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BLOODMENORRHAGIAHEMOSTASIS

MAXNA (The Product)

Blood is a specialized body fluid. Blood is the fluid pumped by the heart

that circulates throughout the body via the arteries, veins, and capillaries

Blood is a connective tissue. It provides communication between the cells of different part of the body and the external environment.

An adult male of average size normally has about 5.6 liters of blood

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The blood carries oxygen and nutrients to the body tissues and removes carbon dioxide and other wastes

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Fluid, known as Plasma.(55%)

Blood cells(45%), (Red cells, White cells, Platelets.)

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Gases Nutrients Hormones Heat Productive substances Clotting material

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Respiration Nutrition Removal of waste products Regulation Of Body Temperature Hormones transportion Defense of body

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HEMOSTASISHEMOSTASIS PlateletPlatelet FibrinogenFibrinogen SerumSerum

IMMUNOLOGYIMMUNOLOGY LymphocytesLymphocytes PHAGOCYTOSISPHAGOCYTOSIS LuecocytesLuecocytes

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Events in Hemostasis 1) vasoconstriction 2) platelet plug formation 3) blood clotting

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1) Acitvation of plasminogen into plasmin2) Lysis of a clot or thrombus

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1) Intrinsic – begins with activation of (Hagman) Factor XII

2) Extrinsic – starts with tissue injury and release of Tissue Factor (thromboplastin)

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I.I. FibrinogenFibrinogenII.II. ProthrombinProthrombinIII.III. ThromboplastinThromboplastinIV.IV. Ca++Ca++V.V. Labile factorLabile factorVI.VI. Number no Number no

longer usedlonger usedVII.VII. Stable factorStable factor

viii.viii. Antihaemophilic Antihaemophilic factorfactor

ix.ix. Christmas factorChristmas factorx.x. Stuart-prower Stuart-prower

fcatorfcatorxi.xi. PTAPTAxii.xii. Hagman factorHagman factorxiii.xiii. Fibrin Fibrin

stabilizing stabilizing factorfactor

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BLOOD CLOT

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1) Menstruation at regular cyclic intervals but with excessive flow and duration

2) Total blood loss exceeding 80ml per cycle or menses lasting longer than 7 days

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Organic causes 1)Infections= STDs 2)PIDs

Coagulation disorders Hepatic failure

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Hypothyriodism Hyperthyriodism Anovulatory cycles

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Uterine fibroids Endometrial hyperplasia

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IUDs Steriod hormones Anticoagulatns PG E Progesterone

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A)Drug treatment 1)NSAIDs (20-24%) 2)Antifibrinolytics (Tranexamic acid

58%) B)Hormones (progesterone30%)

(COCP 43%) C)Surgical options(D&C)

(Hysterectomy)

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Synthetic amino acid Tranexamic acid Antiplasminic Absorption 30-50% (oral) PHL ~1.4h Excreted unchanged through kidney

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Maxna inhibits conversion of plasminogen to plasmin by blocking the lysine binding sites of plasminogen, hence prevents breakdown of clot.

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Tissue ThromboplastinTissue Thromboplastin BloodBlood ThromboplastinThromboplastin

ProthrombinProthrombin

ThrombinThrombin

FibronogenFibronogen Fibrin or ClotFibrin or Clot

Tisse ActivitorTisse Activitor Blood ActivitorBlood Activitor

PLASMINOGENPLASMINOGEN

PLASMINPLASMIN

F.D.PF.D.P

PROTHROMBINPROTHROMBIN

FIBRINOGENFIBRINOGEN FIBRIN OR CLOTFIBRIN OR CLOT

TISSUE TTHROMBOPLASTINTISSUE TTHROMBOPLASTIN

THROMBINTHROMBIN

PLASMINOGENPLASMINOGEN

PLASMINPLASMIN

F.D.PF.D.P

BLOOD ACTIVITORBLOOD ACTIVITOR

BLOOD THROMBOPLASTINBLOOD THROMBOPLASTIN

TISSUE ACITVATORTISSUE ACITVATOR

COAGULATION & FIBRINOLYTIC SYSTEMCOAGULATION & FIBRINOLYTIC SYSTEMGNK 29

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Lysine Binding Lysine Binding SiteSite

FIBRINFIBRIN

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PlasminogenPlasminogentPAtPA

FibrinFibrin

Maxna blocks lysing-binding

site and prevents bleeding

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To prevent blood loss in DUB IUd PPh APH During and after surgery. In trauma

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Maxna capsulesMaxna capsules Moderate bleeding= 250-500mg 3-4

times daily Severe bleeding= 500-1000mg 3-4

times daily

InjectionInjection 250-500mg I.V or I.M 1-2 times daily.

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Generally well tolerated May cause G.I. disorder, nausea,

vomiting, and headache after oral administration.

Increased risk of adverse thrombotic events

No increase risk of DVT.

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Maxna capsules: 250mg *20’s Maxna capsules:500mg*20’s Maxna injection:500mg*10’s

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THANK YOU.THANK YOU.

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By Gul Nawaz Khangulnawazpk@gmail.com0333-9151163

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