Types of involuntary - oregon.providence.org/media/Files/Providence OR PDF/Events... · MRI CSF...
Transcript of Types of involuntary - oregon.providence.org/media/Files/Providence OR PDF/Events... · MRI CSF...
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Types of involuntary movements
Tremor
Dystonia
Chorea
Myoclonus
Tics
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Tremor
Rhythmic shaking of muscles that produces an oscillating movement
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Parkinsonian tremor
Rest tremor > posture > kinetic
Re-emergent tremor with posture
Usually asymmetric
Pronation-supination tremor
Distal joints involved primarily
Often posturing of the limb
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Parkinsonian tremor
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Other parkinsonianfeatures
Bradykinesia
Rigidity
Postural instability
Many, many other motor and non-motor features
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Bradykinesia
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Rigidity
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Essential tremor
Kinetic > postural > rest
Rest in 20%, late feature, only in arms
Intentional 50%
Bringing spoon to mouth is challenging!!
Mildly asymmetric
Gait ataxia – typically mild
Starts in the arms but can progress to neck, voice and jaw over time
Jaw tremor occurs with action, not rest
Neck tremor should resolve when patient is lying flat
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Essential tremor
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Many other tremor types
Physiologic tremor
Like ET but faster rate and lower amplitude
Drug-induced tremor –
Lithium, depakote, stimulants, prednisone, beta agonists, amiodarone
Anti-emetics (phenergan, prochlorperazine), anti-psychotics (except clozapine and Nuplazid)
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Many other tremor types
Primary writing tremor
only occurs with writing
Orthostatic tremor
leg tremor with standing, improves with walking and sitting, causes imbalance
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Many other tremor types
Cerebellar tremor
slowed action/intention tremor
Holmes tremor
mid-brain lesion, unilateral
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Dystonia
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Dystonia
Muscle contractions that cause sustained or intermittent torsion of a body part in a repetitive motion
Dystonia can be associated with tremor
Irregular, not rhythmic or oscillatory (rotational around a central plane)
Head tremor is present in supine position
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Take Away Point
Dystonic neck tremor can sometimes be present without any observable torsion or posturing
Neck tremor with minimal arm tremor is likely dystonic
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Dystonia
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Chorea
Irregular abrupt movements that produce a dance-like presentation
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Chorea
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Myoclonus
Brief jerk that occurs once or multiple times in a row
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Myoclonus
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Tics
Repeated movements or sounds that are associated with an urge to produce the movement and can be suppressed
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Tics
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Psychogenic tremor
Abrupt onset, variable pattern, distractible, suggestible, entrainable
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Psychogenic tremor
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Name the disorder - Case 1
CC: bilateral hand tremor
62 year old man
Onset of tremor 2 years ago
Difficulty eating, drinking and writing
h/o lumbar radiculopathy, HTN
Meds: GBP, HCTZ, metoprolol
FHx of tremor (father)
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Case 1
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Case 1 – Is it . . .?
A. Chorea
B. Dystonia
C. Essential tremor
D. Myoclonus
E. Parkinson’s
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Name the Disorder - Case 2
CC: left hand tremor
67 yo RH man
Onset of tremor 7 years ago, mild imbalance, mild hand slowness
FHX: cardiac disease
h/o DM, HTN
Meds: propranolol, lovastatin, glipizide
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Case 2
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Case 2 – Is it . . .?
A. Chorea
B. Dystonia
C. Essential tremor
D. Myoclonus
E. Parkinson’s
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Name the disorder - Case 3
CC: head tremor
76 yo woman
Head tremor x 10 years, no hand tremor, no improvement with primidone
Meds: Sybicort inhaler
h/o COPD
FHx: HTN, DM
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Case 3
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Case 3 – Is it . . .?
A. Chorea
B. Dystonia
C. Essential tremor
D. Myoclonus
E. Parkinson’s
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Name the disorder - Case 4
CC: involuntary body movement
94 yo woman
Onset 5 years ago. Symptoms occur in clusters for minutes to hours. Sometimes unilateral limb, sometimes entire body. Better with Valium
Meds: tylenol 3, Norco, Effexor
PMHx: Arthritis and breast ca
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Case 4
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Case 4 – Is it . . .?
A. Chorea
B. Dystonia
C. Essential tremor
D. Myoclonus
E. Parkinson’s
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Name the disorder - Case 5
CC: gait dysfunction
77 yo man
Involuntary head movements, slowed arms and legs, shuffling gait and cognitive decline x 2 years
Meds: ASA, metoprolol
h/o CAD, aortic valve replacement
FHx: Parkinson’s mother and MGM
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Case 5
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Case 5 – Is it . . .?
A. Chorea
B. Dystonia
C. Essential tremor
D. Myoclonus
E. Parkinson’s
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Notes for PCP
Q: when should I refer to movement disorders?
You suspect Parkinson’s
Essential tremor is poorly controlled with first line medications
Abnormal movement with other associated features like imbalance or cognitive impairment
Q: Should I order any imaging?
No. Most of the time imaging is not needed. Sometimes I need to order unusual images that PCP would not have ability to order (e.g. DaTscan)
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Things to think about
If the patient looks like they have Parkinson’s, please review medication list for antipsychotics and anti-emetics
If the patient looks like they have essential tremor, please review medication list for tremor inducing agents like valproic acid, lithium and amiodarone.
Likely my first recommendation is to reduce or wean off these medications before attempting medications for PD or ET
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Most common gait disorders in my clinic
Parkinson’s
Normal pressure hydrocephalus
Ataxia – central or peripheral/sensory
Lumbar stenosis
Cervical lesions
Orthopedic conditions
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Parkinson’s disease gait
Amplitude reduction
Small step length and height, slowed gait
Reduction in arm swing
Freezing of gait – difficulty initiating gait
En bloc turns
Kyphosis
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Parkinson’s disease gait
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Lower body Parkinsonian gaits
No parkinsonism in upper body, only lower body
Higher-level gait disorder
Vascular parkinsonism
Normal pressure hydrocephalus
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Higher-level gait disorder
Associated with frontal lobe dysfunction
Frontotemporal dementia
Alzheimer’s disease
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Vascular parkinsonism
Associated with strokes involving the basal ganglia or diffuse white matter disease changes
External rotation of legs and wider base
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Vascular Parkinsonism
CONTINUUM: Lifelong Learning in Neurology. 19(5, Movement Disorders):1189–1212, OCT 2013
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Normal pressure hydrocephalus
Gait impairment
Urinary incontinence
Cognitive impairment
Assessment: MRI brain or CT head: Ventriculomegaly
MRI CSF flow, large volume LP
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Normal pressure hydrocephalus
Ventriculoperitoneal Shunt Placement for Normal Pressure HydrocephalusN Engl J Med 2017; 377:e35 DOI: 10.1056/NEJMicm1701226
Evan’s ratio> 31%Frontal horn/Int skull
Callosal angle< 100 degreeAngle lat ventat post commis
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Ataxia
Physical finding, not a disease
Impaired coordination of voluntary muscle movement
Causes:
Cerebellar disorder (genetic or acquired)
Impaired vestibular input
Impaired proprioceptive input (dorsal column, sensory nerves)
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Features associated with ataxia
Wide stance, Unstable gait
Dysdiadokinesia
impairment of rapidly alternating movements
Intention tremor
Increased amplitude of oscillation when trying to hit target
Dysmetria
Miss target due to overshoot
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Features associated with ataxia
Cerebellar features: Dysarthric speech
Nystagmus
Ocular dysmetria Saccades over or undershoot target
Sensory and vestibular ataxia features:
Balance worse in the dark
Positive Romberg
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Ataxic gait
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Spastic gait/hemipareticgait
Due to lesion of the corticospinal tract
Lesions in brain, brainstem or spinal cord
Bilateral – scissoring gait
Unilateral – hemiparetic gait
Associated features:
Leg extension and foot plantarflexion
Hip circumduction
Spasticity – rate dependent increased tone
Hyperreflexia, clonus, Babinski
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Hemiparetic gait
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Scissoring gait
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Other gait types
Psychogenic
Antalgic – pain
Trendelenburg gait
gluteal muscle weakness
Hip instability
Waddling – proximal weakness
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Name that gait - Case 1
CC: imbalance
65 yo woman with history of fall 4 years ago with posisble head trauma and rhabdomyolysis. Continued unstable gait and diplopia since then.
PMHx/Meds/SHx/FHx – not pertinent
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Name that gait - Case 1
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Case 1 – Is it?
A. Ataxia
B. Parkinsonian gait
C. Psychogenic gait
D. Spastic gait
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Name that gait – Case 2
CC: unstable gait and neck forward flexion
82 yo woman with onset of imbalance and neck starting 2 years ago
PMHx: breast cancer
Meds/FHx/SHx: not pertinent
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Name that gait – Case 2
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Case 2 – Is it?
A. Ataxia
B. Parkinsonian gait
C. Psychogenic gait
D. Spastic gait
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Name that gait – Case 3cc: progressive unstable gait, urinary incontinence and cognitive impairment
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Case 3 – Is it?
A. Ataxia
B. Parkinsonian gait
C. Psychogenic gait
D. Spastic gait
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Take Away Points
Q: Which patients with unusual gaits should I send to movement disorder neurologists?
A: All of them – unless you are fairly certain that the patient has an orthopedic cause for symptoms
Q: Do I need to get imaging on patients with parkinsonian gaits?
A: No. I can usually tell if someone has idiopathic (typical) PD without imaging. If there is a question, I will order imaging myself
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Any questions?