UC CAI University of California Center for Accelerated ... Overview_Final.dg.pdfUC CAI University of...
Transcript of UC CAI University of California Center for Accelerated ... Overview_Final.dg.pdfUC CAI University of...
UC CAI University of California Center for Accelerated Innovation Michael Palazzolo, MD, PhD UC CAI Center Director
NHLBI • Jodi Black, PhD, MMSc
– Acting Director, Office of Translational Alliances and Coordination (OTAC),
– Deputy Director, Division of Extramural Research Activities, NHLBI
• Bishow Adhikari, PhD – Program Director, Division of
Cardiovascular Sciences
• Ram Aiyar, PhD, MBA – Entrepreneur in Residence, Office
of Translational Alliances and Coordination, Division of Extramural Research Activities
• Steve Flaim, PhD, FAHA, FACC
– Special Advisor, Office of Translational Alliances and Coordination, Division of Extramural Research Activities, NHLBI
• Eric Padmore, MHSA – Program Analyst, Office of
Translational Alliances and Coordination, Division of Extramural Research Activities, NHLBI
• Kathleen Rousche, PhD – Program Director, NIH Centers for
Accelerated Innovations (NCAI), Office of Translational Alliances and Coordination, Division of Extramural Research Activities
Presentations • UC BRAID Overview – S. Dubinett • UC CAI Overview & Progress – M. Palazzolo • Technology Solicitation and Selection Process – D. Gellene • Tracking Progress and Needs Assessment – P. Davidson • Skills Development and Education - V. Krishnan • Tools – R. Dennis • Project Management and Discussion – M. Palazzolo • Emerging Technology – C. Chiu • UCLA DGSOM Accelerator – M. Palazzolo • Business Development Strategies – B. Boyle • CTSI Clinical Research Laboratories – S. Dubinett • UC Research Exchange and Los Angeles Data Repository – D.
Bell • Drug and Device Discovery and Development – C. Tralau-Stewart
Overview
• Goals • Year 1 Progress • Challenges Addressed • Plans for the Coming Year • Questions and Discussion Topics
Goals
Goal 1 • Engage University of California heart lung
and blood disease innovators through a comprehensive education, training and mentorship program.
Goals
Goal 2 • Solicit and select technologies with high
commercial potential that align with NHLBI’s mission and address unmet medical needs or significant scientific opportunity.
Goals
Goal 3 • Incubate our most promising
technologies in accordance with industry requirements to facilitate their translation to commercial products that improve patient care and enhance health.
Goals
Goal 4 • Create a high-performing, sustainable
infrastructure that will serve as a model to academic research centers.
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PROGRESS
Technology Development Pipeline • Approved Projects
– Kennedy (UCD) “Nanophotonic detection of bacterial and fungal infections”
– Ganz (UCLA) “Diagnostic antibodies for Erythroferrone”
– Nishimura (UCSF) “Therapeutic antibodies for TGF-B”
• Still Under Review – Chiu (UCSF) “NextGen Sequencing for
pulmonary differential diagnosis” • Next RFA: late summer
Updates
• Stephen Nishimura "Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease” Science Translational Medicine, June 18
• Charles Chiu “Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing” NEJM, June 4
Skills Development • Vish Krishnan
– Resource catalog – Technology Development Primer
• Pamela Davidson – Needs Assessment and Evaluation
• Bill Boyle – Insight into business development – 3 case studies
• Therapeutic antibodies • Digital health • Diagnostic platform
• I-Corps Hub application submitted June 2014
I-Corps Hub • Leverage UCSF experience
- Led by Stephanie Marrus • Lean Launch Pad curriculum for life sciences
and health care • Piloted in fall 2013
- 25 teams (7 therapeutics, 5 devices, 7 diagnostics, 6 digital health)
- 98% of participants would recommend to a colleague • Trainers include venture capitalist, director of
digital incubator, entrepreneurship experts • 31 mentors with industry experience in
diagnostics, devices or therapeutics
External Advisory Board • Consists of no fewer than 5 members • Experienced business leaders • Includes NHLBI Program Officer • Advice about operations, project development
Catherine Mackey, PhD Former Senior VP, Pfizer
Founder, MindPiece Partners
Julie M. Cherrington, PhD President and CEO
Pathway Therapeutics
Jay G. Wohlgemuth, M.D. Senior VP, Medical, Science and Innovation, Quest Diagnostics
Lawrence Souza, PhD Former Senior VP, Amgen
Founder, Coastview Capital
Francis Duhay, MD VP Medical Affairs and CMD
Edwards Lifesciences
Business Review Panel • Five members • VCR on each campus appoints one member • Evaluate Center’s progress toward sustainability
Bill Ouchi, PhD UCLA
Professor of Management and Organizations
Claudia Bird Schoonhoven UC Irvine
Professor of Organization and Strategy Director, Beall Center for
Innovation and Entrepreneurship
Toby E. Stuart UC Berkeley
Professor, Entrepreneurship and Innovation
Kimberly D. Elsbach UC Davis
Associate Dean and Professor of Organizational Behavior
Vish Krishnan UC San Diego
Endowed Chair, Professor of Innovation, Technology & Operations
Site Infrastructure • UC Davis
– Anuurad Erdembileg (Admin) – Gabriela Lee (PM)
• UC Irvine – Randy Berg and Andria Pontello (Admin)
• UCLA – Denise Gellene, Anne Skinner (Admin) – Elvira Liclican (PM)
• UCSF – Catherine Tralau-Stewart (Admin and PM)
• UC BRAID – Nate Buscher (Admin)
Center Infrastructure at UCLA
• Administration – Anne Skinner, Emily Sondergaard
• Communications – Denise Gellene, Jessica Byrne
• Evaluation – Terry Nakazono, Jim Morrison
• Fund management – Matt McPeck, Rachel Hintz
• Website and software development – Robert Dennis, Maryam Ariannejad, Paul Babin
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CHALLENGES ADDRESSED AND FUTURE PLANS
Challenges Addressed
• Reviews – Quality control – Surveys and metrics
• California Law 1090 • Conflict of Interest in Reviews • Integrate the effort across 5 campuses
Future Plans
• Manage Projects launched – Project management – Business development
• Identify issues and solutions on other campuses
• Upcoming RFA • Make the review process more systematic
What About Unfunded Projects?
• Projects that didn’t get funded – Superalarm – Omics platform – metabolic diseases – Read through small molecules – muscular
dystrophy – Nanoelectric diagnostics
What Does a Successful Skills Development Program Look Like?
• Broad educational system – Webinars – Courses – Simulation – But if the faculty is the target*
• Skills development as business development – More like residency than medical school – Need to be data driven – Great variability between projects
For Consideration… • Importance of keeping our investigators
engaged • How do we define projects to be compatible
with NHLBI’s agenda? • When is a project in the sweet spot? Not too
early, not too late? • What is an exit? • How many metrics should we be tracking? • What is the best type of project
management?