Patent n 102019000000583 © 2019 UpSurgeOn - All rights reserved

Endorsed by

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 817346

UpSim Neurosurgical Box is a simulator for the advanced training in neurosurgery which combine digital and physical components.

It reproduces all the steps of a microsurgical procedure, combining a physical model with an augmented reality simulation, from the skin incision to microsurgical manipulation of deep neuroanatomy.

Developed by neurosurgeons for neurosurgeons Train all microsurgical skills to become an expert neurosurgeon

A revolution in neurosurgery training Hybrid, modular, revolutionary

UpSim is a Hybrid System conceived to fuse virtual simulation for mental training and physical simulation for manual training.

The UpSurgeOn team, composed of neurosurgeons, analysed all critical aspects of mental and manual training in neurosurgery.

Mental training is essential for procedural automatisms during any step of a surgical procedure. It is also crucial for the preoperative planning (e.g. patient positioning) and microsurgical strategy (e.g. the tridimensional imagination necessary to predict the position of the surgical target).

A revolution in neurosurgery training Hybrid, modular, revolutionary

Manual training is arguably the hardest part of neurosurgical education. Microsurgical manipulation of ultra-soft structures under the magnified vision of a surgical microscope requires years of training to master.

A revolution in neurosurgery training Hybrid, modular, revolutionary

UpSim is a modular system designed to make any neurosurgical approach reproducible and low cost.

It is made by interchangeable parts allowing to switch to other microsurgical scenarios by changing only the internal specific components.

It is possible to open UpSim, remove some component and progressively visualize the deep neuroanatomy. This is the best way to train your microsurgical 3D orientation when you explore UpSim under a surgical microscope.

A revolution in neurosurgery training Hybrid, modular, revolutionary

Simulation has never been so real How we realized the first life-like neurosurgical simulator

The manufacturing processes

UpSim is handmade by an Italian team of 3D modelers and expert manufacturers. Through a sophisticated manufacturing processes, we have produced each UpSim using ultra-soft materials for an incomparable realism. The anatomical parts are assembled under a microscope by a team of experts.

The Scientific 3D modelling

The anatomical 3D models used to create UpSim have been realized by neurosurgeons and digital artists through a novel process called “Scientific 3D Modelling”. Through more than 1,000 hours of intraoperative validation, the anatomical accuracy of the UpSim models is of a level higher than any prior simulator.

Simulation has never been so real How we realized the first life-like neurosurgical simulator

The most realistic simulation ever

The physical models of UpSim resemble a freshly injected cadaver specimen with an impressive accuracy.

Softness, consistency, color: UpSim provides an ultra-realistic experience of microsurgical manipulation.

Simulation has never been so real High level of anatomical accuracy

Augmented Reality: augmented proficiency! The AR improves your mental training – from patient positioning to procedural steps

UpSim is a hybrid simulator, a new concept of training tool. It is a physical scenario which interact with a mobile App for AR (Augmented Reality).

The App complete the physical box projecting on it the exact position of the patient and simulating all the steps of the superficial approach, from skin incision to the dura opening.

In this way you can train your mental and manual skills learning each step of a neurosurgical approach and of a microsurgical exploration through physical and digital information.

Augmented Reality: augmented proficiency! UpSim fills the educational gap between theory and practice on patient or in cadaver lab

AR-guided craniotomies through low-cost disposable parts: UpSim Neurosurgical Box allows you to replicate a specific approach anytime you need before approaching a patient.

Pterional, subfrontal, supraorbital keyhole approach… replace the disposable components, select the approach on the app and start again with another craniotomy following the indications in AR.

1. Change the disposable skull 2. Select the craniotomy on the UpSim App 3. Perform the craniotomy with a drill following the AR

UpSurgeOn The Team

Federico Nicolosi Neurosurgeon Founder & CEO

Giannantonio Spena Neurosurgeon Co-founder

Paolo Raimondo Business Advisor Member of the Board

Zefferino Rossini Neurosurgeon Chief Editor

Nicola Pedrali Developer 3D code

Marco Soresina Digital Artist 3D modelling

Giorgio Cantù Mechanical Engineer Design

Giovanna Ianni Lawyer Legal Advisor

UpSurgeOn S.r.l.Viale Monza 347, 20126, Milan - Italy

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