The origin of post-injury neointimal cells in the rat balloon injury model by Luis...

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The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania Mateu, Marian Calfa, Amir A. Rahnemai-Azar, Gary Striker, Si M. Pham, and Roberto I. Vazquez-Padron Cardiovasc Res Volume 81(1):46-53 January 1, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Transcript of The origin of post-injury neointimal cells in the rat balloon injury model by Luis...

Page 1: The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania.

The origin of post-injury neointimal cells in the rat balloon injury model

by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania Mateu, Marian Calfa, Amir A. Rahnemai-Azar, Gary Striker, Si M. Pham, and

Roberto I. Vazquez-Padron

Cardiovasc ResVolume 81(1):46-53

January 1, 2009

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 2: The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania.

Assessment of GFP transgene expression in rat iliac arteries by immunofluorescence and confocal microscopy.

Luis Rodriguez-Menocal et al. Cardiovasc Res 2009;81:46-53

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 3: The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania.

Post injury neointimal cells are of local origin in the rat balloon-injury model.

Luis Rodriguez-Menocal et al. Cardiovasc Res 2009;81:46-53

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 4: The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania.

Inflammatory cells involved in the arterial response to balloon-injury are of BM origin.

Luis Rodriguez-Menocal et al. Cardiovasc Res 2009;81:46-53

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 5: The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania.

Neointimal cells of aortic isografts are of donor origin.

Luis Rodriguez-Menocal et al. Cardiovasc Res 2009;81:46-53

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 6: The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania.

Vascular smooth muscle cells migrated through the media to the neointima in response to vascular injury.

Luis Rodriguez-Menocal et al. Cardiovasc Res 2009;81:46-53

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]