Trifunctional Aminoamide Cellulose Derivative and its

Characterization

Outline• Objectives• Problem statement and motivation of

the study• Presuppositions from Literature• Methodology

Objectives• To illustrate how to use a couple of

techniques to confirm the structural of a newly synthesized material and its intermediate.

• To illustrate how to use a couple of techniques to characterize a final product and so provide some information for applications.

Problem statement and motivation of the study

• What are dendrimers?• “A dendrimer is a

molecule with a form like the branches of a tree.”[1]

• Dendrimers can be used in pharmaceutics, genetics, catalyst chemistry and superconductor currently or potentially. [2][1] Wikipedia[2] Sand, Anders. Dendrimers and Their Technical Applicability

Cellulose-based dendrimers

Zhang, Changde et al. Biomacromolecules (2006), 7(1), 139-145.

Presuppositions from Literature• Narrow molecular weight

distribution• The most exciting physical

property of dendrimers is the variation of their intrinsic viscosities with molecular weight. [6] It is found that, when the generation increases beyond a certain point, the intrinsic viscosity begins to decline, contrary to the behavior of linear polymers (Fig.4).

[6] http://www.dendritech.com/pamam.html

Methodology • Using 1H to confirm the structural of intermediate

product:• Using FT-IR to confirm and characterize the

structural of CMCBA and CMCBADMPDA:• Using NMR to confirm and characterize the

structural of CMCBA and CMCBADMPDA: • Using TGA to Characterize the Degree of

Substitution of CMCBA and CMCBADMPDA: • Using Intrinsic Viscosity to characterize the

conformation of CMCBADMPDA:• Using GPC-LS to characterize the MW and MWD of

CMCBADMPDA:

Using 1H to confirm the structural of intermediate product:

Using FT-IR to confirm and characterize the structural

Using NMR to confirm and characterize the structural of CMCBA

and CMCBADMPDA:

Using TGA to Characterize the Degree of Substitution

Using Intrinsic Viscosity to characterize the conformation

• CMC 5.62 dL/g, • CMCDMPDA 3.57 dL/g • CMCBADMPDA 0.39 dL/g

Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:

Conclusions• The author got the “right ” product.• The product is of very low viscosity,

which is suitable for drug delivery.