uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example...

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Transcript of uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example...

Page 1: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 2: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 3: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 4: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 5: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 6: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 7: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 8: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 9: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 10: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 11: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 12: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 13: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 14: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase
Page 15: uh.eduuh.edu/sibs/faculty/cstath/Chapter8_1.pdf · 'ABLE 8.3 Six major classes of enzymes Example Lactate dehydrogenase Nucleoside monophosphate kinase (NMP kinase) Chymotrypsin Fumarase

Kinase Assay Overview

Kinase Assay Overview

Pharmacological, Mechanistic, and Pharmacokinetic Assessment … · kinase kinase MEK1/2, MEK5, and phosphoinositide 3-kinase (PI3K)inhibitors.C4andC5inhibitedtamoxifen-resistantMCF-7

Pharmacological, Mechanistic, and Pharmacokinetic Assessment … · kinase kinase MEK1/2, MEK5, and phosphoinositide 3-kinase (PI3K)inhibitors.C4andC5inhibitedtamoxifen-resistantMCF-7

Reseptor tirosin kinase

Reseptor tirosin kinase

Kinase screening:Layout 1

Kinase screening:Layout 1

tpk Kinase

tpk Kinase

Protein tyrosine kinase 2: a novel therapeutic target to ......Protein tyrosine kinase 2 (PTK2) or focal adhesion kinase is a member of the non-receptor protein tyrosine kinase family

Protein tyrosine kinase 2: a novel therapeutic target to ......Protein tyrosine kinase 2 (PTK2) or focal adhesion kinase is a member of the non-receptor protein tyrosine kinase family

HER2Neu kinase

HER2Neu kinase

Tyrosine kinase ppt

Tyrosine kinase ppt

Tyrosine kinase inhibitors

Tyrosine kinase inhibitors

targeting Cancer With Small Molecule Kinase Inhibitorssdjohnston.faculty.noctrl.edu/360/kinase inhibitors.pdf · ated considerable interest in the development of small molecule kinase

targeting Cancer With Small Molecule Kinase Inhibitorssdjohnston.faculty.noctrl.edu/360/kinase inhibitors.pdf · ated considerable interest in the development of small molecule kinase

Kinase Inhibitors

Kinase Inhibitors

...Mechanism of action Kinase inhibitor Tyrosine kinase inhibitor Proteasome inhibitor Kinase inhibitor, targets HER2 Immunomodulatory drug Kinase inhibitor Non-steroidal aromatase

...Mechanism of action Kinase inhibitor Tyrosine kinase inhibitor Proteasome inhibitor Kinase inhibitor, targets HER2 Immunomodulatory drug Kinase inhibitor Non-steroidal aromatase

déficience en glycogène phosphorylase kinase … · 453 Déficience en glycogène phosphorylase kinase hépatique, un diagnostic difficile kinase. Cette enzyme permet d’hydrolyser

déficience en glycogène phosphorylase kinase … · 453 Déficience en glycogène phosphorylase kinase hépatique, un diagnostic difficile kinase. Cette enzyme permet d’hydrolyser

integrin-linked kinase

integrin-linked kinase

Knockdown of Ron Kinase Inhibits Mutant PI3 Kinase and ...Knockdown of Ron Kinase Inhibits Mutant PI3 Kinase and Reduces Metastasis in Human Colon Carcinoma Jing Wang1*, Ashwani Rajput2,

Knockdown of Ron Kinase Inhibits Mutant PI3 Kinase and ...Knockdown of Ron Kinase Inhibits Mutant PI3 Kinase and Reduces Metastasis in Human Colon Carcinoma Jing Wang1*, Ashwani Rajput2,

HM71224, a selective Bruton’s tyrosine kinase inhibitor ...Bruton’s tyrosine kinase (BTK) is a non-receptor tyro-sine kinase belonging to the tec protein tyrosine kinase (TEC)

HM71224, a selective Bruton’s tyrosine kinase inhibitor ...Bruton’s tyrosine kinase (BTK) is a non-receptor tyro-sine kinase belonging to the tec protein tyrosine kinase (TEC)

Effect of phosphoinositide 3-kinase (PI3-kinase ... · Effect of phosphoinositide 3-kinase (PI3-kinase) inhibition on wound healing and cell proliferation Introduction Cell proliferation

Effect of phosphoinositide 3-kinase (PI3-kinase ... · Effect of phosphoinositide 3-kinase (PI3-kinase) inhibition on wound healing and cell proliferation Introduction Cell proliferation

University of Groningen Inflammation and remodelling in ...TGF-β-activated kinase 1 (TAK1), a serine/threonine kinase, is a member of the mitogen activated protein kinase kinase kinase

University of Groningen Inflammation and remodelling in ...TGF-β-activated kinase 1 (TAK1), a serine/threonine kinase, is a member of the mitogen activated protein kinase kinase kinase

Thymidylate Kinase

Thymidylate Kinase

Role of tyrosine kinase and protein kinase C in the steroidogenic ...

Role of tyrosine kinase and protein kinase C in the steroidogenic ...