunization strategy against cervical cancer and pre-malignant cervical disease Antivir Ther. 2006 Nov;11(6):717-27.

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Table of contents

Chapter 7 Viral vector-based immunization regimens: evidence for a central role of T cell competition Manuscript submitted for publication.

Chapter 8 Heterologous prime-boost immunization protocols with a recombinant Semliki Forest virus vector and virosomes Manuscript submitted for publication.

Part III: Discussion and summary

Chapter 9 Discussion and future perspectives

Chapter 10 Summary

Chapter 11 Samenvatting (Summary in Dutch)

Appendices

I Dankwoord (Acknowledgments)

II List of contributing authors

III List of abbreviations

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