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The Mouse (Mus musculus) T Cell Receptor Beta Variable ...
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IMGT Locus in Focus Exp Clin Immunogenet 2000;17:216–228 The Mouse (Mus musculus) T Cell Receptor Beta Variable (TRBV), Diversity (TRBD) and Joining (TRBJ) Genes Nathalie Bosc Marie-Paule Lefranc Laboratoire d’ImmunoGénétique Moléculaire, Institut de Génétique Humaine, CNRS, Université Montpellier II, Montpellier, France Received: April 28, 2000 Prof. Marie-Paule Lefranc, IMGT, Laboratoire d’Immuno Génétique Moléculaire, LIGM, UPR CNRS 1142, IGH, 141 rue de la Cardonille F–34396 Montpellier Cedex 5 (France) Tel. +33 4 99 61 99 65, Fax +33 4 99 61 99 01 E-Mail [email protected], IMGT: http://imgt.cines.fr:8104 ABC Fax + 41 61 306 12 34 E-Mail [email protected] www.karger.com © 2000 S. Karger AG, Basel 0254–9670/00/0174–0216$17.50/0 Accessible online at: www.karger.com/journals/eci Key Words Mouse genes W IMGT W T cell receptor W Beta variable regions W Beta diversity regions W Beta joining regions Abstract ‘The Mouse (Mus musculus) T cell Receptor Beta Variable (TRBV), Diversity (TRBD), and Joining (TRBJ) Genes’, the 14th report of the ‘IMGT Locus in Focus’ section, comprises 8 tables entitled: (1) ‘Number of mouse (Mus musculus) germline TRBV genes at 6A–C and potential repertoire’; (2) ‘Mouse (Mus mus- culus) germline TRBV genes at 6A–C’; (3) ‘Mouse (Mus musculus) TRBV allele table’; (4) ‘Mouse (Mus musculus) germline TRBD genes and alleles’; (5) ‘Mouse (Mus muscu- lus) germline TRBJ genes’; (6) ‘Mouse (Mus musculus) TRBJ allele table’; (7) ‘Correspon- dence between the different mouse (Mus musculus) TRBV gene nomenclatures’; (8) ‘Mouse (Mus musculus) TRBV genes and re- lated human TRBV genes’. These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Montpel- lier II, CNRS, Montpellier, France. Copyright © 2000 S. Karger AG, Basel Introduction ‘The Mouse (Mus musculus) T cell Recep- tor Beta Variable (TRBV), Diversity (TRBD) and Joining (TRBJ) Genes’ is the 14th report of the ‘IMGT Locus in Focus’ section launched in the April 1998 issue of Experimental and Clin- ical Immunogenetics [1–14]. The complete repertoire of the human germline TRBV, TRBD and TRBJ genes has previously been reported [8, 11, 14]. This 14th report on the mouse (Mus musculus) T cell receptor beta variable, diversity and joining genes describes, for the first time, the complete murine germ- line TRB repertoire, with the same standard- ized rules of the IMGT scientific chart [15]
Transcript of The Mouse (Mus musculus) T Cell Receptor Beta Variable ...
IMGT Locus in Focus
Exp Clin Immunogenet 2000;17:216–228
The Mouse (Mus musculus) T CellReceptor Beta Variable (TRBV),Diversity (TRBD) and Joining (TRBJ)Genes
Nathalie Bosc Marie-Paule Lefranc
Laboratoire d’ImmunoGénétique Moléculaire, Institut de Génétique Humaine, CNRS,Université Montpellier II, Montpellier, France
Received: April 28, 2000
Prof. Marie-Paule Lefranc, IMGT, Laboratoire d’Immuno GénétiqueMoléculaire, LIGM, UPR CNRS 1142, IGH, 141 rue de la CardonilleF–34396 Montpellier Cedex 5 (France)Tel. +33 4 99 61 99 65, Fax +33 4 99 61 99 01E-Mail [email protected], IMGT: http://imgt.cines.fr:8104
ABCFax + 41 61 306 12 34E-Mail [email protected]
© 2000 S. Karger AG, Basel0254–9670/00/0174–0216$17.50/0
Accessible online at:www.karger.com/journals/eci
Key WordsMouse genes W IMGT W T cell receptor W Betavariable regions W Beta diversity regions W
Beta joining regions
Abstract‘The Mouse (Mus musculus) T cell ReceptorBeta Variable (TRBV), Diversity (TRBD), andJoining (TRBJ) Genes’, the 14th report of the‘IMGT Locus in Focus’ section, comprises 8tables entitled: (1) ‘Number of mouse (Musmusculus) germline TRBV genes at 6A–C andpotential repertoire’; (2) ‘Mouse (Mus mus-culus) germline TRBV genes at 6A–C’; (3)‘Mouse (Mus musculus) TRBV allele table’;(4) ‘Mouse (Mus musculus) germline TRBDgenes and alleles’; (5) ‘Mouse (Mus muscu-lus) germline TRBJ genes’; (6) ‘Mouse (Musmusculus) TRBJ allele table’; (7) ‘Correspon-dence between the different mouse (Musmusculus) TRBV gene nomenclatures’; (8)‘Mouse (Mus musculus) TRBV genes and re-lated human TRBV genes’. These tables are
available at the IMGT Marie-Paule page fromIMGT, the international ImMunoGeneTicsdatabase (http://imgt.cines.fr:8104) createdby Marie-Paule Lefranc, Université Montpel-lier II, CNRS, Montpellier, France.
Copyright © 2000 S. Karger AG, Basel
Introduction
‘The Mouse (Mus musculus) T cell Recep-tor Beta Variable (TRBV), Diversity (TRBD)and Joining (TRBJ) Genes’ is the 14th report ofthe ‘IMGT Locus in Focus’ section launched inthe April 1998 issue of Experimental and Clin-ical Immunogenetics [1–14]. The completerepertoire of the human germline TRBV,TRBD and TRBJ genes has previously beenreported [8, 11, 14]. This 14th report on themouse (Mus musculus) T cell receptor betavariable, diversity and joining genes describes,for the first time, the complete murine germ-line TRB repertoire, with the same standard-ized rules of the IMGT scientific chart [15]
Mouse TRBV, TRBD and TRBJ Genes Exp Clin Immunogenet 2000;17:216–228 217
which were used for the description of thehuman TRB repertoire [8, 11, 14]. This reportcomprises 8 tables entitled: (1) ‘Number ofmouse (Mus musculus) germline TRBV genesat 6A–C and potential repertoire’; (2) ‘Mouse(Mus musculus) germline TRBV genes at 6A–C’; (3) ‘Mouse (Mus musculus) TRBV alleletable’; (4) ‘Mouse (Mus musculus) germlineTRBD genes and alleles’; (5) ‘Mouse (Musmusculus) germline TRBJ genes’; (6) ‘Mouse
(Mus musculus) TRBJ allele table’; (7) ‘Corre-spondence between the different mouse (Musmusculus) TRBV gene nomenclatures’; (8)‘Mouse (Mus musculus) TRBV genes and re-lated human TRBV genes’. These tables areavailable at the IMGT Marie-Paule page fromIMGT, the international ImMunoGeneTics da-tabase (http://imgt.cines.fr:8104) created byMarie-Paule Lefranc, Université MontpellierII, CNRS, Montpellier, France [15, 16].
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Acknowledgments
We thank Valérie Contet for contribution to themanuscript and Gérard Lefranc for helpful discussion.IMGT is funded by the European Union’s BIOTECHprogramme (BIO4CT96-0037), the Centre National dela Recherche Scientifique, the Ministère de l’Educa-
tion Nationale, and the Ministère de la Recherche.Subventions have been received from the Associationpour la Recherche sur le Cancer, Association de laRecherche sur la Polyarthrite, Fondation pour la Re-cherche Médicale, Ligue Nationale contre le Cancerand the Région Languedoc-Roussillon.
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