Taconic Products and Services Catalog - EU Version

European Edition

European

Edition

Cardiovascular

Toxicology

Neurodegeneration

OncologyImmunology

Metabolic

Transgenic

Model

Generation Support

Imaging

For over 60 years Taconic has been an innovator and leader in establishing new products, service and standards of quality in the laboratory animal industry. Taconic was a pioneer in providing genetically modified models to researchers for over 25 years. What began with small colonies of tumor-prone mice for carcinogenicity assays continues today with a portfolio of over 4,000 genetically modified, spontaneously mutant and unmodified mouse and rat lines. Taconic scientists have generated or in-licensed 1000s of novel lines, characterized and optimized their performance, scaled production and prepared them for studies. These scientists can be your valued partner when your studies require the use of complex, translational models. They can help you reach your research goals quickly and efficiently through use of our custom genetic engineering service, repositories of gene targeted mice, and custom breeding services. Only Taconic offers you these services as a fully integrated system that can save you months in getting your studies up and running. Consult with our molecular biologists, geneticists, veterinarians, immunologists, oncologists and other Taconic scientists to determine the best model for your needs on the fastest timeline possible.

Translational animal models provide unique, invaluable data necessary to advance disease research and drug discovery. Today, the use of more human relevant models requires rapid access to genetically modified and human tissue engrafted mice and rats. From mice that express plaques and tangles (the hallmark pathologies of Alzheimer’s disease) to human tumor-bearing mice with reconstituted human immune systems, Taconic provides researchers with rodent models that more closely mimic human conditions. Through fast access to the most relevant and well-defined models, Taconic helps investigators accelerate the in vivo studies that are crucial to finding solutions to today’s most pressing health issues.

Model AcquisitionChoosing the most appropriate animal line is critical in designing a relevant in vivo study, and the time required to acquire it is often a key factor. Taconic provides easy access to relevant models through the broadest portfolio of rat and mouse lines – from inbred and outbred mice and rats to gene targeted and transgenic models such as the APPSWE model of Alzheimer’s disease. The long tail of research means no vendor can offer every disease model from a live colony, but Taconic greatly speeds model access in two ways: through our extensive repositories and our custom model generation services.

Taconic’s repositories of cryopreserved models include over 4,000 genetically modified mice and rats, providing easy access to models licensed for use in drug discovery and enabling you to avoid time-consuming licensing negotiations. The most widely used transgenic models are available from live colonies scaled to meet demand, with fast delivery and comprehensive health, genetic and phenotype data on each model. When a project requires generation of a custom knockout, knockin, or knockdown model, Taconic provides the innovative technologies to design and deliver the most appropriate model for your research. Our cutting-edge model generation technologies, combined with our advanced breeding technologies and barrier systems, enable unrivaled access

and speed of delivery for the novel, genetically modified models vital to in vivo studies. Browse this catalog for our most common lines, or search our full product offering online at www.taconic.com. For details on Taconic’s custom model generation services, see pages 41-44.

Model Characterization & OptimizationWhen researchers obtain models that need further development, Taconic can help define the model’s characteristics and assure its stable performance through its health and genetics services. Taconic’s International Health Monitoring System™ (IHMS™) is a globally recognized platform for monitoring and reporting the microbiological status of rodent colonies, providing the consistent, comprehensive health status data you need (see pages 34-37) Our Custom Breeding Solutions maintain your colony economically and at a health standard that enables easy entry into your lab or the labs of your collaborators. Taconic’s industry-leading array of single-nucleotide polymorphism (SNP) testing and analysis services allow you to precisely determine the genetic background of your study animal. And our backcross program enables you to rapidly backcross genes of interest onto a defined background. For more on our genetic services, see page 32.

Scale Up, Breeding & PreservationTaconic understands that research timelines don’t always allow for naturally expanding a colony to generate sufficient study cohorts. Taconic’s in vitro fertilization and large-scale embryo transfer methodologies can rapidly expand your colony from a few pair to hundreds of animals, for use as a single, age-matched experimental group or to accelerate establishing your breeding colony in a Taconic Barrier Unit. The Rapid Colony Expansion procedure also resets the health of your colony to the status of your choice, whether Taconic’s Germ Free, Defined Flora Restricted Flora™ (RF™) or Murine Pathogen Free™ (MPF™) status. Our custom breeding services also give you access to eTaconic, the leading Web-based colony management application. Through your password-protected eTaconic account, available 24/7 and updated every 24 hours, you can quickly survey your breeding projects and access their breeding plans, activity reports, animal inventory, genotyping data and project-specific reports. Your project management team also can provide standard project, breeding production and financial reports from our eBusiness suite on request.

Study-ReadyBiomedical research is all about speed and accuracy. Taconic specializes in providing animals with fully documented characteristics, fully prepared for immediate use – what we call “study-ready”. Preparing your animals for a study can be as simple as tattooing them before shipment or administering a special diet as we do with our Diet Induced Obese B6 mice. Or, Taconic can perform surgical modifications and cannulations, implant telemetry device for remotely monitoring key biological functions, or age your mice as needed. We also offer superovulation injections, preparation and selection of pseudopregnant mice and timed pregnant animals, available on most Taconic commercial models or your proprietary animals bred at Taconic. Learn more about these services on page 46.

As a leader in genetically modified models, Taconic takes you from acquisition, importation and licensing, to development, production, distribution, and long term storage of your

models. And as the leader in the development and production of genetically modified mice, we help you reach your research goals quickly and efficiently through our many breeding,

model derivation, and model preservation services. Consult with the in vivo leader to determine the best model for your needs and put it to use in your research on the fastest

timeline possible.

The Changing Nature of Mice and Rats in in vivo Studies

DETERMINE PROGRAM RESEARCH NEEDS

CONDUCT STUDIES

Taconic is the only breeder who can accelerate your research program by providing a fully integrated system for fast, convenient access to more than 4,000 mouse and rat models, plus a service

to design, generate and breed custom models for your exclusive use. Taconic will stabilize the health and genetic status of your new mouse and help you define and understand its characteristics

so you can use it more effectively in your research program. When it comes to the design of appropriate breeding plans for efficient breeding of mice with multiple mutations, no one does it better

than Taconic. We’ve been breeding and protecting valuable genetically modified models for PIs for over 25 years. Before your mice are delivered to your lab, Taconic can perform a variety of

services to make them immediately ready for your studies. Our scientists and highly trained technicians can perform special surgeries or xenografts per your specifications. If you need special diet

administration or aged mice, Taconic can do it for you so you can start your studies faster. Consult with our scientists, use our innovative genetic modifying technologies and rely on our

veterinarians and Animal Care Technicians to deliver the right study-ready animal to you in the minimum amount of time.

Consult with our scientists, use our innovative genetic modifying technologies and rely on our veterinarians and animal care staff to deliver the right study-ready animal to you in the minimum amount of time.

• HEALTH DEFINED VIA QUARANTINE OR DERIVATION• SPEED CONGENICS• VERIFY GENETIC BACKGROUND• VALIDATE EFFICIENT GENOTYPING ASSAY(S)• COLLECT PHENOTYPE DATA

• RAPID COLONY EXPANSION• FLEXIBLE COLONY SIZE• COMPLEX BREEDING PROJECTS• PROJECT MANAGEMENT• ONLINE COLONY MANAGEMENT (eTACONIC)• CRYOPRESERVATION AND RECOVERY

TACONIC CAN CREATE STUDY-READY MODELS THAT PERFORM RELIABLY AND ARE A SIGNIFICANT ADVANTAGE FOR YOUR EARLY DISCOVERY AND DEVELOPMENT WORK.

ACQUIREMODEL

• HEALTH DEFINED VIA

MODEL CHARACTERIZATION& OPTIMIZATION

• RAPID COLONY EXPANSION

SCALE UP, BREEDING& PRESERVATION

TACONIC CAN CREATE

STUDY-READY

Taconic is the only breeder who can accelerate your research program by providing a fully integrated system for fast, convenient access to more than 4,000 mouse and rat models, plus a service to design, generate and breed custom models for your exclusive use.

Taconic will stabilize the health and genetic status of your new mouse or rat and help you de�ne and understand its characteristics so you can use it more e�ectively in your research program.

When it comes to the design of appropriate breeding plans for e�cient breeding of mice with multiple mutations, no one does it better than Taconic. We’ve been breeding and protecting valuable genetically modi�ed models for PIs for over 25 years.

Before your mice are delivered to your lab, Taconic can perform a variety of services to make them immediately ready for your studies. Our scientists and highly trained technicians can perform special surgeries per your speci�cations. If you need special diet administration or aged mice, Taconic can do it for you so you can start your studies faster.

• TACONIC TRANSGENIC EXCHANGE• IN-LICENSE OR IMPORT FROM PUBLIC REPOSITORIES• TACONIC CUSTOM-DESIGNED MODELS

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Taconic is the partner of choice for investigators who demand fast, easy, global access to translational mice and rats that will speed up their research. Taconic provides you with access to critical capabilities in the fields of genetic engineering, model generation, phenotype characterization, complex breeding, health and genetic testing, embryology, cryopreservation, and colony management. All for the exclusive purpose of reliably delivering the quantities of high quality animals your project demands within time lines that meet your expectations and are unmatched in the industry.

When you partner with Taconic, your research goals become our goals. We facilitate your drug target validation and drug discovery efforts by enabling you to obtain more relevant data from your in vivo studies so you can reduce costs, speed time-to-market, and compete more effectively. To help you achieve those objectives, Taconic draws from a broad portfolio of solutions – including genetically humanized models, custom-designed models, disease-specific models, and our extensive repositories of transgenic and gene targeted models. If we don’t have the mouse or rat line that you need, our scientists will collaborate with you to genetically engineer the right model for your research. Once you have acquired the model you want, Taconic’s scientists will work with you to select the most efficient program to produce, quality control, and deliver the study-ready mice and rats needed to immediately start your studies.

We invite you to explore this catalog and Taconic.com to learn about our industry-leading offerings and to discover what makes Taconic the researcher’s partner for quality laboratory animals and services.

Table of Contents

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New Products and Services ....................................... 4-6

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Research Applications Guide ....................................... 7-20Research Models ................................................... 8-11tADMET™.................................................................... 12Metabolic and Cardiovascular Disease ................ 13Neurodegeneration ................................................... 14tONCO™ ...................................................................... 15Immunology ................................................................ 16Toxicology .................................................................... 17Imaging ........................................................................ 18Transgenic Model Generation Support ................ 19

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Animal Quality Standards ........................... 21-26Taconic Genetic Standards ..................................... 23Genetic Monitoring Program ............................. 24-25Quality Standards ..................................................... 26

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Production and Research Solutions ......... 27-40Custom Breeding Solutions ............................... 28-29Oncology Discovery Services .................................. 30Testing Solutions .................................................. 31-38Animal Care Products ......................................... 39-40

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Custom Model Generation Solutions ...... 41-44Genetically Humanized Mouse Models ................. 44

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Animal Models................... 45-96Study-Ready Options ................................................ 46

Models129S6 .......................................................................... 47Abb (H2-Ab1) ................................................................. 47Ahr Knockout Mouse ....................................................... 47ApoB100 ....................................................................... 48Apoe(ApoE) .................................................................... 48APOE2 .......................................................................... 48APOE3 .......................................................................... 48APOE4 .......................................................................... 48APPSWE ....................................................................... 49APPSWE-Tau ............................................................. 49-50β-actin-luc LPTA® ....................................................... 50-51

Animal Models (continued)B2m (β2m) .................................................................... 51B6 Albino ....................................................................... 51B6 Albino A++ ................................................................. 51B6 nude ......................................................................... 51B6.SJL .......................................................................... 52B6129F1 ....................................................................... 52B6C3F1 ......................................................................... 52B6D2F1 ........................................................................ 53B6SJLF1 ....................................................................... 53BALB/c .......................................................................... 53BALB/c nude .................................................................. 54BALB/cABom ................................................................. 54BALB/cJBom .................................................................. 54Bcrp .............................................................................. 54Black 6 .......................................................................... 55Black 6JBom .................................................................. 55Black Swiss .................................................................... 55Brca1-Associated Breast Cancer Model ............................ 56C.B-17 scid ................................................................... 56C3H .............................................................................. 56CamKII-cre ..................................................................... 56Car Knockout Mouse ....................................................... 57CETP ............................................................................. 57CETP-ApoB100 .............................................................. 57CIEA BRG Mouse ............................................................ 57CIEA NOG mouse® .......................................................... 58COX-1 ........................................................................... 58COX-2 ........................................................................... 58Cre Deleter .................................................................... 58CreERT2 ......................................................................... 59CRE-Luc GPCR Reporter Mouse, Line 11 .......................... 59CRE-Luc GPCR Reporter Mouse, Line 64 .......................... 59CRE-Luc GPCR Reporter Mouse, Line 187 ........................ 59Cyp1a1/1a2 Knockout Mouse .......................................... 59Cyp2c Knockout Mouse ................................................... 59Cyp2d Knockout Mouse ................................................... 60Cyp3a (7-gene) Knockout Mouse ...................................... 60Cyp3a (8-gene) Knockout Mouse ...................................... 60Cyp3a-Cyp2d-Cyp2c Knockout Mouse ............................... 60Dark Agouti .................................................................... 60DBA/1 ........................................................................... 61DBA/2 ........................................................................... 61Diabetic ......................................................................... 61Diet Induced Obese ......................................................... 62Fcer1g (FcRy) ................................................................ 62Fcgr2b (FcγIII) ................................................................ 62Fischer .......................................................................... 63Floxed Ink4a/Arf Mouse ................................................... 63Floxed p53 Mouse .......................................................... 63Flp Deleter ..................................................................... 63FVB ............................................................................... 64Gfap-luc LPTA® ............................................................... 64Goto-Kakizaki .................................................................. 64Gsk3A (Glycogene Synthase Kinase 3 Alpha) KinaseSwitch Mouse ..................................................... 65

Gsk3b (Glycogene Synthase Kinase 3 Beta) KinaseSwitch Mouse ..................................................... 65

HLA-A1 ......................................................................... 65HLA-A2.1 ...................................................................... 65HLA-A11 ....................................................................... 66

NEW

CMGS

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Table of Contents

Animal Models (continued) HLA-A24 ........................................................................ 66HLA-B7 .......................................................................... 66HLA-B44 ........................................................................ 66HRN™ ........................................................................... 67HRN™ nude ................................................................... 67Humanized AHR Mouse .................................................. 67Humanized CAR Mouse .................................................. 67Humanized CYP1A1/1A2 Mouse ...................................... 67Humanized CYP2D6 Mouse ............................................. 68Humanized CYP3A4/3A7 Mouse ....................................... 68Humanized Gut CYP3A4 Mouse ........................................ 68Humanized Liver & Gut CYP3A4 Mouse ............................. 68Humanized Liver CYP2C9 Mouse ..................................... 69Humanized Liver CYP3A4 Mouse ...................................... 69Humanized MRP2 Mouse ................................................ 69Humanized OATP1B1 Mouse ............................................ 69Humanized OATP1B1/1B3 Mouse ..................................... 69Humanized OATP1B3 Mouse ............................................ 70Humanized PXR Mouse .................................................... 70Humanized PXR-CAR Mouse ............................................ 70Humanized PXR-CAR-AHR Mouse ..................................... 70Humanized PXR-CAR-CYP3A4/3A7 Mouse ........................ 70Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse ......................................................................... 71

Humanized PXR-CAR-CYP3A4/3A7-CYP2D6-CYP2C9 Mouse ............................................................ 71

Humanized PXR-CAR-PPARα Mouse.................................. 71Humanized UGT1A1*1 Mouse .......................................... 71ICR ................................................................................ 72ICR scid ......................................................................... 72Invasive Lobular Breast Cancer Model ............................... 72Jh ................................................................................. 72Levin .............................................................................. 73Lewis ............................................................................. 73Long Evans ..................................................................... 74Mdr1a ........................................................................... 74Mdr1a/b ........................................................................ 74Mdr1a/b-Bcrp ................................................................. 75Mrp1 ............................................................................. 75Mrp2 ............................................................................. 75NCr nude ....................................................................... 75NFκB-RE-luc LPTA® ......................................................... 75NIH nude ........................................................................ 76NMRI ............................................................................. 76NMRI nude ..................................................................... 76NOD .............................................................................. 77NOD scid ....................................................................... 77Ntrk1 (Neurotrophic Tyrosine Kinase Receptor Type 1) KinaseSwitch Mouse ............................ 77

Ntrk2 (Neurotrophic Tyrosine Kinase Receptor Type 2) KinaseSwitch Mouse ............................ 77

Oatp1a/b Cluster Knockout Mouse .................................... 78Oct1/2 ........................................................................... 78Pfp/Rag2 ........................................................................ 78Pparα ............................................................................ 78Pxr Knockout Mouse ........................................................ 78Pxr-Car Knockout Mouse .................................................. 79Pxr-Car-Ahr Knockout Mouse ........................................... 79Pxr-Car-Pparα Knockout Mouse ....................................... 79Rag2 ........................................................................ 79-80Rag2/OT-I ....................................................................... 80

Animal Models (continued) Rag2/OT-II ...................................................................... 80rasH2 ............................................................................ 80scid-beige ...................................................................... 81SJL ............................................................................... 81Spontaneously Hypertensive ............................................. 81Sprague Dawley® ............................................................ 82Stat1 ............................................................................. 83Swiss nude ..................................................................... 83Swiss Webster ............................................................... 83Tau ................................................................................ 84TNF-α ............................................................................ 84TSG-p53® ................................................................. 84-85Wistar Hannover GALAS™ .............................................. 85Wistar Kyoto .................................................................. 86

Cryopreserved Taconic Lines .................................. 87Custom Hybrids ......................................................... 88Emerging Models ....................................................... 89The Michael J. Fox FoundationEmerging Models ..................................................... 90

Parkinson’s Disease Rat Models ........................... 90Amyotrophic Lateral Sclerosis Association Emerging Model ....................................................... 90

University of Cambridge –NOD Congenic Exchange Program ...................... 90

The National Institute for Allergy and InfectiousDisease (NIAID) Exchange Program .................... 91

CRE-Luc GPCR Reporter Mouse Models ............... 92KinaseSwitch Models ............................................... 92Light Producing Transgenic Animals® ................... 93The Taconic Knockout (KO) Repository ........... 94-95

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Surgical Services............ 97-100Cannulations/Catheterizations .............................. 98Procedures ................................................................. 99Surgical Models ....................................................... 100

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Reference/Index ........... 101-115How to Order ........................................................... 102Pregnant Animal Policies ....................................... 103Cancellation and Change Orders ......................... 103Terms and Conditions of Sale ............................... 104Taconic Transgenic Exchange ............................... 105Label License: Conditions of Use for Taconic Transgenic Models™ ............................... 105

Model Reference Guide ................................... 106-109Light Producing Transgenic Animals® (LPTA®) Conditions of Use ................................... 110

Model Name Index ........................................... 111-112Model Number Index ....................................... 113-114Service Name ........................................................... 115

New Products and Services

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New B6 Albino ModelsThe B6 Albino A++ (Model 11227) features two mutations, a mutation in the Tyr (tyrosinase) gene and a reversion of the nonagouti locus (a) to the agouti locus (A). The B6 Albino (Model 11971) carries just the tyrosinase mutation. Both models are on the C57BL/6NTac background, the substrain background of many popular B6-derived ES cells. These two new models are ideal for use as blastocyst hosts with B6-derived ES cells. Available only from Taconic!

B6 Albino (Model 11971) ............................ See page 51 B6 Albino A++ (Model 11227) ...................... See page 51

CRE-Luc GPCR ReporterMouse PlatformAn in vitro / in vivo luciferase reporter system to assay ligand activation of GPCRs in a native system.

• A panel of luciferase reporter mice to assay GPCR ligand binding and pathway activation in a native system, avoiding artificial, engineered systems

• Supports multiple assay formats for either in vitro, in vivo, or ex vivo assays

• The platform can provide rapid in vivo PK/PD profiling of compounds with quantitative data to compare pharmacological action

• Assay can be used for two main GPCR classes, Gs and Gi

• Three new models added in 2013

CRE-Luc GPCR Reporter Mouse, Line 11(Model 11515) ............................................... See page 59CRE-Luc GPCR Reporter Mouse, Line 64(Model 11518) ............................................... See page 59CRE-Luc GPCR Reporter Mouse, Line 187(Model 11520) ............................................... See page 59

CIEA BRG mouse A highly immunodeficient mouse useful for research on humanization, infectious disease, autoimmune disease and in xenograft assays. CIEA BRG mouse (Model 11503) ................ See page 57

SAP/Sh2d1a Knockout The SAP-deficient mouse model recapitulates several features of X-linked lymphoproliferative-disease and has been extensively used for studying germinal center responses and for analyses of innate T cell development. Part of the NIAID Exchange Program.

SAP/Sh2d1a Knockout (Model 8424) .... See page 91

New KinaseSwitch ModelsTaconic expands its KinaseSwitch offering in 2013 to include the KinaseSwitch mouse models for the following genes of interest:

Btk (Model 9723) ........................................ See page 92EphB4 (Model 7742) ................................... See page 92Gsk3a (Model ART0069) .............................. See page 65Gsk3b (Model ART0059) .............................. See page 65Mapk14 (Model ART0073) .......................... See page 92Met (Model ART0048) .................................. See page 92Ntrk1 (Model ART0066) .............................. See page 77Ntrk2 (Model ART0067) ............................. See page 77Pdgfr-β (Model 9070) .................................. See page 92Rps6kb1 (Model 8026) ............................... See page 92Src (Model ART0042) ................................... See page 92

CamKII-cre Tissue-specific deleter useful for generation of forebrain neuron-specific gene deletions.

CamKII-cre (Model ART0009) ..................... See page 56

New Taconic Cancer Models Taconic introduces four new cancer models. In addition to a vast array of immunodeficient mice raised at industry-leading health standards and in sufficient quantities to support your xenograft studies, Taconic distributes relevant transgenic oncology models. In 2013, Taconic offers four new mouse mutants from the Netherlands Cancer Institute:

Brca1-Associated Breast Cancer Model(Model 11510) ............................................... See page 56Invasive Lobular Breast Cancer Model(Model 11509) ............................................... See page 72Floxed Ink4a/Arf Mouse(Model 11511) ............................................... See page 63Floxed p53 Mouse (Model 11512) ............ See page 63

tONCO™ – Expanded Access to Oncology Discovery ServicesIn collaboration with Oncodesign, Taconic offers a broad portfolio of translational models for use in oncology drug discovery. Our expanded tONCO™ portfolio includes:

• Over 400 xenograft models representing many human cancers

• Access to patient-derived xenograft models and associated drug profiling services

• NOG mice reconstituted with a human immune system• Access to a larger portfolio of imaging solutions including:

MRI PET SPECT CT Ultrasound Cyclotron and radiochemistry labs

tONCO™ Portfolio ................................... See page 15

New Products and Services

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New tADMET™ Models and Services

Cyp1a1/1a2 Knockout Mouse (Model ITI0122) .............................................. See page 59Cyp3a-Cyp2d-Cyp2c Knockout Mouse (Model ITI0117) .............................................. See page 60Humanized CYP1A1/1A2 Mouse (Model ITI0111) .............................................. See page 67Humanized OATP1B1/1B3 Mouse (Model 11594) ............................................... See page 69Humanized PXR-CAR-AHR Mouse(Model ITI0082) .............................................. See page 70Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse (Model ITI0134) ............... See page 71Humanized PXR-CAR-CYP3A4/3A7-CYP2D6-CYP2C9 Mouse (Model ITI0100) ............... See page 71Humanized PXR-CAR-PPARα Mouse (Model ITI0123) .............................................. See page 71Humanized UGT1A1*1 Mouse(Model 11996) ............................................... See page 71Pxr-Car-Pparα Knockout Mouse (Model ITI0141) .............................................. See page 79

Research Applications Guide

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Research Applications GuideResearch ModelstADMET™Metabolic & Cardiovascular DiseaseNeurodegenerationtONCO™ImmunologyToxicologyImagingTransgenic Model Generation Support


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Model Research Applications

Rat Models Page tADMET™ Immunology

Metabolic & Cardiovascular

Disease Neurodegeneration tONCO™ Toxicology

Transgenic Model

Generation Support Imaging

Dark Agouti 60 Fischer 63 Goto-Kakizaki 64 Levin 73 Lewis 73 Long Evans 74 NIH nude 76 Spontaneously Hypertensive 81

Sprague Dawley® 82 Wistar Hannover GALAS™ 85

Mouse Models Page tADMET™ Immunology



Transgenic Model


129S6 47 Abb (H2-Ab1) 47 Ahr Knockout Mouse 47 ApoB100 48 Apoe (ApoE) 48 Apoe2 48 Apoe3 48 Apoe4 48 APPSWE 49 APPSWE-Tau 49-50 β-actin-luc LPTA® 50-51 B2m (β2m) 51 B6 Albino 51 B6 Albino A++ 51 B6 nude 51 B6.SJL 52 B6129F1 52 B6C3F1 52 B6D2F1 53 B6SJLF1 53 BALB/c 53 BALB/c nude 54 BALB/cABom 54 BALB/cJBom 54 Bcrp 54 Black 6 55 Black 6JBom 55 Black Swiss 55 Brca1-Associated Breast Cancer Model 56

C.B-17 scid 56

(Continued next page)

Research Models


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C3H 56 CamKll-cre 56 Car Knockout Mouse 57 CETP 57 CETP-ApoB100 57 CIEA BRG mouse 57 CIEA NOG mouse® 58 COX-1 58 COX-2 58 Cre Deleter 58 CreERT2 59 Cyp19-luc 93 Cyp1a1/1a2 Knockout Mouse 59

Cyp1a1-luc 93 Cyp1a2-luc 93 Cyp2c Knockout Mouse 59 Cyp2c9-luc 93 Cyp2d Knockout Mouse 60 Cyp3a (7-gene) Knockout Mouse 60

Cyp3a (8-gene) Knockout Mouse 60

Cyp3a-Cyp2d-Cyp2c Knockout Mouse 60

CYP3A4-luc 93 CYP3A4-luc (SD rat) 93 Cyp3a11-luc 93 DBA/1 61 DBA/2 61 Diabetic 61 Diet Induced Obese 62 Fcer1g (FcRγ) 62 Fcgr2b (FcγII) 62 Floxed Ink4a/Arf Mouse 63 Floxed p53 Mouse 63 Flp Deleter 63 FVB 64 Gfap-luc LPTA® 64 Gsk3a KinaseSwitch Mouse 65 Gsk3b KinaseSwitch Mouse 65 HLA-A1 65 HLA-A2.1 65 HLA-A11 66 HLA-A24 66 HLA-B7 66 HLA-B44 66


Research Models (continued)Model Research Applications




Transgenic Model



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HRN™ 67 HRN™ nude 67 Humanized AHR Mouse 67 Humanized CAR Mouse 67 Humanized CYP1A1/1A2 Mouse 67

Humanized CYP2D6 Mouse 68 Humanized CYP3A4/3A7 Mouse 68

Humanized Gut CYP3A4 Mouse 68

Humanized Liver & Gut CYP3A4 Mouse 68

Humanized Liver CYP2C9 Mouse 69

Humanized Liver CYP3A4 Mouse 69

Humanized MRP2 Mouse 69 Humanized OATP1B1 Mouse 69 Humanized OATP1B1/1B3 Mouse 69

Humanized OATP1B3 Mouse 70 Humanized PXR Mouse 70 Humanized PXR-CAR Mouse 70 Humanized PXR-CAR-AHR Mouse 70

Humanized PXR-CAR-CYP3A4/3A7 Mouse 70

Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse

71

Humanized PXR-CAR-CYP3A4/3A7-CYP2D6-CYP2C9 Mouse

71

Humanized PXR-CAR-PPARα Mouse 71

Humanized UGT1A1*1 Mouse 71

ICR 72 ICR scid 72 Invasive Lobular Breast Cancer Model 72

Jh 72 Mdr1a 74 Mdr1a/b 74 Mdr1a/b-Bcrp 75 Mdr1-luc 93 Mrp1 75 Mrp2 75 NCr nude 75 NFκB-RE-luc LPTA® 75 NMRI 76 NMRI nude 76 NOD 77

Research Models (continued)






Transgenic Model



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Research Models (continued)

NOD scid 77 Ntrk1 KinaseSwitch Mouse 77 Ntrk2 KinaseSwitch Mouse 77 Oatp1a/b Cluster Knockout Mouse 78

Oct1/2 78 Pfp/Rag2 78 Pparα 78 Pxr Knockout Mouse 78 Pxr-Car Knockout Mouse 79 Pxr-Car-Ahr Knockout Mouse 79

Pxr-Car-Pparα Knockout Mouse 79

Rag2 79-80 Rag2/OT-I 80 Rag2/OT-II 80 rasH2 80 scid-beige 81 SJL 81 Stat1 83 Swiss nude 83 Swiss Webster 83 Tau 84 TNF-α 84 TSG-p53® 84-85





Transgenic Model


tADMET™

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Xenoreceptor Models Page Drug Transporter Models PageAhr Knockout Mouse 47 Bcrp Mouse (Knockout) 54Car Knockout Mouse 57 Humanized MRP2 Mouse (inquire) 69Humanized AHR Mouse 67 Humanized OATP1B1 Mouse 69Humanized CAR Mouse 67 Humanized OATP1B1/1B3 Mouse 69Humanized PXR Mouse 70 Humanized OATP1B3 Mouse 70Humanized PXR-CAR Mouse 70 Mdr1a Mouse 74Humanized PXR-CAR-AHR Mouse 70 Mdr1a/b Mouse (Knockout) 74Humanized PXR-CAR-PPARα Mouse 71 Mdr1a/b-Bcrp Mouse (Knockout) 75Pparα Mouse (Knockout) 78 Mrp1 Mouse (Knockout) 75Pxr Knockout Mouse 78 Mrp2 Mouse (Knockout) 75Pxr-Car Knockout Mouse 79 Oatp1a/1b Cluster Knockout Mouse 78Pxr-Car-Ahr Knockout Mouse 79 Oct1/2 Mouse (Knockout) 78Pxr-Car-Pparα Knockout Mouse 79

Composite Models PageCytochrome P450 Models Page Humanized PXR-CAR-CYP3A4/3A7 Mouse 70Cyp1a1/1a2 Knockout Mouse 59 Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse 71Cyp2c Knockout Mouse 59 Humanized PXR-CAR-CYP3A4/3A7-CYP2D6-

CYP2C9 Mouse71

Cyp2d Knockout Mouse 60Cyp3a (7-gene) Knockout Mouse 60Cyp3a (8 gene) Knockout Mouse 60 Related Models PageCyp3a-Cyp2d-Cyp2c Knockout Mouse 60 HRN™ Mouse 67Humanized CYP1A1/1A2 Mouse 67 HRN™ nude Mouse 67Humanized CYP2D6 Mouse 68Humanized CYP3A4/3A7 Mouse 68 Carcinogenicity Models PageHumanized Gut CYP3A4 Mouse 68 rasH2 Mouse 80Humanized Liver & Gut CYP3A4 Mouse 68 TSG-p53® Mouse 84-85Humanized Liver CYP2C9 Mouse 69Humanized Liver CYP3A4 Mouse 69 Traditional Models Page

Black 6 Mouse 55Phase 2 Models Page ICR Mouse 72Humanized UGT1A1*1 Mouse 71 NIH nude rat 76

NMRI Mouse 76

Light Producing Transgenic Animals® (LPTA®)

Page Sprague Dawley® Rat 82Wistar Hannover GALAS™ Rat 85

CYP3A4-luc 93CYP3A4-luc (SD rat) 93 Surgically Modified Models PageCyp3a11-luc 93 Bile Duct with Duodenal Return 98Cyp1a1-luc 93 Carotid Artery Catheterization 98Cyp1a2-luc 93 Femoral Artery Catheterization 98Cyp2c9-luc 93 Femoral Vein Catheterization 98Cyp19-luc 93 Jugular Vein Catheterization 98Mdr1-luc 93 Portal Vein Catheterization 98

Telemetry Implants 99

tADMET™ offers a unique and evolving portfolio of translational mouse models and services for an improved prediction of the Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) characteristics of new compounds in humans.

Applications• Drug-drug interaction studies• Human metabolite testing• Assessment of bioavailability and clearance• PKPD modeling• Carcinogenicity testing

tADMET™ components• Humanized and knockout mouse models for

xenoreceptors, cytochrome P450s, phase 2 enzymes and drug transporters

•Mouse models for short-term carcinogenicity testing

New Products 2013• Humanized PXR-CAR-CYP3A4/3A7-

CYP2D6-CYP2C9 Mouse• Humanized UGT1A1*1 Mouse• Humanized OATP1B1/1B3 Mouse

Metabolic and Cardiovascular Disease

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Taconic Transgenic Models™and Emerging Models Study-Ready OptionsModels Page Model PageApoB100 Mouse 48 Diet Induced Obese Black 6 62Apoe Mouse 48APOE2 Mouse 48 Production and Research SolutionsAPOE3 Mouse 48 PageAPOE4 Mouse 48 Diet Administration Protocols 46CETP Mouse 57CETP-ApoB100 Mouse 57EphB4 KinaseSwitch Mouse 92Light Producing Transgenic Animals® (LPTA®) including the following models:

mIns2-luc Retn-lucRIP-luc

93

Pparα Mouse 78Rps6kb1 KinaseSwitch Mouse 92

University of Cambridge -NOD Congenic Exchange Program

90

Traditional Animal ModelsModels Page129S6 Mouse 47Black 6 Mouse 55Goto-Kakizaki Rat 64Levin Diet-Resistant Rat 73Levin Diet-Sensitive Rat 73NOD Mouse 77Spontaneously Hypertensive Rat 81

Spontaneous Mutant ModelsModel PageDiabetic Mouse 61

Cardiovascular and metabolic disorders are increasingly vital areas of research. With the incidence of diabetes, hypertension, heart disease, and obesity on the rise, the availability of relevant animal models for the study of these diseases is more important than ever. Taconic offers ready access to a wide range of animal models and services that support the study of metabolic and cardiovascular disease, including spontaneous mutants, transgenic models, and study-ready models such as our off-the-shelf Diet Induced Obese model (DIO).

Neurodegeneration

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Taconic Transgenic Models™and Emerging ModelsModels PageAPOE2 Mouse 48APOE3 Mouse 48APOE4 Mouse 48APPSWE Mouse 49APPSWE-Tau Mouse 49-50EphB4 KinaseSwitch Mouse 92Human Alpha Synuclein A53T Rat 90Human Alpha Synuclein E46K Rat 90Human Alpha Synuclein Rat 90Human LRRK2 G2019S Rat 90Human LRRK2 R1441G Rat 90

Light Producing Transgenic Animals® (LPTA®) including the following model:

Gfap-luc

64

SOD1 Rat 90Tau Mouse 84

Traditional Animal ModelsModels Page129S6 Mouse 47B6D2F1 53BALB/c Mouse 53BALB/cABom 54BALB/cJBom 54Black 6 (male mice up to 12 months of age) 55Black 6JBom 55C3H Mouse 56DBA/2 Mouse 61

Surgical ServicesPage

Brain Cannulations 98Microdialysis Implants 98Samaritan Alzheimer’s Rat Model™ 100

Unilateral 6-Hydroxydopamine Lesion of the Nigrostriatal Pathway

100

As the human population ages, investigators are placing greater emphasis on neurodegenerative disorder research. Taconic is responding with animal models uniquely suited to these studies. Taconic provides fast, easy access to valuable models for the study of Alzheimer’s and Parkinson’s diseases, ALS and other disorders – including many models available exclusively from Taconic and offered with full use licenses.

tONCO™

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Spontaneous Tumor Models Traditional ModelsModels Page Models PageBrca1-Associated Breast Cancer Model 56 Black 6 55Floxed Ink4a/Arf Mouse 63 Black 6JBom 55Floxed p53 Mouse 63 Dark Agouti 60Invasive Lobular Breast Cancer Model 72 Fischer 63PIRC 87 ICR 72Stat1 83 NMRI 76TSG-p53® 84-85

Oncology Discovery ServicesImmunodeficient Models PageModels Page Drug efficacy testing using xenografts 30Nudes Mice carrying a human immune system 30B6 nude 51 Patient-derived xenograft platform 30BALB/c nude 54 Pharmacoimaging solutions 30HRN™ nude 67NCr nude 75NIH nude 76NMRI nude 76Swiss nude 83ScidsC.B-17 scid 56ICR scid 72NOD scid 77Rag2Rag2 (129S6) 79Rag2 (BALB/c) 79Rag2 (C57BL/6) 80Rag2 (B6.SJL) 80Models with Multiple ImmunodeficienciesCIEA BRG mouse 57CIEA NOG mouse® 58Rag2/Il2rg Double Knockout Mouse 91Scid-beige 81

tONCO™ allows easy access to a comprehensive portfolio of translational rodent models and services covering every stage of preclinical in vivo oncology research, including exclusive, in-licensed genetically modified mouse models resembling human cancer development, patient-derived tumor grafts, access to multiple molecular imaging technologies, and study-ready NOG mice reconstituted with a human immune system. Together with a diverse portfolio of high quality immunodeficient models for xenograft studies, including our exclusive NCr nude mouse, Taconic can offer the right in vivo model for you at every stage of the preclinical oncology drug discovery process.

tONCO™ — Taconic’s oncology portfolio brought to you in collaboration with Oncodesign.

Immunology

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Traditional Animal Models (continued)

Models PageFischer Rat 63Lewis Rat 73NOD mouse 77

Emerging ModelsModels PageAbb Knockout/Transgenic HLA-DR4 Mouse 91B10.Q/Ai Mouse 91Ccr1 Knockout Mouse 91Cd4-cre Transgenic Mouse 91CIEA BRG mouse 57CIEA NOG mouse® 58Cx3cr1 Knockout Mouse 91Flt3l Knockout Mouse 91H2-Db Knockout Mouse 91H2-Kb H2-Db Double Knockout Mouse 91H2-Kb Knockout Mouse 91Il15 Knockout Mouse 91Il4ra Knockout Mouse 91Lck-cre Transgenic Mouse 91

Light Producing Transgenic Animals® (LPTA®) including the following models:

Cox2-lucEpx-lucGadd45b-lucIκBα-lucIl2-lucSaa1-lucTNFα-luc

93

LTH-1 Transgenic Mouse 91NFκB-RE-luc 75Nos2 Knockout Mouse 91Rag1 Knockout/Transgenic OT-I TCell Receptor Mouse

91

Rag1 Knockout/Transgenic OT-II T CellReceptor Mouse

91

Rag2 Knockout/Transgenic Cyt5CC7 T CellReceptor Mouse

91

Rag2 Knockout/Transgenic DO11.10 T CellReceptor Mouse

91

Rag2 Knockout/Transgenic DO11.10 T CellReceptor Mouse

91

Rag2 Knockout/Transgenic LCMV-P14 T CellReceptor Mouse

91

Rag2/Il2rg Double Knockout Mouse 91

SAP/Sh2d1A Knockout Mouse 91

Tcrα Knockout/Transgenic LCMV-P14 T Cell Receptor Mouse

91

Transgenic D011.10 T Cell Receptor/Transgenic CARΔ Mouse

91

The immune system plays a pivotal role in the pathogenesis of many common diseases, including autoimmune and infectious disease, cancer, atherosclerosis, and allergies. Taconic is the exclusive provider of the CIEA NOG mouse®, the best mouse commercially available for experiments involving humanization of the immune system. In addition, Taconic offers an expansive portfolio of knockout and humanized models, including the transgenic humanized HLA mice, which express human HLA molecules for use in vaccine testing and basic research.

Spontaneous Mutant ModelsModels PageB6 nude Mouse 51BALB/c nude Mouse 54C.B-17 scid Mouse 56ICR scid Mouse 72NCr nude Mouse 75NIH nude Rat 76NMRI nude Mouse 76NOD scid Mouse 77Scid-beige Mouse 81Swiss nude Mouse 83

Traditional Animal ModelsModels PageB6.SJL Mouse 52BALB/c Mouse 53BALB/cABom Mouse 54BALB/cJBom Mouse 54Black 6 Mouse 55Black 6JBom 55C3H 56Dark Agouti Rat 60DBA/1 Mouse 61

Taconic Transgenic Models™Models PageAbb Mouse 47B2m Mouse 51Ccr2 Mouse 87Ccr5 Mouse 87COX-1 Mouse 58COX-2 Mouse 58Fcer1g Mouse 62Fcgr2b Mouse 62HLA-A1 Mouse 65HLA-A2.1 Mouse 65HLA-A11 Mouse 66HLA-A24 Mouse 66HLA-B7 Mouse 66HLA-B27 Rat 87HLA-B44 Mouse 66Rag2 (129S6) Mouse 79Rag2 (B6.SJL) Mouse 80Rag2 (BALB/c) Mouse 79Rag2 (C57BL/6) Mouse 80Rag2/OT-I Mouse 80Rag2/OT-II Mouse 80TNF-α Mouse 84

Toxicology

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When you use lab animals in your research, it is imperative that you can be confident in the reproducibility of your research findings. But the variables of genetic drift, opportunistic infection, and phenotypic characteristics can impact your protocol – making it vital for you to rely on a stable breeding program. Taconic offers a variety of stable animal models that are especially useful for toxicology studies. The rasH2 and TSG-p53® mouse models have been validated by the International Life Science Institute Health and Environmental Science Institute (ILSI/HESI) Alternative Carcinogenicity Testing (ACT) project for use in short-term carcinogenicity bioassays.

Taconic Transgenic Models™ and Emerging ModelsModels PageLight Producing Transgenic Animals® (LPTA®) including the following models:

Gadd45α-lucGadd153-lucSod1-lucγGcs-h-luc

93

rasH2 Mouse 80TSG-p53® Mouse 84-85

Traditional Animal ModelsModels PageB6C3F1 Mouse 52BALB/c 53BALB/cABom 54BALB/cJBom 54Black 6 Mouse 55Black 6JBom 55Black Swiss 55Fischer Rat 63ICR 72Long Evans Rat 74NIH Nude Rat 76Sprague Dawley® Rat 82Swiss Webster 83Wistar Hannover GALAS™ Rat 85

Surgical ServicesPage

Telemetry Implants 99Vascular Catheters 98

Imaging

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Use of imaging technologies for in vivo experiments provides numerous benefits, including the ability to non-invasively monitor the same animals over multiple time points and reduced animal usage. Taconic offers exclusive animal models for imaging as well as advanced imaging services (through its oncology collaborator, Oncodesign). In 2013, Taconic launches the CRE-Luc portfolio, which offers a diverse GPCR reporter system to assay GPCR ligand/receptor interactions via real time bioimaging in live animals or in primary cells and tissues.

Taconic Transgenic Models™ and Emerging ModelsModels PageLight Producing Transgenic Animals® (LPTA®)β-actin-luc (FVB) 50β-actin-luc (B6;FVB albino) 51Gfap-luc 64NFκB-RE-luc 75

Over 30 cryopreserved models available forcontract production

93

CRE-Luc portfolioCRE-Luc line 11 59CRE-Luc line 31 92CRE-Luc line 33 92CRE-Luc line 64 59CRE-Luc line 175 92CRE-Luc line 187 59CRE-Luc line 219 92

Production and Research SolutionsPage

Pharmacoimaging solutions 30

Traditional ModelsModels PageB6C3F1 52B6D2F1 53BALB/cABom 54BALB/cJBom 54

Transgenic Model Generation Support

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Emerging ModelsModels PageB6 Albino 51

B6 Albino A++ 51CamKII-cre 56Cre Deleter 58CreERT2 59Flp Deleter 63

Traditional ModelsModels Page129S6 Mouse 47B6129F1 Mouse 52B6SJLF1 Mouse 53BALB/c Mouse 53Black 6 (C57BL/6NTac and C57BL/6JBomTac) Mouse 55Black Swiss Mouse 55Fischer Rat 63FVB Mouse 64Lewis Rat 73Sprague Dawley® Rat 82Swiss Webster Mouse 83

Study-Ready ModelsModels PagePseudopregnant Mice 46Superovulated Mice and Rats 46

Custom Model Generation SolutionsPage

Gene Inactivation 43Gene Mutation or Replacement 43Inducible/Reversible Control of Gene Function 43Transgene Expression 43

Production and Research SolutionsPage

Embryo Cryopreservation 29Small Scale Breeding and Cohort Production 29SNP Testing 32Sperm Cryopreservation 29

Taconic offers a complete portfolio of products and services to assist transgenic core facilities and individual researchers who generate new genetically modified models. Two new B6 albino models will be available in 2013; these models serve as improved blastocyst donors for use with B6-derived ES cells. Taconic enables transgenic labs to conserve animals, space, and labor by providing both superovulated and pseudopregnant females. Take advantage of Taconic’s Custom Model Generation Services to increase capacity or gain access to our large portfolio of technologies (see pages 41-44).

Animal Quality Standards

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Quality, First and ForemostToday’s sophisticated and complex biomedical research efforts demand lab animals that meet the precise needs of each investigation, and the associated breeding, testing, and protocol administration services must be performed in compliance with internationally recognized standards. Across the enterprise, Taconic demonstrates our commitment to meeting these requirements through our programs centered on: • Health• Genetics• Quality Standards and Performance

Indicators• Scientific Expertise• Advanced Facilities

Health StandardsSophisticated biomedical research programs require the use of precise genetically-defined laboratory rats and mice with secure pathogen-free health profiles. Our commitment to an extensive health monitoring system is a key component of Taconic’s comprehensive quality control program. The Taconic International Health Monitoring System™ (IHMS™) includes testing for a comprehensive list of microbiological agents which meets or exceeds the animal health guidelines used by virtually all research institutions. The IHMS™ is defined by a comprehensive list of microbiological agents, test frequencies, and test methods. Strict Standard Operating Procedures dictate the number, selection, and use of sentinels or barrier population animals, procedures to enhance detection, frequency of sampling, and the test methodology employed.

Historically, most of Taconic’s traditional inbred, hybrid, and outbred mice and rats have been raised at the Murine Pathogen Free™ (MPF™)health status. As today’s facilities increase the use of sophisticated genetically modified models, traditional animals used for the purpose of backcrossing, sentinels, foster dams, etc will be required at a higher health status. Therefore, Taconic will raise increasing numbers of traditional animals at the Restricted Flora™ (RF™) health status. Several lines are already available, such as Black Swiss, Black 6, SD, 129SVE, C3H, and SW. Additional lines will be converted to the RF™ health status through new barrier start ups, barrier recycling, or test and cull. Please visit www.taconic.com/reportsbyanimalmodel for the most current list of RF™ animals available plus Health Standards for all commercially available animal models.

Taconic augments the routine IHMS™ health testing of RF™ colonies with monthly microbiological testing in our Quality Control Laboratory. This additional testing monitors certain agents that are not tolerated at the RF™ health designation, but are accepted in MPF™ health designation. This supplemental testing increases the likelihood of identifying opportunistic agents that may have gained access to the barrier sooner than routine IHMS™ testing.

Communications with CustomersIf an untolerated organism is confirmed in a barrier, Taconic continues to adhere to the policy of rapidly notifying all customers that have been directly impacted. Shipments are suspended from barriers where a suspect positive has been identified. If a suspect finding is confirmed as positive, all shipments since the last negative test result or six weeks are identified. Customers are contacted via phone call or email. In addition, notification will be posted on www.taconic.com.

Taconic Genetic StandardsGenetic Monitoring ProgramQuality Standards


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To assist investigators in selecting the correct Taconic animal model to meet the microbiological/health standards of their study, Taconic has established the following health standards for its animal models. The current health standard and colony location of each animal model is specified via Taconic’s online health reports. For a complete list of tolerated/not tolerated microorganisms by health standard, please visit www.taconic.com.

The appropriate label is affixed to each Taconic Transit Cage™ containing Taconic animals.

Murine Pathogen Free™ (MPF™) MPF™ rats and mice are monitored to verify that they do not harbor microorganisms that are known to be pathogenic under a variety of study conditions. Organisms eliminated by testing and culling in the RF™ designation are tolerated in MPF™ environments and animals but are regarded as undesirable. MPF™ animals are maintained in virtually all types of Taconic Barrier Units. Results of these health tests are fully documented in Taconic’s International Health Monitoring System™ (IHMS™) Reports. The Isolated Barrier Unit™ System has an unparalleled record for keeping MPF™ animals free of Helicobacter spp. (H. bilis, H. hepaticus, H. rodentium, H. typhlonius, H. trogontum, H. muridarium*), Parvoviruses, Pasteurella pneumotropica, and other pathogenic organisms. All MPF™ animals are packed in filtered plastic shipping containers within their Barrier Unit of origin.

* If detected, other species of Helicobacter will be managed on a case-by-case basis.

Restricted Flora™ (RF™) RF™ animals harbor a wide variety of commensal microorganisms in their flora but the animals and their environment are intensively monitored to detect the presence of specific opportunistic bacteria that can be pathogenic in immunocompromised rodents. The animals are maintained in Barrier Units (Isolated Barrier Units™, Multiple Barrier Units, Bio Bubble Units, and European Barrier Units) utilizing special husbandry and gowning procedures to protect the animals from opportunistic organisms which may be carried by human technicians. Taconic’s quality control laboratory screens monthly for 5 organisms that are not accepted in the RF™ colonies: Beta hemolytic Streptococcus species, Klebsiella pneumoniae and Klebsiella oxytoca, Pseudomonas aeruginosa, and Staphylococcus aureus. A description of the RF™ microbial monitoring procedures and the test results are available on www.taconic.com. If an unacceptable organism is detected and confirmed in a Barrier Unit housing RF™ animals, extensive testing and culling is performed to eliminate the organism. RF™ animals are shipped in Taconic’s filtered plastic shipping containers.

Defined Flora (DF) Literally, defined flora environments and animals can be comprised of any set of microorganisms which are known and defined. In practice, Defined Flora rodents generally harbor only a specific “cocktail” of organisms that is intentionally administered for a specific purpose. Taconic’s Defined Flora animals are given a cocktail of eight, urease-negative, anaerobic bacteria (the Altered Schaedler Flora). The Defined Flora status of these animals is verified on a routine basis by Taconic’s quality control laboratory. A limited number of other microorganisms (i.e. yeast, mold, etc.) may be tolerated. Like Germfree animals, Defined Flora animals are maintained in flexible-film or semi-rigid isolators using strict gnotobiotic techniques. Defined Flora animals are generally shipped in filtered plastic shipping containers. Studies that call for maintenance of the Defined Flora status may request the use of Germfree shippers.

Germfree (GF) Germfree rodents are free of all aerobic and anaerobic organisms with the possible exception of endogenous viruses. Germfree, or axenic, animals are maintained in flexible-film or semi-rigid isolators. Detection of any microorganism in Germfree isolators is cause for immediate tear-down of the isolator. All supplies are sterilized and entered into the isolator using strict gnotobiotic techniques. Shipment of these extremely delicate animal models is done in the Taconic Germfree Shipper.


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Taconic Genetic StandardsGenetic Quality is an integral factor in every scientific research program. Taconic strives for the highest standard of genetic quality and it has in place many different checks at different points of the breeding program to ensure customer confidence.

What is Genetic Quality?Genetic Quality is a level of assurance on the genetics of a model that is being used. In order to guarantee genetic quality, a Genetic Monitoring Program is in place as part of the breeding program. This includes genotyping, genetic background testing, and phenotypic characterization when appropriate. All of this testing is in addition to other husbandry practices that avoid genetic drift and genetic contamination.

Inbreeding ProgramInbred strains are generally bred to the ‘pyramid’ representation. When implemented correctly, the program prevents crossbreeding, genetic drift, and the development of genetic sub-strains. The ‘pyramid’ is sorted as follows: the top is covered with the Foundation Colony, or FC, and is the only self-perpetuating colony. The Foundation Colony is started by a Common Ancestor (CA) pair. There is only one Foundation Colony at Taconic for each inbred strain. All breeders in the FC are brother x sister mated. The Pedigreed Expansion Colony (PEC) is an extension of the Foundation Colony and receives all of its breeders from it; all matings in the PEC are also BxS. The PEC produces breeders for the Expansion Colony (EC), where Taconic once again utilizes BxS matings. The EC produces breeders for the Production Colony (PC), where random mating is utilized to scale up breeding for production of animals that will be shipped to customers. Consequently, inbred mice or rats obtained from Taconic’s Germantown PC are typically not more than ten BxS generations removed from the foundation colony.

Genetic HarmonizationAll production sites follow the same pyramid-breeding scheme in order to ensure that all production sites are genetically harmonized. When multiple Production Colonies are maintained at geographically distinct production sites, each site has its own PEC, but standard operating procedures require that each of these sites receive a new PEC from the Germantown FC every two years (approximately every four generations). Thus, no PC colony can be more than 10 BxS generations removed from the strain’s current Foundation Colony, which, at present, is housed in the Germantown Gnotobiotic Center.

Genetic TestingTaconic uses state of the art technology when performing genetic testing.

SNP PanelsTaconic currently uses Single Nucleotide Polymorphisms (SNPs) Panels to assess the Genetic Integrity of most of its breeding colonies. SNPs are DNA sequence variations that occur when a single nucleotide in the genome is altered. SNPs are dispersed throughout the entire mouse genome. SNPs, like the previously used biochemical and microsatellite markers, produce unique fingerprints that can be mapped to identify the genetic profile of an inbred mouse strain. SNPs usually occur in only two alleles, (e.g. either A or C) and therefore a combination of SNPs is necessary to identify a mouse strain. The advantage of SNP marker-panels is that they are high-throughput so that hundreds or thousands of SNPs can be tested in one sample, and hundreds of samples can be tested simultaneously. Taconic has in-house the Illumina® platform which gives the flexibility needed for fast turnaround of the genetic data. Taconic has incorporated three major SNP marker panels that test for 1449 SNPs, 377 SNPs or 96 SNPs. See page 32 for more information.

PCR and q-PCR Testing Taconic uses Polymerase Chain Reaction (PCR) and its most refined quantitative-PCR (q-PCR) technology to perform most of the genotyping tests needed to verify the presence, absence, and in some cases the number of copies of a particular allele.

Southern Blot AnalysisIn a few instances, genetic results are more challenging to interpret and require further analysis via classical Southern blot assays.


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Genetic Monitoring ProgramTaconic has an established genetic monitoring program that is intimately intertwined with its breeding program.

Inbred Mouse StrainsAll of our inbred mouse strains are under continuous genetic monitoring via an established Genetic Monitoring Program. Taconic has established numerous production procedures that minimize the risk of genetic contamination. Our Genetic Monitoring Program is grounded in the identification of points in the production program where there is a higher risk of an undetected accidental mating or strain misidentification. By focusing genetic screening methods on these critical high-risk points, while scrutinizing quality control throughout, a genetic monitoring program can prevent a single mistake from becoming catastrophic.Taconic’s overall Genetic Monitoring Program is based on a combination of three strategies: (1) visual characteristics of strains (most notably, coat color); (2) production procedures that minimize co-localization and/or movement of strains of similar colors and that promote careful record keeping and strain segregation; and (3) standard operating procedures outlining DNA-based marker testing of animals at specific risk points in the production process.

Genetic Testing of Common Ancestor

• Taconic maintains a single, fully pedigreed FC under defined flora and gnotobiotic conditions, in a plastic-film isolator. The genetic quality control for the FC consists of characterizing the Common Ancestor pair with a 1449 SNP marker panel. Every time an FC is established the strain is characterized with this genetic test.

Genetic Check of Animal Movement

• To minimize the risk of accidental crossbreeding, the traditional pyramid production plan is enhanced by maintaining all four colonies (Foundation, Pedigreed Expansion, Expansion, and Production) in isolation or, where possible, separated from other colonies of similarly colored animals. To complete the flow of animals in the pyramid breeding scheme, replacement breeders have to be transferred, unidirectionally, from the FC to the PEC, and then from the PEC to the EC and PC. However, a risk does exist that animals from an FC housing a similarly colored strain (e.g., BALB/c and FVB) could be transferred to the wrong PEC, one animal in each group of transferred animals is assayed for transfer testing with Taconic’s 96 GenMon SNP panel that has been developed in-house to distinguish the genetic background of all Taconic inbred strains. Every time a strain is transferred from one place to another one animal is tested.

Raising Similarly Colored Strains in One Location

• Generally an inbred strain produced in a Barrier Unit colony is assigned a room or location where it is the only strain of a particular coat color produced in that room. Unfortunately, separation of all strains by coat color is not always possible. One of a number of examples is production of F1 hybrids that requires the use of two similarly colored strains as the inbred parents. Because Taconic prohibits barrier-to-barrier transfers for health reasons, both BALB/cAnNTac and A/JCrTac strains must be produced in the same Isolated Barrier Unit™ (IBU™) to produce the CAF1 hybrid. All three of these models are albino, so genetic monitoring plays an especially important role in situations such as this. Taconic has established SOPs for genetic monitoring so that statistical sampling of the population can provide a high degree of confidence that no mix-up has occurred. In situations where similarly colored strains must be raised in the same production locations, genetic monitoring is done on a number of animals from that strain considering the genetic risk for that barrier and the number of new matings set up on a bi-weekly basis. Barrier personnel select animals from that strain to satisfy the scheduled number for that cycle; each animal selected must be a first-litter pup from a breeding cage that has not been sampled previously. This type of “Production” genetic monitoring continues biweekly as long as there are similarly colored animals in that location. These samples are tested with the GenMon 96 SNP marker panel mentioned above.

Detecting an Unexpected Variant within a Strain

•When coat color variants are reported, Taconic’s procedure is to begin appropriate genetic monitoring assays immediately to ascertain whether this variation is due to accidental strain contamination or is due to a spontaneous mutation in an otherwise pure inbred strain. Typically any unexpected mouse, regardless of strain, location, suspected mode of inheritance of the variant, etc., is analyzed immediately for molecular markers to verify the purity of the strain in which the variant appeared as expeditiously as possible. The 96 SNP GenMon panel is used.

All of our Genetic Monitoring tests in mice are done in-house. This facilitates and guarantees rapid access to testing results.


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Congenic and Genetically Modified StrainsTaconic’s Genetic Monitoring Program stresses the day-to-day importance of maintaining rigorous production and sampling procedures, to provide genetic quality control for our animal models. These same principles of genetic monitoring apply to Taconic Transgenic Models™ (TTMs™) as well as Taconic’s traditional inbred and hybrid models.

Production of TTMs™ on inbred backgrounds follows the same pyramid pattern as inbred strains. For all TTMs™, extensive testing is done on common ancestors to verify background strain (e.g. C57BL/6, FVB, etc.) by the 1449 SNP marker panel. This set of tests can be revealing since many transgenic models are initially created using hybrids and then backcrossed to an inbred strain. It is often found that even after suitable backcrossing some measurable residual heterozygosity exists. Also, there are situations where some strain-defining genes are in close proximity to the transgene and therefore it is extremely difficult to backcross them “out” of the genome and still retain the transgene.

In addition to testing for the background strain, Taconic performs DNA-based genotyping assays to verify the homozygosity of the transgene in the common ancestors of those TTMs™ where transgene homozygosity is a desired result. In cases where the molecular assay does not provide an unequivocal answer on zygosity (as is the case for a number of microinjection transgenic lines where the transgene-integration site has not been cloned), test matings are performed to confirm the common ancestors’ homozygosity. When all of these tests have been performed, the genetic profile of the common ancestors is then documented and the TTM™ is ready for scale-up production.

Ironically, verification of the genetic integrity of transgenic or mutant strains can often be more easily accomplished than with inbred strains, especially in models where the transgene is homozygous. In these situations, the transgene or mutated gene can serve as a marker for the entire genetic profile of the strain. For microinjection or knockout/knockin transgenes that must be maintained in heterozygotes, transgene genotyping is obviously essential for maintenance of the line. However, for TTMs™ in which the transgene is continually homozygous, Taconic has elected to genotype each breeder at mating setup although such genotyping is really not necessary for ensuring presence of the transgene. The logic here is that confirmation of the homozygosity of the transgene of interest indicates that all previous matings in the production scheme have been performed properly (a past contamination would result in heterozygosity for the transgene, unexpected in a homozygous TTM™). Taconic follows this practice with all Taconic Transgenic Models™ that are distributed as homozygotes, instead of repeatedly testing the transgenic line’s background genetic profile.

Outbred MiceOutbred mice are yearly tested to assess the level of heterozygosity on each outbred strain. This testing is done with Taconic’s 96 mouse SNP Panel. All of the breeding precautions, such as visual characteristics of the model, minimizing co-localization of same coat color animals, and careful movement of animals are applied. In addition, Taconic’s outbred stocks are bred using a breeding scheme that assures maximal heterogeneity.

Inbred RatsSimilar to inbred mice except that the testing is done by using a 96 SNP Rat Panel that has been developed by Taconic to differentiate all strains and stocks produced at Taconic.

Outbred RatsSimilar to outbred mice but the yearly testing is done with Taconic’s 96 Rat SNP Panel. In the case of Wistar Hannover GALAS™ for which allelic frequencies are monitored yearly at the global level with a panel of 20 biochemical markers, we are working on the transition to the 96 Rat SNP Panel.

Genetically Modified RatsSame as genetically modified mice but for Common Ancestor, the 96 Rat SNP Panel is used for inbred rats and the mutation is tested at breeder setup.

Strain Cryopreservation ProgramTo avoid the loss of a mouse/rat strain(s) or genetic drift, Taconic has an established Cryopreservation Program. Any new line or strain that is ready to be commercially available is cryopreserved upon receipt and/or rederivation. When a mouse strain at Taconic is scheduled for cryopreservation, Taconic tests donor mice with the 96 GenMon SNP Marker Panel to verify the genetic background of the strain, in addition to pertinent genotyping tests, if applicable.

Genetic RefreshmentTo avoid genetic drift or the unwanted fixation of a sub-strain, all inbred and congenic mouse strains are recovered every five years from cryopreserved embryos to assure the preservation of genetic quality.


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Quality StandardsThroughout our organization, Taconic procedures are governed by and adhere to the highest quality standards, including: • Taconic Global Standard, a rigorous standard we developed

for areas of our organization not governed by the GLP or cGMP regulations.

• Federation of European Laboratory Animal Science Associations (FELASA) standards, which govern the operational procedures at our Denmark facilities.

CertificationTaconic is certified according to 9001:2008 and 14001:2004. We have been certified in the 9001 and 14001 standards since 2007, and a re-certification was achieved in 2010 and all breeding sites are accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALACI).

Key Performance Indicators (KPIs)•% Issue free orders >98.5%• Corrective action closure (days) <30• Animal quality >99.5%• On-time shipments >99.5%• Order accuracy >99%• Invoice accuracy >99%

Scientific ExpertiseTaconic’s commitment to quality is further evidenced in the investment we make and the value we place on employee training and development. U.S. Animal Care Technicians attend intensive training in Standard Operating Procedures, followed by an on-site certification program that provides more in-depth training in key operational areas. They can also employ Taconic’s educational resources to pursue certification by the highly respected AALAS (American Association for Laboratory Animal Science). European technicians complete the authority-certified education required by Danish regulations, which includes a combination of theoretical and practical training.

Taconic offers an experienced, international team to provide information and process your orders for models and services. The team consists of Scientific Directors, Biomedical Research Solution Managers, and Taconic Representatives who together with Customer Service Representatives have an extended access to animal production personnel and board certified veterinarians.

Advanced FacilitiesBeyond our significant training investment, Taconic continually reinvests our profits into the animal facilities, laboratories, and technologies needed to meet our clients’ evolving needs. Taconic’s unique facility barrier systems significantly reduce the risk of colony contamination, while advanced automated systems monitor temperature, humidity, and other variables 24/7. The Taconic barrier systems include Isolated Barrier Units™ (IBUs™), Multiple Barrier Units (MBUs), BioBubble Barrier Units (BBUs), European Barrier Units (EBUs) for Murine Pathogen Free™ and Restricted Flora™ animals, and gnotobiotic isolators for Germfree and Defined Flora animals.

Production and Research Solutions

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Production and Research SolutionsCustom Breeding SolutionsOncology Discovery ServicesTesting SolutionsAnimal Care Products

For 60 years, researchers worldwide have turned to Taconic to breed the mouse and rat models their critical

projects demand. Taconic offers a continuum of services from custom model generation through model

development and breeding. Taconic’s breeding solutions are highly customized to achieve your research goals.

Whether we’re breeding rodents to relieve capacity constraints at your facility, performing derivations to

improve the health of your animals, cryopreserving embryos and sperm to preserve and secure your lines,

or managing complex, multiple gene crossbreeding projects, Taconic can design a program to help you reach

your objectives quickly and efficiently.

Our Project Management Team will work with you to design a breeding program specific to your project. You

will have direct access to our professional level Subject Matter Experts in Embryology, Molecular Analysis,

and Genetics as well as other disciplines. We offer a range of health standards from which to choose. Our

Derivation programs give you control over your animals’ health status and greater confidence in the data

generated from them. Our Rapid Colony Expansion service allows you to quickly develop a large research

colony, while our Cryopreservation services help protect and store your valuable animal lines.

As you review the services offered in this section, please keep in mind that all of our services have been

designed to help speed cohort delivery to you. Let Taconic focus on cohort development so that you can focus

on achieving your research goals.

Custom Breeding Solutions

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Taconic has run over 10,000 projects through 20 years of outsourced breeding services. We offer the most complete and versatile portfolio of services to rapidly expand and efficiently breed your rat or mouse models. We pioneered rapid expansion services, offering the ability to deliver 300 offspring with the same date of birth. Our Project Management Team is second to none and will lead you through seamless importation of donors and development of a comprehensive breeding plan resulting in on-time cohort delivery. Let us focus on cohort production while you focus on attaining your research goals.

TACONIC CUSTOMBREEDING SOLUTIONS

PROJECTMANAGEMENT

eTACONIC FOR 24/7 WEB-BASED ACCESS TO PROJECT DATA

eBUSINESS SUITE PROVIDES PRODUCTION & FINANCIAL REPORTS

ROUTINE COMMUNICATION WITH A DEDICATED PROJECT MANAGER

ACCESS TO PH.D. SCIENTISTS FROM DESIGN TO DELIVERY

PROJECT DEVELOPED BASED ON YOUR RESEARCH GOALS

DEVELOP MILESTONE BASED PROJECT PLAN

SUBJECT MATTER EXPERTS REVIEW PLAN

ENSURE SPEED, QUALITY & VALUE

SEAMLESS IMPORT OF YOUR ANIMALS

DIRECT IMPORT, NO REDERIVATION REQUIRED

REVITALIZATION OF LINES FROM CRYOPRESERVED STOCK

EMBRYO AND SPERM CRYOPRESERVATION & STORAGE

REDERIVATION TO DEFINED HEALTH STATUS AVAILABLE

TACONIC’S GLOBALLY RECOGNIZED HEALTH STANDARDS

OVERSIGHT BY BOARD-CERTIFIED VETERINARIANS

STATE-OF-THE-ART GENETIC CHARACTERIZATION SERVICES

SPEED BACKCROSSING TO DEFINED BACKGROUND

QUICK GENOTYPING RESULTS

MONITORING BREEDING EFFICIENCY

PHENOTYPING ASSAYS AVAILABLE

IMMEDIATE REPORTING OF UNEXPECTED PHENOTYPES

RAPID EXPANSIONS TO ACCELERATE BREEDING COLONY

EFFICIENT BREEDING FORMATS REDUCE TOTAL NUMBER OF ANIMALS PRODUCED

FAST DELIVERY OF COHORTS

ANIMALS SHIPPED WHEN YOU NEED THEM

MULTIPLE ANIMAL IDENTIFICATION TECHNOLOGIES AVAILABLE

WORLDWIDE DISTRIBUTION

PROJECTDESIGN

IMPORTATION OF MODEL

COHORTPRODUCTION

HEALTH

GENETICS

PHENOTYPE

DELIVERYTACONIC TRANSIT CAGE™

Custom Breeding Solutions

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Breeding and HusbandryTaconic offers a variety of venues to house and breed your animals allowing us to match the needs of your project. Your dedicated Project Management Team will guide you through the available options, and as part of a customized breeding and housing plan will recommend the housing environment that is most suitable to meet your needs. Our experts will employ multiple breeding strategies to meet the goals of your project, including standard continuous breeding, synchronized, and peak breeding to generate cohorts of predictable age and size, or timed-mating to produce age-matched cohorts.

Project ManagementWhen you choose Taconic as your solution for custom breeding, you immediately have access to a dedicated Project Management team. Our Project Managers will work alongside a Project Manager to guide you through the variety of available options, and to generate a customized breeding plan that will meet your study needs while balancing quality, speed, efficiency, and cost. Your dedicated Project Manager will serve as your single-point of contact, maintaining regular and informative communication with you and your research team.

Health MonitoringTaconic’s International Health Monitoring System™ (IHMS™) is a globally recognized platform for monitoring and reporting the microbiological status of rodent colonies (see pages 34-37 for additional information on Taconic’s IHMS™). If rederived, your Custom Breeding Solutions (CBS) colony may be maintained at Taconic’s Murine Pathogen Free™ (MPF™) or Restricted Flora™ (RF™) health status. If you choose to bypass derivation, we can apply the necessary testing to determine the health status of your original donor animals, and then maintain your colony at status quo. Housing your CBS colony in compliance with Taconic IHMS™ standards facilitates collaboration and sharing of animals between laboratories by providing consistent, uniform data on animal health status.

Genetic Sciences & GenotypingInherent to breeding genetically modified mice and rats is the need for regular genotyping of animals. Taconic recognizes your need for accuracy, speed, and access to genotyping data for your breeding project. Through an exclusive distributor agreement with Transnetyx, Inc., the world leader in fully-automated genotyping services for genetically modified mice and rats, your Custom Breeding project has access to all the services and advantages that Transnetyx offers. In addition, Taconic offers more conventional genotyping assay capabilities, full assay development and optimization, 3 day turnaround (24 hour turnaround available), and access to consultation by Ph.D.-level molecular biologists and geneticists. Taconic also offers an extensive array of single-nucleotide polymorphism (SNP) testing and analysis services to allow you to better determine the genetic background strain of your study animals (see page 32 for description of Taconic’s genetic services).

Improving Colony Health StatusThe presence of undesired bacterial and viral organisms in your animal colony may affect your experimental results, often in ways that are difficult to detect. Infection with pathogens may prohibit you from shipping animals to your collaborators’ facilities, pose challenges when securing outside funding, or lead to animal welfare

concerns. At Taconic, using just a small number of donor animals from your colony, we can rederive the line using embryo transfer techniques to generate offspring of a defined health status. Your newly rederived colony is available for shipment back to your animal facility, or may be relocated to one of our Custom Breeding facilities for expansion to generate study cohorts. Taconic has no restrictions on the health status of your incoming donor animals, we will accept anything!

Rapid Colony ExpansionTaconic understands the need to generate experimental results with a balance of speed and quality. Research often cannot tolerate the time required to naturally expand a breeding colony to the size necessary to generate study cohorts of the appropriate size. In such cases, Taconic employs in vitro fertilization and large scale embryo transfer methodologies to rapidly expand your colony from a small number of donor animals to hundreds of animals in a single event. The resulting cohort may be used as a single, age-matched experimental group or to accelerate the establishment of your breeding colony in one of our Custom Breeding facilities.

CryopreservationTaconic’s sperm and embryo cryopreservation services provide secure and permanent preservation of your valuable research models. Cryopreservation of your rodent line may serve as a low-cost backup to your active colony to guard against genetic drift or disasters in an animal facility, as a method to archive intermediate genotypes during intercross or backcross breeding, or as an inexpensive alternative for sharing your line with collaborators around the globe. Taconic provides consultation on the cryopreservation platform (sperm or embryo) that is most appropriate for your line. Donor animals for cryopreservation may be shipped directly to Taconic or selected from your Custom Breeding Solutions colony.

CryorecoveryThe ability to revitalize your line from cryopreserved stock is critical to the security provided by cryopreservation. At Taconic, we provide cryorecovery services for lines you have preserved at Taconic or elsewhere. Upon choosing Taconic to revitalize your line, you gain immediate access to consultation by our Embryologist. All animals produced from cryopreserved stock come with a full IHMS™-52 health report (see pages 34-37 for details on Taconic’s IHMS™ health reporting platform) and are available for shipment back to your animal facility, or relocation to one of our Custom Breeding facilities for expansion to generate study cohorts.

eTaconic: Online Colony ManagementWhen you choose Taconic as your solution for custom breeding, you immediately have access to eTaconic, the number one web-based colony management application. eTaconic is a secure, online service that provides 24/7 access to project design information, activity reports, project management tools and colony inventory data. You can make changes to project goals, request sample or animal deliveries, and even initiate new projects through our secure web-based interface. Data are updated every 24 hours. You may also grant access to your projects to multiple laboratory staff, collaborators, and partners per their own individual accounts. eTaconic allows researchers to manage their colonies and move projects forward wherever they are and whenever they need.

Oncology Discovery Services

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In collaboration with Oncodesign, Taconic offers a broad portfolio of translational models and services for use in oncology drug discovery. Each study is custom-designed to best meet our clients’ needs. Interpretive data analysis and summary reports are provided at the completion of each study. Directly benefit from many years of experience in preclinical in vitro / in vivo evaluation of therapeutic drug efficacy. Our expanded tONCO™ portfolio includes:

Drug Efficacy Testing Using Xenografts• More than 400 cancer cell lines for in vivo testing• Xenogeneic, syngeneic, ectopic, orthotopic, or metastatic

in vivo models• Rat cancer models: more than 150 subcutaneous and

orthotopic, xenogeneic, or syngeneic rat tumor models, including chemo-induced and patient-derived tumor models

• All models are standardized with reference drugs and positive controls for quality assurance

tONCO™ gathers the entire range of skills, assays, and databases for drug screening, lead, and clinical candidate selection:

• Drug formulation for in vivo administration• Mechanism of action determination• PK profiling and PD biomarker identification• Dose and schedule optimization• Drug combination evaluation• Drug efficacy and resistance evaluation

Our Ph.D.-led team works with you to select the most appropriate program design and screening method to conduct preclinical assays. A large panel of techniques are routinely used, such as automated in vitro screening; cytotoxicity evaluation; flow cytometry analysis; molecular biology; angiogenesis assays; drug formulation; histopathology and immunohistochemistry; long term in vivo infusion; microsurgery; analytical chemistry for PK, biodistribution, and metabolism of compounds; and imaging of drug efficacy.

Pharmacoimaging SolutionstONCO™ offers the expertise of translational mouse models in combination with an unparalleled panel of imaging instrumentation through Pharmimage®. This imaging platform unites complementary skills in computer science, physics, electronics, chemistry, radiochemistry, biology, medicine, and pharmacology to provide our clients efficient and comprehensive drug evaluation solutions.

Through Pharmimage®, you have access to a unique expertise in multi-parametric pharmacoimaging for both preclinical and clinical applications:

• Magnetic resonance imaging (MRI) and spectroscopy (MRS)

• Positron emission tomography (PET) • Single photon emission computed tomography (SPECT)• X-ray computerized tomography (CT)• Ultrasound (US)• Cyclotron• Radiochemistry labs

Humanized Mouse Models — Predictive Tools for Testing Novel Therapeutics

Immunodeficient Mice Carrying a Human Immune System – the CIEA NOG mouse®

As a super immune deficient mouse and a better recipient for engraftment of human cells, the CIEA NOG mouse® is the best model known for humanization experiments.

• NOG mice can be engrafted with a human immune system using a variety of tissue sources, including PBMCs and hematopoietic stem cells from umbilical cord blood.

• Engrafted human hematopoietic stem cells differentiate in vivo to form a functioning human immune system in a mouse.

Humanized mouse models are refined tools to study the effect of human immune cells in preclinical oncology:

• Assessment of therapeutic immunomodulatory activities• Evaluation of antitumor activity related to antibody

dependent cell cytotoxicity (ADCC)• Study of hematopoiesis • Analysis of innate and adaptive immunity

Patient-Derived Xenograft Platform (PDX): In collaboration with Oncodesign, Taconic provides access to PDX models offering an array of opportunities for translational research:

• More in depth evaluation of targeted therapies compared to immortalized cancer cell lines

• Target identification and validation using fresh clinical and preclinical biological samples

• “Preclinical Phase II” pharmacological proof of concept studies using a panel of human tumors

Inquire today to learn more about the full range of preclinical oncology services offered by Taconic.

tONCO™ — Taconic’s oncology portfolio brought to you in collaboration with Oncodesign.

Testing Solutions

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Testing SolutionsTaconic understands that successful research demands accurate assessment of health and genetic status of the animal model. Our comprehensive Molecular Analysis program, which encompasses Genetic Characterization, Background Strain Characterization and Speed Congenics (using SNP Marker analysis), Real-time PCR Based Genotyping, Gel Based PCR Genotyping, and mRNA Expression Analysis, enables the researcher to perform complete and precise genetic characterization of a research model.

As a provider of the most comprehensive line of testing solutions, Taconic follows the most stringent quality control processes, uses state-of-the-art high-throughput automated technology, and provides fast and accurate results to keep you informed every step of the way. Ph.D.-level scientists and ACLAM-certified veterinarians guide our testing services and work with you to interpret test results as needed.

Taconic’s MolecularAnalysis ProgramTaconic’s Molecular Analysis program provides a comprehensive solution to a customer’s Genetic Testing needs. Verifying the genetic status of a research model is of utmost importance. The quality of your research results largely depends upon accurate, efficient, and consistent genotyping. Taconic’s Molecular Analysis program uses a variety of technologies to fulfill all of the genetic testing needs of our customers. Taconic’s highly skilled scientific staff can assist you in choosing the best services for your research.

Genetic Testing ServicesThrough Taconic’s exclusive distributorship agreement with Transnetyx, Taconic offers its customers a fully automated, high-throughput platform for the genotyping of all of your transgenic, knock-out, knock-in, and conditional animal models. Service includes both a 24* hour and 72 hour turnaround time, secure online ordering and results reporting, and shipping supplies.

Item Number Description Price/sampleGENO-FPCR-1ALLE Genotyping Fluorescence Based PCR 1 Allele €13.85GENO-FPCR-2ALLE Genotyping Fluorescence Based PCR 2 Allele €15.50GENO-FPCR-3ALLE Genotyping Fluorescence Based PCR 3 Allele €17.20 GENO-FPCR-4ALLE Genotyping Fluorescence Based PCR 4 Allele €19.50 GENO-FPCR-5ALLE Genotyping Fluorescence Based PCR 5 Allele €22.75GENO-FPCR-6ALLE Genotyping Fluorescence Based PCR 6 Allele €25.25 GENO-FPCR-7ALLE Genotyping Fluorescence Based PCR 7 Allele €26.80 GENO-FPCR-8ALLE Genotyping Fluorescence Based PCR 8 Allele €28.60 GENO-FPCR-SETUP Initial Set-up (Assay Development)* €423.00*Please inquire for 24 hour pricing.

Gel Based PCRGel based PCR provides the convenience of genotyping your animals without complete transgene sequence information. All of our gel based PCRs are manually performed by our scientific staff using high quality extracted DNA (no tissue lysates). Results are emailed within a 5-7 day turnaround after the transfer of your gel based protocol to our scientific staff.

Item Number Description Price/sampleGENO-PCR-TEST PCR €23.30GENO-PCR-SETUP Initial Set-up (Assay Development)* €423.00* Price includes a comprehensive assay development report.

Zygosity TestingZygosity testing, utilizing quantitative real-time PCR methods, can drastically reduce the timeframe required for test mating. qPCR methods can determine the allele distribution of the transgene (hetero/hemi or homozygote), thereby reducing costs and time associated with traditional backcrossing.

Item Number Description Price/sampleGENO-ZYG-DESIGN Assay Set-up Fee €1276.75GENO-ZYG-1 Zygosity Testing €27.50

Testing Solutions

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Genetic Characterization

Background Strain CharacterizationUnderstanding the underlying causes for phenotype requires a thorough characterization of the genetic background of the animal. Breeding mishaps can happen even in the best managed colonies, and the background genetics can greatly impact research outcomes. Taconic’s Single Nucleotide Polymorphism (SNP) panels will allow you to determine with accuracy the genetic background necessary to ensure the congenics of your line. Please contact your Taconic Representative or e-mail [email protected] for more information.

Item Number Description Price/sampleGENMON-377 377 Marker SNP Panel for Background Strain Characterization €130.10GENMON-1449 1449 Marker SNP Panel for Background Strain Characterization €190.50GENMON-B6N B6 96 Marker SNP Panel for Background Strain Characterization €82.50GENMON-96R Rat 96 Marker SNP Panel for Background Strain Characterization €82.50

Speed CongenicsTraditional backcrossing is cumbersome and time consuming. Our SNP Marker based Speed Congenics program can drastically reduce the time frame to reach a desired congenic background. Our scientific staff is available for consultation and panel selection for your background project. Please contact your Taconic Representative or e-mail [email protected] for more information.

Item Number Description Price/sampleGENCON-Panel 2A 96 Marker SNP Panel - Customized €82.50GENCON-Panel 3A 377 Marker SNP Panel for Speed Congenics €130.10GENCON-Panel 4A 1449 Marker SNP Panel for Speed Congenics €190.50GENCON-B6N B6 96 Marker SNP Panel for Speed Congenics €82.50 (per jvit)

Speed Congenics PackagePackages designed to include Genotyping and Speed Congenics for your backcrossing project. Please contact your Taconic Representative for more information.

mRNA Expression AnalysisOver the past couple of years studies involving RNAi knockdown models have gained center stage. Taconic’s scientists can help you with your RNAi studies in the following area:

Analysis of mRNA levels in tissues of RNAi knockdown modelsTaconic can quantitate the effectiveness of target gene knockdown in your Taconic RNAi model (page 43) to make your model study-ready. A typical project would involve 8 animals (including controls). Service includes induction of gene knockdown, tissue harvest, RNA extraction, cDNA synthesis, and determination of knockdown levels in up to 10 tissues. Please contact our scientific specialists or your dedicated project manager for more information.

Additional ServicesIn addition to the comprehensive Molecular Analysis program, Taconic offers various support services to researchers. Such services include high quality DNA extraction from tissue biopsies.

Item Number Description Price/sampleGENO-DNA-EXTRWH DNA Extraction (each) €22.80

Testing Solutions

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Cell Line Screening Assays for Viral PathogensTaconic offers several RapidMAP™ panels, which provide assurance that cell lines are free of rodent pathogens. Such assurance is essential for cell lines that are destined to enter an animal facility. If you are ready to use your cell lines for in vivo research, or simply want to be sure your cultures are free of Mycoplasma contamination, our RapidMAP™ panels are the perfect solution.

Mycoplasma by PCRA test for cell lines that are used for in vivo and in vitro research, this assay screens for the presence of Mycoplasma species commonly found as cell culture contaminants. Recommended for all cell lines.

Item Number Description Price/sampleMYCO-781 Mycoplasma Test €49.00

RapidMAP™For speed and accuracy, RapidMAP™ utilizes optimized real-time PCR methods. Panels are aligned from common to extensive arrays of rat and mouse viruses. RapidMAP™ panels are recommended for screening cell lines that are destined to enter the animal facility.

Agent Type RapidMAP-12 RapidMAP-21 RapidMAP-24 RapidMAP-27Mycoplasma spp. (MYCO) DNA • • • •

Corona Virus (COR)* DNA • • • •Rodent Parvovirus (PARV)** DNA • • • •Lactate Dehydrogenase Elevating Virus (LDHV) RNA • • • •

Sendai Virus (SEN) RNA • • •Encephalomyelitis (TMEV) RNA • • •Rotavirus (EDIM) RNA • • •Respiratory Enteric Virus III (REO3) RNA • • •Ectromelia Virus (ECTR) DNA • • •Pneumonia Virus of Mice (PVM) RNA • • •Lymphocytic Choriomeningitis Virus (LCM) RNA • • •

Polyoma Virus (POLY) DNA • • •Mouse Cytomegalovirus (MCMV) DNA • • •Mouse Adenovirus (FL) (MAV-1) DNA • • •Mouse Adenovirus (K87) (MAV-2) DNA • •K Virus (KV) DNA • •Rodent Herpes Virus (MTV, RCMV, MCMV) DNA •

Hantaan Virus (HAN) RNA •Price per sample tested €145.75 €340.00 €381.00 €429.00*Corona Virus = MHV, RCV/SDAV**Rodent Parvovirus = MMV, MPV, RMV, RPV, LuIII, Kilham’s Rat Virus, Toolan’s H1

Testing Solutions

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Agent IHMS™-2M IHMS™-6M IHMS™-13M IHMS™-26M IHMS™-52M Method

Viruses (Serology tests)Mouse Hepatitis Virus (MHV) • • • • • ELISAMinute Virus of Mice (MMV) • • • • • ELISAMouse Parvovirus (MPV-1, MPV-2) • • • • • ELISAMouse Rotavirus (EDIM) • • • • • ELISAEncephalomyelitis Virus (GD7) • • • • ELISAPneumonia Virus of Mice (PVM) • • • • ELISASendai Virus (SEN) • • • • ELISALymphocytic Choriomeningitis Virus (LCM) • • • ELISA

Mouse Norovirus (MNV) • • • ELISAEctromelia Virus (ECTR) • • ELISAHantaan Virus (HAN) • • ELISAMouse Adenovirus (MAV-1, MAV-2) • • ELISA

Mouse Cytomegalovirus (MCMV) • • ELISARespiratory Enteric Virus III (REO3) • • ELISA

K Virus (KV) • ELISALactate Dehydrogenase Elevating Virus (LDHV) • Biochem.

AssayPolyoma Virus (POLY) • ELISAMouse Thymic Virus (MTV) • IFA

International Health Monitoring System™ | Mice

Comprehensive Test Panels — MouseTaconic’s comprehensive test panels offer an extensive and economical solution for your animal diagnostic needs. Panels include serology, microbiology, parasitology, histopathology, and molecular analysis, depending on the level of testing selected.

Item Number Description Price/sampleIHMS-2M IHMS™-2 Mouse €32.50IHMS-6M IHMS™-6 Mouse €344.75IHMS-13M IHMS™-13 Mouse €482.25IHMS-26M IHMS™-26 Mouse €535.50IHMS-52M IHMS™-52 Mouse €714.50

Serology Panels Only — MouseRoutine serologic diagnostic panels, based on the IHMS™ design, are available.

Item Number Description Price/sampleIHMS-2S-M Mouse Panel—Serology Only €25.25IHMS-6S-M Mouse Panel—Serology Only €45.25IHMS-13S-M Mouse Panel—Serology Only €55.25IHMS-26S-M Mouse Panel—Serology Only €80.25IHMS-52S-M Mouse Panel—Serology Only €131.25

There is an explosion in the worldwide use of transgenic models. Collaborators need to share these models and transfer them from one facility to another. Veterinarians and facility managers need to be able to easily access consistent uniform data on the microbial profile of these animals to secure and control their facilities. The Taconic International Health Monitoring System™ (IHMS™) gives scientists worldwide a standardized system to determine and communicate the health status of rodent models used in their in vivo studies. IHMS™ meets the most rigorous requirements of scientists worldwide. The comprehensive system meets most standards set by the Federation of European Laboratory Animal Science Associations (FELASA) in Europe.

The IHMS™ is defined by a comprehensive list of agents, test frequency and test methods. Go to www.taconic.com/ihms to see a comprehensive description of IHMS™ panels available as well as the individual agents making up each IHMS™ panel.

International Health Monitoring System™

Testing Solutions

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Bacteria, Mycoplasma, and Fungiβ-hemolytic Streptococcus • • • • CultureBordetella bronchiseptica • • • • CultureCitrobacter rodentium • • • • CultureClostridium piliforme • • • • ELISACorynebacterium kutscheri • • • • CultureKlebsiella oxytoca • • • • CultureKlebsiella pneumoniae • • • • CultureMycoplasma pulmonis /arthritidis • • • • ELISA

Pasteurella pneumotropica • • • • CulturePseudomonas aeruginosa • • • • CultureSalmonella spp. • • • • CultureStaphylococcus aureus • • • • CultureStreptobacillus moniliformis • • • • PCRStreptococcus pneumoniae • • • • CultureCilia Associated Respiratory Bacillus (CARB) • • • ELISA

Corynebacterium bovis* • • • CultureHelicobacter spp. • • • PCRPneumocystis murina • • PCR* Cornyebacterium bovis is tested in immunodeficient animals only (e.g. mice with scid mutation or mice or rats with nude mutation).

International Health Monitoring System™ | Mice (continued)


ParasitesAspiculuris spp. • • • • MicroscopyEimeria spp. • • • • FlotationEntamoeba muris • • • • MicroscopyGiardia muris • • • • MicroscopyLiponyssus spp. • • • • MicroscopyMyobia spp. • • • • MicroscopyMyocoptes spp. • • • • MicroscopyNotoedres spp. • • • • MicroscopyPolyplax spp. • • • • MicroscopyPsorergates spp. • • • • MicroscopyRadfordia spp. • • • • MicroscopySpironucleus spp. • • • • MicroscopySyphacia spp. • • • • MicroscopyTrichomonads • • • • MicroscopyRodentolepis nana • • • • FlotationHymenolepis spp. • • • • Flotation Klossiella muris • • HistopathologyEncephalitozoon cuniculi • ELISAHistopathologyIlium, Kidneys, Liver, and Lungs • • Histopathology

Testing Solutions

www.taconic.com • +45 70 23 04 0536

Agent IHMS™-2R IHMS™-6R IHMS™-13R IHMS™-26R IHMS™-52R Method

Viruses (Serology tests)Kilham’s Rat Virus (KRV) • • • • • ELISARat Coronavirus (SDAV/RCV) • • • • • ELISARat Parvovirus (RPV) • • • • • ELISARat Minute Virus (RMV) • • • • • ELISAToolan’s H-1 Parvovirus (TH1) • • • • • ELISA

Encephalomyelitis Virus (GD7/RTV) • • • • ELISA

Pneumonia Virus of Mice (PVM) • • • • ELISA

Sendai Virus (SEN) • • • • ELISAHantaan Virus (HAN) • • ELISAMouse Adenovirus (MAV-1, MAV-2) • • ELISA

Respiratory Enteric Virus III (REO3) • • ELISA

International Health Monitoring System™ | Rats

Comprehensive Test Panels — RatTaconic’s comprehensive test panels offer an extensive and economical solution for your animal diagnostic needs. Panels include serology, microbiology, parasitology, histopathology, and molecular analysis, depending on the level of testing selected.

Item Number Description Price/sampleIHMS-2R IHMS™-2 Rat €43.00IHMS-6R IHMS™-6 Rat €355.00IHMS-13R IHMS™-13 Rat €492.50IHMS-26R IHMS™-26 Rat €535.50IHMS-52R IHMS™-52 Rat €669.50

Serology Panels Only — RatRoutine serologic diagnostic panels, based on the IHMS™ design, are available.

Item Number Description Price/sampleIHMS-2S-R Rat Panel—Serology Only €27.75IHMS-6S-R Rat Panel—Serology Only €47.75IHMS-13S-R Rat Panel—Serology Only €52.75IHMS-26S-R Rat Panel—Serology Only €72.75IHMS-52S-R Rat Panel—Serology Only €99.50

Testing Solutions

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International Health Monitoring System™ | Rats (continued)


Bacteria, Mycoplasma, and Fungiβ-hemolytic Streptococcus • • • • CultureBordetella bronchiseptica • • • • CultureClostridium piliforme • • • • ELISACorynebacterium kutscheri • • • • CultureKlebsiella oxytoca • • • • CultureKlebsiella pneumoniae • • • • CultureMycoplasma pulmonis/arthritidis • • • • ELISA

Pasteurella pneumotropica • • • • CulturePseudomonas aeruginosa • • • • CultureSalmonella spp. • • • • CultureStaphylococcus aureus • • • • CultureStreptobacillus moniliformis • • • • PCRStreptococcus pneumoniae • • • • CultureCilia Associated Respiratory Bacillus (CARB) • • • ELISA

Corynebacterium bovis * • • • CultureHelicobacter spp. • • • PCRPneumocystis carinii • • PCR* Cornyebacterium bovis is tested in immunodeficient animals only (e.g. mice with scid mutation or mice or rats with nude mutation).


ParasitesAspiculuris spp. • • • • MicroscopyEimeria spp. • • • • FlotationEntamoeba muris • • • • MicroscopyGiardia muris • • • • MicroscopyLiponyssus spp. • • • • MicroscopyMyobia spp. • • • • MicroscopyMyocoptes spp. • • • • MicroscopyNotoedres spp. • • • • MicroscopyPolyplax spp. • • • • MicroscopyPsorergates spp. • • • • MicroscopyRadfordia spp. • • • • MicroscopySpironucleus spp. • • • • MicroscopySyphacia spp. • • • • MicroscopyTrichomonads • • • • MicroscopyTrichosomoides crassicauda • • • • Histopathology

Rodentolepis nana • • • • FlotationHymenolepis spp. • • • • Flotation Klossiella muris • • • Histopathology

Encephalitozoon cuniculi • ELISAHistopathologyIlium, Kidneys, Liver, and Lungs • • Histopathology

Testing Solutions

www.taconic.com • +45 70 23 04 0538

Serological TestsIndividual ImmunoassaysIndividual health testing requirements differ among institutions. Taconic offers the option of customizing a serology panel that meets your needs. Discounts are available for custom panels that would be run on a repeated basis.

Item Number Abbr Agent ELISA IFASERO-201-027 CARB Cilia Associated Respiratory Bacillus €11.25 €23.60 SERO-201-029 CPIL Clostridium piliforme-Tyzzer's Disease €11.25 €23.60 SERO-201-011 ECTR Ectromelia Virus €11.25 €23.60 SERO-201-021 ECUN Encephalitozoon cuniculi €11.25 €23.60 SERO-201-016 EDIM Epizootic Diarrhea of Infant Mice €11.25 €23.60 SERO-201-018 HAN Hantaan Virus €11.25 €23.60 SERO-201-005 KV K Virus €11.25 €23.60 SERO-201-013 KRV Kilham’s Rat Virus €11.25 €23.60 SERO-201-008 LCM Lymphocytic Choriomeningitis Virus €11.25 €23.60

SERO-201-010 MAV-1, MAV-2 Mouse Adenovirus (MAV-1, MAV-2) €11.25 €23.60

SERO-201-019 MCMV Mouse Cytomegalovirus/Salivary Gland Virus €11.25 €23.60 SERO-201-004 MHV Mouse Hepatitis Virus €11.25 €23.60 SERO-201-001 MMV Mouse Minute Virus €11.25 €23.60 SERO-201-035 MNV Mouse Norovirus €11.25 €23.60

SERO-201-030 MPV1, 2 Mouse Parvovirus (MPV-1, MPV-2) €11.25 €23.60

SERO-201-017 MYCO Mycoplasma pulmonis €11.25 €23.60 SERO-201-002 PVM Pneumonia Virus of Mice €11.25 €23.60 SERO-201-012 POLY Polyoma Virus €11.25 €23.60 SERO-201-033 RMV Rat Minute Virus €11.25 —SERO-201-031 RPV Rat Parvovirus €11.25 €23.60 SERO-201-003 RE03 Respiratory Enteric Orphan III Virus (ELISA) €11.25 €23.60 SERO-201-007 SEN Sendai Virus €11.25 €23.60

SERO-201-015 SDAV/RCV Sialodacryoadenitis Virus/Rat Coronavirus €11.25 €23.60

SERO-201-006 GD7 Theiler's Meningoencephalomyelitis Virus Group €11.25 €23.60 SERO-201-014 TH1 Toolan’s H-1 Parvovirus €11.25 €23.60

Price/Method* Per Serum Sample

Animal Care Products

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Taconic is dedicated to the responsible care, feeding, and shipment of your valuable animal models. The same high-quality products we use in fulfilling that mission are available for your purchase as well. These products enable you to take a consistent approach to raising and maintaining your laboratory animals, to ensure their heath and well-being, and to minimize unnecessary variability in your research. Taconic shipping products provide the optimal environment for transporting your animals safely and securely.


Gnotobiotic EquipmentItem Number Description PriceCON_GF Germfree Shipper €478.20

Animal FeedTaconic makes the NIH-31M diet, which is fed to our animals, available to researchers in 30 lb. autoclavable bags. Customers may specify shipments to be non-autoclaved or autoclaved and over-wrapped. Visit www.taconic.com for formulation and proximate analysis.

Item Number Description PriceAutoclavable NIH-31M DietFEED_NONAUTOCLV Non-Autoclaved* €30.10FEED_AUTOCLV Autoclaved and over-wrapped* €54.30*10% discount on 2+ bags

Animal BeddingBedding comprised solely of hardwood chips is supplied in 30 lb. bags. The bags are made of 2-ply Kraft paper and are fully autoclavable. All chips are free of splinters, excessive dust, and foreign particles.

Item Number Description PriceHardwood Chip BeddingBED_NONAUTOCLV Non-Autoclaved €18.60BED_AUTOCLV Autoclaved €34.40


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Taconic Transit Cage™The Taconic Transit Cage™ (TTC™) provides the optimal shipping environment for today’s sophisticated rats and mice. The TTC™ offers the following:

• The top rim of the lid is recessed, allowing for easier removal.• Ribs are extended for easier access to insert and remove dividers.• A bar below the wire tie holes makes it easier to access the zip tie for cutting.

Item Number Description Price1-49 50+

CON_TTC_CLR TTC™ with standard clear lid €33.00 €31.00CON_TTC_CLRHIGH TTC™ with clear high profile lid €33.00 €31.00Item Number Description PriceCON_LABEL Live Animal Labels (20 per package) €6.60CON_GEL Gel Pack (8 oz. each) €8.80CON_DIV Plastic Dividers (Specify Low or High Lid) (each) €4.90CON_SEC_TIES Security Ties (100) €5.90CON_TTC_BOT Cage Bottom with Filter €15.30CON_TTC_LO/CL OR HI/CL Lid with Filter (Specify Low or High Lid) (each) €15.30

CMGSCustom Model Generation Solutions

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Custom Model Generation Solutions

Genetically modified mice and rats have proven to be critically important in elucidating the roles

of genes in both health and disease. In addition, these custom models are playing an increasingly

important role in enabling biomedical researchers to reduce time spent on target validation and

assay development during preclinical drug development. Taconic provides researchers with a

wide variety of custom made, genetically modified mice and rats that will advance and accelerate

both basic research and drug discovery. Custom models produced by Taconic include constitutive

and conditional knockouts, humanization, random and targeted transgenesis, and constitutive

as well as conditional gene knock ins. Taconic also offers highly innovative custom models such

as inducible and reversible RNAi knock down and microRNA expressing mice and rats as well as

KinaseSwitch mice.

From model design to phenotypic data, Taconic offers comprehensive solutions of highest quality

and with rapid time lines, including model generation and breeding of study-ready cohorts.

Our experienced scientists can help you choose the best model for your specific research needs

and a dedicated project management team will assist you in all technical aspects of your

custom project.


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CMGS

Taconic offers the most versatile portfolio of technologies to generate mouse and rat models. And we take you through the entire process of custom model generation — from design to data — in the shortest possible time!

CONDITIONAL KNOCK OUT

CONSTITUTIVE KNOCK OUT

CONDITIONAL KNOCK OUTWITH CRE-ER GENE SWITCH

CONSTITUTIVE WITH THEOPTION FOR CONDITIONALKNOCK OUT

GENE INACTIVATION

TARGETED TRANSGENESIS

CONDITIONAL TARGETEDTRANSGENESIS

RANDOM TRANSGENESIS

TRANSGENE EXPRESSION

INDUCIBLE/REVERSIBLECONTROL OF

GENE FUNCTION

KINASESWITCH

INDUCIBLE/REVERSIBLERNA INTERFERENCE

INDUCIBLE AND REVERSIBLEOVEREXPRESSION OF miRNAs

CONSTITUTIVE KNOCK IN

HUMANIZATION

HUMANIZATION WITH OPTIONAL CONDITIONAL KNOCK OUT

CONDITIONAL KNOCK IN

CONSTITUTIVE KNOCK IN WITH OPTIONAL CONDITIONAL KNOCK OUT

GENE MUTATIONOR REPLACEMENT

CUSTOM MODELGENERATION SOLUTIONS

CMGSCustom Model Generation Solutions

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GENE INACTIVATION

• CONSTITUTIVE KNOCKOUTEliminates gene function in all cells throughout development of the mouse. Valuable for gene function analysis and drug target validation. Useful for basic gene function analysis, disease modeling, drug target validation, and compound studies. Model Generation: 38 weeks.

• CONDITIONAL KNOCKOUTEliminates gene function in a tissue-specific pattern. Allows examination of gene function in the desired tissue when combined with the appropriate Cre line. Useful for advanced gene function analysis, disease modeling, drug target validation, and compound studies.Model Generation: 40 weeks.

• CONDITIONAL KNOCKOUT WITH CRE-ER GENE SWITCH

Eliminates gene function in an inducible manner using our proprietary Cre-ER technology. Allows examination of gene function or target validation at the desired stage of mouse development. Useful for advanced gene function analysis, disease modeling, and drug target validation.Model Generation: 40 weeks.

• CONSTITUTIVE WITH THE OPTION FOR CONDITIONAL KNOCKOUT

Allows the flexibility to generate both the constitutive knockout and the conditional knockout from the same gene targeting event, saving time and resources. Constitutive Model Generation: 40 weeks (conditional model an additional 12 weeks, or upon request in parallel).

GENE MUTATION OR REPLACEMENT

• CONSTITUTIVE KNOCK INIntroduction of a mutation and/or reporter gene to follow gene function and/or expression. Can also be combined with conditional approaches. Useful for advanced gene function analysis, disease modeling, drug target validation, and compound testing.Model Generation: 40 weeks.

• HUMANIZATIONReplacement of the murine gene with the human counterpart in a single step, placing the gene in the same transcriptional context as the murine gene. Very useful for in vivo testing of compounds against human proteins in the mouse and modeling of human disease.Model Generation: 40-42 weeks.

• HUMANIZED KNOCK IN WITH OPTIONAL CONDITIONAL KNOCKOUT

Combines the humanization with conditional approaches, resulting in the ability to also delete the humanized gene in a ubiquitous, spatial, or temporal manner. Useful for in vivo testing of compounds against human proteins in the mouse and comparing the effect of the compound against the null allele. Model Generation: 44 weeks.

• CONDITIONAL KNOCK INThese sophisticated custom mouse models allow you to switch from the expression of the endogenous version of a gene to a mutant version in a conditional manner. Useful for advanced gene function analysis and drug target validation.Model Generation: 40-44 weeks.

• CONSTITUTIVE KNOCK IN WITH CONDITIONAL KNOCKOUT

Allows the ubiquitous, spatial, or temporal removal of a part of or the entire constitutive knock in allele. Useful for comparing the effect of a mutant allele against the null background in e.g. compound testing studies or advanced gene function studies.Model Generation: 42 weeks.

TRANSGENE EXPRESSION

• TARGETED TRANSGENESISEfficient and directed introduction of a gene at a well-characterized, transcriptionally active locus in the mouse genome, with multiple advantages over the pronuclear injection approach. Useful for basic gene function studies, disease modeling, drug target validation, and compound testing.Model Generation: 34 weeks.

• CONDITIONAL TARGETED TRANSGENESISAllows tissue specific or inducible expression of a transgene in combination with the appropriate Cre line. Useful for advanced gene function studies, disease modeling, drug target validation, and compound testing.Model Generation: 34 weeks.

• RANDOM TRANSGENESISRandom integration of gene(s) by pronuclear injection (PNI). Taconic’s Custom Transgenic Program enables you to generate mouse/rat models carrying a single or multiple gene copy numbers at a random integration site. Useful for basic gene function studies, disease model generation, drug target validation, and compound testing.Model Generation: 9-12 weeks for transgenic founder production.

INDUCIBLE/REVERSIBLE CONTROL OF GENE FUNCTION

• REVERSIBLE RNA INTERFERENCE (RNAi)Inducible and reversible RNA-mediated knock down. Stable introduction of short hairpin RNA (shRNA) by Targeted Transgenesis into the mouse genome allows for inducible and reversible knock down of target gene expression by 70-90%. We offer knock down of single targets or multiple targets at the same time. Useful for advanced gene function analysis and to mimic the effects of a specific drug for drug target validation.Model Generation: 38 weeks.

• INDUCIBLE AND REVERSIBLE OVEREXPRESSION OF miRNAs

Stable introduction of an expression cassette into the mouse genome by Targeted Transgenesis allows inducible expression of miRNAs from a PolIII promoter. Useful for functional analysis of microRNAs.Model Generation: 38 weeks.

• KINASESWITCHInducible and reversible in vivo inhibition based on proprietary technology using silent point mutations to make kinases exquisitely sensitive to a well characterized small molecule inhibitor. Allows rigorous validation of kinases as drug targets.(See page 92).


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CMGS

Genetically Humanized Mouse Models

Native or Mutant Human Gene

Therapy

Genetically Humanized Mouse Models provide a far more predictive tool than wild type mice to model human disease and for testing the efficacy of therapeutic compounds. By replacing key murine genes with their human counterparts, these models enable you to increase the impact of your research on human diseases, speed drug discovery, and reduce the time-to-market of new therapeutics.

Experience: With more than 150 genetically humanized models generated, Taconic is the market leader in genetic humanizations. Our experienced scientific team has a large track record of success, proven by many publications in high-impact scientific journals.

Expertise: Exchange of up to 30 kb of genomic sequence can be routinely done at Taconic. We are continuously pushing the envelope to increase the size limit for single-step gene replacements. Typically, humanized targeting constructs take only about 8-10 weeks to generate.

Speed & Quality: Our strict adherence to multiple quality controls during all steps of our integrated production process ensures you will get the most reliable and meaningful data from your humanized mouse in the shortest possible time.

Animal Models

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Study-Ready Optionsavailable see page 46

Please see the Conditions of Use for Taconic Transgenic Models™ on page 105. The terms and conditions of use for Emerging Models varies by model. Please visit the website for details on your model of interest.

Animal ModelsTraditional and Spontaneous Mutant ModelsTaconic Transgenic ModelsCyropreserved Taconic LinesEmerging ModelsTaconic Knockout (KO) Repository

Taconic recognizes the important role that readily accessible, well-defined animal models play in your drug

discovery efforts. That's why we offer a wide range of mouse and rat models.

Taconic provides a large number of traditional models widely used in toxicology, immunology, and

pharmacology safety testing projects, and naturally occurring spontaneous mutant models used in the

study of diabetes, obesity, cancer, and immune deficiency. Taconic study-ready models enable investigators

to outsource the development and maintenance of models that require custom diet administration, timed

injections, or a combination of manipulations, as well as rodents that have been surgically modified.

Taconic also produces pseudopregnant and superovulated mice that can speed your research by allowing

you to expand a colony quickly.

Several unique Taconic programs bring transgenic rodent models to the research community faster and

more efficiently than ever before. The Taconic Transgenic Models™ portfolio (TTM™) offers ready access to

fully licensed transgenic models available off-the-shelf in typical study quantities with full use rights. Our

TTMs™ are widely used in ADME, metabolic and cardiovascular disease, neurodegeneration, short-term

carcinogenicity bioassays, immunology, and oncology studies. The Taconic Emerging Models Program

facilitates the sharing of new transgenic models rapidly and widely across the scientific community,

by maintaining a repository of investigator-sponsored models bred and distributed by Taconic. When

proprietary knockout models are needed on a fast time line, Taconic’s unrivaled portfolio of more than

4,000 knockout mouse lines provides easy access – eliminating the long lead times required for model

design and development.

Animal Models

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Study-Ready OptionsStudy-ready options are available for Taconic commercial animals. Let Taconic help you reduce costs and speed your time to market by preparing models for your studies. Letting us prepare your models enabling you to focus on your research.

Basic Phenotyping Assays Performing basic phenotypic assays on your genetically modified models can provide key data points to better prepare your models for studies. Taconic offers the following basic phenotyping assays: blood and urine chemistry panels, hematology, body and organ weight measurements, histopathology, and prenatal evaluation and analyses.

Diet Administration Protocols Taconic offers custom diet administration studies that entail maintaining animals on modified diets with live animal shipment or other end points. Using client-directed protocols, all variables can be set to meet research needs.

AgingMost Taconic commercial mouse and rat models can be aged to your specifications. This allows you to receive the animals in your facility at the right age and time for your study.

Murine Biospecimen Collection Organs, fluids, and tissues can be harvested from Taconic animal models or Contract Breeding Lines. Biospecimens are available as fresh harvest, frozen, or flash frozen using liquid nitrogen or in RNAlater® for gene expression studies.

Pseudopregnant Mice Used as a recipient for embryo implantation after embryonic stem cell injection and embryo transfer derivations. Produced by mating adult female mice to vasectomized males. Observation for a copulatory plug determines 0.5 post-coitus (pc) pseudopregnancy. Delivery at day 1.5 pc or greater.

Superovulated Models Superovulated mice are used as a source for donor blastocysts typically at 3.5 days pc. Mice and rats are produced by an injection regimen of PMSG and hCG hormones to prepubescent females, which are then bred to males. Observation for a copulatory plug determines day 0.5 pc pregnancy. Black 6 mice and Sprague Dawley® rats are typically used for superovulation.

Taconic provides dependable and humane solutions for all of your research needs. When you need individually identified mouse and rat models to keep your research moving further, faster — Taconic offers a truly customized solution.

Animal Models

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129S6 INBRED

Applications Health Age (weeks) Males Females

Metabolic/ Cardiovascular DiseaseNeurodegenerationTransgenic Model Generation Support

MPF 3 to 4 €31.20 €34.005 to 6 €35.50 €37.507 to 8 €39.30 €41.209 €44.80 €46.7010 €43.20 €45.1011 €47.10 €49.0012 €51.00 €52.90Retired Breeder €41.20 €41.20Untimed pregnant* €119.50Timed pregnant €135.10

RF 3 to 4 €33.40 €37.505 to 6 €37.50 €41.807 to 8 €41.30 €45.309 €50.30 €51.90Retired Breeder €44.60 €44.60Untimed pregnant* €137.80

* Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

Model Number: 129SVENomenclature129S6/SvEvTac

TRADITIONAL & SPONTANEOUS MUTANT | MOUSE

Ahr KnockoutMouse CONSTITUTIVE KNOCKOUT

Applications Zygosity User Male or Female

CYP InductionDrug Toxicity, and Efficacy

Homozygous (M) Non-Profit €115.00

Homozygous (M) For-Profit €150.00

Model Number: 9166NomenclatureC57BL/6-Ahrtm1.2Arte

EMERGING MODEL

Model Number: 4026NomenclatureB6.SJL(129)-Ptprca H2-Ab1tm1Gru

/BoyAiTacAbb (H2-Ab1) CONSTITUTIVE KNOCKOUT

Applications Zygosity Age (weeks) Male or Female

Immunology Homozygous (M) 4 to 8 €68.209 to 12 €79.50Retired breeder €79.50

TACONIC TRANSGENIC MODEL™

Abb (H2-Ab1) CONSTITUTIVE KNOCKOUT



Model Number: ABBN12NomenclatureB6.129-H2-Ab1tm1Gru N12


Animal Models

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Apoe (ApoE) CONSTITUTIVE KNOCKOUT


Lipid Metabolism & Atherosclerosis

Homozygous (M) 4 to 8 €87.509 to 12 €94.90Retired breeder €117.60

Model Number: APOENomenclatureB6.129P2-Apoetm1Unc N11


ApoB100 MICROINJECTED


Lipid Transport & Atherosclerosis

Hemizygous (T) 4 to 8 €254.909 to 12 €270.10Retired breeder €291.10

Model Number: 1004NomenclatureB6.SJL-Tg(APOB)1102Sgy N20+?


APOE3 HUMANIZED KNOCK IN


Humanpolymorphism in lipid metabolism, atherosclerosis, and neurodegeneration


Model Number: 1548NomenclatureB6.129P2-Apoetm2(APOE*3)Mae N8




Humanpolymorphism in lipid metabolism, atherosclerosis, and neurodegeneration






Humanpolymorphism in lipid metabolism and atherosclerosis




Animal Models

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APPSWE MICROINJECTED


Mechanisms and treatment of Alzheimer’s disease

Hemizygous (T) 6 to 12 €333.00Retired breeder €454.70 (male)

Wild Type (W) 6 to 12 €97.20

Model Number: 1349NomenclatureB6;SJL-Tg(APPSWE)2576Kha





Hemizygous (T) 6 to 12 €424.00

Wild Type (W) 6 to 12 €136.00

Animals that have pink or red eyes, associated with certain coat colors, or are homozygous for the Pde6brd1 retinal degenerationmutation can be blind by weaning. 1349-RD1 mice have pigmented eyes, are wild type or heterozygous for the Pde6brd1

mutation and do not exhibit the blindness phenotype.

Model Number: 1349-RD1NomenclatureB6;SJL-Tg(APPSWE)2576Kha





Hemizygous (T) 6 to 12 €333.00Retired breeder €454.70 (male)

Wild Type (W) 6 to 12 €136.00

Model Number: 2789Nomenclature129S6.Cg-Tg(APPSWE)2576Kha N20+?


APPSWE-Tau MICROINJECTED



Hemizygous/Hemizygous (TT)

4 to 12 €376.30

Wild Type/Hemizygous (WT)

4 to 12 €182.50

Model Number: 2469NomenclatureSTOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc


Animal Models

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4 to 12 €406.40

Wild Type/Hemizygous (WT)

4 to 12 €197.10

Animals that have pink or red eyes, associated with certain coat colors, or are homozygous for the Pde6brd1 retinal degenerationmutation can be blind by weaning. 2469-RD1 mice have pigmented eyes, are wild type or heterozygous for the Pde6brd1

mutation and do not exhibit the blindness phenotype.

Model Number: 2469-RD1NomenclatureSTOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc




Mechanisms and treatment of Alzheimer’s disease (control mice)

Wild Type/Wild Type (WW)

4 to 12 €147.80

Animals that have pink or red eyes, associated with certain coat colors, or are homozygous for the Pde6brd1 retinal degeneration mutation can be blind by weaning. 3273-RD1 mice have pigmented eyes, are wild type or heterozygous for the Pde6brd1 mutation and do not exhibit the blindness phenotype.

Model Number: 3273-RD1NomenclatureSTOCK





Wild Type/Wild Type (WW)

4 to 12 €136.80

Model Number: 3273NomenclatureSTOCK


Model Number: 10498NomenclatureFVB/NTac-Tg(Actb-luc)46Xenβ-actin-luc LPTA® MICROINJECTED

Applications Zygosity User Age (weeks) Male or Female

Imaging: adoptive transfer. Donor animals for studying the transplantation of various tissue types.

Hemizygous (T)

Non-Profit 5 to 12 €160.00For-Profit 5 to 12 €235.00

EMERGING MODEL

Animal Models

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Model Number: 10500NomenclatureB6;FVB-Tyrc-2J Tg(Actb-luc)46Xenβ-actin-luc LPTA® MICROINJECTED


Imaging: adoptive transfer. Donor animals for studying the transplantation of various tissue types.

Hemizygous (T)


EMERGING MODEL

B2m (β2m) CONSTITUTIVE KNOCKOUT



Model Number: B2MN12NomenclatureB6.129-B2mtm1Jae N12


B6 Albino CONSTITUTIVE KNOCK IN


Model Generation: Improved blastocyst host for B6-derived ES cells

Homozygous (M)

3 to 5 €28.006 to 8 €32.009 to 12 €36.00

Model Number: 11971NomenclatureC57BL/6NTac-Tyrtm1Arte

EMERGING MODEL

Model Number: 11227NomenclatureC57BL/6NTac-Atm1.1Arte Tyrtm1Arte

CONSTITUTIVE KNOCK IN/B6 Albino A++ CONSTITUTIVE KNOCKOUT


Model Generation: improved blastocyst host for B6-derived ES cells

Homozygous/Homozygous (MM)

3 to 5 €50.006 to 8 €55.009 to 12 €60.00

EMERGING MODEL

B6 nude SPONTANEOUS MUTANT – T-CELL DEFICIENT

Applications Zygosity Health Age (weeks) Males Females

ImmunologyOncology

Homozygous (M)

Heterozygous (T)

RF 4 to 8 €112.80 €124.109 to 12 €124.50 €141.20

Retired breeder* €126.70 €126.70

* Heterozygous female or homozygous male

Model Number: B6NUNomenclatureB6NTac.Cg-Foxn1nu/Tac


Animal Models

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B6C3F1 HYBRID


ImmunologyToxicologyTransgenic Model Generation Support

MPF 3 to 4 €13.30 €15.405 to 6 €14.80 €16.707 to 9 €16.10 €18.2010 €20.00 €22.10


Not available off-the-shelf - animals setup at order placement.

Model Number: B6C3F1NomenclatureB6C3F1/Tac


B6129F1 HYBRID



MPF 3 to 4 €16.10 €16.105 to 6 €18.30 €18.307 to 9 €20.50 €20.5010 €24.70 €24.70B6 female with litter (5 B6129 pups) €95.60Untimed pregnant* €87.10


Model Number: B6129NomenclatureB6129S6F1/Tac


B6.SJL CONGENIC


ImmunologyTransplantation

MPF 3 to 4 €31.40 €36.205 to 6 €36.50 €43.607 to 8 €43.50 €53.209 €43.50 €58.9010 €47.60 €64.6011 €51.60 €70.2012 €55.60 €75.90Retired breeder €53.60 €53.60Female with litter (8 pups) €202.80Untimed pregnant* €140.80


Model Number: 4007NomenclatureB6.SJL-Ptprca/BoyAiTac


Animal Models

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BALB/c INBRED


AgingCardiovascular DiseaseGeneral PurposeImmunologyMonoclonal Antibody ProductionPharmacology

1-199 200+ 1-199 200+

MPF 3 to 4 €12.40 €12.40 €13.50 €13.505 to 6 €13.20 €13.20 €14.30 €14.307 to 8 €14.10 €14.10 €15.20 €15.209 €16.30 €16.30 €17.40 €17.4010 €18.00 €18.00 €19.10 €19.10Retired Breeder €15.20 €15.20


Model Number: BALBNomenclatureBALB/cAnNTac


B6SJLF1 HYBRID



MPF 3 to 4 €19.80 €22.905 to 6 €21.80 €24.707 to 9 €24.10 €27.0010 €28.00 €30.90Untimed pregnant* €126.00


Model Number: B6SJLNomenclatureB6SJLF1/Tac


B6D2F1 HYBRID


BehaviorImmunologyToxicologyTransgenic Model Generation Support

MPF 3 to 4 €13.30 €15.305 to 6 €14.80 €16.507 to 9 €16.50 €18.2010 €20.40 €22.10Untimed pregnant* €84.00

* Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit. Not available off-the-shelf - animals setup at order placement.

Model Number: B6D2F1NomenclatureB6D2F1/Tac


Animal Models

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BALB/cJBom INBRED



MPF 3 to 4 €14.00 €15.105 to 6 €14.60 €16.007 to 8 €15.80 €17.10Retired Breeder €17.10 €17.10Untimed Pregnant €89.00

Ships from European colonies.

Model Number: BALJBONomenclatureBALB/cJBomTac


BALB/cABom INBRED



MPF 3 to 4 €14.40 €15.505 to 6 €15.20 €16.407 to 9 €16.30 €17.60

Model Number: BALBOMNomenclatureBALB/cABomTac


SPONTANEOUS MUTANT BALB/c nude – T-CELL DEFICIENT


ImmunologyOncology

Homozygous (M)

Heterozygous (T)

RF 4 to 8 €89.80 €89.809 to 12 €102.00 €102.00Retired breeder* €89.80 €89.80Untimed pregnant €439.30

DF 4 to 8 €114.20 €114.209 to 12 €129.90 €129.90Retired breeder* €114.20 €114.20Untimed pregnant €475.80

* Heterozygous female or homozygous male

Model Number: BALBNUNomenclatureC.Cg-Foxn1nu/AnNTac


Bcrp CONSTITUTIVE KNOCKOUT


Drug Disposition Homozygous (M) 4 to 8 €163.009 to 12 €169.00Retired breeder €163.00

Model Number: 2767NomenclatureFVB.129P2-Abcg2tm1Ahs N7


Animal Models

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Black 6 INBRED


AddictionAgingBehaviorCardiovascular DiseaseImmunologyMetabolic DiseaseOncologyToxicologyTransgenic Model Generation Support

1-199 200+ 1-199 200+

MPF 3 to 4 €13.70 €13.20 €14.40 €13.805 to 6 €14.50 €14.00 €15.10 €14.707 to 9 €15.50 €15.10 €16.10 €15.6010 €22.30 €22.30 €20.00 €19.6011 €22.30 €22.30 €23.90 €23.5012 €22.30 €22.30 €27.80 €27.40Retired Breeder €16.10 €16.10

RF 3 to 4 €16.60 €17.205 to 6 €17.30 €18.107 to 9 €18.70 €19.3010 €24.60 —Retired Breeder €16.70 €16.70

Model Number: B6NomenclatureC57BL/6NTac


Black 6JBom INBRED


AddictionAgingBehaviorCardiovascular DiseaseImmunologyMetabolic DiseaseOncologyToxicologyTransgenic Model Generation Support

MPF 3 to 4 €13.60 €14.205 to 6 €14.30 €15.007 to 9 €15.40 €15.90

Model Number: B6JBOMNomenclatureC57BL/6JBomTac


Black Swiss OUTBRED


Behavior - ManiaReproductive BiologyTransgenic Model Generation SupportToxicology

RF 3 to 4 €6.10 €6.605 to 6 €6.60 €7.307 to 8 €7.90 €8.209 to 10 €14.30 €14.7011 €20.70 €21.1012 €27.20 €27.50Retired Breeder €7.30 €7.30


Model Number: BLKSWNomenclatureNTac:NIHBS


Animal Models

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Brca1-Associated CONDITIONAL Breast Cancer Model KNOCKOUT


Oncology: breast cancer model driven by deletion of Brca1 and p53 in epithelial cells.

Homozygous Floxed/Homozygous Floxed/Carrier (PPC)


Homozygous Floxed/Homozygous Floxed/Wild Type (FFW)


Model Number: 11510NomenclatureSTOCK Trp53tm1Brn Brca1tm1Brn

Tg(KRT14-cre)8Brn

EMERGING MODEL

C3H INBRED


ImmunologyNeurodegenerationOpthalmology

RF 3 to 4 €18.30 €19.305 to 6 €19.30 €20.307 to 9 €20.90 €21.8010 €25.00 €25.90Retired Breeder €21.80 €21.80

Model Number: C3HNomenclatureC3H/HeNTac


SPONTANEOUS MUTANT C.B-17 scid – T&B CELL DEFICIENT

Applications Zygosity Health Age (weeks) Male Female

ImmunologyOncology

Homozygous (M)

RF 4 €48.90 €57.305 to 6 €55.40 €66.807 to 8 €57.30 €69.20Retired breeder €69.20Untimed pregnant €205.40

1-49 50+ 1-49 50+

DF 4 €56.10 €54.10 €67.40 €62.305 to 8 €67.60 €63.60 €79.30 €75.70Retired breeder €76.50Untimed pregnant €221.80

Model Number: CB17SCNomenclatureC.B-Igh-1b Prkdcscid/IcrTac


Model Number: ART0009NomenclatureC57BL/6NTac-Tg(Camk2a-cre)159Kln/ArteCamKII-cre MICROINJECTED

Applications

Generation of forebrain neuron-specific gene deletions

License fee applies. Please see website for more information.

EMERGING MODEL

Animal Models

57www.taconic.com • +45 70 23 04 05



Car KnockoutMouse CONSTITUTIVE KNOCKOUT


CYP induction, drug toxicity, and efficacy

Homozygous (M) Non-Profit €108.00Homozygous (M) For-Profit €142.00

Model Number: 9103NomenclatureC57BL/6-Nr1i3tm1.1Arte

EMERGING MODEL

CETP MICROINJECTED


HDL cholesterol and atherosclerosis

Hemizygous (T) 4 to 8 €195.909 to 12 €203.80

Retired homozygous breeder

€542.00

Model Number: 3715NomenclatureB6.SJL-Tg(APOA-CETP)1Dsg N11


Model Number: 3716NomenclatureB6.SJL-Tg(APOA-CETP)1Dsg Tg(APOB)1102Sgy N10CETP-ApoB100 MICROINJECTED

Applications Zygosity Age (weeks) Male or FemaleHypercholesterolemia, HDL/LDL cholesterol imbalance and atherosclerosis


4 to 8 €333.60

9 to 12 €349.10


CIEA BRG mouse CONSTITUTIVE KNOCKOUT

Applications Zygosity Age (weeks) User Male or FemaleVery immunodeficient mouse, for use in humanization studies, xenograft studies using difficult to engraft cell lines and primary tumors, as well as many other research applications.

Homozygous/Homozygous (MM) (Females)Homozygous/Hemizygous (MT) (Males)

4 to 8Non-Profit €80.00For-Profit €170.00

Model Number: 11503NomenclatureC.Cg-Rag2tm1Fwa Il2rgtm1Sug/JicTac

EMERGING MODEL

Animal Models

www.taconic.com • +45 70 23 04 0558



CIEA NOG SPONTANEOUS MUTANT/mouse® CONSTITUTIVE KNOCKOUT

Applications Zygosity Health User Age (weeks) Male Female

Super immunodeficient mouse, for use in humanization studies, xenograft studies using difficult to engraft cell lines and primary tumors, as well as many other research applications.

1-49 50+ 1-49 50+

Homozygous/Homozygous (MM) (Females)

Homozygous/Hemizygous (MT)(Males)

DFNon-Profit

4 to 8 €79.46 €76.24 €92.40 €89.409 to 12 €84.62 €81.40 €98.40 €95.40

For-Profit4 to 8 €184.80 €177.30 €231.00 €223.509 to 12 €196.80 €189.30 €246.00 €238.50

RFNon-Profit

4 to 8 €58.48 €55.26 €68.00 €65.009 to 12 €61.92 €58.70 €72.00 €69.00

For-Profit4 to 8 €136.00 €128.50 €170.00 €162.509 to 12 €144.00 €136.50 €180 €172.50

Model Number: NOGNomenclatureNOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac

EMERGING MODEL

COX-1 CONSTITUTIVE KNOCKOUT

Applications Zygosity Age (weeks) Male Female

Immunology: Inflammation

Homozygous (M) 5 to 8 €221.30 €221.309 to 12 €226.30 €226.30Retired homozygous male breeder

€221.30 —

Heterozygous (T) orWild Type (W)

5 to 8 €91.50 €98.409 to 12 €98.40 €103.30Retired heterozygous female breeder €98.40

Model Number: 2180NomenclatureB6;129P2-Ptgs1tm1Unc


COX-2 CONSTITUTIVE KNOCKOUT


Immunology: Inflammation

Homozygous (M) 5 to 8 €221.30 €221.309 to 12 €226.30 €226.30Retired breeder €221.30 —

Heterozygous (T) or Wild Type (W)

5 to 8 €91.50 €98.409 to 12 €98.40 €103.30Retired heterozygous breeder €98.40

Model Number: 2181NomenclatureB6;129P2-Ptgs2tm1Unc


EMERGING MODEL

Cre Deleter TARGETED MUTATION

Applications

Ubiquitously active general Cre deleter


Model Number: 6467NomenclatureC57BL/6NTac-Gt(ROSA)26Sortm16(cre)Arte

Animal Models

59www.taconic.com • +45 70 23 04 05



Model Number: 11515NomenclatureFVB/NTac-Tg(CRE/Tk-luc)11Hgp

CRE-Luc* GPCR Reporter Mouse, Line 11 MICROINJECTED


GPCR Studies Homozygous (M) 4 to 8 €200.00License fee applies for for-profit users. Please see website for more information. *CRE in CRE-Luc stands for cAMP Response Element.

EMERGING MODEL




EMERGING MODEL






EMERGING MODEL

Cyp1a1/1a2 Knockout Mouse CONSTITUTIVE KNOCKOUT


Drug biovailability and clearance


Non-Profit €150.00For-Profit €200.00

EMERGING MODEL

Model Number: ITI0122

Cyp2c KnockoutMouse CONSTITUTIVE KNOCKOUT




Model Number: 9177NomenclatureC57BL/6-Cyp2ctm1104Arte

EMERGING MODEL

EMERGING MODEL

CreERT2 TARGETED MUTATION

Applications

Inducible general cre deleter


Model Number: 10471NomenclatureC57BL/6NTac-Gt(ROSA)26Sortm9(cre/ESR1)Arte

Animal Models

www.taconic.com • +45 70 23 04 0560



Cyp3a (7-gene) KnockoutMouse CONSTITUTIVE KNOCKOUT




Model Number: 8841NomenclatureC57BL/6NTac-Del(5Cyp3a57-Cyp3a59)1Arte

EMERGING MODEL

Cyp3a (8-gene) CONSTITUTIVEKnockout Mouse KNOCKOUT



Homozygous/Homozygous Deletion (M)

5 to 8 €192.709 to 12 €207.20


Model Number: 9011NomenclatureFVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1Ahs

Cyp3a-Cyp2d-Cyp2c Knockout Mouse CONSTITUTIVE KNOCKOUT



Homozygous/Homozygous/Homozygous (MMM)

Non-Profit €200.00

For-Profit €345.00

EMERGING MODEL


Dark Agouti INBRED

Applications Health Age (weeks) Male or Female

ImmunologyOncologyTransplantation

MPF 3 €38.40

4 €42.10

5 €47.006 €52.507 €57.508 €64.009 €70.2010 €76.4011 €83.6012 €90.70Retired Breeder €41.70

Model Number: DANomenclatureDA/MolTac

TRADITIONAL & SPONTANEOUS MUTANT | RAT

Cyp2d KnockoutMouse CONSTITUTIVE KNOCKOUT




Model Number: 9178NomenclatureC57BL/6-Del(15Cyp2d22-Cyp2d26)1Arte

EMERGING MODEL

Animal Models

61www.taconic.com • +45 70 23 04 05



DBA/1 INBRED


ImmunologyInflammation

MPF 3 to 4 €29.20 €29.205 to 6 €32.20 €32.207 to 8 €35.50 €35.509 to 10 €39.40 €39.40Retired breeder €35.50 €35.50Female with litter (6 pups) €147.00Untimed pregnant* €115.20

RF 3 to 4 €30.70 €32.305 to 6 €31.70 €33.507 to 8 €33.70 €34.909 €41.00 €41.00Retired breeder €42.40 €42.40Untimed pregnant* €101.80


Model Number: DBA1BONomenclatureDBA/1JBomTac


DBA/2 INBRED


Hearing LossNeurologySeizures

MPF 3 to 4 €17.90 €19.805 to 6 €20.30 €22.007 to 9 €23.40 €24.50

10 €27.40 €28.50

Retired breeder €19.30 €19.30Female with litter (5 pups) €112.20Untimed pregnant* €96.60


Model Number: DBA2NomenclatureDBA/2NTac


Diabetic SPONTANEOUS MUTANT – DIABETES/OBESITY

Applications Zygosity Health Age (weeks) Male or Female

Metabolic Disease Varies MPF 5 to 6 €104.60

7 to 8 €114.80

* Zygosity of animals determined by phenotype (black fat, black lean or misty lean)

Model Number: DBNomenclatureBKS.Cg-Leprdb Dock7m/BomTac


Animal Models

www.taconic.com • +45 70 23 04 0562



Diet Induced ObeseApplications Health Age (weeks) Weeks on Diet DIO_B6 Control B6 Male

Metabolic Disease MPF 10 4 €38.80 €22.3011 5 €43.50 €22.3012 6 €48.40 €22.3013 7 €53.20 €27.1014 8 €57.90 €29.8015 9 €62.80 €32.7016 10 €67.50 €35.3017 11 €72.50 €38.0018 12 €77.20 €40.6019 13 €82.00 €43.4020 14 €86.90 €46.2021 15 €91.70 €48.9022 16 €96.40 €51.6023 17 €101.20 €54.3024 18 €106.00 €57.0025 19 €110.90 €59.7026 20 €115.60 €62.50

Males & Females now available - please specify when ordering.

C57BL/6NTac mice are shipped in sterilized Taconic Transit Cages™ (TTC™) with enough food and moisture for their duration in transit. Shipping stress may cause the mice to lose weight and seem almost wet on arrival. Do not worry – this is normal. After a week at your facility, they should be back to their normal weights, settled, and ready for testing. We strongly encourage you to continue the C57BL/6NTac mice on the diet they were raised on. (Research Diets RDI #12492)

Model Number: DIONomenclatureC57BL/6NTac


Fcer1g (FcRγ) CONSTITUTIVE KNOCKOUT



Model Number: 583NomenclatureB6.129P2-Fcer1gtm1Rav N12


Fcgr2b (FcγIII) CONSTITUTIVE KNOCKOUT



Model Number: 580NomenclatureB6.129S4-Fcgr2btm1Ttk N12


Animal Models

63www.taconic.com • +45 70 23 04 05



Fischer INBRED


AgingImmunologyOncologyToxicology

MPF 3 €18.40 €18.104 €20.10 €20.705 €22.60 €23.606 €25.20 €27.407 €28.70 €31.108 €33.20 €34.909 €36.90 €37.6010 €39.90 €40.6011 €43.30 €44.4012 €46.40 €47.90Retired Breeder €24.90 €24.90Female with litter (8 pups) €132.00Untimed pregnant* €79.90


Model Number: F344NomenclatureF344/NTac


Floxed Ink4a/Arf CONDITIONAL Mouse ALLELE


Oncology Homozygous Floxed (F) 4 to 8 €200.00License fee applies. Please see website for more information.

Model Number: 11511NomenclatureB6.129P2-Cdkn2atm2Brn/A

EMERGING MODEL

Flp Deleter MICROINJECTED

Applications

Ubiquitously active general Flp deleter


Model Number: 7089NomenclatureC57BL/6NTac-Tg(CAG-Flpe)2Arte N5

EMERGING MODEL

Model Number: 11512NomenclatureB6.129P2-Trp53tm1Brn/AFloxed p53 Mouse CONDITIONAL ALLELE


Oncology Homozygous Floxed (F) 4 to 8 €200.00License fee applies. Please see website for more information.

EMERGING MODEL

Animal Models

www.taconic.com • +45 70 23 04 0564



FVB INBRED



MPF 3 to 4 €12.40 €13.505 to 6 €14.60 €15.807 to 9 €17.70 €18.8010 €21.80 €22.9011 €25.90 €27.0012 €30.00 €31.10Retired breeder €14.60 €14.60Female with litter (8 pups) €111.40Untimed pregnant* €75.30Timed pregnant €102.30


Model Number: FVBNomenclatureFVB/NTac


Gfap-luc LPTA® MICROINJECTED


Imaging: CNS inflammation. Astrocyte regeneration, including physical trauma, chemical insult, and bacterial infections.

Homozygous (M)


Model Number: 10501NomenclatureFVB/N-Tg(Gfap-luc)53Xen

EMERGING MODEL

Goto-Kakizaki INBRED


Metabolic Disease MPF 3 €164.40 €140.804 €181.80 €155.905 €198.00 €170.106 €216.00 €185.407 €234.40 €200.708 €249.30 €213.709 €266.40 €228.5010 €279.60 €243.9011 €312.90 €277.2012 €346.20 €310.5013 €379.50 —14 €412.80 —15 €446.10 —16 €479.40 —

Model Number: GKNomenclatureGK/MolTac[cc]


Animal Models

65www.taconic.com • +45 70 23 04 05



Gsk3a (GlycogeneSynthase Kinase 3Alpha) KinaseSwitch CONSTITUTIVEMouse KNOCK INApplications

Kinase research in the areas of neuroscience, cancer, and metabolic diseases


Model Number: ART0069NomenclatureC57BL/6-Gsk3atm1Arte

EMERGING MODEL

Gsk3b (GlycogeneSynthase Kinase 3Beta) KinaseSwitch CONSTITUTIVEMouse KNOCK INApplications

Kinase research in the areas of neuroscience, oncology, and metabolic diseases


Model Number: ART0059NomenclatureC57BL/6-Gsk3btm1Arte

EMERGING MODEL

HLA-A1 MICROINJECTED


Immunology: immunogenicity testing for vaccine research, infectious disease studies, and protein therapeutic evaluation

Hemizygous (T) 4 to 8 €185.309 to 12 €199.80

Wild Type (W) 4 to 8 €63.409 to 12 €77.90Retired transgenic B6 male breeder

€199.80

Model Number: 9662NomenclatureCB6F1-Tg(HLA-A*0101/H2-Kb)A1.01


HLA-A2.1 MICROINJECTED



Hemizygous (T) 4 to 8 €185.309 to 12 €199.80Retired homozygous B6 male breeder

€199.80

Model Number: 9659NomenclatureCB6F1-Tg(HLA-A*0201/H2-Kb)A*0201


Animal Models

www.taconic.com • +45 70 23 04 0566







€199.80






Hemizygous (T) 4 to 8 €185.309 to 12 €199.80Retired transgenic B6 male breeder

€199.80



HLA-B7 CONSTITUTIVE KNOCKOUT/ MICROINJECTED



Heterozygous/Hemizygous/Hemizygous (TTT)

4 to 8 €185.309 to 12 €199.80Retired transgenic B6 male breeder

€199.80

Model Number: 9661NomenclatureCB6F1-B2mtm1Unc Tg(B2M)55HplTg(HLA-B*0702/H2-Kb)B7.xx


HLA-B44 MICROINJECTED




€199.80

Model Number: 9664NomenclatureCB6F1-Tg(HLA-B*4002/H2-Kb)B44.01


Animal Models

67www.taconic.com • +45 70 23 04 05



CONDITIONAL KNOCKOUT/HRN™ nude SPONTANEOUS MUTANT


Oncology and ADMET: a xenograft host which lacks liver P450 activity and therefore cannot metabolize most small molecule drugs

Homozygous Floxed/Homozygous/Carrier (FMC)

4 to 8 €154.00

9 to 12 €163.00

Model Number: 9066NomenclatureCrTac:NCr-Portm1Wolf Foxn1nu Tg(Alb-cre)21Mgn

EMERGING MODEL

HRN™ CONDITIONAL KNOCKOUT


Determine role of Cytochrome P450s in drug disposition; Efficacy studies

Homozygous Floxed/Homozygous (FM)

4 to 8 €156.009 to 12 €164.00

Retired breeder €156.00 (homozygous floxed/homozygous)

Model Number: 7353NomenclatureB6.Cg-Portm1Wolf Tg(Alb-cre)21Mgn N7


Humanized AHR Mouse HUMANIZED




Model Number: 9165NomenclatureC57BL/6-Ahrtm1.1(AHR)Arte

EMERGING MODEL

Humanized CAR Mouse HUMANIZED




Model Number: 9101NomenclatureC57BL/6-Nr1i3tm1(NR1I3)Arte

EMERGING MODEL

Humanized CYP1A1/1A2 Mouse HUMANIZED


Bioavailability and clearance, drug metabolism, drug-drug interaction, human metabolites



EMERGING MODEL


Animal Models

www.taconic.com • +45 70 23 04 0568



Humanized CYP2D6Mouse HUMANIZED



Homozygous Deletion/Homozygous (MM)


Model Number: 11584NomenclatureC57BL/6-Is(15CYP2D6;Del15Cyp2d22-Cyp2d26)3Arte

EMERGING MODEL

Humanized CYP3A4/3A7Mouse HUMANIZED




Model Number: 8842NomenclatureC57BL/6-Del(5Cyp3a57-Cyp3a59)1Artetm1(CYP3A4-CYP3A7)Arte

EMERGING MODEL

Humanized Gut CYP3A4Mouse HUMANIZED



Homozygous/Homozygous Deletion/Homozygous (MMM)


Model Number: 9047NomenclatureFVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1AhsTg(Vil1-CYP3A4)1Ahs

EMERGING MODEL

Humanized Liver & GutCYP3A4 Mouse HUMANIZED



Homozygous/Homozygous Deletion/Homozygous/Homozygous (MMMM)


Model Number: 9049NomenclatureFVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1AhsTg(Vil1-CYP3A4)1Ahs Tg(APOE-CYP3A4)A1Ahs

EMERGING MODEL

Animal Models

69www.taconic.com • +45 70 23 04 05



Humanized Liver CYP3A4Mouse HUMANIZED



Homozygous/Homozygous Deletion/Homozygous (MMM)


Model Number: 9048NomenclatureFVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1AhsTg(APOE-CYP3A4)A1Ahs

EMERGING MODEL

Humanized MRP2 Mouse* HUMANIZED


Drug bioavailability, drug-drug interaction, drug toxicity

Homozygous (M) Non-Profit €183.00Homozygous (M) For-Profit €226.00*Not available for distribution within the United States

Model Number: 9179NomenclatureC57BL/6-Abcc2tm1(ABCC2)Arte

EMERGING MODEL

Humanized Liver CYP2C9 Mouse HUMANIZED





Model Number: 11746

EMERGING MODEL

Humanized OATP1B1 Mouse HUMANIZED


Hepatic drug uptake, drug-drug interaction, and drug toxicity


4 to 8 €321.809 to 12 €328.60

Model Number: 10708NomenclatureFVB.129P2-Del(Slco1b2-Slco1a5)1AhsTg(APOE-SLCO1B1)1Ahs


Humanized OATP1B1/ 1B3 Mouse HUMANIZED



Homozygous Deletion/Homozygous/Homozygous (MMM)

4 to 8 €345.009 to 12 €355.00

Model Number: 11594NomenclatureFVB.129P2-Del(Slco1b2-Slco1a5)1Ahs Tg(APOE-SLCO1B1)1Ahs Tg(APOE-SLCO1B3)1Ahs


Animal Models

www.taconic.com • +45 70 23 04 0570



Humanized OATP1B3 Mouse HUMANIZED




4 to 8 €321.809 to 12 €328.60

Model Number: 10725NomenclatureFVB.129P2-Del(Slco1b2-Slco1a5)1Ahs Tg(APOE-SLCO1B3)1Ahs


Humanized PXR Mouse HUMANIZED




Model Number: 9104NomenclatureC57BL/6-Nr1i2tm1(NR1I2)Arte

EMERGING MODEL

Humanized PXR-CARMouse HUMANIZED





Model Number: 8223NomenclatureC57BL/6-Nr1i2tm1(NR1I2)Arte Nr1i3tm1(NR1I3)Arte

EMERGING MODEL

Humanized PXR-CAR-AHR Mouse HUMANIZED






EMERGING MODEL

HumanizedPXR-CAR-CYP3A4/3A7Mouse HUMANIZED


CYP induction, drug-drug interaction, pharmacokinetics, drug toxicity, and efficacy



Model Number: 11585NomenclatureC57BL/6-Nr1i3tm1(NR1I3)Arte Is(5CYP3A4-CYP3A7;Del5Cyp3a57-Cyp3a59)2Arte Nr1i2tm1(NR1I2)Arte

EMERGING MODEL

Animal Models

71www.taconic.com • +45 70 23 04 05



Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse HUMANIZED






EMERGING MODEL

Humanized PXR-CAR-CYP3A4/3A7-CYP2D6-CYP2C9 Mouse HUMANIZED



Homozygous/Homozygous/Homozygous/Homozygous/Homozygous (MMMMM)



EMERGING MODEL

Humanized UGT1A1*1 Mouse HUMANIZED



Homozygous/Homozygous Deletion (MM)

4 to 8 €345.009 to 12 €355.00

Model Number: 11996NomenclatureB6.Cg-UgttmRhtu Tg(UGT1A1*28)1Rhtu


Humanized PXR-CAR-PPARα Mouse HUMANIZED


CYP induction, drug toxicity, and efficacy, non-genotoxic carcinogenicity testing



EMERGING MODEL


Animal Models

www.taconic.com • +45 70 23 04 0572



SPONTANEOUS MUTANT ICR scid – T&B CELL DEFICIENT


ImmunologyOncology

Homozygous (M)

RF 3 to 8 €24.70 €35.80Retired breeder €49.20 €49.20Female with litter €222.90Timed pregnant €49.20Untimed Pregnant €32.50

Model Number: ICRSCNomenclatureIcrTac:ICR-Prkdcscid


ICR OUTBRED


AgingGeneral purposeOncologyToxicologyVaccine Research

1-99 100+

MPF 3 to 4 €4.50 €4.205 to 6 €4.80 €4.407 to 8 €5.10 €4.609 €5.50 €5.20Retired Breeder €3.70 €3.70Female with litter (10 pups) €43.50


Model Number: ICRNomenclatureIcrTac:ICR


Invasive Lobular CONDITIONAL Breast Cancer Model KNOCKOUT


Oncology: invasive breast cancer model driven by tissue specific deletion of E-cadherin and p53

Homozygous Floxed/Homozygous Floxed/Carrier (PPC)


Homozygous Floxed/Homozygous Floxed/Wild Type (FFW)


Model Number: 11509NomenclatureFVB.Cg-Cdh1tm1Jjon Trp53tm1Brn

Tg(KRT14-cre)8Brn/A

EMERGING MODEL

Jh CONSTITUTIVE KNOCKOUT



Model Number: 1147NomenclatureSTOCK Igh-Jtm1Dhu N?+N2


Animal Models

73www.taconic.com • +45 70 23 04 05



Model Number: DSNomenclatureTacLevin:CD(SD)DR

Model Number: DRNomenclatureTacLevin:CD(SD)DIO

Levin OUTBRED


Metabolic Disease DR DS DR DS

MPF 3 €39.90 €49.60 €35.80 €44.704 €43.20 €54.00 €39.00 €48.605 €47.70 €59.60 €42.90 €53.606 €52.90 €66.10 €47.70 €59.607 €58.30 €72.70 €52.40 €65.508 €63.50 €79.30 €57.20 €71.40

Outbred Sprague Dawley® rats were selectively bred by Dr. Barry Levin, Veterans Affairs Medical Center, East Orange New Jersey, for either susceptibility (DS) or resistance (DR) to diet induced obesity. Taconic Levin rats are maintained on standard chow. Taconic does offer custom projects where we can administer high fat diet prior to shipping.


Lewis INBRED


ImmunologyTransplantation

MPF 3 €18.20 €18.204 €21.20 €21.205 €23.60 €23.606 €27.40 €27.407 €31.00 €31.008 €34.80 €34.809 €37.70 €37.7010 €40.70 €40.7011 €44.20 €44.2012 €48.20 €48.20Retired Breeder €25.10 €25.10Female with litter (8 pups) €144.10Untimed pregnant* €86.70Timed pregnant €132.30


Model Number: LEWISNomenclatureLEW/MolTac


Animal Models

www.taconic.com • +45 70 23 04 0574



Long Evans OUTBRED

Applications Health Weight (grams) Males Females

BehaviorGeneral PurposeOphthalmologyToxicology

MPF 40-50 €11.90 €11.9051-100 €17.00 €13.30101–125 €17.00 €17.00126–150 €18.60 €18.90151–175 €20.30 €20.80176–200 €20.30 €22.30201–225 €23.80 €24.50226–250 €25.60 €26.40251–275 €27.60 €29.10276–300 €29.70 €31.40326–350 €34.10 —351–375 €36.30 —Retired Breeder €32.40 €32.40Female with litter (10 pups) €74.20Untimed pregnant* €55.40Timed pregnant €70.90


Model Number: LONGEVNomenclatureSimTac:LE


Mdr1a CONSTITUTIVE KNOCKOUT


Blood brain barrier penetration, oral biovailability, and multi drug resistance in tumors

Homozygous (M) 4 to 8 €163.009 to 12 €170.00

Retired breeder €163.00

Model Number: MDR1ANomenclatureFVB.129P2-Abcb1atm1Bor N7


Mdr1a/b CONSTITUTIVE KNOCKOUT



Homozygous/ Homozygous (MM)

4 to 8 €166.009 to 12 €173.00

Retired breeder €166.00 (double homozygous)

Model Number: 1487NomenclatureFVB.129P2-Abcb1atm1BorAbcb1btm1Bor N12


Animal Models

75www.taconic.com • +45 70 23 04 05



Mdr1a/b-Bcrp CONSTITUTIVE KNOCKOUT




4 to 8 €166.009 to 12 €194.00

Retired breeder €166.00 (triple homozygous)

Model Number: 3998NomenclatureFVB.129P2-Abcb1atm1Bor Abcb1btm1Bor

Abcg2tm1Ahs N7


Mrp1 CONSTITUTIVE KNOCKOUT



Model Number: 1486NomenclatureFVB.129P2-Abcc1atm1Bor N12


Mrp2 CONSTITUTIVE KNOCKOUT



Model Number: 6621NomenclatureFVB.129P2-Abcc2atm1Ahs N7


SPONTANEOUS MUTANT NCr nude – T-CELL DEFICIENT


ImmunologyOncology

Homozygous (M)

Heterozygous (T)

RF 4 €24.40 €35.705 to 6 €27.70 €40.607 to 9 €32.30 €44.30Retired breeder €32.30 (homozygous) €32.30 (heterozygous)Female with litter €44.50Untimed pregnant €44.30

Model Number: NCRNUNomenclatureCrTac:Ncr-Foxn1nu


NFκB-RE-luc LPTA® MICROINJECTED


Imaging: inflammation and oncology

Hemizygous (T)


Model Number: 10499NomenclatureBALB/c-Tg(Rela-luc)31Xen

EMERGING MODEL

Animal Models

www.taconic.com • +45 70 23 04 0576



NIH nude SPONTANEOUS MUTANT – T-CELL DEFICIENT


ImmunologyOncology

1-49 50+

RF 4 €123.00 €116.905 to 8 €133.00 €126.409 to 12 €149.20 €141.70Retired Breeder €149.20 (homozygous) €149.20 (heterozygous)Untimed pregnant €573.20Female w/ natural litter €897.80


Model Number: NIHRNUNomenclatureNTac:NIH-Whn


NMRI OUTBRED


AgingGeneral purposeOncologyToxicologyVaccine Research

1-99 100-299 300+

MPF 3 to 4 €8.80 €8.40 €8.105 to 6 €9.20 €8.80 €8.407 to 8 €9.30 €8.90 €8.609 €14.60 €14.20 €13.8010 €19.50 €19.10 €18.70

Female with litter (10 pups)

€68.00

* Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit. Ships from European colonies.

Model Number: NMRINomenclatureBomTac:NMRI


SPONTANEOUS MUTANT NMRI nude – T-CELL DEFICIENT


ImmunologyOncology

Homozygous (M)

Heterozygous (T)

RF 3 to 4 €59.00 €62.705 to 6 €61.60 €65.507 to 8 €66.10 €70.70Retired breeder €70.70 (homozygous) €70.70 (heterozygous)Female with litter €327.00Untimed prengant €309.30

Model Number: NMRINUNomenclatureBomTac:NMRI-Foxn1nu


Animal Models

77www.taconic.com • +45 70 23 04 05



SPONTANEOUS MUTANT NOD scid – T&B CELL DEFICIENT & REDUCED NK CELLS


ImmunologyOncology

Homozygous (M)

RF 3 to 4 €101.20 €111.005 to 6 €106.40 €116.507 to 8 €115.70 €126.609 €121.40 €132.30Retired breeder €126.60 €126.60Female with litter €729.60Untimed pregnant €367.60

*Inquire for quantity discounts

Model Number: NODSCNomenclatureNOD/MrkBomTac-Prkdcscid


NOD INBRED


Diabetes (Type I)Immunology

MPF 4 €21.20 €24.705 to 6 €24.50 €29.807 to 9 €29.40 €36.10

Taconic is unable to ship retired breeders, female with litters, and pregnant mice for this model due to phenotype. We cannot ship mice over 10 weeks of age due to their tendency to develop diabetes during transit.

Model Number: NODNomenclatureNOD/MrkTac


Ntrk1 (NeurotrophicTyrosine KinaseReceptor Type 1) CONSTITUTIVEKinaseSwitch Mouse KNOCK INApplications

Kinase research in the areas of neuroscience and cancer


Model Number: ART0066NomenclatureC57BL/6-Ntrk1tm1Arte

EMERGING MODEL

Ntrk2 (NeurotrophicTyrosine KinaseReceptor Type 2) CONSTITUTIVEKinaseSwitch Mouse KNOCK INApplications

Kinase research in the areas of neuroscience and metabolic diseases


Model Number: ART0067NomenclatureC57BL/6-Ntrk2tm1Arte

EMERGING MODEL

Animal Models

www.taconic.com • +45 70 23 04 0578



Oct1/2 CONSTITUTIVE KNOCKOUT


Hepatic, intestinal, and renal drug transport


4 to 8 €166.009 to 12 €173.00Retired breeder €X166.00 (double homozygous)

Model Number: 6622NomenclatureFVB.129P2-Slc22a1tm1Ahs Slc22a2tm1Ahs N7


Oatp1a/b Cluster CONSTITUTIVEKnockout Mouse KNOCKOUT


Hepatic drug uptake and drug toxicity

Homozygous Deletion (M)

4 to 8 €193.00

9 to 12 €199.00

Model Number: 10707NomenclatureFVB.129P2-Del(Slco1b2-Slco1a5)1Ahs


Pfp/Rag2 CONSTITUTIVE KNOCKOUT


Immunology: Immunodeficient


4 to 8 €154.109 to 12 €175.20Retired breeder €154.10

Model Number: 1177NomenclatureB6.129S6-Rag2tm1Fwa Prf1tm1Clrk N12


Ppar CONSTITUTIVE KNOCKOUT


Lipid and glucose homeostasis, non-genotoxic carcinogenicity testing

Homozygous (M) 4 to 8 €120.009 to 12 €132.00


Model Number: 1640NomenclatureB6.129S4-Pparatm1Gonz N12


Pxr KnockoutMouse CONSTITUTIVE KNOCKOUT




Model Number: 9100NomenclatureC57BL/6-Nr1i2tm3Arte

EMERGING MODEL

Animal Models

79www.taconic.com • +45 70 23 04 05



Pxr-Car KnockoutMouse CONSTITUTIVE KNOCKOUT


CYP induction, drug toxicity and efficacy, non-genotoxic carcinogenicity testing



Model Number: 8222NomenclatureC57BL/6-Nr1i2tm3Arte Nr1i3tm1.1Arte

EMERGING MODEL

Pxr-Car-Ahr KnockoutMouse CONSTITUTIVE KNOCKOUT




Non-Profit €175.00

For-Profit €250.00

Model Number: 11583NomenclatureC57BL/6-Nr1i3tm1.1Arte Ahrtm1.2Arte Nr1i2tm3Arte

EMERGING MODEL

Pxr-Car-Pparα Knockout Mouse CONSTITUTIVE KNOCKOUT


CYP induction, drug toxicity and efficacy, non-genotoxic carcinogenicity testing



EMERGING MODEL


Rag2 CONSTITUTIVE KNOCKOUT




Model Number: RAG2Nomenclature129S6/SvEvTac-Rag2tm1Fwa






Model Number: 601NomenclatureC.129S6(B6)-Rag2tm1Fwa N12


Animal Models

www.taconic.com • +45 70 23 04 0580






Homozygous (M) 4 to 8 €97.709 to 12 €107.60Retired Breeder €107.60

Model Number: 461NomenclatureB6.SJL(129S6)-Ptprca/BoyCrTac-Rag2tm1Fwa N10






Model Number: RAGN12NomenclatureB6.129S6-Rag2tm1Fwa N12


Rag2/OT-I CONSTITUTIVE KNOCKOUT/MICROINJECTED


Immunology Homozygous/Homozygous (MM)


Model Number: 2334NomenclatureB6.129S6-Rag2tm1Fwa Tg(TcraTcrb)1100Mjb


CONSTITUTIVE KNOCKOUT /Rag2/OT-II MICROINJECTED


Immunology Homozygous/Homozygous (MM)


Model Number: 1896NomenclatureB6.129S6-Rag2tm1Fwa Tg(TcraTcrb)425Cbn


rasH2 MICROINJECTED


Short-term carcinogenicity studies

Hemizygous (T) 4 to 12 €468.40

Wild Type (W) 4 to 12 €222.40

Model Number: 1178NomenclatureCByB6F1-Tg(HRAS)2Jic


Animal Models

81www.taconic.com • +45 70 23 04 05



SPONTANEOUS MUTANT scid-beige – T, B & NK CELL DEFICIENT


ImmunologyOncology


DF 3 to 5 €81.306 to 8 €94.909 to 12 €98.50Retired breeder €98.50

Model Number: CBSCBGNomenclatureC.B-Igh1b Prkdcscid Lystbg/GbmsTac


SJL INBRED


Immunology MPF 3 to 4 €29.10 €30.505 to 6 €30.40 €32.307 to 9 €33.20 €34.80Retired breeder €34.80 €34.80Female with litter (5 pups) €156.30Untimed pregnant* €117.80


Model Number: SJLNomenclatureSJL/JCrNTac


SpontaneouslyHypertensive OUTBRED


Cardiovascular DiseaseGenetic Hypertension

MPF 3 €42.20 €42.204 €42.20 €42.205 €46.00 €46.006 €51.00 €51.007 €55.30 €55.308 €62.20 €62.209 €68.20 €68.2010 €74.20 €74.2011 €80.00 €80.0012 €87.00 €87.0013 €94.50 €94.5014 €96.40 €96.4015 €104.90 €104.9016 €111.80 €111.8017 €120.20 —18 €128.50 —Retired Breeder €87.30 €87.30

Female with litter(8 pups)

€297.90

Untimed pregnant* €230.50Timed pregnant €290.70


The SHR rat is an inbred model but bred in an outbred mating scheme to improve reproductive performance.


Model Number: SHRNomenclatureNTac:SHR

Animal Models

www.taconic.com • +45 70 23 04 0582



Model Number: SDNomenclatureNTac:SDSprague Dawley®


BehaviorGeneral PurposePharmacologyToxicology

Weight Price Weight Price

MPF 3 40-70 €9.80 40-70 €8.604 70-115 €10.90 70-110 €9.805 115-165 €13.80 110-150 €11.006 165-215 €15.10 135-175 €12.907 170-240 €17.80 170-215 €14.008 230-290 €20.40 190-235 €15.209 270-320 €23.30 195-250 €16.4010 290-350 €24.20 210-270 €17.7011 320-380 €29.00 225-290 €19.2012 330-400 €32.60 240-300 €20.3013 375-430 €32.60 240-300 €27.3014 390-450 €39.60 250-310 €34.4015 400-475 €46.70 250-310 €41.4016 425-490 €53.70 — —Retired Breeder — €36.90 — €36.90Female with litter (10 pups) €113.40Untimed pregnant * €78.70Timed pregnant €104.40



Sprague Dawley®


BehaviorGeneral PurposePharmacologyToxicology

Weight Price Weight Price

RF 3 40-70 €12.10 40-70 €11.804 70-115 €14.30 70-110 €14.205 115-165 €18.80 110-150 €16.506 165-215 €21.00 135-175 €19.107 170-240 €25.50 170-215 €21.408 230-290 €28.70 190-235 €23.409 270-320 €33.10 195-250 €26.0010 290-350 €37.10 210-270 €28.0011 320-380 €44.00 225-290 €31.3012 330-400 €47.30 240-300 €35.3013 375-430 €47.30 240-300 €39.0014 390-450 €59.00 250-310 €43.8015 400-475 €70.60 250-310 €48.7016 425-490 €82.30 265-325 —Retired Breeder — €45.80 — €45.80Female with litter €114,50Untimed pregnant* €80.90Timed pregnant €104.40


Model Number: SDNomenclatureNTac:SD


Animal Models

83www.taconic.com • +45 70 23 04 05



SPONTANEOUS MUTANT Swiss nude – T-CELL DEFICIENT


ImmunologyOncology

Homozygous (M)

Heterozygous (T)

DF 4 €59.105 to 8 €69.30Retired breeder* €55.20 (homozygous male or heterozygous female)Female with litter €312.80Untimed pregnant €245.50

Model Number: NSWNUNomenclatureNTac:NIHS-Foxn1nu


Stat1 CONSTITUTIVE KNOCKOUT


ImmunologyOncology


Model Number: 2045Nomenclature129S6/SvEv-Stat1tm1Rds


Swiss Webster OUTBRED


AgingBehaviorGeneral PurposeReproductive StudiesToxicologyTransgenic Model Generation Support

MPF 3 to 4 €4.20 €4.205 to 6 €4.40 €4.407 to 8 €4.70 €4.709 €5.10 €5.1010 €9.00 €9.0011 €12.80 €12.5012 €16.70 €16.40Retired Breeder €3.50 €3.50Untimed Pregnant €21.60

RF 3 to 4 €7.60 €7.605 to 6 €8.90 €8.907 to 8 €10.30 €10.309 to 10 €11.00 €11.00Retired Breeder €11.00 €11.00Untimed Pregnant €43.10

Germ Free*

3 to 4 €95.20 €95.205 to 6 €104.90 €104.907 to 8 €119.00 €119.009 to 10 €144.40 €144.40

*All Germ Free mice are shipped in Germ Free Shippers.

Model Number: SWNomenclatureTac:SW


Animal Models

www.taconic.com • +45 70 23 04 0584



Tau MICROINJECTED



Homozygous (M) 4 to 12 €257.30


Model Number: 2508NomenclatureSTOCK Tg(Prnp-MAPT*P301L)JNPL3Hlmc


Tau MICROINJECTED



Hemizygous (T) 4 to 12 €260.00 €260.00

Wild Type (W) 4 to 12 €87.20 €93.80

Model Number: 1638NomenclatureSTOCK Tg(Prnp-MAPT*P301L)JNPL3Hlmc


TNF-α MICROINJECTED


Immunology: inflammation and arthritis

Hemizygous (T) 5 to 8 €269.009 to 12 €284.60Retired male breeder

€269.00

Wild Type (W) 5 to 8 €102.309 to 12 €139.80

Model Number: 1006NomenclatureB6.Cg(SJL)-Tg(TNF) N21+?


TSG-p53® CONSTITUTIVE KNOCKOUT


Oncology Homozygous (M) 5 to 8 €348.109 to 12 €364.70Retired homozygous male breeder

€308.80

Retired heterozygous female breeder

€328.50

Model Number: P53N4NomenclatureB6;129-Trp53tm1Brd N4


Animal Models

85www.taconic.com • +45 70 23 04 05





Only TSG-p53® model approved by the FDA for use in short-term carcinogenicity testing

Heterozygous (T) 5 to 12 €396.50

Model Number: P53N5NomenclatureB6;129-Trp53tm1Brd N5




Oncology Homozygous (M) 5 to 8 €406.109 to 12 €450.60Retired male breeder

€320.30

Heterozygous (T) 5 to 8 €305.809 to 12 €320.30Retired female breeder

€305.80

Model Number: P53N12NomenclatureB6.129-Trp53tm1Brd N12


Model Number: WHNomenclatureHanTac:WHWistar Hannover GALAS™ OUTBRED


General PurposePharmacologyToxicology

MPF 3 €10.10 €8.904 €11.40 €10.205 €14.40 €11.406 €15.60 €13.307 €18.50 €14.608 €19.90 €15.609 €22.70 €17.0010 €25.20 €19.9011 €26.50 €21.10


Animal Models

www.taconic.com • +45 70 23 04 0586



Wistar Kyoto OUTBRED

Applications Health Age (weeks) Male Female

Control for GK RatsControl for SHR Rats

MPF 4 €32.60 €32.605 €35.80 €35.806 €39.50 €39.507 €43.60 €43.608 €49.00 €49.009 €54.00 €54.0010 €58.80 €58.8011 €63.30 €63.3012 €68.70 €68.7013 €74.80 €74.8014 €79.90 €79.9015 €87.00 €87.0016 €92.70 €92.7017 €100.40 —18 €108.10 —Retired Breeder €65.00 €65.00

Female with litter(8 pups)

€224.10

Untimed pregnant* €173.20Timed pregnant €218.70


Model Number: WKYNomenclatureHanTac:WKY


Animal Models

87www.taconic.com • +45 70 23 04 05



Model Number Model Name Nomenclature Model Generation Technology463 Rag2/TCRβ B6.SJL(Cg)-Ptprca/BoyCrTac-Rag2tm1Fwa

Tg(Tcrb)Dlo N5Constitutive Knockout/Microinjected

557 XPC B6;129S7-Xpctm1Brd Constitutive Knockout578 Rag2 B10.129(B6)-Rag2tm1Fwa N13 Constitutive Knockout579 Fcgr2b C.129S4(B6)-Fcgr2btm1TtK/cAnNTac N12 Constitutive Knockout584 Fcer1g C.129P2(B6)-Fcer1gtm1Rav N12 Constitutive Knockout610 Mmp3 STOCK H2r-Mmp3tm1Mrl Constitutive Knockout612 IL-1β STOCK H2r-Il1btm1Lvp Constitutive Knockout993 K6/ODC B6.Cg-Tg(K6-Odc)55Tgo Microinjected1005 sPLA2 B6.Cg-Tg(PLA2G2A)703 N16+? Microinjected1055 Cd4 B6.129S2-Cd4tm1Nik N12 Constitutive Knockout1175 Cd4/CD4 C57BL/6-Cd4tm1Nik Tg(CD4) N7 Constitutive Knockout/Microinjected1480 ERKO-α B6.129-Esr1tm1Ksk N10 Constitutive Knockout1642 Serotonin Transporter B6.129-Slc6a4tm1Kpl N10 Constitutive Knockout1954 ERKO-β B6.129-Esr2tm1Unc N9 Constitutive Knockout2013 Egr1 B6.129-Egr1tm1Jmi N12 Constitutive Knockout3427 T-bet B6.129S6-Tbx21tm1Glm N10 Constitutive Knockout3469 T-bet C.129S6(B6)-Tbx21tm1Glm N10 Constitutive Knockout3736 Ccr2 B6.129P2-Ccr2tm1Mae Constitutive Knockout3737 Ccr5 B6.129P2-Ccr5tm1Kuz Constitutive Knockout4010 Black 10 Inbred C57BL/10SgSnAiTac Traditional Model4051 HY B10.Cg-Tg(TcraH-Y,TcrbH-Y)71Vbo N12 Microinjected4079 Rag2/HY B10.Cg-Rag2tm1Fwa Tg(TcraH-Y,TcrbH-

Y)71Vbo N10Constitutive Knockout/Microinjected

4080 Abb-B2m B6.129-H2-Ab1tm1Gru B2mtm1Jae N17 Constitutive Knockout9012 Inducible Type II

Diabetes RatNTac:SD-Tg(H1/tetO-RNAi:Insr)29Bdr Reversible RNAi Knockdown

9189 Inducible Type II Diabetes Mouse

C57BL/6NTac-Gt(ROSA)26Sortm31(H1/tet0-RNAi:Insr)Arte

Reversible RNAi Knockdown

AJ A Strain Inbred A/JCrTac Traditional ModelCB17 C.B17 C.B-Igh1b/IcrTac Spontaneous MutantCBA CBA Inbred CBA/JBomTac Traditional ModelHLAB27 HLA-B27 F344/NTac-Tg(HLA-B2705, β2M)33-3Trg MicroinjectedNIHBNX NIHS-III Spontaneous

MutantNIHS-LystbgFoxn1nuBtkxid

T, B & NK CELL DEFICIENTTac:NIHS Background

Spontaneous Mutant

OB Obese ob/ob B6.V-Lepob/JBomTac Spontaneous MutantPFPN12 Pfp B6.129S6-Prf1tm1Clrk N12 Constitutive KnockoutPIM Pim-1 STOCK Tg(Pim1)pp64aBrn MicroinjectedPIRC PIRC F344/NTac-Apcam1137 ENU-induced

Taconic offers access to a number of genetically modified models from cryopreserved stock. Some of these lines were previously produced as live colonies, but demand fell below the threshold needed to keep a live colony. Other lines were brought in directly for storage as cryopreserved stock due to expected lower demand. Taconic is pleased to be able to offer a broader selection of models through the inclusion of cryopreserved models. To access a cryopreserved line, typically a customer must sign a license agreement, pay a yearly license fee, and pay for cryorecovery of the line at Taconic. If you are interested in any of these cryopreserved lines, please contact your Taconic Representative to discuss cryorecovery and breeding of the line. Terms and Conditions of Use vary by model.

Cryopreserved Taconic Lines

Animal Models

www.taconic.com • +45 70 23 04 0588



Custom HybridsApplications

Hybrid crosses are available utilizing any Taconic MPF™ Traditional, Spontaneous Mutant, and/or Taconic Transgenic Model™ as parental stock. Customers must allow four weeks plus the age of the animal when ordering.

Please inquire for pricing and additional information.

Model Number: CUSHYB

Animal Models

89www.taconic.com • +45 70 23 04 05



The Taconic Emerging Models Program makes rodent models more readily available earlier in their

life cycle, through a repository of investigator-sponsored models that are bred and distributed

by Taconic. The Emerging Models Program is designed for researchers and institutions wishing

to sponsor mouse and rat models ready to be shared by collaborators and other investigators.

Taconic establishes your model in our commercial Murine Pathogen Free™ barriers and markets

it for you. Taconic handles order administration, MTAs, and delivery, while sponsors receive a

discount on Taconic husbandry. Our goal at Taconic is to support the development and sharing of

new and potentially important rodent models with the research community. Sponsorship is open

to Principal Investigators from academia and industry for individual models and also to institutions

supporting multiple lines. Let the Emerging Models Program remove some of the obstacles

involved in sharing your research tools with collaborators and the research community at large.

The program currently includes more than 50 different models in the areas of immunology,

neurodegeneration, and diabetes. Sponsoring institutions include universities, for-profit

institutions, and government institutes. Some of Taconic’s most successful commercial Taconic

Transgenic Models™ got their start in our Emerging Models Program. That intermediate step

allows investigators all over the world to access newly developed models and assist in their

characterization and validation. The APPSWE mouse model of Alzheimer’s disease (see pages 49- 50) is an example of a model that transitioned to full commercial status after distribution through

the Emerging Models Program.

The Emerging Models Program continues to grow. The following pages highlight various sponsors

and models in the Program, but is not a comprehensive list. Please visit www.taconic.com/

EmergingModels for the most complete and up to date listings as well as to learn more about

sponsorship in the program.

Emerging Models

Animal Models

www.taconic.com • +45 70 23 04 0590



The Michael J. Fox Foundation Emerging Models

Parkinson’s Disease Rat ModelsModel Number Model Name Nomenclature10677 Human LRRK2 R1441G Rat NTac:SD-Tg(LRRK2*R1441G)358Cjli10678 Human Alpha Synuclein A53T Rat NTac:SD-Tg(SNCA*A53T)268Cjli10679 Human Alpha Synuclein E46K Rat NTac:SD-Tg(SNCA*E46K)70Cjli10680 Human Alpha Synuclein Rat NTac:SD-Tg(SNCA)446Cjli10681 Human LRRK2 G2019S Rat NTac:SD-Tg(LRRK2*G2019S)571Cjli

Mutations in the LRRK2 and SNCA (alpha synuclein) genes are associated with familial Parkinson’s disease. These five new rat models each feature a transgene expressing one of these two human genes, either as wild type or with relevant mutations. These animals are being analyzed for their pathological, neurochemical, and behavioral phenotypes.

Origin: Developed by Dr. Chenjian Li, with funding support from The Michael J. Fox Foundation for Parkinson’s Research.

Please visit www.taconic.com/pdrats for more information on these models, including access terms and pricing.

University of Cambridge - NOD Congenic Exchange ProgramThe University of Cambridge Exchange Program is a special partnership within Taconic’s Emerging Models Program. The mission of thisprogram is to provide critical tools to assist in the identification of the quantitative trait loci (QTL) that affect the course of diabetespathogenesis. Dr. Linda Wicker at the University of Cambridge, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes andInflammation Laboratory, has constructed NOD Congenic Mouse Models that reproducibly alter the parental NOD phenotype and display varying levels of resistance from autoimmune diabetes.

The availability of the NOD Congenic Mouse Models will complement transgenic model approaches for understanding the immune system and for gaining an appreciation of the complexities of polygenic diseases. The University of Cambridge maintains the NOD Congenic Mouse Models at Taconic and generously sponsors the availability of these strains to the scientific community. This support allows investigators access to these genetically defined congenic strains with the goal of encouraging further study and expanding the knowledge of the loci involved in autoimmune diseases.

Various models are available. Check www.taconic.com/EmergingModels for a current list.

Amyotrophic Lateral Sclerosis Association Emerging ModelModel Number Model Name Nomenclature2148 SOD1 NTac:SD-Tg(SOD1G93A)L26H

Hemizygous rats express SOD1G93A in the spinal cord ~8-fold above endogenous SOD1. SOD1 rats develop motor neuron disease beginning with hind limb abnormal gait and progressing to paralysis.

Animal Models

91www.taconic.com • +45 70 23 04 05



Model Number Model Name4059 B10.Q/Ai

4087 Ccr1 Knockout

4091 Rag2 Knockout/Transgenic DO11.10 T Cell Receptor

4094 Rag2 Knockout/Transgenic Cyt5CC7 T Cell Receptor

4111 Rag2/Il2rg Double Knockout

4138 Tcrα Knockout/Transgenic LCMV P14 T Cell Receptor

4149 Abb Knockout/Transgenic HLA-DR4

4167 Cx3cr1 Knockout

4169 Fpr1 Knockout

4175 Rag1 Knockout/Transgenic OT-I T Cell Receptor

4177 Il4ra Knockout

4196 Cd4-cre Transgenic

4197 Lck-cre Transgenic

4207 Flt3l Knockout

4215 H2-Kb H2-Db Double Knockout

4216 H2-Kb Knockout

4217 H2-Db Knockout

4219 Rag2 Knockout/Transgenic DO11.10 T Cell Receptor

4234 Rag1 Knockout/Transgenic OT-II T Cell Receptor

4236 Nos2 Knockout

4245 LTH-1 Transgenic

4269 Il15 Knockout

4285 Transgenic DO11.10 T Cell Receptor/Transgenic CARΔ

4356 Rag2 Knockout/Transgenic LCMV-P14 T Cell Receptor

8424 SAP/Sh2d1A Knockout

Please visit www.taconic.com/EmergingModels for technical information, pricing, and access conditions for the NIAID Emerging Models. This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272201200029C.

The NIAID Exchange Program is a special partnership within Taconic’s Emerging Model Program. The mission of the NIAID Exchange Program is to increase availability to the scientific community of immunology-related transgenic models from the NIAID Transgenic Repository, which is maintained at Taconic.

The National Institute for Allergy and Infectious Diseases (NIAID) Exchange Program

Animal Models

www.taconic.com • +45 70 23 04 0592



Model Number Model Name Nomenclature Model Generation TechnologyART0042 Src (Rous Sarcoma

oncogene) KinaseSwitch mouse

C57BL/6-Srctm1Arte Constitutive Knock In

ART0048 Met (met Proto-oncogene) KinaseSwitch mouse

C57BL/6-Mettm1Arte Constitutive Knock In

ART0073 Mapk14 (Mitogen-activated Protein Kinase 14) KinaseSwitch mouse

C57BL/6-Mapk14tm1Arte Constitutive Knock In

7742 EphB4 (Ephrin Receptor B4) KinaseSwitch mouse

B6.129S6-EphB4tm1Cgi Constitutive Knock In

8026 Rps6kb1 (Ribosomal S6-kinase) KinaseSwitch mouse

B6.129-Rps6kb1tm1Cgi Constitutive Knock In

9070 Pdgfr-β KinaseSwitch mouse

B6.129-Pdgfrbtm1Cgi Constitutive Knock In

9723 Btk (Bruton's Tyrosine Kinase) KinaseSwitch mouse

C57BL/6-Btktm1Arte Constitutive Knock In

KinaseSwitch Models

Model Number Model Name Nomenclature Model Generation Technology11516 CRE-Luc GPCR Reporter

Mouse, Line 31FVB/NTac-Tg(CRE/Tk-luc)31Hgp Microinjected

11517 CRE-Luc GPCR Reporter Mouse, Line 33

FVB/NTac-Tg(CRE/Tk-luc)33Hgp Microinjected





CRE-Luc GPCR Reporter Mouse Models


Cryopreserved Emerging ModelsTo access a cryopreserved line, typically a customer must sign a license agreement, pay a yearly license fee, and pay for cryorecovery of the line at Taconic. If you are interested in any of these cryopreserved lines, please contact your Taconic Representative to discuss cryorecovery and breeding of the line. Terms and Conditions of Use vary by model.

Animal Models

93www.taconic.com • +45 70 23 04 05



Model Number Model Name Nomenclature Model Generation Technology10502 Vegfr2-KI nude STOCK Kdrtm1(luc)126Xen Foxn1nu Constitutive Knock In/Spontaneous

Mutant10627 Gadd45b-luc CD1-Tg(Gadd45B-luc)81Xen Microinjected10628 Epx-luc FVB/N-Tg(EPO-luc)334Xen Microinjected10629 Saa1-luc BALB/c-Tg(Saa1-luc)-Xen Microinjected10630 Il2-luc CD1-Tg(IL-2-luc)62Xen Microinjected10646 Cox2-luc BALB/c-Tg(Cox2-luc)53Xen Microinjected10647 TNF-luc BALB/cJ-Tg(Tnf-luc)13Xen Microinjected10650 IκBα-luc BALB/c-Tg(IκBα-luc)-26Xen Microinjected10655 Vegfr2-luc FVB/N-Tg(Kdr-luc)#Xen Microinjected10657 Vegfr2-KI STOCK-Kdrtm1(luc)126Xen Tyrc Constitutive Knock In/Spontaneous

Mutant10664 Vegf-luc FVB/N-Tg(Vegfa-luc)Xen Microinjected10665 EL1-luc/EL1-Tag FVB/N-(Ela1-Luc/Ela1-TAg)116Xen Microinjected10667 CYP3A4-luc FVB/N-Tg(CYP3A4)-Xen Microinjected10668 Cyp3a11-luc FVB/N-Tg(CYP3A11MH-luc)-Xen Microinjected10669 CYP3A4-luc (SD rat) NTac:SD-Tg(CYP3A4-luc)-633Xen Microinjected10687 Gadd153-luc CRL:CD-1 (ICR)BR-Tg(Ddit3-luc)44Xen Microinjected10688 Cyp1a1-luc CRL:CD-1-Tg(Cyp1a1)-51Xen Microinjected10689 Cyp1a2-luc CRL:CD-1 (ICR)BR-Tg(Cyp1a2-luc)-80Xen Microinjected10690 Cyp2c9-luc CRL:CD-1-Tg(Cyp2c9-luc)-20Xen Microinjected10691 Cyp19-luc Crl:CD-1 Tg(Cyp19a1-luc)125Xen Microinjected10694 yGcs-h-luc CRL:CD-1 (ICR)BR-Tg(yGcs-h-luc)-45Xen Microinjected10695 Sod1-luc CRL:CD-1 (ICR)BR-Tg(SOD1-luc)-104Xen Microinjected10696 Mdr1-luc CRL:CD-1 (ICR)BR-Tg(Mdr1-luc)-75Xen Microinjected10697 Gadd45α-luc CRL:CD-1 (ICR)BR-Tg(Gadd45α-luc)-

100XenMicroinjected

10698 Kap-luc FVB/N-Tg(KAP-luc)-Xen Microinjected10699 pS2-luc FVB/N-Tg(pS2/TFF1-luc)-110Xen Microinjected10700 Mup1-luc FVB/N-Tg(Mup-luc)-43Xen Microinjected10701 Esr1-luc CD-1-Tg(Esr1-luc)-101Xen Microinjected10704 Esr1-luc CD-1-Tg(Esr1-luc)-94Xen Microinjected10705 pS2-luc FVB/N-Tg(pS2/TFF1-luc)-78Xen Microinjected10706 RIP-luc FVB/N-Tg(Ins1-luc)#1Xen Microinjected10709 Retn-luc C57BL/6J-Tyrc-2J-Tg(Retn-luc)-7Xen Microinjected/Spontaneous Mutant10710 mIns2-luc C57BL/6J-Tyrc-2J-Tg(mlns2-luc)-44Xen Microinjected/Spontaneous Mutant10713 Bmp4-luc FVB/N-Tg(BMP418-luc)-18Xen Microinjected10756 Bmp4-luc FVB/N-Tg(BMP437-luc)-37Xen Microinjected

Light Producing Transgenic Animals®

Cryopreserved Emerging Models (continued)

Animal Models

www.taconic.com • +45 70 23 04 0594



The Taconic Knockout (KO) Repository

Taconic, one of the world’s leading providers and breeders of genetically modified mice, now offers immediate access to a vastly expanded database of KO models. With its high concentration of “druggable” gene class KO mice, the Taconic KO Repository will help fast track your drug discovery research. Instant access to KO mice combined with Taconic’s full array of breeding services gives you a competitive advantage by compressing time lines and accelerating your drug discovery research.

The Taconic KO Repository is one of the most versatile research tools available today — a 4,000-plus database that’s broader, deeper, and more inclusive than anything in the industry. To search the entire repository and view model descriptions, visit www.taconic.com/KOrepository.

Why KO Mice?

• Approximately 97% of human genes have a counterpart in the mouse genome.

• KO mice are ideal for exploring the effects of gene disruption.

• Characteristics of KO models help define the function and pharmaceutical utility of the protein that the disrupted gene encodes.

• There is a direct correlation between KO phenotype and Drug action for 85% of target knockouts. (Nature Reviews Drug Discovery, January 2003, Volume 2)

Why Taconic KO mice?

•More models, easier access, faster turnaround.• The Taconic KO Repository — with 4,000-plus models

and growing — is unique because most of our knockout models are not readily available from any other source.

• The high quality mouse models in the Taconic KO Repository were created using patented gene targeting or gene trapping technologies.

Taconic KO Repository: The superior choice for novel models.

The Taconic KO Repository focuses on genes encoding novel protein targets that are most suitable for pharmaceutical interdiction. Currently available models are represented within the following gene classes:

Ion Channel 6%

Enzyme 24%

GPCR 9%

Kinase 11%Membrane 8%

Phosphatase 4%

Protease 6%

Secreted 9%

Signaling 4%Molecule

Transporter 7%

Other 13%

Animal Models

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The Taconic Knockout (KO) RepositoryThe Taconic KO Repository has a relevant mutant mouse line that will help you reach your goal. Here are just a few of the single KO’s that can be found in the Taconic KO Repository that have applications for studying human conditions.

OncologyKOR Model GeneTF0762 Skap2TF0322 Igf1rTF0103 Cd274TF2135 Fcer1gTF0553 Pik3c2bTF0329 Idh1TF2637 Cxcl9TF0308 IkbkeTF0137 Csmd1TF2680 Egr1TF2964 Adarb2TF0028 AurkcTF3033 Tbk1TF2834 Usp15TF0378 Olr1TF0303 Cxxc4TF0266 Gpr141TF0197 EsrraTF0184 Enpp2TF0094 Csnk2a1TF0071 Card14TF0041 Ap2b1TF1038 Dusp4

Cardiovascular DiseaseKOR Model GeneTF0128 Cfl2TF0505 Hcn1TF2430 Slc20a1TF3135 PparaTF2813 Adipor1TF3016 GperTF0168 Ddah2TF0125 Ldb2TF2997 Hdac5TF0287 Hcn4TF0319 Itpr3TF0278 Grk4

Obesity and DiabetesKOR Model GeneTF0888 Wfs1TF1854 Brs3TF2054 GhsrTF0224 Gpr120TF0260 Gpr84TF0377 Ldlrap1TF1282 Map4k4TF0504 Gpbar1TF0002 AdipoqTF0690 RoraTF1946 DgkgTF1293 Gpr119TF3056 DgkkTF0400 Mtnr1bTF0346 Kcnj11TF0164 Dgkb

Mental DisordersKOR Model GeneTF1240 Htr2cTF0003 Htr5bTF0349 Kcnk2TF0502 Slc6a15TF0532 Pde10a

NeurodegenerationKOR Model GeneTF2765 Hdac6TF0320 IdeTF1296 Sirt1TF0055 Bace2TF0054 Bace1TF0038 Aph1aTF0827 TsnTF0127 Cfl1TF1997 Lrrk2

Surgical Services

97www.taconic.com • +45 70 23 04 05

Surgical ServicesCannulations/CatheterizationsProceduresSurgical Models

Your research applications often demand sophisticated models that are surgically modified to

meet your unique requirements. Yet, those procedures require staff, facilities, and space that you

may not be able to devote to the task. Taconic offers a variety of surgical services that enable you

to obtain the precise model your research requires, while focusing your in-house resources on the

business of research.

Through our advanced facilities and highly trained surgical technicians – overseen by ACLAM

board-certified veterinarians – Taconic provides a wide range of catheterizations, cannulations,

and implants, along with surgical models of disease and surgery procedures customized to

your specific needs. When your research requires vascular catheterized models, Taconic can

provide its standard models or customized models to meet your specific needs. Our staff can

perform surgical procedures on Taconic models or your models bred by Taconic, sourcing them

from controlled-environment barrier units that minimize pre-op and post-op stress. Close daily

monitoring by our staff assures full recovery before animals are shipped to you in sterilized Taconic

Transit Cages™.

Surgical Services

www.taconic.com • +45 70 23 04 0598

Vascular CatheterizationsThe lock solution is Heparinized Glycerol (500 IU/ml): 10.0 mL stock heparin (1000 IU/mL) + 10.0 mL 99% Glycerol solution (Sigma). Taconic can provide custom catheters and/or lock solutions upon request.

Item Number Description PriceCAC-R Carotid Artery—Rat €65.90CAC-M Carotid Artery—Mouse €100.30FAC-R Femoral Artery—Rat €76.00FVC-R Femoral Vein—Rat €64.20JVC-R Jugular Vein—Rat €53.00JVC-M Jugular Vein—Mouse €72.70 PVC-R Portal Vein—Rat €102.81Upon request, Taconic will consider the use of a customer-specified catheter vendor for a minor charge.

Cannulations/CatheterizationsTaconic uses various catheter materials for each procedure. For catheterizations, patency is guaranteed for up to 7 days from receipt of animals, without flushing. Need something customized for you? Contact our surgical experts at [email protected] to initiate a discussion on special projects.

Brain Cannulations

Item Number Description PriceICVC-R Intracerebroventricular—Rat €83.50ICVC-ALZET-M Intracerebroventricular—Mouse (With Alzet™ Infusion Kit) €121.68ICVC-ALZET-R Intracerebroventricular—Rat (With Alzet™ Infusion Kit) €103.60ICVC-M Intracerebroventricular—Mouse €101.70

ICVC-SCREEN Angiotensin II Screen of ICVC—Rat €62.90THIRDVEN-R Third Ventricle Cannulation—Rat €91.80MICRODIAL-M Microdialysis Probe Implant—Mouse €141.60MICRODIAL-R Microdialysis Probe Implant—Rat €105.60CUST-ICVC-R Custom Brain Cannulations—Rat (Customer to Provide Coordinates) €99.80CUST-ICVC-M Custom Brain Cannulations—Mouse (Customer to Provide Coordinates) €118.80The price of the animal is in addition to the surgical service. Animals ordered by weight will arrive within a reasonable tolerance to weight specifications. Though weight-specific surgeries are possible upon request, please contact Customer Service for more information about your specific procedure.

Other Catheterizations

Item Number Description PriceINTRATHE-R Intrathecal—Rat €125.20DUODEN-R Intestinal—Duodenal—Rat InquireDUODEN-M Intestinal—Duodenal—Mouse InquireBILERET-R Bile Duct w/Duodenal Return—Rat InquireMultiple cannulations and/or catherizations may be performed upon a single animal for an additive price. IACUC approval may be needed for some cannulation and/or catherization combinations.

Surgical Services

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Optional Items

Item Number Description Rat Price Mouse PriceJACKET Jackets €30.40 €30.40PLUG Stainless Steel Plugs for Cannulas €1.36 €1.36HOLD-M Daily Post Surgery Barrier Holding - Mouse — €2.40HOLD-R Daily Post Surgery Barrier Holding - Rat €4.30 —EARTAG Individual Ear Tag Identification €3.80 €3.80POLYU Polyurethane catheter €13.73 €13.73SPLOCK Custom lock solution €7.22 €7.22PORT Custom port €8.11 €8.11IACUCREG Regulatory Fee for IACUC Submission €283.61 €283.61

Procedures

Telemetry Implants*Item Number Description PriceTEL-PBT-R Pressure, Biopotential, Temperature and Activity—Rats €137.90TEL-2PTA-M Two Biopotential, Temperature and Activity—Mice €120.80TEL-2PTA-R Two Biopotential, Temperature and Activity—Rats €112.00TEL-3PA-R Three Biopotential and Activity—Rats €152.80TEL-PA-M Pressure and Activity—Mice €120.10TEL-PA-R Pressure and Activity—Rats €107.60TEL-TA-M Temperature and Activity—Mice €78.50TEL-TA-R Temperature and Activity—Rats €72.60ETAF20 Biopotential, Temperature and Activity—Rats €77.60ETAF10 Biopotential, Temperature and Activity—Mice €76.00

Other Procedures

Item Number Description Rat Price Mouse PriceSPLENEC-R Splenectomy €17.90 —SPLENEC-M Splenectomy — €20.80IMPLANT Implants (SQ)* €11.30 €11.30INJ-IP Injection (IP) €4.00 €4.00INJ-SQ Injection (SQ) €4.00 €4.00INJ-IV Injection (IV) €4.01 €4.01* Implants do not include cost of device.

Taconic’s surgical department provides analgesics to all surgically modified animals. Animals are modified using gaseous anesthesia. Exceptions to this policy will be considered by Taconic’s IACUC based on the scientific justification provided by the Principal Investigators (PIs) as part of their overall research protocol. Only after Taconic IACUC approval is obtained for withholding analgesics will animals be modified.

• Fee of €30.80 is added to all orders requiring less than 10 animals.• Fee of €11.20 per animal is added to all orders for immunodeficient mice or rats – additional precautions are taken to help minimize the

risk of changing from RF™ to MPF™ health status.• Sham prices are 75% of full surgical procedure price.• Surgeries for Taconic Transgenic Models™ (TTMs™) will require a custom quote.• The price of the animal is in addition to the surgical service. Animals ordered by weight will arrive within a reasonable tolerance

to weight specifications. Though weight-specific surgeries are possible upon request, please contact Customer Service for more information about your specific procedure.

Taconic also offers custom pilot projects for surgical procedures not listed in the catalog. Please email [email protected] for details.

Surgical Services

www.taconic.com • +45 70 23 04 05100

Surgical ModelsPlease refer to www.taconic.com for our care and use documentation.

Neurological Models

Item Number Description Rat Price Mouse PriceFAB Samaritan Alzheimer's Rat Model™ €289.00 —6OHDA 6-Hydroxydopamine Lesion of the Nigrostriatal

Pathway—Including 21 day post-lesion (Less €16.06 without evaluations)

€290.12 —

Endocrine Models

Item Number Description Rat Price Mouse PriceADRNLECTOMY Adrenalectomy €16.80 €18.40HYPOX Hypophysectomy (Rats < 45gm)* €30.80 —THYPARA Thyro-Parathyroidectomy €33.90 —*Price includes 6 to 10 day post op holding charges

Reproductive Models

Item Number Description Rat Price Mouse PriceCASTR Castration €15.20 €16.10OVR Ovariectomy €15.80 €16.30VASEC Vasectomy €20.40 €20.80

Renal Disease Models

Item Number Description Rat Price Mouse Price56NEPREC Subtotal Nephrectomy

Subtotal 5/6 Nephrectomy - 2 Stage (Rat)Subtotal 3/4 Nephrectomy - 1 Stage (Mouse)

€98.79—

—€88.91

NEPREC Nephrectomy €24.60 €23.60

Taconic’s surgical department provides analgesics to all surgically modified animals. Animals are modified using gaseous anesthesia. Exceptions to this policy will be considered by Taconic’s IACUC based on the scientific justification provided by the Principal Investigators (PIs) as part of their overall research protocol. Only after Taconic IACUC approval is obtained for withholding analgesics will animals be modified.

• Fee of €30.80 is added to all orders requiring less than 10 animals.• Fee of €11.20 per animal is added to all orders for immunodeficient mice or rats – additional precautions are taken to help minimize the

risk of changing from RF™ to MPF™ health status.• Sham prices are 75% of full surgical procedure price.• Surgeries for Taconic Transgenic Models™ (TTMs™) will require a custom quote.• The price of the animal is in addition to the surgical service. Animals ordered by weight will arrive within a reasonable tolerance

to weight specifications. Though weight-specific surgeries are possible upon request, please contact Customer Service for more information about your specific procedure.

Taconic also offers custom pilot projects for surgical procedures not listed in the catalog. Please email [email protected] for details.

Reference / Index

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Reference/IndexHow to OrderPregnant Animal PoliciesCancellation and Change OrdersTerms and Conditions of SaleTaconic Transgenic ExchangeLabel License: Conditions of Use for Taconic Transgenic Models™Model Reference GuideLight Producing Transgenic Animals® (LPTA®) Conditions of UseModel Name IndexModel Number IndexService Index

Reference / Index

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How To Order

Contact Customer Services:Europe Direct: +45 70 23 04 05 Fax: +45 86 84 16 99 E-mail (orders): [email protected]

Hours Monday - Thursday: 08:00 - 16:00 (CET) Friday: 08:00 - 15:00 (CET)

To Facilitate Your Order Please Provide:• Your Taconic Master Customer Number or Complete

Company Name, Address, and VAT Number• Invoice Address• Delivery Address• Purchase Order Number• Investigator Name

Orders are considered confirmed only when a Sales Order Number is provided by the Customer Service Representative.

Shipping and Payment Terms:

• Shipments must be inspected upon receipt, and any discrepancies must be reported within one business day to Taconic Customer Services.

• Please contact your dedicated Customer Service Representative to find out more about the specific deadlines that apply for shipments in your region.

• Payment Terms -- Net 30 days or prepayment.• Animals are delivered EXW (Incoterms 2010) —

Point of Origin.• All prices are in EURO.• Prices subject to change.• All purchases are subject to the Terms and Conditions of

Sale on pages 104 and 105.

Shipment Containers

• Rat and Mouse Models are packed in their Barrier Unit of origin or laminar flow hoods and shipped in sterilized Taconic Transit Cages™ (TTC™) with a food and hydration source.

• Traditional and Spontaneous Mutant Models: No Charge for TTC™.

• Taconic Transgenic Models™ and Emerging Models: €15.50/TTC™.• Germfree Rats and Mice are packed in special Germfree

vinyl shipping containers: €446.00 for shipments to Europe.

Transgenic Support Products can be shipped on wet ice for €12.50 per carton or dry ice for €17.90 per carton.

Birth Dates

•Week of Birth and source Barrier Unit identification are provided on shipping labels. For exact “date of birth” requests on Traditional Models, place orders prior to the needed birth date.

•Week of Birth: (Date of birth +/- 3 days): No Charge.• Exact Date of Birth: €3.60/animal (Traditional Models).

Orders Requiring Animals of aParticular Weight

•Mice and rats can lose up to 10% of their body weight in transit, however after 48 hours acclimation can be expected to regain any weight lost in shipment.

• All animals selected for orders will be within a typical weight range for the corresponding age. Weight charts are provided as a guide, however more detailed weight data is available for some lines at the client’s request.

• All weights are weights at the time of packing and are rounded to the nearest whole number.

• Taconic will select animals within a typical weight range for its corresponding age at no additional charge. Orders for specific weight spans take additional time to select and pack and as such will be assessed a nominal fee of €0.50 per animal. This fee will not apply to SD and Long Evans rats, which are typically ordered by weight.

•Mice (excluding Taconic Transgenic Models™ and Emerging Models) can be ordered with a minimum 3 gram span and rats with a minimum 25 gram span.

Reference / Index

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Pregnant Animal Policies

Type of ModelsUnder 14 Days Gestation

14+ DaysGestation

SD Rats 95% 100%Outbred Rats (other than SD) 75% 100%

Inbred Rats 60% 75%Outbred Mice 75% 100%Inbred Mice 60% 75%

Cancellation and Change OrdersOrders can be canceled or changed up to the cutoff time listed. Be sure to cancel an order prior to the cutoff time or cancellation fees may apply.

Order Type Cutoff Day/TimeTraditional Models; Spontaneous Mutant Models By 3:00 pm, two days prior to packing date Special setups, exact date of birth and timed pregnants orders Before breeders are set up or isolatedTaconic Transgenic Models™; Emerging Models 4 weeks prior to ship dateSurgically Modified Animals By 5:00 pm, day prior to animal transfer to surgeryAged Animals Prior to animals entering the aging colonyEmbryo Derivations and Cryopreservation Prior to animals arriving at TaconicMolecular Analysis; Animal Health Testing Prior to receipt of samplesMurine Biospecimens; Contract Breeding Projects Prior to project initiation

In order to allow clients to plan for studies accordingly, the chart below lists the percentage of animals that clients can expect to be pregnant based on animal model and gestational age. Taconic recommends orders for pregnant mice be less than 18 days gestation, and orders for pregnant rats be less than 19 days in order to prevent the animals from delivering in transit.

If problems are encountered with gestational age or pregnancy with timed pregnant orders, customers should immediately contact Taconic’s Customer Service Department to provide information regarding the number of animals involved and how non-pregnancy or mistiming was determined. Taconic will issue the appropriate credit.

All untimed pregnant orders are filled using late gestational age pregnant females selected from Production Colony breeders. Customers should be aware that untimed pregnant mice and rats may deliver their litters while in transit and that no assurances are given regarding the size of the litter.

Reference / Index

www.taconic.com • +45 70 23 04 05104

Terms and Conditions of Sale

Products

Limited Warranty:(a) Taconic Farms, Inc., warrants that the animal models provided shall conform to Taconic’s published specifications. Any claim by a customer for breach of this warranty shall be made in writing to Taconic no later than thirty (30) days after receipt of the animal models by customer. Customer’s sole remedy and Taconic’s exclusive liability for a breach of this limited warranty shall be, at Taconic’s option, either the replacement of the animal models or a refund of the fee paid for the animal models in question.

(b) THE FOREGOING WARRANTY IS IN LIEU OF ANY AND ALL OTHER WARRANTIES RELATING TO THE ANIMAL MODELS DELIVERED, EXPRESSED OR IMPLIED, INCLUDING, WITHOUT LIMITATION, ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR FOR NON-INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS.

Limitations of Liabilities:(a) In no event shall Taconic be liable to Client or to any third party claiming by or through the Client for any special, incidental, consequential, exemplary, punitive, multiple, or other indirect damages, or for loss of profits arising out of the provision of animal models, failure to deliver animal models conforming to the specifications or delay in delivery of the animal models, whether based upon warranty, contract, tort, strict liability, or otherwise, even if Taconic has been advised of the possibility of such damages or losses.

(b) Taconic’s liability arising out of provision of animal models, failure to deliver animal models conforming to the specifications or delay in delivery of the animal models, whether based upon warranty, contract, tort, strict liability, or otherwise, shall not exceed the fee paid by Client for such animal model.

(c) An action for breach of the limited warranty may not be brought by Client more than one (1) year after the provision of animal models, failure to deliver animal models conforming to the specifications or delay in delivery of the animal models.

Indemnification:Client agrees to defend Taconic and its affiliates at Client’s cost and expense, and will indemnify and hold Taconic, its affiliates, and their respective directors, officers, employees, and agents (the “Taconic Indemnified Parties”) harmless from and against any losses, costs, damages, fees, or expenses arising out of any third party claim relating to the design and manufacture of the materials or any products obtained therefrom, including strict liability claims.

Clients may not sell animal models, or any progeny of animal models, to any third party without the prior written permission of Taconic.

Services

Limited Warranty:(a) Taconic Farms, Inc. (“Taconic”) provides services to its clients (each a “Client”) on a contractual fee-for-service basis. Taconic warrants that it will perform the services with due care and in accordance with agreed-upon protocols or if no protocols are specifically agreed upon then in accordance with standard protocols for the relevant services being provided. Any claim by Client for breach of this warranty shall be made in writing to Taconic no later than ninety (90) days after the date that the report regarding the services is delivered to Client. Client’s sole remedy and Taconic’s exclusive liability for a breach of this limited warranty shall be, at Taconic’s option, either the re-performance of the service or a refund of the fee paid for the service in question.

(b) THE FOREGOING WARRANTY IS IN LIEU OF ANY AND ALL OTHER WARRANTIES RELATING TO THE SERVICES TO BE PERFORMED OR THE ACCURACY OF THE RESULTS OBTAINED, EXPRESSED OR IMPLIED, INCLUDING, WITHOUT LIMITATION, ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR FOR NON-INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS.

Limitations of Liabilities:(a) In no event shall Taconic be liable to Client or to any third party claiming by or through the Client for any special, incidental, consequential, exemplary, punitive, multiple, or other indirect damages, or for loss of profits arising out of the performance of the services or the failure, negligence, or delay in performance of the services, whether based upon warranty, contract, tort, strict liability, or otherwise, even if Taconic has been advised of the possibility of such damages or losses.

(b) Taconic’s liability arising out of the performance of the services or failure or delay to perform the services, whether based upon warranty, contract, tort, strict liability, or otherwise, shall not exceed the fee paid by Client for such services.

(c) An action for breach of the limited warranty may not be brought by Client more than one (1) year after the services are performed by Taconic.

Indemnification:For each service that Client provides materials (including compounds, biological materials, and other materials, the “Client Materials”) for use by Taconic in the performance of the service the Client agrees to defend Taconic and its affiliates at Client’s cost and expense, and will indemnify and hold Taconic, its affiliates, and their respective directors, officers, employees, and agents (the “Taconic Indemnified Parties”) harmless from and against any losses, costs, damages, fees, or expenses arising out of any third party claim relating to the Client Materials, the use of the Client Materials by Taconic for the performance of the services, or to the use by Client of any product or result obtained through the services, including strict liability claims.

Reference / Index

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Taconic Transgenic Exchange

Access to Intellectual Property and the Value of Taconic Transgenic Models™

Every Taconic Transgenic Model™ carries a label license granting you a license under Taconic’s in-licensed patent right(s) to use the model in your research. TTMs™ are produced and distributed under rights to patents that Taconic has licensed from various institutions, including exclusive distribution rights to Positive Negative Selection technology. Taconic is the only commercial breeder that can supply transgenic models with these licenses for use in your research.

Label License: Conditions of Use for Taconic Transgenic Models™TACONIC TRANSGENIC MODELS™ are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Model(s) to purchasers, and grants to each purchaser a right under Taconic’s sublicensable rights in such licensed patents and intellectual property to use the purchased MODEL in consideration of purchaser’s acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:

• Title to these MODELS and biological materials derived from them remains with TACONIC FARMS, INC.;

• The MODELS will be used for research purposes only;• The MODELS will not be bred except to obtain embryos or

fetuses required for research purposes;• The MODELS and biological materials derived from

them will not be distributed to third parties or used for commercial purposes.

The terms and conditions of use for Emerging Models varies by model. Please visit the website for details on your model of interest.

Reference / Index

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Model Nomenclature Breeding Scheme Production* Coat Color Coat Color Loci MHCNY IN CA DK

4007B6.SJL-Ptprca/BoyAiTac

Congenic MPF MPF Black

4010 C57BL/10SgSnAiTac Inbred Black RT1-A1

4011B10.A-H2aH2-T18a/SgSnAiTac

Congenic MPF Black

1296SVE 129S6/SvEvTac InbredRF, MPF

MPF MPFWhite-bellied Black Agouti

Aw RT1-A1

AJ A/JCrTac Inbred Albino a, Tyrp1b, Tyrc

B6 C57BL/6NTac InbredRF, MPF

RF, MPF

MPF MPF Black a

B6129 B6129S6F1/Tac Congenic MPF White-Bellied Agouti

B6C3F1 B6C3F1/Tac Hybrid MPF Black Agouti

B6D2F1 B6D2F1/Tac Hybrid MPF Black

B6JBOM C57BL/6JBomTac Inbred MPF MPF Black a

B6NU B6NTac.Cg-Foxn1nu /Tac

Spontaneous Mutant T-cell Deficient

RF RF RF Black a

B6SJL B6SJLF1/Tac Hybrid MPF Black Agouti H2b

BALB C.Cg-Foxn1nu/AnNTac Inbred MPF MPF Albino Tyrp1b, Tyrc H2d

BALBNU C.Cg/AnNTac-Foxn1nu NE9

Spontaneous Mutant T-cell Deficient

DF RF RF Albino Tyrc, Tyrp1b H2-T18c, H2d

BALBOM BALB/cABomTac Inbred MPF Albino Tyrp1b, Tyrc H2d

BALJBO BALB/cJBomTac Inbred MPF Albino Tyrp1b, Tyrc H2d

BHR SHWKF1/Tac Hybrid Albino Tyrc

BLKSW NTac:NIHBS Outbred RF Black a H2b

C3H C3H/HeNTac InbredRF, MPF

Black Agouti A/A H2k

CB17 C.B-Igh1b/IcrTac Congenic RF Albino Tyrp1b, Tyrc H2q

CB17SCC.B-Igh1b Prkdcscid

/IcrTacSpontaneous Mutant T&B Cell Deficient

DF RF RFRF, MPF

Albino Tyrc, Tyrp1b H2q

CBA DBA/1JBomTac InbredDilute Brown Non-Agouti

a, Tyrp1b, Myo5ad

CBSCBGC.B-Igh1b Prkdcscid

Lystbg/GbmsTac

Spontaneous Mutant - T, B & NK Cell Deficient

DF RF Albino Tyrp1b, Tyrc, Lystbg H2q

DA DA/MolTac Inbred MPF Agouti MHC RT1-Aa H2q

Model Reference Guide

*Production sites may change during the year.

Reference / Index

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Model Immunology Applications Pde6brd1 Avg. litter size1 2 3 4

4007 Immunology Adoptive transfer Transgenic and knockout models

•

4010 Immunology Inflammation Aging General Purpose CRYO

4011T cell development and tolerance

Immunology Inflammation 5

129S6VE ES cell productionTargeteed mutations

8

AJ ImmunizationHarvesting of spleen cells to create hybridomas

Metabolic/Cardiovascular Disease

Neurodegeneration CRYO

B6 Ptprcb, Thy1b, H2-T18bDiet induced obesity/ metabolic disease

ImmunologyTransgenic Production

Oncology

B6129Targeted mutation mice

5

B6C3F1Embryo donors in transgenic research

Toxicology 6

B6D2F1 Radiation BehaviorBioassays of nutrients, drugs and hormones

5

B6JBOM Oncology Immunology Toxicology

B6NU Oncology Immunology

B6SJLMicroinjection of transgenes

5

BALBProduction of monoclonal antibodies

Pharmacology Neurodegeneration Immunology 8

BALBNU Oncology Immunology

BALBOMProduction of monoclonal antibodies

Pharmacology Aging General Purpose 8

BALJBOProduction of monoclonal antibodies

Pharmacology Aging General Purpose 8

BHREnviromental hypertension

BLKSW Pseudopregnant female recipients

Targeted mutation chimeras

• 8

C3H Oncology Toxicology Infectious disease Neurodegeneration • Cryo

CB17Control for C.B17 scid

Cryo

CB17SC Oncology Immunology

CBA Immunology Inflammation • Cryo

CBSCBG Oncology Immunology

DA Immunology Oncology

Reference / Index

www.taconic.com • +45 70 23 04 05108

DBBKS.Cg-Leprdb Dock7m

/BomTacSpontaneous Mutant Diabetes/Obesity

MPF Black H2g7

DBA1BO DBA/1JBomTac Inbred MPF MPFDilute Brown Non-Agouti

a, Tyrp1b, Myo5ad H2q

DBA2 DBA/2NTac Inbred MPFDilute Brown Non-Agouti

a, Tyrp1b, Myo5ad

DR TacLevn:CD(SD)DR Outbred MPF Albino

DS TacLevin:CD(SD)DIO Outbred MPF Albino H2q

FVB FVB/NTac Inbred MPF MPF Albino Tyrc

GK GK/MolTac (cc) Inbred MPF Albino a, Tyrc

ICR IcrTac:ICR Outbred MPF Albino Tyrc

ICRSC IcrTac:ICR-Prkdcscid Spontaneous Mutant T&B Cell Deficient

RF RF Albino Tyrc

LEWIS LEW/MolTac Inbred MPF Albino a, Tyrcc

LONGEV SimTac:LE Outbred MPF Black-hooded a, h

NCRNU CrTac:Ncr-Foxn1nu Spontaneous Mutant T-cell Deficient

RF RF RF Albino Tyrc

NIHRNU NTac:NIH-Whn Spontaneous Mutant RF Various H2d

NMRI BomTac:NMRI Outbred MPF Albino A/A, Tyrc

NMRINU BomTac:NMRI-Foxn1nu Spontaneous Mutant T-cell Deficient

RF Albino Tyrc

NOD NOD/MrkTac Inbred MPF Albino Tyrc

NODSC NOD/MrkBomTac-Prkdcscid

Spontaneous Mutant T&B Cell Deficient

RF RF Albino Tyrc H2d

NSWNU NTac:NIHS-Foxn1nu Spontaneous Mutant T-cell Deficient

DF Albino Tyrc H2d

SD NTac:SD OutbredRF, MPF

MPF MPF Albino Tyrc

SHR NTac:SHR Outbred MPF Albino Tyrc

SJL SJL/JCrNTac Inbred MPF Albino Tyrc, p

SW Tac:SW OutbredGF, RF, MPF

RF MPF Albino Tyrc

WH HanTac:WH Outbred MPF Albino a, Tyrc, h

WKY NTac:WKY Outbred RF Albino a, Tyrc, h

Model Nomenclature Breeding Scheme Production* Coat Color Coat Color Loci MHCNY IN CA DK

Model Reference Guide

*Production sites may change during the year.

Reference / Index

109www.taconic.com • +45 70 23 04 05

DB

Type II Non-Insulin Dependent Diabetes Mellitus (NIDDM)

NephropathyDiabetic neuropathology

DBA1BO Immunology Inflammation Arthritis

DBA2 Seizures Hearing Loss Neurology 5

DR Obesity Hypertension Insulin resistance Hyperlipidemia

DS Obesity Hypertension Insulin resistance Hyperlipidemia

FVBTransgenic model production

• 8

GK RT2a Type 2 diabetes Retinopathy MicroangiopathyNephropathy; Neuropathy

ICR Toxicology Pharmacology Product safety • 10

ICRSC Oncology Immunology

LEWIS RT2a, RT3a ImmunologyAutoimmune Disease

Diabetes - streptozotocin induced

Transgenic model production

8

LONGEV Neurology Toxicology Ophthalmology 10

NCRNU Oncology Immunology

NIHRNU Oncology Immunology Toxicology

NMRI General Biology Toxicology Pharmacology Renal disease 10

NMRINU Oncology Immunology 6

NOD

Type I Insulin-DependentDiabetesMellitus (IDDM)

Destructive autoimmune pancreatic insulitis

NODSC Oncology Immunology

NSWNU Oncology Immunology Chemotherapeutic screening

SD Toxicology Pharmacology Safety testing 10

SHRGenetic Hypertension

Cardiovascular research

ADHD 8

SJLCardiovascular disease

Hodgkins disease • 5

SW Safety testingReproduction studies

Pharmacology Toxicology • 10

WH Toxicology General purpose Pharmacology 10

WKYNormotensive control for the SHR

Control for GK 8

Model Immunology Applications Pde6brd1 Avg. litter size1 2 3 4

Reference / Index

www.taconic.com • +45 70 23 04 05110

Title to the LPTA® Models is not transferred to researcher. Researcher has only the following limited rights to use the LPTA® Models. Researcher may obtain derivatives from the LPTA®

Models, consisting of tissues or organs, for their research use, however researcher shall have no right to establish luciferase containing cell lines from such derivatives. Researcher may not breed or propagate the LPTA® Models without the prior express written consent of Taconic. Researcher may not transfer the LPTA® Models or any derivatives to a third party. TACONIC MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING FOR NON-INFRINGEMENT, MERCHANTABILITY, OR FITNESS FOR A PARTICULAR PURPOSE WITH REGARDS TO THE LPTA® MODELS.

Use of the LPTA® Models may require a license to perform certain methods of non-invasive in vivo imaging of mammals that are covered by patents controlled by Caliper Life Sciences, Inc., including without limitation U.S. Patent Nos. 5,650,135; 6,217,847; 7,198,774; 6,649,143; 6,939,533; 6,916,462; 6,923,951; 6,890,515; and 6,908,605. The purchase of the LPTA® Models does not convey any license rights under such patents. Researcher should contact Caliper Life Sciences, Inc. to obtain license rights to such patents.

Promega Corporation provides the following limited use license with respect to the luciferase gene (the “product”) contained within the LPTA® Models.

BY USE OF THE PRODUCT, RESEARCHER AGREES TO BE BOUND BY THE TERMS OF THIS LIMITED USE STATEMENT. If the researcher is not willing to accept the conditions of this limited use statement, and the product is unused, Taconic will accept written certification that the product was destroyed prior to use and will provide the researcher with a full refund.

Researchers may use this product for research use only, no commercial use is allowed. Commercial Use means any and all uses of this product and derivatives by a party for monetary or other consideration and may include but is not limited to use in: (1) product manufacture; and (2) to provide a service, information or data; and/or resale of the product or its derivatives, whether or not such product or derivatives are

resold for use in research. Researchers shall have no right to modify or otherwise create variations of the nucleotide sequence of the luciferase gene except that Researchers may: (1) create fused gene sequences provided that the coding sequence of the resulting luciferase gene has no more than four deoxynucleotides missing at the affected terminus compared to the intact luciferase gene sequence, and (2) insert and remove nucleic acid sequences in splicing research predicated on the inactivation or reconstitution of the luminescence of the encoded luciferase. No other use or transfer of this product or derivatives is authorized without the prior express written consent of Promega. In addition, Researchers must either: (1) use luminescent assay reagents purchased from Promega Corporation for all determinations of luminescence activity of this product and its derivatives; or (2) contact Promega Corporation to obtain a license for use of the product and its derivatives. Researchers may transfer derivatives to others for research use provided that at the time of transfer a copy of this label license is given to the recipients and recipients agree to be bound by the terms of this label license. With respect to any uses outside this label license, including any diagnostic, therapeutic, or prophylactic uses, please contact Promega Corporation for supply and licensing information. PROMEGA MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING FOR MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE WITH REGARDS TO THE PRODUCT. The terms of this license shall be governed under the laws of the State of Wisconsin, USA. The above license relates to Promega patents and/or patent applications on improvements to the luciferase gene.

Light Producing Transgenic Animal® (LPTA®) Conditions of UseSTOP, READ BEFORE USE OF ANIMALS!

Reference / Index

111www.taconic.com • +45 70 23 04 05

Model Name129S6 (Model 129SVE) .................. 47A Strain (Model AJ) ........................ 87Abb (H2-Ab1) (Model 4026) ............ 47Abb (H2-Ab1) (Model ABBN12) ....... 47Abb Knockout/Transgenic HLA-DR4

(Model 4149) ............................. 91Abb-B2m (Model 4080) .................. 87Ahr Knockout Mouse (Model 9166) .. 47ApoB100 (Model 1004) .................. 48Apoe (ApoE) (Model APOE) .............. 48APOE2 (Model 1547) ..................... 48APOE3 (Model 1548) ..................... 48APOE4 (Model 1549) ..................... 48APPSWE (Model 1349) .................. 49APPSWE (Model 1349-RD1) ........... 49APPSWE (Model 2789) .................. 49APPSWE-Tau (Model 2469) ............. 49APPSWE-Tau (Model 2469-RD1) ..... 50APPSWE-Tau (Model 3273) ............. 50APPSWE-Tau (Model 3273-RD1) ..... 50β-actin-luc LPTA® (Model 10498) ..... 50β-actin-luc LPTA® (Model 10500) ..... 51B10.Q/Ai (Model 4059) .................. 91B2m (β2m) (Model B2MN12) .......... 51B6 Albino (Model 11971) ................ 51B6 Albino A++ (Model 11227) .......... 51B6 nude (Model B6NU) ................... 51B6.SJL (Model 4007) ..................... 52B6129F1 (Model B6129) ................ 52B6C3F1 (Model B6C3F1) ................ 52B6D2F1 (Model B6D2F1) ............... 53B6SJLF1 (Model B6SJL) ................. 53BALB/c (Model BALB) ..................... 53BALB/c nude (Model BALBNU) ......... 54BALB/cABom (Model BALBOM) ....... 54BALB/cJBom (Model BALJBO) ......... 54Bcrp (Model 2767) ......................... 54Black 10 (Model 4010) ................... 87Black 6 (Model B6) ......................... 55Black 6JBom (Model B6JBOM) ........ 55Black Swiss (Model BLKSW) ............ 55Bmp4-luc (Model 10713) ................ 93Bmp4-luc (Model 10756) ................ 93Brca1-Associated Breast Cancer Model (Model 11510) ................. 56Btk KinaseSwitch mouse (Model 9723) ............................. 92C.B17 (Model CB17) ...................... 87C.B-17 scid (Model CB17SC) .......... 56C3H (Model C3H) ........................... 56CamKII-cre (Model ART0009) .......... 56Car Knockout Mouse (Model 9103) .. 57CBA (Model CBA) ........................... 87Ccr1 Knockout (Model 4087) ........... 91Ccr2 (Model 3736) ........................ 87Ccr5 (Model 3737) ........................ 87Cd4 (Model 1055) .......................... 87Cd4/CD4 (Model 1175) .................. 87Cd4-cre Transgenic (Model 4196) .... 91

CETP (Model 3715) ........................ 57CETP-ApoB100 (Model 3716) ......... 57CIEA BRG mouse (Model 11503) ..... 57CIEA NOG mouse® (Model NOG) ...... 58COX-1 (Model 2180) ...................... 58COX-2 (Model 2181) ...................... 58Cox2-luc (Model 10646) ................. 93Cre Deleter (Model 6467) ............... 58CreERT2 (Model 10471) .................. 59CRE-Luc GPCR Reporter Mouse, Line 11 (Model 11515) ............... 59CRE-Luc GPCR Reporter Mouse, Line 31 (Model 11516) ............... 92CRE-Luc GPCR Reporter Mouse, Line 33 (Model 11517) ............... 92CRE-Luc GPCR Reporter Mouse, Line 64 (Model 11518) ............... 59CRE-Luc GPCR Reporter Mouse, Line 175 (Model 11519) ............. 92CRE-Luc GPCR Reporter Mouse, Line 187 (Model 11520) ............. 59CRE-Luc GPCR Reporter Mouse, Line 219 (Model 11521) ............. 92Cx3cr1 Knockout (Model 4167) ....... 91Cyp1a1-luc (Model 10688) ............. 93Cyp1a1/1a2 Knockout Mouse (Model ITI0122) .......................... 59Cyp1a2-luc (Model 10689) ............. 93Cyp2c Knockout Mouse (Model 9177) ............................. 59Cyp2d Knockout Mouse (Model 9178) ............................. 60Cyp2c9-luc (Model 10690) ............. 93Cyp3a (7-gene) Knockout Mouse (Model 8841) ............................. 60Cyp3a (8-gene) Knockout Mouse (Model 9011) ............................. 60CYP3A4-luc (Model 10667) ............ 93CYP3A4-luc (Model 10669) ............ 93Cyp3a11-luc (Model 10668) ........... 93Cyp3a-Cyp2da-Cyp2c Knockout Mouse (Model ITI0117) ............... 60Cyp19-luc (Model 10691) ............... 93Dark Agouti (Model DA) .................. 60DBA/1 (Model DBA1BO) ................. 61DBA/2 (Model DBA2) ...................... 61Diabetic (Model DB) ........................ 61Diet Induced Obese (Model DIO) ....... 62Egr1 (Model 2013) ........................ 87EL1-luc/EL1-Tag (Model 10665) ...... 93EphB4 KinaseSwitch mouse (Model 7742) ............................. 92Epx-luc (Model 10628) ................... 93ERKO-α (Model 1480) .................... 87ERKO-β (Model 1954) ..................... 87Esr1-luc (Model 10701) ................. 93Esr1-luc (Model 10704) ................. 93Fcer1g (FcRy) (Model 583) ............. 62Fcer1g (Model 584) ....................... 87

Fcgr2b (FcγIII) (Model 580) ............. 62Fcgr2b (Model 579) ....................... 87Fischer (Model F344) ..................... 63Floxed Ink4a/Arf Mouse (Model 11511) ........................... 63Floxed p53 Mouse (Model 11512) ... 63Flp Deleter (Model 7089) ................ 63Flt3l Knockout (Model 4207) ........... 91Fpr1 Knockout (Model 4169) ........... 91FVB (Model FVB) ............................ 64Gadd153-luc (Model 10687) ........... 93Gadd45α-luc (Model 10697) ........... 93Gadd45b-luc (Model 10627) ........... 93Gfap-luc LPTA® (Model 10501) ........ 64Goto-Kakizaki (Model GK) ................. 64Gsk3a KinaseSwitch Mouse (Model ART0069) ....................... 65Gsk3b KinaseSwitch Mouse (Model ART0059) ....................... 65H2-Db Knockout (Model 4217) ......... 91H2-Kb H2-Db Double Knockout (Model 4215) ............................. 91H2-Kb Knockout (Model 4216) ......... 91HLA-A1 (Model 9662) .................... 65HLA-A2.1 (Model 9659) ................. 65HLA-A11 (Model 9660) .................. 66HLA-A24 (Model 9663) .................. 66HLA-B7 (Model 9661) .................... 66HLA-B27 (Model HLAB27) .............. 87HLA-B44 (Model 9664) .................. 66HRN™ (Model 7353) ..................... 67HRN™ nude (Model 9066) ............. 67Human Alpha Synuclein A53T Rat (Model 10678) ........................... 90Human Alpha Synuclein E46K Rat (Model 10679) ........................... 90Human Alpha Synuclein Rat (Model 10680) .............................. 90Human LRRK2 G2019S Rat (Model

10681) ..................................... 90Human LRRK2 R1441G Rat (Model 10677) ........................... 90Humanized AHR Mouse (Model 9165) ............................. 67Humanized CAR Mouse (Model 9101) ............................. 67Humanized CYP1A1/1A2 Mouse (Model ITI0111) .......................... 67Humanized CYP2D6 Mouse (Model 11584) ........................... 68Humanized Cyp3A4/3A7 Mouse (Model 8842) ............................. 68Humanized Gut CYP3A4 Mouse (Model 9047) ............................. 68Humanized Liver & Gut CYP3A4 Mouse (Model 9049) ................... 68Humanized Liver CYP2C9 Mouse (Model 11746) ........................... 69

Reference / Index

www.taconic.com • +45 70 23 04 05112

Humanized Liver CYP3A4 Mouse (Model 9048) ............................. 69Humanized MRP2 Mouse (Model 9179) ............................. 69Humanized OATP1B1 Mouse (Model 10708) ........................... 69Humanized OATP 1B1/1B3 Mouse (Model 11594) ........................... 69Humanized OATP1B3 Mouse (Model 10725) ........................... 70Humanized PXR Mouse (Model 9104) ............................. 70Humanized PXR-CAR Mouse (Model 8223) ............................. 70Humanized PXR-CAR-AHR Mouse (Model ITI0082) .......................... 70Humanized PXR-CAR-CYP3A4/3A7

Mouse (Model 11585) ................. 70Humanized PXR-CAR-Cyp3A4/3A7-

CYP2D6 Mouse (Model ITI0134) .. 71Humanized PXR-CAR-CYP3A4/3A7-

CYP2D6-CYP2C9 Mouse (Model ITI0100) .......................... 71Humanized PXR-CAR-PPARα Mouse

(Model ITI0123) .......................... 71Humanized UGT1A1*1 Mouse(Model 11996) ............................... 71HY (Model 4051) ............................ 87ICR (Model ICR) .............................. 72ICR scid (Model ICRSC) ................... 72Il15 Knockout (Model 4269) ............ 91IL-1β (Model 612) ........................... 87Il2-luc (Model 10630) ..................... 93Il4ra Knockout (Model 4177) ........... 91Inducible Type II Diabetes Mouse (Model 9189) ............................. 87Inducible Type II Diabetes Rat (Model 9012) ............................. 87Invasive Lobular Breast Cancer Model (Model 11509) ................. 72IκBα-luc (Model 10650) ................... 93Jh (Model 1147) ............................ 72K6/ODC (Model 993) ...................... 87Kap-luc (Model 10698) ................... 93Lck-cre Transgenic (Model 4197) ..... 91Levin (DR, DS) ................................ 73Lewis (Model LEWIS) ...................... 73Long Evans (Model LONGEV) ............ 74LTH-1 Transgenic (Model 4245) ....... 91Mapk14 KinaseSwitch mouse (Model ART0073) ....................... 92Mdr1a (Model MDR1A) ................... 74Mdr1a/b (Model 1487) ................... 74Mdr1a/b-Bcrp (Model 3998) ............ 75Mdr1-luc (Model 10696) ................. 93Met KinaseSwitch mouse (Model ART0048) ....................... 92mIns2-luc (Model 10710) ................ 93Mmp3 (Model 610) ........................ 87Mrp1 (Model 1486) ........................ 75Mrp2 (Model 6621) ........................ 75Mup1-luc (Model 10700) ................ 93

NCr nude (Model NCRNU) ............... 75NFκB-RE-luc LPTA® (Model 10499) .. 75NIH nude (Model NIHRNU) ............... 76NIHS-III (Model NIHBNX) ................. 87NMRI (Model NMRI) ........................ 76NMRI nude (Model NMRINU) ........... 76NOD (Model NOD) .......................... 77NOD scid (Model NODSC) ................ 77Nos2 Knockout (Model 4236) .......... 91Ntrk1 KinaseSwitch Mouse (Model ART0066) ....................... 77Ntrk2 KinaseSwitch Mouse (Model ART0067) ....................... 77Oatp1a/b Cluster Knockout Mouse (Model 10707) ........................... 78Obese ob/ob (Model OB) .................. 87Oct1/2 (Model 6622) ...................... 78Pdgfr-β KinaseSwitch mouse (Model 9070) ............................. 92Pfp (Model PFPN12) ....................... 87Pfp/Rag2 (Model 1177) ................... 78Pim-1 (Model PIM) .......................... 87PIRC (Model PIRC) .......................... 87Pparα (Model 1640) ....................... 78pS2-luc (Model 10699) ................... 93pS2-luc (Model 10705) ................... 93Pxr Knockout Mouse (Model 9100) ... 78Pxr-Car Knockout Mouse (Model 8222) ............................. 79Pxr-Car-Ahr Knockout Mouse (Model 11583) ........................... 79Pxr-Car-Pparα Knockout Mouse (Model ITI0141) .......................... 79Rag1 Knockout/Transgenic OT-I T Cell Receptor (Model 4175) ......... 91Rag1 Knockout/Transgenic OT-II T Cell Receptor (Model 4234) ......... 91Rag2 (Model 461) .......................... 80Rag2 (Model 578) .......................... 87Rag2 (Model 601) .......................... 79Rag2 (Model RAG2) ........................ 79Rag2 (Model RAGN12) .................... 80Rag2 Knockout/Transgenic Cyt5CC7 T Cell Receptor (Model 4094) ...... 91Rag2 Knockout/Transgenic DO11.10 T Cell Receptor (Model 4091) ...... 91Rag2 Knockout/Transgenic DO11.10 T Cell Receptor (Model 4219) ...... 91Rag2 Knockout/Transgenic LCMV-P14 T Cell Receptor (Model 4356) ...... 91Rag2/HY (Model 4079) ................... 87Rag2/Il2rg Double Knockout (Model 4111) ............................. 91Rag2/OT-I (Model 2334) .................. 80Rag2/OT-II (Model 1896) ................. 80Rag2/TCRβ (Model 463) .................. 87rasH2 (Model 1178) ....................... 80Retn-luc (Model 10709) .................. 93RIP-luc (Model 10706) .................... 93Rps6kb1 KinaseSwitch mouse (Model 8026) ............................. 92Saa1-luc (Model 10629) ................. 93

SAP/Sh2d1A Knockout (Model 8424) ............................. 91scid-beige (Model CBSCBG) ............. 81Serotonin Transporter (Model 1642) . 87SJL (Model SJL) ............................. 81SOD1 (Model 2148) ....................... 90Sod1-luc (Model 10695) ................. 93sPLA2 (Model 1005) ...................... 87Spontaneously Hypertensive (Model SHR) ............................... 81Sprague Dawley® (Model SD) ........... 82Src KinaseSwitch mouse (Model ART0042) ....................... 92Stat1 (Model 2045) ........................ 83Swiss nude (Model NSWNU) ............ 83Swiss Webster (Model SW) ............. 83Tau (Model 1638) ........................... 84Tau (Model 2508) ........................... 84T-bet (Model 3427) ......................... 87T-bet (Model 3469) ......................... 87Tcrα Knockout/Transgenic LCMV P14 T Cell Receptor (Model 4138) ...... 91TNF-luc (Model 10647) ................... 93TNF-α (Model 1006) ....................... 84Transgenic DO11.10 T Cell Receptor/

Transgenic CARΔ (Model 4285) ... 91TSG-p53® (Model P53N4) ............... 84TSG-p53® (Model P53N5) ............... 85TSG-p53® (Model P53N12) ............. 85Vegf-luc (Model 10664) .................. 93Vegfr2-KI (Model 10657) ................ 93Vegfr2-KI nude (Model 10502) ......... 93Vegfr2-luc (Model 10655) ............... 93Wistar Hannover GALAS™ (Model WH) ................................ 85Wistar Kyoto (Model WKY) .............. 86XPC (Model 557) ............................ 87yGcs-h-luc (Model 10694) ............... 93

Reference / Index

113www.taconic.com • +45 70 23 04 05

Model Number129SVE (129S6) ........................... 47461 (Rag2) ................................... 80463 (Rag2/TCRβ) ........................... 87557 (XPC) ..................................... 87578 (Rag2) ................................... 87579 (Fcgr2b) ................................. 87580 (Fcgr2b (FcγIII)) ....................... 62583 (Fcer1g (FcRy)) ....................... 62584 (Fcer1g) ................................. 87601 (Rag2) ................................... 79610 (Mmp3) .................................. 87612 (IL-1β) .................................... 87993 (K6/ODC) ................................ 871004 (ApoB100) ........................... 481005 (sPLA2) ................................ 871006 (TNF-α)................................. 841055 (Cd4) ................................... 871147 (Jh) ...................................... 721175 (Cd4/CD4) ............................ 871177 (Pfp/Rag2) ............................ 781178 (rasH2) ................................ 801349 (APPSWE) ............................ 491349-RD1 (APPSWE) ..................... 491480 (ERKO-α) .............................. 871486 (Mrp1) ................................. 751487 (Mdr1a/b) ............................. 741547 (APOE2) ............................... 481548 (APOE3) ............................... 481549 (APOE4) ............................... 481638 (Tau) .................................... 841640 (Pparα) ................................. 781642 (Serotonin Transporter) .......... 871896 (Rag2/OT-II) .......................... 801954 (ERKO-β) .............................. 872013 (Egr1) .................................. 872045 (Stat1) ................................. 832148 (SOD1) ................................. 902180 (COX-1) ................................ 582181 (COX-2) ................................ 582334 (Rag2/OT-I) ........................... 802469 (APPSWE-Tau) ...................... 492469-RD1 (APPSWE-Tau) ............... 502508 (Tau) .................................... 842767 (Bcrp) .................................. 542789 (APPSWE) ............................ 493273 (APPSWE-Tau) ...................... 503273-RD1 (APPSWE-Tau) ............... 503427 (T-bet) .................................. 873469 (T-bet) .................................. 873715 (CETP) ................................. 573716 (CETP-ApoB100) ................... 573736 (Ccr2) .................................. 873737 (Ccr5) .................................. 873998 (Mdr1a/b-Bcrp) ..................... 754007 (B6.SJL) ............................... 524010 (Black 10) ............................. 874026 (Abb (H2-Ab1)) ..................... 474051 (HY) ..................................... 874059 (B10.Q/Ai) ............................ 91

4079 (Rag2/HY) ............................ 874080 (Abb-B2m) ............................ 874087 (Ccr1 Knockout) .................... 914091 (Rag2 Knockout/Transgenic

DO11.10 T Cell Receptor) ........... 914094 (Rag2 Knockout/Transgenic

Cyt5CC7 T Cell Receptor) ............ 914111 (Rag2/Il2rg Double Knockout) . 914138 (Tcrα Knockout/Transgenic LCMV P14 T Cell Receptor) ......... 914149 (Abb Knockout/Transgenic HLA-DR4) ................................... 914167 (Cx3cr1 Knockout) ................. 914169 (Fpr1 Knockout) .................... 914175 (Rag1 Knockout/Transgenic OT-I T Cell Receptor).................... 914177 (Il4ra Knockout) ..................... 914196 (Cd4-cre Transgenic) ............. 914197 (Lck-cre Transgenic) ............... 914207 (Flt3l Knockout) ..................... 914215 (H2-Kb H2-Db Double Knockout) ................................... 914216 (H2-Kb Knockout) ................... 914217 (H2-Db Knockout) ................... 914219 (Rag2 Knockout/Transgenic

DO11.10 T Cell Receptor) ........... 914234 (Rag1 Knockout/Transgenic OT-II T Cell Receptor) ................... 914236 (Nos2 Knockout) .................... 914245 (LTH-1 Transgenic) ................. 914269 (Il15 Knockout) ...................... 914285 (Transgenic DO11.10 T Cell

Receptor/Transgenic CARΔ) ......... 914356 (Rag2 Knockout/Transgenic

LCMV-P14 T Cell Receptor) ......... 916467 (Cre Deleter) ........................ 586621 (Mrp2) ................................. 756622 (Oct1/2) ............................... 787089 (Flp Deleter) ......................... 637353 (HRN™) ............................... 677742 (EphB4 KinaseSwitch Mouse).. 928026 (Rps6kb1 KinaseSwitch Mouse) 928222 (Pxr-Car Knockout Mouse) ...... 798223 (Humanized PXR-CAR Mouse) . 708424 (SAP/Sh2d1A Knockout Mouse) ...................................... 918841 (Cyp3a (7-gene) Knockout Mouse) ...................................... 608842 (Humanized Cyp3A4/3A7 Mouse) ...................................... 689011 (Cyp3a (8-gene) Knockout Mouse) ...................................... 609012 (Inducible Type II Diabetes Rat) ........................................... 879047 (Humanized Gut CYP3A4 Mouse) ...................................... 689048 (Humanized Liver CYP3A4 Mouse) ...................................... 69

9049 (Humanized Liver & Gut CYP3A4 Mouse) ......................... 689066 (HRN™ nude) ....................... 679070 (Pdgfr-β KinaseSwitch Mouse) 929100 (Pxr Knockout Mouse) ............ 789101 (Humanized CAR Mouse) ........ 679103 (Car Knockout Mouse) ............ 579104 (Humanized PXR Mouse) ........ 709165 (Humanized AHR Mouse) ........ 679166 (Ahr Knockout Mouse) ............ 479177 (Cyp2c Knockout Mouse) ........ 599178 (Cyp2d Knockout Mouse) ........ 609179 (Humanized MRP2 Mouse) ..... 699189 (Inducible Type II Diabetes Mouse) ...................................... 879659 (HLA-A2.1) ........................... 659660 (HLA-A11) ............................ 669661 (HLA-B7) .............................. 669662 (HLA-A1) .............................. 659663 (HLA-A24) ............................ 669664 (HLA-B44) ............................ 669723 (Btk KinaseSwitch Mouse) ...... 9210471 (CreERT2) ............................ 5910498 (β-actin-luc LPTA®) ............... 5010499 (NFκB-RE-luc LPTA®) ............ 7510500 (β-actin-luc LPTA®) ............... 5110501 (Gfap-luc LPTA®) .................. 6410502 (Vegfr2-KI nude) .................. 9310627 (Gadd45b-luc) ..................... 9310628 (Epx-luc) ............................. 9310629 (Saa1-luc) ........................... 9310630 (Il2-luc) .............................. 9310646 (Cox2-luc) ........................... 9310647 (TNF-luc) ............................ 9310650 (IκBα-luc) ............................ 9310655 (Vegfr2-luc) ........................ 9310657 (Vegfr2-KI) .......................... 9310664 (Vegf-luc) ............................ 9310665 (EL1-luc/EL1-Tag) ................ 9310667 (CYP3A4-luc) ...................... 9310668 (Cyp3a11-luc) ..................... 9310669 (CYP3A4-luc) ...................... 9310677 (Human LRRK2 R1441G Rat) ........................................... 9010678 (Human Alpha Synuclein A53T Rat) .................................. 9010679 (Human Alpha Synuclein E46K Rat) .................................. 9010680 (Human Alpha Synuclein Rat) ........................................... 9010681 (Human LRRK2 G2019S Rat) ........................................... 9010687 (Gadd153-luc) ..................... 9310688 (Cyp1a1-luc) ....................... 9310689 (Cyp1a2-luc) ....................... 9310690 (Cyp2c9-luc) ....................... 9310691 (Cyp19-luc) ......................... 9310694 (yGcs-h-luc) ........................ 9310695 (Sod1-luc) ........................... 93

Reference / Index

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10696 (Mdr1-luc) .......................... 9310697 (Gadd45α-luc) ..................... 9310698 (Kap-luc) ............................. 9310699 (pS2-luc) ............................. 9310700 (Mup1-luc) .......................... 9310701 (Esr1-luc) ............................ 9310704 (Esr1-luc) ............................ 9310705 (pS2-luc) ............................. 9310706 (RIP-luc) ............................. 9310707 (Oatp1a/b Cluster Knockout

Mouse) ...................................... 7810708 (Humanized OATP1B1 Mouse) ...................................... 6910709 (Retn-luc) ............................ 9310710 (mIns2-luc) ......................... 9310713 (Bmp4-luc) .......................... 9310725 (Humanized OATP1B3 Mouse) 7010756 (Bmp4-luc) .......................... 9311227 (B6 Albino A++) .................... 5111503 (CIEA BRG Mouse) ............... 5711509 (Invasive Lobular Breast Cancer Model) ............................ 7211510 (Brca1-Associated Breast Cancer Model) ............................ 5611511 (Floxed Ink4a/Arf Mouse) ...... 6311512 (Floxed p53 Mouse) ............. 6311515 (CRE-Luc GPCR Reporter Mouse, Line 11) .......................... 5911516 (CRE-Luc GPCR Reporter Mouse, Line 31) .......................... 9211517 (CRE-Luc GPCR Reporter Mouse, Line 33) .......................... 9211518 (CRE-Luc GPCR Reporter Mouse, Line 64) .......................... 5911519 (CRE-Luc GPCR Reporter Mouse, Line 175) ........................ 9211520 (CRE-Luc GPCR Reporter Mouse, Line 187) ........................ 5911521 (CRE-Luc GPCR Reporter Mouse, Line 219) ........................ 9211583 (Pxr-Car-Ahr Knockout Mouse) ...................................... 7911584 (Humanized CYP2D6 Mouse) 6811585 (Humanized PXR-CAR-

CYP3A4/3A7 Mouse) .................. 7011594 (Humanized OATP 1B1/1B3

Mouse) ...................................... 6911746 (Humanized Liver CYP2C9) ... 6911971 (B6 Albino) .......................... 5111996 (Humanized UGT1A1*1 Mouse) ...................................... 71ABBN12 (Abb (H2-Ab1)) ................. 47AJ (A Strain) .................................. 87APOE (Apoe (ApoE)) ........................ 48ART0009 (CamKII-cre) .................... 56ART0042 (Src KinaseSwitch Mouse) ...................................... 92ART0048 (Met KinaseSwitch Mouse) ...................................... 92ART0059 (Gsk3b KinaseSwitch Mouse) ...................................... 65

ART0066 (Ntrk1 KinaseSwitch Mouse) ...................................... 77ART0067 (Ntrk2 KinaseSwitch Mouse) ...................................... 77ART0069 (Gsk3A KinaseSwitch Mouse) ...................................... 65ART0073 (Mapk14 KinaseSwitch Mouse) ...................................... 92B2MN12 (B2m (β2m)) .................... 51B6 (Black 6) ................................... 55B6129 (B6129F1) .......................... 52B6C3F1 (B6C3F1) .......................... 52B6D2F1 (B6D2F1) .......................... 53B6JBOM (Black 6JBom) .................. 55B6NU (B6 nude) ............................. 51B6SJL (B6SJLF1) ........................... 53BALB (BALB/c) ............................... 53BALBNU (BALB/c nude) ................... 54BALBOM (BALB/cABom) ................. 54BALJBO (BALB/cJBom) ................... 54BLKSW (Black Swiss) ...................... 55C3H (C3H) ..................................... 56CB17 (C.B17) ................................ 87CB17SC (C.B-17 scid) .................... 56CBA (CBA) ..................................... 87CBSCBG (scid-beige) ....................... 81DA (Dark Agouti) ............................ 60DB (Diabetic) .................................. 61DBA1BO (DBA/1) ........................... 61DBA2 (DBA/2) ................................ 61DIO (Diet Induced Obese) ................. 62DR (Levin) ...................................... 73DS (Levin) ...................................... 73F344 (Fischer) ............................... 63FVB (FVB) ...................................... 64GK (Goto-Kakizaki) ........................... 64HLAB27 (HLA-B27) ........................ 87ICR (ICR) ....................................... 72ICRSC (ICR scid) ............................. 72ITI0082 (Humanized PXR-CAR-AHR

Mouse) ...................................... 70ITI0100 (Humanized PXR-CAR-

CYP3A4/3A7-CYP2D6-CYP2C9 Mouse) ...................................... 71 ITI0111 (Humanized CYP1A1/1A2

Mouse) ...................................... 67ITI0117 (Cyp3a-Cyp2da-Cyp2c Knockout Mouse) ...................................... 60ITI0122 (Cyp1a1/1a2) .................... 59ITI0123 (Humanized PXR-CAR-PPARα

Mouse) ...................................... 71ITI0134 (Humanized PXR-CAR-

Cyp3A4/3A7-CYP2D6 Mouse) ...... 71ITI0141 (Pxr-Car-Pparα Knockout Mouse) ...................................... 79LEWIS (Lewis) ................................ 73LONGEV (Long Evans) ..................... 74MDR1A (Mdr1a) ............................. 74NCRNU (NCr nude) ......................... 75NIHBNX (NIHS-III) ........................... 87NIHRNU (NIH nude) ......................... 76NMRI (NMRI) ................................. 76

NMRINU (NMRI nude) ..................... 76NOD (NOD) .................................... 77NODSC (NOD scid) ......................... 77NOG (CIEA NOG mouse®) ................ 58NSWNU (Swiss nude) ..................... 83OB (Obese ob/ob) ........................... 87P53N4 (TSG-p53®) ......................... 84P53N5 (TSG-p53®) ......................... 85P53N12 (TSG-p53®) ....................... 85PFPN12 (Pfp) ................................. 87PIM (Pim-1) ................................... 87PIRC (PIRC) .................................... 87RAG2 (Rag2) .................................. 79RAGN12 (Rag2) ............................. 80SD (Sprague Dawley®) ..................... 82SHR (Spontaneously Hypertensive).... 81SJL (SJL) ....................................... 81SW (Swiss Webster) ...................... 83WH (Wistar Hannover GALAS™) ..... 85WKY (Wistar Kyoto) ....................... 86

Reference / Index

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Service NameAnimal Bedding .......................................................... 39Animal Feed ............................................................... 39Basic Phenotyping Assays ........................................... 46Cannulations/Catheterizations ...................................... 98Cell Line Screening Assays for Viral Pathogens .............. 33Cryopreservation ........................................................ 29Diet Administration Protocols ...................................... 46Emerging Models Program .......................................... 89eTaconic: Online Colony Management ............................ 29Genetic Characterization ............................................. 32Genotyping and Other Testing Services ......................... 31Germfree Derivation ................................................... 22Gnotobiotic Equipment ................................................ 39International Health Monitoring System™ (IHMS™) . 34-37mRNA Expression Analysis .......................................... 32Mycoplasma by PCR ................................................... 33RapidMAP™ .............................................................. 33Rapid Colony Expansion ............................................... 29Serological Tests ........................................................ 38Speed Congenics ........................................................ 32Study-Ready Options ................................................... 46Surgical Models ....................................................... 100Taconic’s Molecular Analysis Program ........................... 31Taconic Transit Cage™ ............................................... 40Zygosity Testing ......................................................... 31

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Notes

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