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  • 1. FROMTHE CHIEF.- Dear Friends of UCSD Dermatology, Despite the challenges of 2009, this year has been one of continued growth and success for UCSD Dermatology. In this newsletter we will introduce to you several new members of our family, repre- senting success in our efforts for excellence in clinical care, education and research. I am par- ticularly happy to welcome our newest full time faculty members Dr. Robert Lee and Dr. Jo- seph Lillis. Dr Lee comes to us from the University of Pennsylvania and is heading up our der- matopathology service with an immediate goal of modernizing many aspects of the information processing and communication system. Dr. Lillis comes to us from OHSU and, among many contributions in medical dermatology, has initiated the first medical continuity clinic for our residents. Other highlights of the past year have been our growth into new basic research labo- ratory space at the University Research Center (photos below) and a dramatic increase in the dermatology research funding. We are very optimistic that the coming year will continue us on our trajectory of excellence. Our success is rooted in the extraordinary team that has assembled under the banner of UCSD Dermatology but is also fed by the generosity of the community. Gifts to our program are ena- bling us to establish the first pigmented lesion clinic in San Diego with a goal to serve the needs of our community for the care of patients with high-risk for melanoma. Also, gifts and grants to our research program have allowed UCSD Dermatology to become a national leader at the cut- ting edge of a new understanding of the biology of the skin. Thanks to all who have made our work possible, Richard L. Gallo, M.D., Ph.D. WINTER 2010 DIVISION OF DERMATOLOGY NEWSLETTER VOLUME 4 ISSUE 3 INSIDE THIS ISSUE MESSAGE FROM THE CHIEF 1 NEW FACULTY & ANNOUNCE- MENTS 2 RESIDENCY PROGRAM & GRAND ROUNDS SCHEDULE 3 RECENT PUBLICATIONS 4 DR. TERRY OGRADY DERMATO- PATHOLOGY LECTURESHIP 7 SUPPORT 8 Derm awards, research UPDATES 5 & 6 University of California, San Diego Division of Dermatology 200 W. Arbor Drive #8420 San Diego, CA 92103-8420 http://dermatology.ucsd.edu/ Newsletter contact: Paula Rushton [email protected] 858-822-4608 UCSD DERMATOLOGYUCSD DERMATOLOGYUCSD DERMATOLOGY

2. NEW FACULTY & NEW ADDITIONS PAGE 2 Robert Lee, M.D. , Ph.D. Dr. Lee joined the Dermatology faculty in September 2009. He is an Assistant Clinical Professor in the Division of Dermatology and Director of Dermatopathology at UCSD. Dr. Lee received his M.D. and Ph.D. at the UCLA David Geffen School of Medicine and went on to St. Vincent's Catholic Medical Center in Manhattan for his medical internship. He completed his residency in dermatology and fellowship in dermatopathology at the Hospital of the University of Pennsylvania. He further developed his interest in teaching and academic medicine as a Clinician-Educator fellow and Clinical Instructor at Penn. In addition to medical dermatology and dermatopathology, Dr. Lee's research interest include cutaneous adnexal diseases, tropical dermatology, telemedicine and medical edu- cation. Dr. Lee's clinical practice is located at the Ambulatory Care Center in Hillcrest and at the Perlman Clinic in La Jolla. Joseph Lillis, M.D. Dr. Lillis is an Assistant Clinical Professor in the Division of Dermatology at UCSD. He received his M.D. at the Georgetown University School of Medicine in Washington DC. He completed his medical internship with the Legacy Health System and his residency in dermatology at Oregon Health Science University, both in Portland, Oregon. He further developed his interest in teaching and academic medicine during his third year of residency where he served as chief resident with duties that included involvement in medical student education, organizing resident schedules and organizing the dermatology resident curriculum. In addition to medical dermatology, Dr. Lillis interests include psoriasis, atopic dermati- tis, contact dermatitis and skin disease in acute and chronically immunosuppressed pa- tients. Dr. Lillis clinical practice is located at the Ambulatory Care Center in Hillcrest and at the Perlman Clinic in La Jolla. Michael R. Lerner, M.D., Ph.D. Dr. Michael Lerner is an Assistant Clinical Professor in the Division of Dermatology. He trained in Dermatology at the University of Texas Southwestern Medical Center and received his MD degree at Yale where he also received his PhD in Molecular Biophysics and Biochemistry. Dr. Lerner completed a medical internship and a postdoctoral fellowship at Washington University in St. Louis. Dr. Lerners clinical practices are located at the Perlman Ambulatory Care Center in La Jolla and the Hillcrest Medical Offices South in San Diego. Dr. Sharon Jacob and her husband Dr. Joseph Soo wel- comed daughter Raegan Ryan on 12/28/08 and son Rhys Alan on 9/21/09 3. Front row: Dr. Pristine Lee, Dr. Michelle Jackson, Dr. Elan Newman, Dr. Michelle Nguyen, Dr. Caroline Piggott Back row: Dr. Gagik Oganesyan, Dr. Shane Hamman, Dr. David Lortscher, Dr. Andrew Krakowski, Dr. Doru Alexandrescu, Dr. Stephan Kempiak January 2010 21st Navy 28th UCSD Practical Ap- proaches to Treating Skin of Color Andrew Alexis, MD, MPH St. Lukes Roosevelt Hospital, NYC February 2010 4th: Navy 11th UCSD Contact Dermati- tis Review Daniel Shaw, MD 18th Navy 25th UCSD Hemangiomas: update from Pediatric Derma- tology Sheila Friedlander, MD Rady Childrens Hospital March 2010 4th: No Grand Rounds 11th UCSD Snakebites Rich- ard Clark, MD Director, Medi- cal Toxicology 18th Navy 25th No Grand Rounds Three residents completed our program in June 2009. Brook Brouha, MD, PhD Kiko Gladsjo, MD, PhD Eugene Huang, MD, PhD 1st year Residents: Doru Alexandrescu, MD Shane Hamman, MD David Lortscher, MD Michelle Nguyen, MD 2nd year Residents: Michelle Jackson, MD Andrew Krakowski, MD Gagik Oganesyan, MD, PhD Caroline Piggott, MD DERMATOLOGY RESIDENCY PROGRAM PAGE 3 RESIDENCY PROGRAM 3rd year Residents: Stephan Kempiak, MD, PhD (Chief Resident) Pristine Lee, MD Elan Newman, MD Grand Rounds Schedule Thursdays 8:3011:30 AM Medical Center/Hillcrest 4. Sebum Free Fatty Acids Enhance the Innate Immune Defense of Human Sebocytes by Upregulating beta-Defensin-2 Expression. Nakatsuji T, Kao MC, Zhang L, Zouboulis CC, Gallo RL, Huang CM. J Invest Dermatol. 2009 Dec 24. Commensal bacteria regulate Toll-like receptor 3-dependent inflamma- tion after skin injury. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL. Nat Med. 2009 Dec;15(12):1377- 82. Epub 2009 Nov 22. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrap- ment. Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SH, Gallo RL, von Kckritz-Blickwede M, Nizet V. J Mol Med. 2009 Dec 4. [Epub ahead of print] Fluorescence and UV resonance Raman study of peptide-vesicle interac- tions of human cathelicidin LL-37 and its F6W and F17W mutants. Ga- ble JE, Schlamadinger DE, Cogen AL, Gallo RL, Kim JE. Biochemistry. 2009 Dec 1;48(47):11264-72. The host defense Peptide cathelicidin is required for NK cell-mediated suppression of tumor growth. Bchau AS, Morizane S, Trowbridge J, Schauber J, Kotol P, Bui JD, Gallo RL. J Immunol. 2010 Jan 1;184 (1):369-78. Epub 2009 Nov 30. Mass spectrometry-based label-free quantitative proteomics. Zhu W, Smith JW, Huang CM. J Biomed Biotechnol. 2010;2010:840518. Epub 2009 Nov 10. Recent development in nano-sized dosage forms of plant alkaloid camp- tothecin-derived drugs. Cuong NV, Hsieh MF, Huang CM. Recent Pat Anticancer Drug Discov. 2009 Nov;4(3):254-61. Elucidation of the percutaneous absorption of chromium compounds by functional proteomics. Pan TL, Wang PW, Huang CM, Chen CC, Fang JY. Proteomics. 2009 Nov;9(22):5120-31. Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS. Muto J, Yamasaki K, Taylor KR, Gallo RL. Mol Immunol. 2009 Dec;47(2-3):449-56. Epub 2009 Sep 24. The antimicrobial activity of liposomal lauric acids against Propionibac- terium acnes. Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang CM, Zhang L. Biomaterials. 2009 Oct;30(30):6035- 40. Epub 2009 Aug 8. Antimicrobial peptides and the skin immune defense system. Schauber J, Gallo RL. J Allergy Clin Immunol. 2009 Sep;124(3 Suppl 2):R13-8. Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. Gao PS, Rafaels NM, Hand T, Murray T, Boguniewicz M, Hata T, Schneider L, Hanifin JM, Gallo RL, Gao L, Beaty TH, Beck LA, Barnes KC, Leung DY. J Allergy Clin Immunol. 2009 Sep;124(3):507-13, 513.e1-7. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, MacLeod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL. J Invest Derma- tol. 2010 Jan;130(1):192-200. Epub . Neutrophil antimicrobial defense against Staphylococcus aureus is medi- ated by phagolysosomal but not extracellular trap-associated catheli- cidin. Jann NJ, Schmaler M, Kristian SA, Radek KA, Gallo RL, Nizet V, Peschel A, Landmann R. J Leukoc Biol. 2009 Nov;86(5):1159-69. Epub 2009 Jul 28. Phenotype of atopic dermatitis subjects with a history of eczema herpeti- cum. Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY. J Allergy Clin Immunol. 2009 Aug;124(2):260-9, 269.e1-7. Epub 2009 Jun 27. Histone H4 is a major component of the antimicrobial action of human sebocytes. Lee DY, Huang CM, Nakatsuji T, Thiboutot D, Kang SA, Monestier M, Gallo RL. J Invest Dermatol. 2009 Oct;129(10):2489-96. Epub 2009 Jun 18. De novo synthesis of human dermis in vitro in the absence of a three- dimensiona