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The Path Forward for Psychedelic Assisted Psychotherapy...meditation [...] R. Griffiths, Journal of...
Transcript of The Path Forward for Psychedelic Assisted Psychotherapy...meditation [...] R. Griffiths, Journal of...
Investor PresentationJuly 2020
The Path
Forward for
Psychedelic
Assisted
Psychotherapy
©2020 Core One Labs
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Our Mission
To bring the world to life through psychedelics and
psychedelic enhanced psychotherapy.
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©2020 Core One Labs
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The Problem
Mental health conditions are on the rise.
Rapid Growth. Limited Treatments.
©2020 Core One Labs
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Current treatments haven’t
changed in decades
and have proven
to be ineffective with
undesired side-effects
Addiction, Insomnia, Agitation, Loss of
Libido, Violent Impulses, Suicidal Impulses
75%
Non-adherence rates to anti-depressants
+2Point improvement on Hamilton
Depression Score (out of 52)
40-71%
Relapse rates
Side Effects
1. Star*D Study
©2020 Core One Labs
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Source: Psilocybin with Psychological Support for Treatment Resistant
Depression, R. Carhart-Harris, The Lancet
Psychedelics: A Promising Solution
Evidence for Psychedelic Therapies
For depression
Extended relief from
depression >3months
For addiction
Addiction decreases after
psilocybin treatment
For general well-being
Sustained improvement in quality
of life and satisfaction
Pe
rce
nt
(%) o
fp
art
icip
an
ts
2 months after
methylphenidate
treatment
(control)
2 months
after
psi locybin
treatment
14 months
after
psi locybin
treatment
Pe
rce
nt
(%) o
f d
rin
kin
gd
ay
s
30
Weeks
1-4
Weeks
5-6
Weeks
9-12
Weeks
13-24
Weeks
25-36
First psilocybin treatment following
week 4 assessments
40
20
10
Severe
depression
Modera te
depression
Mi ld
depression
Before
treatment1
W eek
2
Weeks
3
Weeks
5
Weeks
3
Months
Source: Psilocybin-assisted treatment for alcohol dependence:
A proof- ofconcept study, M. Bogenshutz, Journal of Psychopharmacology
Source: Psilocybin-occasioned mystical-type experience in combination with
meditation [...] R. Griffiths, Journal of Psychopharmacology
The results from the clinical and academical studies on psychedelic-assisted psychotherapy are compelling
50
75
25
©2020 Core One Labs
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Compared to other drugs, psychedelics have a
low harm profile
100=maximum
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*Sour1Source: Global Newswire, Reports and Data, May 2019
2Source: ”Botanical Supplements Market Size and Forecast, Hexa Research
September 20183Estimated at % of global cannabis market based on relative proportion of use.
Global Newswire, Reports and Data, May 2019.
**Source: US Substance Abuse and Mental Health Administration (SAMHSA)
Total Market Potential
$38BBotanical Supplements
Market
$10BIllustrative
Adult Use
Market
$16BAnxiety Disorder
&
Depression Treatment
Market 1
2
3
©2020 Core One Labs
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Our Strategy
We are pursuing the development and
commercialization of rapid onset treatments capable
of improving health outcomes. Our first product is
CannaStrips which we will aim to use as a delivery
tool for cannabis and psychedelic treatments.
We will achieve this through R&D and Clinical Trials at
the University of British Columbia. We offer a fully
operational Clinic in British Columbia with 8 years of
operating history. The Clinic provides training and
education for medical professionals interested in
psychedelic assisted psychotherapy and psychedelic
integration psychotherapy.
Leveraging its existing SOPs, data driven research
sets and practitioner education modules, we will roll
out Clinics across Canada.8
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How Our Solution Works:
Psychedelic Assisted Psychotherapy
Using psychedelic molecules to catalyze the efficacy
of psychotherapy is showing great promise
Treatment Sessions
Approval of the treatment plan
First dosing session
Licensed psychotherapist, immediately
following the dosing session, provide
exploratory therapy.
Dosing sessions are typically
scheduled 2-3 days apart.
Integration Therapy
Psychotherapists will help your patient
integrate the experiences using
different clinical psychology techniques
Drive habit change and outlook/mindset
improvements.
On-Going Care
Typical treatment is 6 dosing sessions
with 3 integration sessions.
Patients will also have access to our
digital patient portal for on-going
support and education to help sustain
the effects of the KAP.
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Cognitive and Psychodynamic
Psychotherapists
Family Therapist
Adult Psychiatrist
Naturopathic Clinician
Indications for Clinical Treatment Rollout
Psychologist
Conduct comprehensive R&D campaigns
targeting the following indications:
Offer specialty therapy as a
complementary, follow-on service
Addiction
PTSD/Brain Injury
Treatment-Resistant Depression (TRD)
Aging/Dementia
Anxiety/Obsessive-Compulsive
Disorder (OCD)
©2020 Core One Labs
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CannaStrips™, a precisely dosed edible polymer delivery strip similar to a breath strip.
Current Delivery SystemEdible Polymer Sublingual Strips
Placed under the tongue CannaStrips™ deliver the active ingredient (functional mushrooms, Psilocybin THC, CBD, others) directly into circulation.
Avoids imprecise dosing and first-pass metabolism in the liver inherent with ingested products.
Core One Labs has control of all stages of production, distribution, transportation and delivery of CannaStrips™.
CannaStrips™ offer an effective dosage with no degradation of the liver. The result is a consistent, precise, and effective experience.
©2020 Core One Labs
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Future TreatmentsPsychedelic-Enhanced Psychotherapy
Our therapy will use regulated dosages of psychedelic compounds like
ketamine and psilocybin in a safe, fully supervised setting. The treatment
will be used alongside psychotherapy.
These lower doses can promote better mental health by disrupting thought
patterns or loops that may be preventing progress.
The experience has been described as ”euphoric,” “calming,” and
“mystical.”
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©2020 Core One Labs
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As of Date to May 20, 2020
*estimated valuation
Comparables
ClinicsIntegrated
ModelFocus Molecule
Intellectual
Property
Valuation
(CAD)
Core One Labs Yes MultiPsilocybin,
Ketamine, THC
Delivery
Technology$45MM
Mydecine
Innovations GroupYes Clinic Psilocybin $140MM
MindMed No Drug Development 18-MC, LSD Phase 1, Phase 2 $145MM
Numinus Yes MultiPsilocybin,
Ketamine
Psilocybin
cultivation and
extraction license
$30MM
Cybin Yes Multi PsilocybinDelivery
Technology$60MM
Champignon
BrandsYes Multi Psilocybin+CBD Pre-clinical $150MM
Field Trip Yes MultiKetamine, FT-
104Ft-104 molecule $69MM
ATAI (Perception,
DemeRx)No
Drug
Development
Arketamine,
IbogaineUnknown $312MM
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©2020 Core One Labs
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1. Post-acquisition of Shacor and Rejuva
Capital Structure
Core One Labs 68,000,0001
Price $0.66
Market Cap $44,800,000
Cash $4,000,000
Assets $20,500,00
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Thank YouCore One Labs Inc
1130 Pender Street West, Suite 820Vancouver, BC V6E 4A4 Canada
+1 (866) 347-5058