The story of the life enhancing Agaricus Blazei Murill

( Part 1b )

1. Introduction Three major types of illnesses related to diet are cancer, strokes and cardio-vascular diseases. Our health is maintained with three factors; 1) sleep that provides rest both physically and mentally; 2) exercise that provides proper stimulation throughout the entire body and mind, and 3)a balanced diet that provides a variety of nutrients. It would seem relatively easy for anyone to maintain a healthy body merely by getting enough sleep, exercise and a proper diet. However the progress of modern society has caused a number of side-effects that stem from the advancement of chemical science and science in general. There has been tremendous damage done to the above three ingredients of a healthy life. Our living space has changed greatly due to environmental destruction in recent decades. Polluted air, water, soil, and the food that is produced under these conditions in addition to food additives and ultraviolet rays, which are a result of ozone layer destruction, are all causing negative effects on our health. However, our bodies have a kind of mechanism that fights to prevent illness and disease. This is what we call a body with a “barrier”. Needless to say, this barrier or immunity does not work permanently. This barrier system peaks at about the age of twenty, and after that it gradually goes downward. What makes one person live longer than another is dependent on how one strives to make this downward curve a slower process. The best way to do this is to maintain a strong immune system. It was believe among the medical world that the immune system would not be a factor against cancer, which has been one of the major causes of death in many countries. Our immune system is for our own cells fighting against foreign cells such as viruses and germs. However, once our own cells have become cancerous they are no longer foreign cells and Our Own White blood cells can no longer distinguish them as foreign. Advanced medical research however, has discovered some of the most mysterious questions of our body system. We do have the kind of immune mechanism that can distinguish cancerous cells from other normal cells, and further fight against them. This mechanism does weaken as one ages. Therefore, older people are more susceptible to illnesses such as cancer. Above all, both preventive measures under normal conditions and treatment measures under abnormal conditions have always existed in our body, and this is the best mechanism for maintaining a healthy life. There are a number of regions in the world where people are relatively disease free all their lives and enjoy longevity. With no exception, they all have in their diet the kind of

food that enhances their immune systems. In this article, I would like to introduce one of the regions of longevity. There is a group of people who live in the mountains of the Piedade region in Brazil who are very proud of their longevity. But behind the secret of their longevity, there was a mysterious food similar to regular mushrooms. For centuries, this kind of mushroom was a part of their diet. It is called Agaricus Blazei Murill (Kawariharatake in Japanese). Because of the changes in environment, many of the conditions needed for this “mysterious mushroom”, Agaricus Blazei Murill, have virtually disappeared in the wild, and production has declined tremendously to a point of near extinction. Under these circumstances, Prof. Luo Shio Chun who is a prominent Chinese authority on cultivating mushrooms, has succeeded in growing Agaricus Blazei Murill. Furthermore, he succeeded in producing large quantity. I would like to share with you how effective this “miracle mushroom” are both clinically and in basic research. 2. Mushrooms as medicine What we call mushrooms are the offspring of mycelium. In Japan, the type of Shiite mushrooms that have been approved as medicine, are used as an anti-cancer medicine. Their content is basically polysaccharide. There are some other types of mushrooms that seem effective particularly in the fight against cancer. The main focus is the content of various mushrooms that seem to have a positive effect such as ß-d glucan, which is seen also in Mattock as its anti-cancer agent. Glucan is also expected to be effective in HIV Positive patients. These mushrooms that have become more medicine than food, tend to have high protein, high sugar content, vitamins, minerals, and high fiber. It is further believed that these mushrooms also contain a number of biological functional elements that have not been clearly defined as of yet. Mattock and regular mushrooms have a high protein content and Shiite and Matsutake have a high sugar content. Agaricus Blazei Murill has both protein and sugar equally. This particular factor is perhaps what makes Agaricus Blazei Murill different from all the other mushrooms. Mushrooms in general do not cause weight gain so from this aspect also, they are the best health food around today.

3. The nature of Agaricus Blazei Murill (Magic mushrooms)

There are approximately 20,000 types of mushrooms in the world. About 300 of them are edible. In the past most mushrooms were for eating, and not necessarily consumed for medicinal purposes. However, as we find out more about mushrooms, there have been some mushrooms that have received attention because they can be cultivated and preserved rather than having to be gathered in the wild. Agaricus is one of those that have become a focus of attention. This is a very delicate kind of mushroom, which requires a variety of necessary conditions to grow. They are native to the Piedade mountain area near San Pauro, in the southeastern part of Brazil. The ideal conditions for Agaricus are, among others, high temperature, high humidity, clear air, soil that contains wild horse wastes in its content, and squall showers in the evening. Without these conditions in place, they do not grow. They possess a surprising medicinal effect so they are called “God mushroom” (Cogmelo-de-Dius) by the natives. The Japanese official name is “Kawariharatake”. They are classified as basidiomycetes mushrooms. This mushroom was first introduced in the academic world as an Agaricus type mushroom by Dr. Heinemann of Belgium in 1967. the official name was Agaricus Blazei Murill. 4. Agaricus and President Ronald Reagan In 1960, two researchers at Pennsylvania University in the United States came up with a hypothesis with regard to Agaricus mushrooms and the low incidence of adult diseases

among the people in the Piedade Mountains in Brazil. They made a presentation at an academic conference on their analysis of Agaricus mushrooms from a nutrition point of view. Moreover, additional studies were introduced concerning the effect of the Agaricus mushroom on high blood pressure, cancer and so forth. Finally, it became a center of attention when President Reagan used Agaricus for a post-operative treatment after he had undergone a skin cancer operation. Despite all the publicity Agaricus mushrooms received, they did not enter the Japanese market immediately. It was because natural conditions in Japan are not suited for them to grow and it was widely believed that it was extremely difficult if not impossible to cultivate them. What was available for export went to the United States, and virtually none came to Japan.

Table 1: Anti-tumor Effect of Various Mushroom in Comparison with Agaricus (100%)

Mushroom Anti-tumor ratio

Lentinus 80.7% Flammulina velutipes 81.1% Pleurotus ostreatus 75.3% Pholiota nameko 86.5% Tricholoma matsutake 1.8% Auricularia auricula-Judas 42.6% Mushrooms 12.7% Coriolus versicolar quell 77.5%

5. Cultivation of Agaricus in China with 4,000 Years of Mushroom Cultivation

History China with 4,000 years of mushroom cultivation history has succeeded in the cultivation of Agaricus. It was in the Fujian Province in China where not only the cultivation of the Agaricus succeeded but also its medicinal value was proven. Agaricus then was proven to be much more effective than Ganoderma mushrooms. In 1991 the Chinese Academy of Sciences began a study of Agaricus to be cultivated in China with the Agaricus fungi from Brazil. It was a very formidable task to research the

many variables such as temperature, humidity, air and soil, among others. Cultivation succeeded in 1993. the cultivation testing was done in 127 different places in 6 different Provinces. At present, Fujian Province has the most suitable conditions for cultivation and is the site where organic and non-organic cultivation has succeeded. 6. Effectiveness of Agaricus Presented at Academic Conferences Many mushrooms have high nutritional value, but it is quite rare that Agaricus mushrooms have been studied for their medicinal properties from the beginning. As mentioned earlier, two American scientists made a presentation at an academic conference in 190 analyzing Agaricus mushrooms from a nutritional perspective. It was a very difficult task to cultivate them in Japan. After about 10 years of study with Agaricus, some research data was gathered. However, large scale cultivation was never feasible then. After several more years of study, green house cultivation was developed so as to produce high quality, large quantity Agaricus. Since cultivation was successful, large quantities of lab samples were produced so that it became possible to do substantial research on Agaricus. In 1980, at the Fifty Third Japan Pharmaceutical Conference, the study entitled “Anti-cancer effect of Agaricus and the Enhancement of Natural Immunity” was presented. In the same year, Dr. Ito and his research team of Mie University, presented at the Japan Cancer Association meeting, “Malignant Suppresser Agent from Agaricus Mushrooms.” Also, they proved that Agaricus is effective on both (organic) cancer and liquid cancer. Since then, we have found out more about Agaricus and its effect on cancer. Mushrooms in general have become known as an effective medicine. Among all the mushrooms, Agaricus mushroom is found to have the greatest medicinal effect in quality, quantity and variety of effective contents. In 1996, Natural Expo, which is the largest health related trade show in the United States, was held in Anaheim, California. A number of different mushrooms were introduced at the Expo, Agaricus mushrooms were introduced by Japan, which had a great repercussion. The miracle power of Agaricus mushrooms was rediscovered, and their effectiveness far exceeds those of other types of mushrooms. More specifically, if the effectiveness of Agaricus is measured to be 100, that of Mattock mushrooms are 60, that of Shiitake are 20, and so on. These numbers were based on the laboratory testing results of which 15 different kinds of mushrooms were used in mice with ascites tumors and extracts of each kind of mushroom were given to see their suppressive effect on the ascites tumor.

7. So, Exactly What Substance Works? Mushrooms in general contain all and every kind of essential nutritional element such as protein, sugar, fat vitamins, mineral, fiber, etc. In addition, some critical nutrients like polysaccharide protein, ß-glucan, water-soluble lignin have been found to be present in mushrooms. Of all the important ingredients, ß-glucan, has a cancer repressive effect and it is present in Hime-matsutake, Mattock, Shiite, Kawaratake, and Suihirotake. Technically, this substance is called ß-D glucan, and there are kinds of ß-D glucan. For instance, Himematsutake has ß(1.6) D glucan, (Fomes japonicus, Mannentake) has ß(1.3) D glucan, the reason that the Agaricus mushroom has received so much attention in recent years is because it contains a large amount of ß-D glucan. Also, its effect ranges far exceed other types of mushrooms. 8. Medicinal Effect of Agaricus Mushroom that Fights Many Illnesses Medicinal effects of mushrooms extend from diabetes, liver diseases, high blood pressure, to atopy, asthma, and such ailments that are allergic in nature, and to different forms of tumors. Agaricus mushrooms are believed to be the best of all mushrooms in the fight against these critical illnesses. Let’s analyze further the amazing medicinal effect of Agaricus mushrooms. 1) Anti-tumor effect As mentioned earlier, Agaricus contains a high quantity of ß(1.6) D glucan that enhances immune cells, particularly macrophage, natural killer cells, T-calls and B-cells. In other words, it increases one’s immune system so as to fight against foreign substances such as viruses and foreign cells. Furthermore, cancer cells are treated as foreign cells so they are also subject to attack. Other than ß-D glucan, food fiber such as hetero-glucan, (chitin), peputed glucan which helps absorb cancerous substances and then eliminate them through natural processes, also works as an anti-tumor substance. They help prevent rectum cancer and conjunctiva cancer. There are also some other substances that help prevent tumors. One of them is lectin (red blood cells) which is a high sugar content protein that functions in identifying particular types of cancer cells as well as promoting the breakdown of lymphatic cells. These mechanisms act as a marker when diagnosing cancer cells and as a missile in the missile treatment. The soluble lignin is called ligneous. Hetero-polymer suppresses liver cancer. It helps reduce by a large extent, the growth of cancer cells.

Table 2: Components of Various Mushrooms J I H G F E D C B A Protein(g) 46.2 47.6 41.1 34.4 28 27.5 26.2 17.1 12.5 9.2 Lipid(g) 3.9 6.1 7.8 3.1 4.0 5.0 4.9 5.1 1.6 1.2 Glucose (g) 44.5 20.7 26.7 42.7 49.3 55 52.4 62.4 60 50.3 Fiber (g) 28 9.8 15.6 11.5 9.3 7.5 8.7 7.7 5.5 24.5 Ash (g) 7.9 15.9 8.9 8.3 9.3 7.5 8.7 7.7 5.5 24.5 Calcium (mg) 52 98 11 11 27 75 10 51 16 347 Phosphorus(mg) 1008 1098 1444 104 1000 825 78 342 240 202 Iron (mg) 25 6.0 6.0 7.0 15.0 13.0 9.0 11.0 5.0 4.1 Sodium (mg) 15.0 37.0 11.0 21.0 120 150 39.0 17.0 21.0 70.7 Potassium (mg) 3060 6832 3666 3543 4000 2250 849 3506 2352 1392 Vit-B1 (mg) 0.52 7.44 2.78 4.17 1.07 2.00 3.01 0.86 0.32 0.16 Vit-B2 (mg) 3.07 7.00 5.40 4.17 6.67 2.50 2.13 4.30 1.90 1.16 Nicotinic acid(mg) 44.2 58.6 101 111 120 82.5 78.6 68.4 20.2 78.6 A: Auricularia auricula-judae B: Lentinus edodes (in 100g of dry powder) C: Tricholoma matsutake D: Pholiota nameko E: Flammulina velutipes F: Tricholoma sulphureum G: Pleurotus ostreatus H: Grifola frondosa I: Mushrooms J: Agaricus Blazei Murill

Table 3: Components of Agaricus B.M. (in 100g of dry power) Protein 46.2 Glucose 44.5g Lipid 3.9g Fiber 28.1g Beta-Glucan 9.3g

Mineral(mg) Vitamin (mg) Amino acid (g) Ca: 52 Vit.B: 0.52 Arginine 2.28 K: 3060 Vit.B: 3.07 Lysine 1.63 Na: 15 Nico. A: 44.2 Histidine 0.63 Fe: 25 Ergosterol: 140 Phenylala 1.09 P: 1008 Tyrosine 0.82 Al: 81 Leucine 1.82 Mg: 267 Isoleucine 1.06 Mn: 1 Methionine 0.37 Cu: 7 Valine 1.33 Zn: 31 Alanine 1.95 Cl: 426 Glycine 1.29 Proline 1.38 Gluta. A 5.14 Serine 1.19 Threonine 1.31 Aspartic A 2.28 Tryptophan 0.38 Cystine 0.34

1.1) Pre-clinical test using Agaricus Mice were used in a lab test. (Sarukoma ) 180 was used for cancer cells. The sarcoma was injected into the subjects (mice) once a day for ten days. The size of the tumors and mortality cases were measured in comparison with those treated with other types of mushrooms. Based on this test, the cancer cell total elimination rate for Agaricus was 90.0%. Grifoin umbellatz (Chiyoremaitake) was also 90.0%. Shiite (lent, nos ededes) was 54.5%. Also, the tumor suppression rates were 99.4% for Agaricus, which far exceeds other types. The amount of extract that was injected was 10mg for Agaricus and Grifoin umbellatz, and 30mg for Shiite. As a result of this series of lab tests, Agaricus showed the highest promise. 1.2) Clinical test using Agaricus The first clinical test result was presented at the second international symposium on the Effect of Mushrooms, in Seoul, South Korea in May, 19994. Side effects such as a decrease in white blood cells are usually seen when chemo-therapy or radiotherapy is applied to a cancer patient. Agaricus helped reduce the side effects. While receiving regular treatment such as chemo-therapy or radio-therapy, Agaricus extract was taken at the same time for three months. A patient with a malignant tumor showed an increase of his/her immunity by a number of symptoms such as an increase in immunogloblin, white blood cell count, hemoglobin, etc. Thereby, the patient did not suffer from vomiting, loss of appetite, fatigue, lack of energy, etc. Agaricus seems to help ease these symptoms associated with traditional treatments. By taking Agaricus, many of the side effects are eliminated and it becomes possible to reduce the amount of traditional treatment so as to increase the immune system, which is essential to fight the cancer. 1.3) Effect of Agaricus Taken with Chemotherapy Agaricus contains six types of steroids, which help suppress further growth of cancer cells. These steroids, which contain cerebusterol inducers and ergosterol inducers, have been shown to be effective in preventing cancer cells from growing further. By the HeLa test (suppressing cell multiplication) using uterine cancer tissue, a very small

amount of steroid (10-30pm) suppressed cancer cells from multiplying. The steroid also contains a large amount of ergosterol. Also, vitamin d-2 is produced as Agaricus becomes dry. These help absorb calcium. Moreover, Agaricus contains a large amount of food fiber that belongs to ß-D glucan, chitinous substance hetero-sugar. Agaricus food fiber absorbs carcinogenic substances so as to quicken the excretion process. The effectiveness of Agaricus used along with such chemotherapy drugs as 5.FV and mitomycin C was studied against solid cancer. This study indicates that it is three to seven times as effective used in combination with these drugs. Similarly, Agaricus used together with radiotherapy is much more effective in eliminating cancer cells. The major asset in using Agaricus with other traditional cancer treatments is reduced cases of side effects in addition to increased immunity to the disease.

Table 4: Anti-tumor Effect of Mushrooms

Kinds Poly-Saccharides Molecular Anti-tumor ratio

Agaricus FA-1-a-α α-glucan 93% FA-α-ß ß-glucan 71% FA-1-a-ß ß-galactoglucan 97% FA-2-b-ß RNA 95% FIII-2-b glucoprotein 99% FIV-2-b Xyloglucan 80%

Grifola frodosa FI-a-ß ß-glucan 84% FA-1-a-ß Acid ß-glucan 100%

Ganoderma Fa-1-α ß-glucan 100% Lucidum FII-1 Acid heteroglucan 100% FIII-2-α heteroglucan 100%

Tricholoma F10-a heteroglucan 60% Sulphureum FII-2-b Xyloglucan 85%

Coriolus FI-a ß-glucan 77% Versicolor

Flammulina FI-a ß-glucan 81% Velutipes

Lentius Edodes FI-b ß-glucan 80%

Table 5: Amazing Anti-cancer Effect of Agaricus

Types Amount/day Complete recovery Prevention ratio Agaricus B.M. 10mg 90.0% 99.4% Grifola frondosa 10mg 90.0% 98.5% Tricholama Matsutake 30mg 55.5% 91.3% Lentinus edodes 30mg 54.5% 80.7% Coriolus Versicolar Quel 30mg 50.5% 77.5% Pleurotus ostreatus 30mg 45.5% 75.3% Pholiota nameko 30mg 30.0% 86.5% Flammulina velutipes 30mg 30.0% 81.1% Ganoderma lucidum 30mg 20.0% 77.8%

2) Enhancing Immunity There are three stages for Agaricus in challenging the cancer mechanism. First, the preventive quality of Agaricus is one major factor; that is, to prevent normal cells from turning into cancerous cells. Second, it is the suppressive quality of Agaricus that helps suppress cancer cells from multiplying. Third, it is the fighting quality of Agaricus that helps battle against cancer cells so as to diminish the tumor. Immuno-therapy for cancer treatment aims at recognizing cancer cells as foreign substances so as to eliminate them from the system. Lymphocyte and thymonucleic system play a major role in that process. Lymphocyte has a B-lymph node and T-lymph node. B-lymph node has immunogloblin on its surface. It produces immunity. Yet, it does not produce all by itself. It needs T-lymph node (helper T-cell) for it to do the job. However, T-lymph node after having been produced in the bone marrow, is not active immediately. Due to the thymonucleic system’s function, a T-lymph node becomes T-cell with specific purposes such as helper T-cell, suppresser T-cell, killer T-cell, and memory T-cell. A thymonucleic system cannot maintain its strength forever. Around the age of 40, the general effectiveness of the thymonucleic system declines; and therefore, the number of T-cells decreases. As a consequence, one’s immune system decreases. One becomes more prone to illnesses. We call this phenomenon aging of T-cells. It becomes easier to become infected with germs, to develop cancer, to suffer from rheumatism and such. In 1976, Dr. Stephen Rosenburg discovered the mechanism of immunity that fights against

cancer fells. So, Immuno therapy, which had not been popular among the medical field, began to receive credibility. The process of the immune system is as follows. Macrophage distinguishes abnormal cells (cancer cells) from normal cells. It directly attacks cancer cells, and at the same time, it tells helper T-cells to eliminate abnormal cells. Helper T-cells mark cancer cells so that they will be easily distinguished. Neutrophil in the white blood cells and natural killer cells, killer T-cells will all come forward to attack cancer cells. In case the cancer cells are hard to fight against B-lymph node produces suppressers, and T-cells develop lymphotoxin in order to get rid of cancer cells. In short, it is the work of all the T-cells together that leads to the total elimination of cancer cells. Above all, it is a fact that both the clinical findings and the laboratory data have indicated that Agaricus is indeed effective in the fight against cancer. Figure 2: Anti-cancer Effect of Agaricus and the Enhancement of Natural Immunity

3) Anti-inflammatory Effect In the spring time, many cases of pollenosis associated with running nose, watery eyes, some fever, and some skin diseases like atopy which were once thought of as a children’s

illness, are treatable by Agaricus because it contains the kind of substances that helps ease or cure those symptoms and disorders. In recent years, high sugar content substances from Agaricus are being studied for their effectiveness on some disorders stemming from allergy and skin disorders. Characteristics of high sugar content substances with regard to immunity are to increase immunity when it is low and to decrease it when it is too high 9a double function). Cancer develops when the immunity is low. On the other hand, allergy and other symptoms such as atopy occur when the immunity is uncontrollably too high. The high sugar content of Agaricus helps control the immune system that has become unmanageably too sensitive by stabilizing cellular tissue. Hetero-galactan protein that has been isolated from Ganoderma (Mannentake) has proven to have a similar effect to Agaricus. 4) Reducing Blood Sugar It is believed that by the year 2,000, those suffer from diabetes will reach 160 million people world-wide. In Japan, we will soon see a diabetic case in one out of every five people. As you know, what is dreadful about this disorder is that once someone becomes diabetic, he/she is prone to be infected by many diseases. The mortality rate is quite high due to diabetic disorders. We have known for a long time that mushrooms in general have substances that help lower the blood sugar level. Agaricus in particular contains abundant types high sugar content substances. Besides ß-D glucan, high sugar protein complex and RNA complex both have a function in lowering the blood sugar level. Agaricus has a double function; that is to straighten over-produced macrophage and lymph nodes into their normal status. Furthermore, it is very likely that Agaricus promotes insulin production by vitalizing pancreas function and by supplying amino-acid and zinc. 5) Controlling blood pressure/Easing Hardening of Arteries Peptide glucan and fucofuruked glucan that are seen in Agaricus function in two ways; that is to lower the blood pressure when it is too high and to raise it when it is too low. In other words, it is extremely beneficial that it helps adjust the heart function to its normal condition. Abundant food fiber and fatty acids absorb and get rid of cholesterol and revitalize the functions and structure of LOL so as not to pump it out into the blood stream. Thereby, it helps as an anti blood clogging agent and as an agent to balance the autonomic nerve system; and hence it help maintain a normal blood pressure level.

6) Improving Osteoporosis Condition One out of three women are likely candidates for osteoporosis. As people turn the age of forty, the amount of calcium and protein in one’s bones starts to decline. One must maintain one percent of calcium in one’s blood. In case there is not enough, the needed calcium is automatically taken out of your bone system. The dry Agaricus has absorbed ample ultraviolet rays in the process. Vitamin D2, which has been transformed from ergosterol, helps absorb calcium. This is only one example of how Agaricus is an ideal medicinal agent for maintaining superb health conditions for everyone. There will be more effective functions to be proven with regard to Agaricus in the future. 7) Food Fiber Effect Plant fiber does not digest in our digestive organs. Agaricus contains a number of fibers such as ß-glucan, chitinous substance, hetero-sugar (pectic substance, hemicellulose, polyuronide). These fibers not only absorb cancer causing substances from the colon; and therefore, prevent them from entering the body; but also, these fiber help the system excrete these substances. This is a cancer preventative function. 8) Anti-Hepatitis Virus Effect ß-D glucan protein complex and hetero glucan protein complex that are present in Agaricus, working as cytokinin inducers, produce TOP (translation inducing protein). The TIP plays a critical role in preventing coat protein, which forms virus shells that are an essential enzyme for viruses. Interferon has no cell toxin. It selectively prevents viruses from multiplying. By the same token, it promotes blood movement in the liver as well as vitalizes lymph nodes while maintaining a healthy liver. 9) Agaricus for Total Health Therapy Agaricus is a very tasty kind of mushroom. This is because it contains the kind of protein (free cells) that many people feel is tasty. It also has various kinds of amino acids (sureonine, alanine, glutamic acid), organic acids (succine acid, fumric acid, malic acid, citric acid) and nucleotide (guanylic acid, uridylic acid, adenylic acid, cytigylic acid). When taken raw, Agaricus has the type of enzyme that is easily absorbed; and therefore, it

is effective in a variety of minor health disorders. Agaricus is first of all a very tasty food source with a high nutritional value in addition to an extremely valuable medicinal substance effective for a wide variety of contemporary illnesses and diseases. It has been reported clinically that Agaricus is effective for the following disorders: 1. cardio-vascular disorders – high blood pressure, low blood pressure, heart disorders,

angina (pectoris), hardening of arteries, pneumonia, leukemia, lymphatic cancer, lung cancer

2. digestive disorders – stomach ulcers, duodenum cancer, chronic stomach inflammation, gastroptosis, stomach cancer, liver disease, liver cancer, Type-B hepatitis, enlarged liver, large intestine cancer, colon cancer, viral intestine infection, stomatitis, constipation, loss of appetite, skin rash, hemorrhoids, pyorrhea.

3. internal secretion disorder – diabetes, high cholesterol, allergy, dropsy, Basedow disease, chronic nose inflammation, pollinosis, joint inflammation.

4. cerebral nerve disorders – diabetes, joint rheumatism, chronic joint rheumatism, autonomic nervous breakdown, Japanese encephalitis.

5. respiratory disorders – chronic bronchitis, influenza, etc. 6. genital disorders – breast cancer, ovary cancer, breast inflammation, women’s disorders,

irregular monthly periods, menopause, decline in sexual activity. 7. urinary disorders – bladder infection, enlarged prostate, kidney infection, kidney failure,

etc. 8. skin disorder – athlete foot, skin rash, atopy, etc. 9. other disorders – cold feet, stiff neck, hangover, back pain, empyema, pyorrhea, eye

problems, etc.

Figure 3: Medical Effect of Agaricus Mushroom that Fights Many Illnesses