U99-2621#821929720

• IgG- strong coarsely granular capillary loop staining,mild to moderate granular peritubular staining

• IgA- moderate mesangial staining with substantial extension to peripheral capillary loops

• IgM- moderate mesangial staining• C3- moderate coarsely granular capillary loop staining,and

mesangial staining,mild granular peritubular staining • C1q- moderate coarsely granular capillary loop staining,and

mesangial staining,mild granular peritubular staining • Kappa-moderate mesangial staining with extension to

peripheral capillary loops • Lambda- moderate coarsely granular capillary loop

staining,and mesangial staining • Fibrin- mild mesangial staining• Albumin- strong hyaline droplet changes in tubular cytoplasm

IF

Diagnosis:Renal Biopsy:Diffuse proliferative SLE in a relative inactivephase.

U06-9986

Native L. Kidney

Longstanding discoid SLE renal biopsy >5 years ago with Lupus Nephritis. Stable with N renal function after Cyclophosphamide. Recently increased HTN, increased proteinuria, increased creatinine. Antiphospholipid Syn.

IF• IgG- moderate coarsely granular capillary loop staining, • IgA- mild to moderate coarsely granular capillary loop

staining IgM- mild coarsely granular capillary loop staining

• C3- mild coarsely granular capillary loop staining• C1q- mild to moderate coarsely granular capillary loop

staining, • Kappa-moderate coarsely granular capillary loop staining• Lambda- moderate coarsely granular capillary loop

staining• Fibrin- moderate interstitial staining• Albumin- negative

IgG

IgA

IgM

C3

Clq

Kappa

Lambda

Fibrin

Diagnosis:Renal Biopsy:Membranous Lupus nephritis with probablesuperimposed chronic infection with scarring and“ thyroid-like” areas in renal parenchyma. Age and hypertension related vascular disease..EM is pending.