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TACONIC BIOSCIENCESIMMUNOLOGY AND INFLAMMATION
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TACONIC BIOSCIENCESIMMUNOLOGY AND INFLAMMATION
Genetically engineered and
immune system engrafted
models offer a unique
opportunity for advancing
immunology and inflammation-
related research.
The immune system plays a pivotal role in the pathogenesis of many diseases, including autoimmune, allergic and infectious diseases, cancer, and atherosclerosis. Taconic Biosciences provides models and services to help explore those connections and model human disease.
Immunology and InflammationSolutions
Taconic Biosciences provides easy access to our exclusive portfolio of immunology and inflammation models designed to help grow and accelerate our clients’ drug discovery pipeline.
In addition to a broad spectrum of mechanistic and disease models in immunology and inflammation, Taconic offers a range of humanized models, including models with human gene replacement or mutations, and cell and tissue engraftment. The use of human immune system engrafted mice has proven to be advantageous in a wide variety of applications including immunomodulatory therapy, and autoimmune and infectious disease studies. Taconic also leads the industry in microbiome research—providing the highest number of health standards, several germ-free models, and related microbiome services including fecal microbiota transplantation and germ-free derivations. This platform allows researchers the ability to study the impact of the microbiome on immunology and inflammation targets and therapeutics.
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TACONIC BIOSCIENCESIMMUNOLOGY AND INFLAMMATION
There is growing evidence that segmented filamentous bacteria (SFB) can alter the immune system. Knowing whether SFB is present or absent in a model allows the investigator to control for this variable, making results more reproducible. While SFB is only one component of the gut microbiome, for many models the impact could be significant. Taconic includes SFB on all health reports. The Taconic Germ Free, Defined Flora, and Excluded Flora health designations exclude SFB.
The microbiome has become a major focus of many studies in the realm of immunology, oncology and inflammation. Taconic offers three key models, Black 6, BALB/c, and Swiss Webster, as off-the-shelf germ-free mice for immediate delivery in typical study sizes. Germ-free mice are devoid of all microorganisms (as determined within the limitations of the detection methods available), including bacteria, fungi and viruses; they have no microbiome. Strict Taconic husbandry and testing programs ensure these mice remain germ-free. Germ-free mice may be maintained as germ-free long-term or they may be associated with a custom microbiota. Taconic provides custom association services using customer-provided materials as well as custom germ-free derivation services and husbandry.
GERM FREE MODELS
SEGMENTED FILAMENTOUS BACTERIA (SFB)
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TACONIC BIOSCIENCESIMMUNOLOGY AND INFLAMMATION
TRADITIONAL MODELS
BLACK 6 INBRED MOUSE C57BL/6NTac
• The most widely used inbred as the
genetic background for transgenic
and mutant mice.
• Popular in research applications of
oncology, immunology and toxicology.
• Now available at the Germ Free health
standard in addition to Excluded Flora,
and Murine Pathogen Free™ health
profiles. The wide variety of health
designations available makes the B6
model ideal for microbiome studies.
• B6NTac is an excellent choice for the
chronic experimental autoimmune
encephalomyelitis model of
multiple sclerosis.
• May also be used for DSS-induced
colitis, induced model of systemic
lupus erythematosus (SLE) and
CIA-induced arthritis.
• Th2-biased.MODEL NUMBER B6
NOMENCLATURE
BALB/cINBRED MOUSE
• Often used for the production of
monoclonal antibodies using hybridomas
of BALB/c spleen cell origin.
• Exhibits good breeding performance and
long reproductive life span.
• Used in ovalbumin induced
hypersensitivity.
• Used in studies of innate and adaptive
immunity.
• Applications in colitis, allergy and asthma
and infectious disease studies.
• Th2-biased.
MODEL NUMBER BALB
BALB/cAnNTac
BALB/c
NOMENCLATURE
MODEL NUMBER BALJBO
BALB/cJBomTac
BALB/c Bom
NOMENCLATURE
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DBA/1 INBRED MOUSE DBA/1JBomTac
• Suitable general-purpose research
model for immunology and
inflammation research.
• Widely used as a model of
autoimmunity, especially for collagen-
induced studies of rheumatoid arthritis.
• High incidence of mammary tumors.
MODEL NUMBER DBA1BO
NOMENCLATURE
B6.SJLCONGENIC MOUSE B6.SJL-Ptprca/BoyAiTac
• Genetically similar to the C57BL/6Boy
strain except that it carries the Ptprca
allele (protein-tyrosine phosphatase,
receptor type c locus previously known
as CD45.1, Ly5.1) and the Pep3b allele
from the SJL/J strain.
• The unique lymphocyte cell surface
antigen produced by Ptprca makes
this strain useful for immunological
adoptive transfer experiments and
useful as a background for GEMs
used in adoptive transfer studies.
MODEL NUMBER 4007
NOMENCLATURE
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TACONIC BIOSCIENCESIMMUNOLOGY AND INFLAMMATION
SPONTANEOUS MUTANT MODELS
NIH nudeSPONTANEOUS MUTANT RAT
T CELL DEFICIENT NTac:NIH-Foxn1rnu
• Exhibits deficient T cell activity with
lymph nodes and Peyers patches
showing lymphocyte depletion in
T-lymphocyte dependent regions.
• In this outbred immunodeficient
model, the whiskers are present in the
homozygous nude rat, but present
as bent with some short hairs on the
head and occasionally on the rest of
the body (with age some hair growth
occurs, but rats become hairless again
within a few weeks).
• Skin of homozygous rat is generally
pigmented, but occasionally an
albino rat is seen.
• Good xenograft host.
• Used in infectious disease studies and
as a model of IBS.
MODEL NUMBER NIHRNU
NOMENCLATURE
B6 nudeSPONTANEOUS MUTANT MOUSE
T CELL DEFICIENT B6.Cg/NTac-Foxn1nu NE10
• The autosomal recessive nude gene in
homozygous (nu/nu) mice causes the
lack of fur and an abnormal thymus.
Deficiency in T cell function allows
athymic mice to accept and grow
xenografts as well as allografts of
normal and malignant tissues.
• Foxn1nu mutation backcrossed to
the C57BL/6NTac inbred strain for
ten generations.
• An appropriate model for adoptive
transfer experiments among other
strains on the B6 background.
• Used to study infectious diseases
including HIV and other viral infections.
MODEL NUMBER B6NU
NOMENCLATURE
BALB/c nudeSPONTANEOUS MUTANT MOUSE
T CELL DEFICIENTC.Cg/AnNTac-Foxn1nu NE9
• Foxn1nu mutation backcrossed to the
BALB/cAnN inbred strain for nine
generations.
• Available in two health designations:
Defined Flora from gnotobiotic
isolators and Restricted Flora™ from
Isolated Barrier Units™.
• Appropriate model for adoptive
transfer experiments among other
strains on the BALB/c background.
MODEL NUMBER BALBNU
NOMENCLATURE
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NCr nudeSPONTANEOUS MUTANT MOUSE
T CELL DEFICIENT CrTac:NCr-Foxn1nu
• Outbred background originated
from an accidental cross between
the BALB/c inbred nude and NIH(S)
outbred nude mice.
• The standard athymic model for
National Cancer Institute (NCI)
studies as well as many
pharmaceutical and institutional
oncology screening programs.
• Used in autoimmune disease studies
and transplantation.
MODEL NUMBER NCRNU
NOMENCLATURE
NMRI nudeSPONTANEOUS MUTANT MOUSE
T CELL DEFICIENTBomTac:NMRI-Foxn1nu
• Foxn1nu mutation backcrossed to the
NMRI outbred stock.
• A good general purpose outbred nude. • Used in autoimmune disease studies
and transplantation.
MODEL NUMBER NMRINU
NOMENCLATURE
C.B-17 scidSPONTANEOUS MUTANT MOUSE
T & B CELL DEFICIENTC.B-Igh-1b/IcrTac-Prkdcscid
• Mice homozygous for the Prkdcscid
mutation lack both T and B cells due
to a defect in V(D)J recombination.
Therefore, they easily accept foreign
tissue transplants, including human
tumors, making them effective models
for testing new cancer treatments and
as hosts for human immune system
tissues (i.e. SCID-hu).
• This is the original congenic
background strain on which Dr. Mel
Bosma discovered the spontaneous
scid mutation.
• Available at two health designations:
Defined Flora from gnotobiotic
isolators and Restricted Flora™ from
Isolated Barrier Units™.
• Used in studies of adaptive immunity
and infectious disease.
MODEL NUMBER CB17SC
NOMENCLATURE
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NOD scidSPONTANEOUS MUTANT MOUSE
T&B CELL DEFICIENT AND REDUCED NK FUNCTIONNOD/MrkBomTac-Prkdcscid
• The scid mutation has been transferred
onto a diabetes-susceptible Non-Obese
Diabetic (NOD) background, making it
a great model for metabolic disorder
research. Note: The NOD scid does not
develop diabetes.
• The multiple immunity defects unique
to this model provide an excellent
system for reconstitution with human
hematopoietic cells, making it an
exceptional model for HIV-1 research
and gene therapy studies.
• Useful model for cancer research into
increased tumor incidence, particularly
lymphomas and thymic tumors.
• Short life span of 8-9 months due to
lethal thymic lymphomas.
• Reduced NK cell activity due to
NOD background.
MODEL NUMBER NODSC
NOMENCLATURE
Scid-beigeSPONTANEOUS MUTANT MOUSE
T&B CELL DEFICIENT AND REDUCED NK CELLSC.B-Igh-1b/GbmsTac-Prkdcscid-Lystbg N7
• The mutations were backcrossed
seven generations to the congenic
C.B-17 background.
• This double mutant model carries the
scid mutation which causes a lack of
both T and B lymphocytes due to a
defect in V(D)J recombination.
• Model also carries the beige mutation
which results in cytotoxic T cell
and macrophage defects as well
as selective impairment of NK cell
functions. As a result, scid-beige mice
are an improved model for some types
of xenotransplants.
• The scid-beige strain has a lower
incidence of serum Ig relative to the
C.B-17 scid strain.
MODEL NUMBER CBSCBG
NOMENCLATURE
ICR scidSPONTANEOUS MUTANT MOUSE
T & B CELL DEFICIENTIcrTac:ICR-Prkdcscid
• Equivalent to the C.B-17 scid in severity
of immunodeficiency, this outbred
background exhibits a significantly
reduced incidence of spontaneous Ig
production (leakiness).
• Gains weight faster than the C.B-17
scid which makes the ICR scid better
suited for ascites production from
heterohybridomas and as a host for
tumor lines.
• Mice homozygous for the Prkdcscid
mutation lack both T and B cells due
to a defect in V(D)J recombination.
Therefore, they easily accept foreign
tissue transplants, including human
tumors, making them effective models
for testing new cancer treatments.
SCID mice are also useful for examining
the relationship between immunity
and disease.
MODEL NUMBER ICRSC
NOMENCLATURE
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IMMUNOLOGY RANGE COMPARISON TABLE
Listed below is information specific to Taconic’s Murine Pathogen Free™ (MPF™), Restricted Flora™ (RF™), Excluded Flora (EF),
and Defined Flora (DF) immunodeficient rodents. Taconic currently produces immunodeficient models (both spontaneous and
genetically modified mutations) on different background strains (and coat colors) and of differing health/microbiological profiles.
To inquire about availability of your model of interest at particular health designations, visit taconic.com/health-standards
MODEL NUMBER MODEL NAME COAT COLOR CELL DEFICIENCIES OTHER IMMUNODEFICIENCIES
BALBNU BALB/c nude mouse
B6NU B6 nude mouse
NCRNU NCr nude mouse
NMRINU NMRI nude mouse
NIHRNU NIH nude rat
1147 Jh mouse
CB17SC C.B.17 scid mouse
ICRSC ICR scid mouse
NODSC NOD scid mouse
Shows reduced NK function
Defective dendritic cells & macrophages and reduced complement activity.
601 Rag2 (BALB/c) mouse
RAGN12 Rag2 (C57BL/6) mouse
CBSCBG Scid-beige mouse
4111Rag2/Il2rg Double Knockout Mouse Dysfunctional dendritic cells
11503 CIEA BRG mouse Dysfunctional dendritic cells
NOG CIEA NOG mouse® Reduced complement activity, dysfunctional macrophages and dendritic cells, deficiencies in immune signaling, including cytokine production.The most immune deficient mouse available.
B2MN12 ß2m (C57BL/6) mouse Depletion of CD8+ T cells
ABBN12 Abb (C57BL/6) mouse Depletion of CD8+ T cells
11490 Rag2/OT-II mouse Expresses altered T cell population
2334 Rag2/OT-I mouseExpresses altered T cell population
White-bellied agouti
COAT COLOR
Black and White Nude Albino Nude
Black Nude
KEY:
Black
Albino
CELL DEFICIENCIES
T Cell Deficient
B Cell Deficient
NK Cell Deficient
MHC Deficient
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GENETICALLY ENGINEERED MODELS
To keep up with today’s fast-paced research, Taconic recognizes our customers’ need for speed and accessibility when it comes to genetically engineered models (GEMs) for immunology research. This portfolio provides quick access to advanced research models that are fully licensed and available in typical study quantities. Each GEM carries a license granting our customers the intellectual property rights to use the GEM in their research. Take advantage of Taconic’s GEM portfolio to avoid the challenges and cost of locating, licensing, and breeding the models you need.
GEMs
Abb (H2-Ab1)CONSTITUTIVE KNOCKOUT
C57BL/6 BACKGROUNDB6.129-H2-Ab1tm1Gru N12
• Contains a disruption of the
H2-Ab1 gene.
• Expresses no A or E MHC class II
molecules and therefore lacks
most CD4+ T cells.
• Useful in transplantation, gene therapy
and immunological disease research.
MODEL NUMBER ABBN12
NOMENCLATURE
B2m (β2m)CONSTITUTIVE KNOCKOUT
C57BL/6 BACKGROUND
• Contains a disruption of the
beta-2-microglobulin gene.
• These MHC class I deficient mice are
depleted of CD8+ T cells (lack the
NK1.1+ CD4+ T cell population as well).
• Useful in transplantation, gene therapy,
and immunological disease research.
MODEL NUMBER B2MN12
NOMENCLATURE
B6.129-B2mtm1Jae N12
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Abb–B2mCONSTITUTIVE KNOCKOUT
C57BL/6 BACKGROUNDB6.129-H2-Ab1tm1Gru B2mtm1Jae N17
• This double targeted mutation contains
disruption of both H2-Ab1 and B2m
genes, combining the characteristics
of the two individual targeted
mutation models.
• Useful in transplantation, gene therapy,
and immunological disease research.
MODEL NUMBER 4080
NOMENCLATURE
Ccr2CONSTITUTIVE KNOCKOUT
C57BL/6 BACKGROUNDB6.129P2-Ccr2tm1Mae N10
• Disruption of the Ccr2 gene results in
defects in macrophage trafficking.
• Useful for elucidating the function of
cells expressing Ccr2 during immune
and inflammatory processes.
• Useful for the study of asthma, arthritis,
and colitis.
MODEL NUMBER 3736
NOMENCLATURE
COX-1CONSTITUTIVE KNOCKOUT
MIXED C57BL/6 AND 129P2 BACKGROUNDB6;129P2-Ptgs1tm1Unc
• Contains a disruption of the Ptgs1 gene,
one of the prostaglandin endoperoxide
synthase/cyclooxygenase genes,
preventing synthesis of the
cyclooxygenase-1 (COX-1) protein.
• Homozygous mice have a significantly
reduced inflammatory response to
arachidonic acid, but not to other
inflammatory agents.
• Mice develop normally, appear healthy,
and do not exhibit gross or microscopic
gastric lesions.
• Useful to study cyclooxygenase
inhibitors and NSAIDs and to examine
the role of cyclooxygenae in
inflammatory disease.
MODEL NUMBER 2180
NOMENCLATURE
CRYOPRESERVED
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COX-2CONSTITUTIVE KNOCKOUT
MIXED C57BL/6 AND 129P2 BACKGROUNDB6;129P2-Ptgs2tm1Unc
• Contains a disruption of the Ptgs2
gene, one of the prostaglandin
endoperoxide synthase/
cyclooxygenase genes, preventing
synthesis of the cyclooxygenase-2
(COX-2) protein.
• Homozygotes develop peritoneal
lesions and exhibit severe, progressive
renal pathology and lesions of varying
severity that cause a progressive
deterioration with aging.
• Homozygotes exhibit normal
inflammatory response to bacterial
assault and to arachidonic acid and
other inflammatory agents.
• Useful to examine the redundant
and compensatory responses of
the cyclooxygenase gene, to study
cyclooxygenase inhibitors and NSAIDs
and to examine the role of COX
enzymes in inflammatory disease.
MODEL NUMBER 2181
NOMENCLATURE
Fcer1g (FcRγ)CONSTITUTIVE KNOCKOUT
• Deficient in the γ chain
subunit of the FcgRI, FcgRIII
and FceRI receptors.
• The deleted gamma chain
subunit is essential for cell
surface expression of
Fc receptors.
• Macrophages, neutrophils,
mast cells, basophils, and
NK cells are functionally
impaired, due to the lack of
the Fc receptors.
• The mice have normal T cell
thymic development and
peripheral T cell function.
• Useful in determining the
role of structurally similar
Fc receptors in mediating
effector immune responses
and studying the pleiotropic
role of the γ chain subunit.
• Mice exhibit several different
types of immunodeficiency
making them useful for
studies to distinguish the
role of the Fc receptors in
antibody-mediated effector
responses and to evaluate
the contribution of IgG
and IgE triggered effector
pathways.
MODEL NUMBER 583
B6.129P2-Fcer1gtm1Rav N12
C57BL/6 BACKGROUND
THESE MICE CARRY THE H2b HAPLOTYPE
NOMENCLATURE
MODEL NUMBER 584
C.129P2(B6)-Fcer1gtm1Rav N12
BALB/c BACKGROUND
THESE MICE CARRY THE H2d HAPLOTYPE
NOMENCLATURE
Fcgr2b (FcγRII)CONSTITUTIVE KNOCKOUT
• Deficient in FcgRIIβ protein,
which is a low affinity
immunoglobulin G receptor.
• The FcgRIIβ protein inhibits
the activation of disparate
effector functions such as
phagocytosis, antibody
dependent cytotoxicity, and
release of inflammatory
mediators. It is also known
to function as an inhibitory
receptor on B cells and
mast cells.
• This inhibitory pathway
for activation of several
immune effector responses
is dysfunctional, resulting
in the inability to regulate
antibody levels in response
to antigenic stimuli
dependent on IgG
immune complexes.
• Useful for studying the
feedback inhibition
pathways that regulate
antibody production and
in studies of allergic and
autoimmune disorders.
MODEL NUMBER 580
B6.129S4-Fcgr2btm1TtK N12
C57BL/6 BACKGROUND
THESE MICE CARRY THE H2b HAPLOTYPE
NOMENCLATURE
MODEL NUMBER 579
C.129S4(B6)-Fcgr2btm1TtK/cAnNTac N12
BALB/c BACKGROUND
THESE MICE CARRY THE H2d HAPLOTYPE
NOMENCLATURE
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HLA-A1RANDOM TRANSGENIC
CB6F1 BACKGROUNDCB6F1-Tg(HLA-A*0101/H2-Kb)A1.01
• Carries a transgene consisting of
fragments of the human HLA-A*0101
gene and mouse H2-Kb gene which
encodes a chimeric class I molecule
consisting of the human HLA-A1
leader, α1 and α2 domains ligated to
the murine α3, transmembrane and
cytoplasmic H2-Kb domains.
• Expresses the chimeric HLA-A1
class I molecule on the surface of
T and B cells.
• Represents the human HLA-A1
supertype.
• Useful for infectious disease research,
vaccine development and testing,
safety and immunogenicity testing,
as well as research directed towards
oncology and autoimmune disorders.
• Permits identification of epitopes
restricted to the HLA-A1 supertype.
MODEL NUMBER 9662
NOMENCLATURE
HLA-A2.1RANDOM TRANSGENIC
CB6F1 BACKGROUNDCB6F1-Tg(HLA-A*0201/H2-Kb)A*0201
• Carries a transgene consisting of
fragments of the human HLA-A*0201
gene and mouse H2-Kb gene which
encodes a chimeric class I molecule
consisting of the human HLA-A2.1
leader, α1 and α2 domains ligated to
the murine α3, transmembrane and
cytoplasmic H2-Kb domains.
• Expresses the chimeric HLA-A2.1
class I molecule on the surface of T
and B cells.
• Represents the human HLA-A2
supertype.
• Useful for infectious disease research,
vaccine development and testing,
safety and immunogenicity testing
as well as research directed towards
oncology and autoimmune disorders.
• Permits identification of epitopes
restricted to the HLA-A2 supertype.
MODEL NUMBER 9659
NOMENCLATURE
HLA-A11RANDOM TRANSGENIC
CB6F1 BACKGROUNDCB6F1-Tg(HLA-A*1101/H2-Kb)A11.01
• Carries a transgene consisting of
fragments of the human HLA-A*1101
gene and mouse H2-Kb gene which
encodes a chimeric class I molecule
consisting of the human HLA-A11
leader, α1 and α2 domains ligated to
the murine α3, transmembrane and
cytoplasmic H2-Kb domains.
• Expresses the chimeric HLA-A11
class I molecule on the surface of
T and B cells.
• Represents the human HLA-A3 supertype.
• Useful for infectious disease research,
vaccine development and testing,
safety and immunogenicity testing
as well as research directed towards
oncology and autoimmune disorders.
• Permits identification of epitopes
restricted to the HLA-A11 supertype.
• This model is produced upon order and
will not be available for delivery at least
6 weeks from order placement.
MODEL NUMBER 9660
NOMENCLATURE
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HLA-A24RANDOM TRANSGENIC
CB6F1 BACKGROUNDCB6F1-Tg(HLA-A*2402/H2-Kb)A24.01
• Carries a transgene consisting of
fragments of the human HLA-A*2402
gene and mouse H2-Kb gene which
encodes a chimeric class I molecule
consisting of the human HLA-A24
leader, α1 and α2 domains ligated to
the murine α3, transmembrane and
cytoplasmic H2-Kb domains.
• Expresses the chimeric HLA-A24
class I molecule on the surface of
T and B cells.
• Represents the human HLA-A24 supertype.
• Useful for infectious disease research,
vaccine development and testing,
safety and immunogenicity testing
as well as research directed towards
oncology and autoimmune disorders.
• Permits identification of epitopes
restricted to the HLA-A24 supertype.
• This model is produced upon order and
will not be available for delivery at least
6 weeks from order placement.
MODEL NUMBER 9663
NOMENCLATURE
HLA-B7
HLA-B44
CONSTITUTIVE KNOCKOUT / RANDOM TRANSGENIC
CB6F1 BACKGROUND
RANDOM TRANSGENIC
CB6F1 BACKGROUND
CB6F1-B2mtm1Unc Tg(B2M)55Hpl
CB6F1-Tg(HLA-B*4002/H2-Kb)B44.01
• Carries a transgene consisting of
fragments of the human HLA-B*0702
gene and mouse H2-Kb gene which
encodes a chimeric class I molecule
consisting of the human HLA-B7
leader, α1 and α2 domains ligated to
the murine α3, transmembrane and
cytoplasmic H2-Kb domains.
• Expresses the chimeric HLA-B7 class I
molecule on the surface of T and
B cells.
• Represents the human HLA-B7
supertype.
• Useful for infectious disease research,
vaccine development and testing,
safety and immunogenicity testing
as well as research directed towards
oncology and autoimmune disorders.
• Permits identification of epitopes
restricted to the HLA-B7 supertype.
• Carries a transgene consisting of
fragments of the human HLA-B*4002
gene and mouse H2-Kb gene which
encodes a chimeric class I molecule
consisting of the human HLA-B44
leader, α1 and α2 domains ligated to
the murine α3, transmembrane and
cytoplasmic H2-Kb domains.
• Expresses the chimeric HLA-B44
class I molecule on the surface of
T and B cells.
• Represents the human HLA-B44
supertype.
• Useful for infectious disease research,
vaccine development and testing,
safety and immunogenicity testing
as well as research directed towards
oncology and autoimmune disorders.
• Permits identification of epitopes
restricted to the HLA-B44 supertype.
MODEL NUMBER 9661
MODEL NUMBER 9664
NOMENCLATURE
NOMENCLATURE
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Abb Knockout/Transgenic HLA-DR4CONSTITUTIVE KNOCKOUT / RANDOM TRANSGENIC
C57BL/6 BACKGROUND
B6.129S2-H2-Ab1tm1Gru Tg(HLA-DRA/H2-Ea,
• The HLA-DR4 allele is associated with
the development of autoimmune
diseases like rheumatoid arthritis
and multiple sclerosis.
• Expresses a hybrid MHC class II
molecule with the peptide binding
domains of human HLA-DRA and
HLA-DRB*0401 and the membrane
proximal domains of mouse I-E (H2-E).
• Useful for studies of autoimmune
disease and vaccine research.
MODEL NUMBER 4149
NOMENCLATURE
JhCONSTITUTIVE KNOCKOUT
STOCK BACKGROUNDSTOCK Igh-Jtm1Dhu N?+N2
• Carries a deletion of the endogenous
murine J segments of the Ig heavy
chain locus.
• In homozygotes, all four JH gene
segments are absent, resulting in
cells that cannot produce a complete,
recombined version of the variable
region of the heavy chain.
• Have no detectable IgM or IgG in
the sera.
• A low level (about 1% of normal) of
rearrangement of the light chain
kappa gene family is detected in
total bone marrow.
• Cells of the B lineage are drastically
altered both in developmental
progression and in cell quantity.
• Contain no mature (immunoglobulin-
bearing) B lymphocytes in the spleen,
bone marrow, lymph nodes, peripheral
blood, or peritoneum.
• Useful for studying non-B cell activity
in pathogen-induced disease and
mechanisms of antibody gene
assembly and expression.
• T lymphocyte development appears
to proceed normally, based on surface
phenotype and quantity of cells in
the spleen; splenic lymphocytes
are enriched for T cells due to the
B cell deficit.
• Provides a null background useful for
gene replacement experimentation
in normal immune response and
autoimmune diseases.
MODEL NUMBER 1147
NOMENCLATURE
Rag2/II2rg Double KnockoutCONSTITUTIVE KNOCKOUT
MIXED BACKGROUND
B10;B6-Rag2tm1Fwa IIrgtm1Wjl
• Lacks mature T, B, and NK cells.
• Applications include xenografts,
transplantation of allogeneic or
xenogeneic stem cells and research on
the role of NK cells in host resistance to
tumors and infectious agents.
• Not appropriate for studies involving
engraftment of human hematopoietic
stem cells.
• Very useful for transplanting allogeneic
or xenogeneic stem cells which are
often rejected by NK cells.
• Available at the Excluded Flora (EF)
health standard.
MODEL NUMBER 4111
NOMENCLATURE
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Rag2/OT-ICONSTITUTIVE KNOCKOUT/
RANDOM TRANSGENICB6.129S6-Rag2tm1Fwa Tg(TcraTcrb)1100Mjb
• Carries a transgene that encodes a
T cell receptor (Vα2-Jα26 and
Vβ5-Dβ2-Jβ.6) specific for a
chicken ovalbumin peptide
fragment (257-264) presented
by the MHC class I molecule H2-Kb.
• Deficient in the recombination
reactivating gene 2 (Rag2) and
therefore does not develop mature
T or B cells expressing endogenous
T cell receptors.
• Virtually all peripheral CD8+ cells
express the transgene.
• Useful as a source of homogeneous
donor CD8+ T cells for in vivo adoptive
transfer studies to investigate T cell
development, activation, memory
and tolerance.
MODEL NUMBER 2334
NOMENCLATURE
MODEL NUMBER 601
C.129S6(B6)-Rag2tm1Fwa N12
BALB/c BACKGROUND
NOMENCLATURE
MODEL NUMBER RAGN12
B6.129S6-Rag2tm1Fwa N12
C57BL/6NTac BACKGROUND
NOMENCLATURE
• Backcrossed twelve generations (N12) to a
BALB/cAnNTac.
• Carries the H2d haplotype.
• Available at Excluded Flora (EF) health standard.
• Backcrossed twelve generations (N12) to a
C57BL/6NTac inbred background.
• Carries the H2b haplotype.
• Available at Murine Pathogen Free™ (MTF™) and
Excluded Flora (EF) health standards.
Rag2CONSTITUTIVE KNOCKOUT
T & B CELL DEFICIENT MODEL
• Contains a disruption of the recombination
activating gene 2 (Rag2).
• Homozygous mice exhibit total inability
to initiate V(D)J rearrangement and fail
to generate mature T or B lymphocytes.
• Useful for vaccine development,
transplantation studies and
hematopoiesis research.
• Rag2 knockouts may be used for
adoptive transfer-induced IBD studies.
MODEL NUMBER RAG2
129S6/SvEvTac-Rag2tm1Fwa
129S6 BACKGROUND
NOMENCLATURE
• The 129S6 strain was the original strain in which the
Rag2 targeted mutation was created.
MODEL NUMBER 461
B6.SJL(129S6)-Ptprca/BoyCrTac-Rag2tm1Fwa N10
B6.SJL-Ptprca BACKGROUND
NOMENCLATURE
• The Ptprca marker on hematopoietic cells of this
congenic strain allows for their identification in
immunological adoptive transfer experiments.
• Similar to C57BL/6 with the H2b haplotype, but
carries Ptprca and Pep3b genes from SJL strain.
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Rag2/OT-IICONSTITUTIVE KNOCKOUT/ RANDOM TRANSGENIC
C57BL/6 BACKGROUNDB6.129S6-Rag2tm1Fwa Tg(TcraTcrb)425Cbn
• Carries a transgene that encodes a T
cell receptor (Vα2 and Vβ5) specific for
a chicken ovalbumin peptide fragment
(323-339) presented by the MHC
class II molecule H2-Ab1 (I-Ab).
• Deficient in the recombination
reactivating gene 2 (Rag2) and does
not develop mature T or B cells
expressing endogenous T cell receptors.
• Virtually all peripheral CD4+ cells
express the transgene.
• Useful as a source of homogeneous
donor CD4+ T cells for in vivo adoptive
transfer studies to investigate T cell
development, activation, memory,
and tolerance.
MODEL NUMBER 11490
NOMENCLATURE
TNF-αRANDOM TRANSGENIC
INFLAMMATORY ARTHRITIS MODEL
C57BL/6NTac BACKGROUND
B6.Cg(SJL)-Tg(TNF) N21+?
• Expresses the human tumor necrosis
factor α (TNF-α) transgene, a cytokine
implicated in the pathogenesis of
human rheumatoid arthritis.
• Exhibits severe chronic arthritis of the
forepaws and hind paws, as shown
by gross observation and histological
analysis by approximately 20 weeks
of age.
• A useful model for studying
inflammatory arthritis which
does not require experimental
manipulation.
• Suitable for efficacy testing of
biosimilars.
MODEL NUMBER 1006
NOMENCLATURE
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LIGHT PRODUCING TRANSGENIC ANIMALS® (LPTA®)
Reporter models expressing luciferase under the control of various promoters, for use in bioluminescent imaging applications.
β-actin-lucRANDOM TRANSGENIC
• Constitutively expresses luciferase in
all tissues.
• Basal expression of the reporter is highest
in skeletal muscle, thymus, skin, heart,
bone, pancreas, and is detectable in all
tissues, including white blood cells.
• The reporter is constitutively expressed
and is not significantly inducible.
• Useful as a donor animal for studying the
transplantation of various tissue types.
MODEL NUMBER 10498
FVB/NTac-Tg(Actb-luc)46Xen
FVB BACKGROUND
NOMENCLATURE
MODEL NUMBER 10500
B6;FVB-Tyrc-2J Tg(Actb-luc)46Xen
B6;FVB ALBINO BACKGROUND
NOMENCLATURE
• SNP testing has shown that the strain background
is equivalent only to 4-5 backcrosses onto B6 albino,
so the background is designated as B6;FVB.
Gfap-lucRANDOM TRANSGENIC
FVB BACKGROUNDFVB/N-Tg(Gfap-luc)53Xen
• Expresses luciferase under control of
the Gfap promoter, which is inducible
following CNS injury.
• Please inquire for timeline and pricing
for F1 hybrids of the Gfap-luc and B6
albino mice for use in EAE studies.
• As a reporter for neuroinflammation,
luciferase expression provides an
additional readout beyond simple
clinical score in EAE studies with
this model.
MODEL NUMBER 10501
NOMENCLATURE
CRYOPRESERVED CRYOPRESERVED
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NFκB-RE-LucRANDOM TRANSGENIC
BALB/c BACKGROUNDBALB/c-Tg(Rela-luc)31Xen
• The model provides for the rapid study
of transcriptional regulation of the
NFκB gene.
• Useful in studying sepsis, arthritis,
inflammatory bowel disease, apoptosis,
tumor development, NFκB gene
regulation, and the treatment of
inflammatory diseases and cancer.
MODEL NUMBER 10499
NOMENCLATURE
ADDITIONAL LPTA® MODELS
AVAILABLE FROM TACONIC’S
CRYOPRESERVED REPOSITORY
MODEL NAME
10627 Gadd45b-luc
10628 Epx-luc
10629 Saa1-luc
10630 IL-2-luc
10646 Cox2-luc
10647 Tnfα-luc
10650 IkBa-luc
• Altered susceptibility to infection, immune
responses and inflammatory responses.
TNF-α KnockoutCONSTITUTIVE KNOCKOUT
C57BL/6 BACKGROUND
LUDWIG INSTITUTE SPONSORED
EMERGING MODEL
MODEL NUMBER 1921
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TACONIC BIOSCIENCESIMMUNOLOGY AND INFLAMMATION
EMERGING MODELS
The Emerging Models program includes distribution of investigator-sponsored models which are bred and distributed by Taconic. Since the sponsor sets distribution requirements for each of the Emerging Models, customers may be required to execute an MTA before certain models are delivered.
MODEL NUMBER NOG
MODEL NUMBER 13395
• The CIEA NOG mouse® is a super
immune deficient mouse with
unparalleled potential to engraft human
cells and tissues.
• This severely immunocompromised
mouse carries the scid mutation and a
targeted mutation of the Il2rg gene on
the NOD/ShiJic genetic background.
• The functional knockout of the IL2
receptor common gamma chain
(IL2rg) results in reduction of residual
innate immunity of the NOD/ShiJic
background and superior engraftment
of human cells and tissues compared to
any other immune deficient model.
• Lack of mature T, B, and NK cells,
reduced complement activity, dysfunc-
tional macrophages, and dendritic cells,
and deficiencies in immune signaling,
including impaired cytokine production.
• The polymorphism of SIRP-α allows the
mouse SIRP-α to bind human CD47,
preventing activation of recipient
macrophages to engulf human cells
therefore making it an ideal model for
human immune system engraftment
and PDX.
• Excellent choice for xenograft studies
using cell lines with poor take rates in
nudes or scids, or for engraftment of
patient-derived tumors.
• The best choice for human
immune system engraftment mice,
with successful engraftment of
various tissues such as PBMCs or
hematopoietic stem cells (HSC).
• Test therapeutic antibodies and
immune-modulating treatments
by combining immune system
engraftment of the immune system
with xenograft of tumor cell lines or
patient-derived tumors.
• Displays a very low incidence of
lymphoma, unlike NOD scid model.
• The Il2rg gene is X-linked, so male
knockouts are hemizygous for the Il2rg
mutant allele.
• Sponsored by the Central Institute for
Experimental Animals (CIEA) and
In-Vivo Science International.
• Applications in research involving
cancer, infectious disease (HIV,
malaria), immuno-oncology, CAR-T,
iPS, and humanization immune system
engraftment.
• Now available pre-engrafted with
human hematopoietic stem cell (hHSC)
as huNOG for immediate delivery at
16 weeks post-engraftment.
• NOG mouse expressing human
GM-CSF and IL-3.
• Supports higher overall engraftment
and superior myeloid cell differentiation
after human HSC engraftment.
• Now available pre-engrafted with HSCs
as huNOG-EXL for immediate delivery
at 10 weeks post-engraftment.
• May be a suitable host for human acute
myeloid leukemia (AML) xenografts
that are dependent on human GM-CSF
and human IL-3.
• The polymorphism of SIRP-α allows the
mouse SIRP-α to bind human CD47,
preventing activation of recipient
macrophages to engulf human cells
therefore making it an ideal model for
human immune system engraftment
and PDX.
• Excellent choice for xenograft studies
using cell lines with poor take rates in
nudes or scids, or for engraftment of
patient-derived tumors that requires
human GM-CSF or human IL-3.
CIEA NOG mouse®
NOG-EXL (hGM-CSF/hIL-3 NOG)
T, B & NK CELL DEFICIENT MOUSE
WITH IMPAIRED MYELOID FUNCTIONS
T, B & NK CELL DEFICIENT MOUSE
WITH IMPAIRED MYELOID FUNCTIONS
NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac
NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(SV40/HTLV-IL3,CSF2)10-7Jic/JicTac
NOMENCLATURE
NOMENCLATURE
NO MTA OR LICENSE FEE IS REQUIRED FOR PURCHASE.
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• NOG mouse expressing human IL-2
cytokine.
• Predominant differentiation of human
NK cells following hHSC engraftment.
• Excellent choice for xenograft studies
using cell lines with poor take rates
in nudes or scids, or for engraftment
of patient-derived tumors or tumor
infiltrating lymphocytes that requires
human IL-2.
• NOG mouse expressing human IL-6
cytokine.
• Enhanced expansion of human
monocytes following hHSC
engraftment.
• May be a suitable host for human IL-6
dependent tumor such as multiple
myeloma (MM) xenografts.
• NOG mouse expressing human IL-15
cytokine.
• Engraftment and expansion of human
NK cells following engraftment with
CD56+ NK cells derived from PBMC.
hIL-2 NOG
hIL-6 NOG
hIL-15 NOG
T, B & NK CELL DEFICIENT MOUSE WITH
IMPAIRED MYELOID FUNCTIONS
T, B & NK CELL DEFICIENT MOUSE WITH
IMPAIRED MYELOID FUNCTIONS
T, B & NK CELL DEFICIENT MOUSE WITH
IMPAIRED MYELOID FUNCTIONS
NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(CMV-IL6)4-2Jic/JicTac
NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(CMV-IL6)1-1Jic/JicTac
NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(CMV-IL2/IL15)1-1Jic/JicTac
NOMENCLATURE
NOMENCLATURE
NOMENCLATURE
MODEL NUMBER 13440
MODEL NUMBER 13686
MODEL NUMBER 13683
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CIEA BRG mouseCONSTITUTIVE KNOCKOUT BALB/C BACKGROUND C.Cg-Rag2tm1Fwa Il2rgtm1Sug/JicTac
• Immunodeficient model lacking mature
T, B, and NK cells.
• Higher radiation tolerance due to Rag2
mutation compared to scid models
(similar to wild type mice).
• Model is completely congenic on
BALB/c background, the preferred
strain background for many
immunology studies.
• Applications in studies on immune
system engraftment, infectious
diseases and autoimmune diseases
as well as cancer xenografts.
• Sponsored by the Central Institute
for Experimental Animals and In-Vivo
Science International.
MODEL NUMBER 11503
NOMENCLATURE
%
SP
EC
IFIC
RE
LE
AS
E
SERUM DILUTION
0
20
40
60
80
100
1/641/321/161/81/41/2
0
20
40
60
80
100
1/641/321/161/81/41/2
%
CY
TO
TO
XIC
ITY
E:T RATIO
0
20
40
60
80
100
100:1100:133:1100:1
0
20
40
60
80
100
100:1100:133:1100:1
HEMOLYTIC COMPLEMENT ACTIVITY – NOD scid AND NOG mice
Defect of hemolytic complement activity in sera of NOD scid and NOG mice.
The CIEA NOG mouse® shows defects in complement activity.
NK ACTIVITIES DEFECT – NOG mice
Defect of NK activities in spleen cells of NOG mice.
The CIEA NOG mouse® lacks NK cell activity.
NOGC.B-17 scid NOD scid
NOGC.B-17 scid NOD scid
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IMMUNOLOGY AND INFLAMMATION TACONIC BIOSCIENCES
TACONIC OFFERS
Human Immune System Engrafted ModelsImmunodeficient mice carrying a reconstituted human immune system
The super immunodeficient CIEA NOG mouse® is the ideal model for engraftment of human cells, and therefore the model of choice for combined immune system and tumor engraftment immuno-oncology experiments.
When reconstituted with various human
tissue sources, NOG mice are indispensable
for basic research probing the human
immune system. Engrafted NOG mice enable
efficacy testing of immunotherapies as
well as the unprecedented ability to study
tumor specific modulation of the immune
system. Taconic offers study-ready cohorts of
hematopoietic stem cell-engrafted NOG mice.
In addition to these models, Taconic offers
access to scientific expertise on use of
the CIEA NOG mouse® for engraftment
and reconstitution with human tissues.
For additional information on these models,
visit taconic.com/his-mice
Immune system engrafted mouse models
are excellent tools to evaluate the effect
of human immune cells in preclinical
oncology:
• Assessment of therapeutic
immunomodulatory activities
• Evaluation of antitumor activity
related to antibody dependent
cell cytotoxicity (ADCC)
• Analysis of innate and
adaptive immunity
• Cytokine readouts
These models are also excellent tools
for other research application, such as:
• Immuno-Oncology Research
• GvHD (Graft versus Host Disease)
• T cell activation model
• B cell depletion studies
• Autoimmune disease
• Allergy
• Inflammation
• HIV Research
• Vaccine development
• Transplantation
• Study of hematopoiesis
HOW CAN IMMUNE SYSTEM
ENGRAFTED NOG MICE BE USED?
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• Model for investigation of adult/
mature cell populations.
• Use is limited to short term studies.
• GvHD response can be used as a
screening system for T cell
modulating drugs.
• Available with normal or patient-
derived PBMCs.
NOG MICE ENGRAFTED WITH HUMAN
PBMCs (PERIPHERAL BLOOD MONONUCLEAR CELLS)
• Stable engraftment of multiple
cell lineages by 12-16 weeks
post-injection.
• Only mice with ≥25% hCD45+ in
peripheral blood are delivered.
• Long-term studies possible.
huNOG ARE AVAILABLE OFF-THE-SHELF!
PLACE YOUR ORDER NOW FOR
IMMEDIATE DELIVERY.
huNOGNOG MICE ENGRAFTED WITH HUMAN
CD34+ HEMATOPOIETIC STEM CELLS (HSCs)
huPBMC-NOG
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huNOG-EXL
• Stable engraftment of multiple cell
lineages, with improved myeloid cell
differentiation.
• Only mice with ≥25% hCD45+ in
peripheral blood are delivered.
• Long-term engraftment enables
long-term studies.
NOG-EXL (HGM-CSF/HIL3-NOG) MICE ENGRAFTED WITH
HUMAN CD34+ HEMATOPOIETIC STEM CELLS (HSCs)
huNOG-EXL MICE ARE AVAILABLE
OFF-THE-SHELF! PLACE YOUR ORDER
NOW FOR IMMEDIATE DELIVERY.
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COMMON MYELOIDPROGENITOR
IL-1IL-3GM-CSFSCF
COMMON LYMPHOIDPROGENITOR
IL-2IL-7IL-12SDF-1
IL-1 IL-6IL-2 IL-7IL-4
B LYMPHOCYTE TNK PROGENITOR
MYELOBLAST
GM-CSF
BASOPHIL
SCFG-CSFGM-CSFIL-3IL-6
NEUTROPHIL
SCFG-CSFGM-CSFIL-3IL-6
EOSINOPHIL
GM-CSFIL-3IL-5
MONOCYTE
SCFM-CSFG-CSFGM-CSFIL-3IL-6
huNOGhIL-2 NOG, hIL-15 NOGhIL-6 NOGhuNOG-EXL(hGM-CSF/hIL-3 NOG)
HEMATOPOIETICSTEM CELL
T LYMPHOCYTE
IL-2IL-7
NK CELL
IL-15IL-7
HEMATOPOIESIS AND HUMAN IMMUNE SYSTEM ENGRAFTED MICE
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CHOOSE TACONIC
For more than 60 years, Taconic has anticipated
the needs of the scientific community to deliver
models and services that meet the diverse needs of
biomedical and biopharmaceutical researchers.
Today that forward thinking and commitment to
working collaboratively has resulted in a client-centric
environment infused with a knowledge bank that
allows you to select the optimum model for your
study based on informed insight into the generation
of genetically engineered mouse and rat models.
YOUR COLLABORATIVE PARTNER
As a full-service biosciences company, Taconic can help
you acquire, test, develop, breed, cryopreserve, prepare,
and distribute highly relevant research lines worldwide.
Whether you require custom genetically engineered,
cell or tissue engrafted models or traditional models,
Taconic’s scientists will partner with you to rapidly
and efficiently deliver the highest quality models.
TALK TO A SCIENTIST
Our scientific teams are happy to meet and talk
with you about the most efficient way to achieve
your study goals. Working in partnership with
clients the world over, our scientific teams offer
expert advice that can help you speed up your
research and reduce your overall costs.
TALK TO A REPRESENTATIVE
For general information, you can talk to a member
of our customer service team. Our customer
service team is here to help you make the right
decisions and get the models you need fast.
Contact us at [email protected]
VISIT TACONIC.COM
For more information on the entire Taconic
portfolio of products and services designed to
help further your research, visit taconic.com
Take Your Research Further
GEMs MANAGEMENT
Taconic’s fully integrated GEMs
Management brings innovative models
from design to study-ready cohorts with
unprecedented speed and transparency.
• Embryology
• Rapid Colony Expansion
• Contract Breeding
• Surgical Services
• Tissue Collection
• Genotyping and Molecular Analysis
• Microbiome and Germ-Free Research
Models and Services
GEMs DESIGN
Taconic Biosciences Genetically
Engineered Models (GEMs) Design
empowers our clients to develop research
models specifically suited to the unique
needs of their discovery and development
studies or therapeutic programs.
• Gene Inactivation
• Gene Mutation or Replacement
• CRISPR Gene Editing
• Transgene Expression
• miRNA Expression
• Cohort Production Packages
PRECISION RESEARCH MODELS
Research organizations demand
precision tools that better reflect human
physiology. Taconic Biosciences leads
the field delivering innovative solutions
to meet these continually evolving
needs. Our core competencies include
the delivery of complex strategies that
both integrate human genetic sequences
and engraft human cells and tissues into
custom mouse and rat models.
• Human Gene Replacement
• Human Cell and Tissue Engraftment
©Taconic Biosciences, Inc. All rights reserved. Contents of this publication
may not be reproduced in any form without prior permission.
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