Table of Contents - IPlanet Health · medical approach. Integrative medicine for mental health is a...

Table of ContentsTable of ContentsEducational ResourcesPayment OptionsGetting Started With Our Lab ServicesFrequently Asked QuestionsTestimonialsTests

Organic Acids Test (OAT)Sample TestReport Analysis

IgG Food Allergy Test w/ CandidaSample Report

Metals TestsGluten / Casein Peptides TestIgE Food and Inhalant Allergy TestsHormone PanelsAmino Acids TestsVitamin D TestAdvanced Cholesterol ProfileImmune Deficiency ProfileComprehensive Stool AnalysisCopper / Zinc ProfileComprehensive Fatty Acids TestGPL-3GPL-4OAT + IgG Food Allergy Test w/ Candida ComboComprehensive Test Panels

Comprehensive Autism PanelComprehensive AD(H)D PanelComprehensive Mental Health PanelComprehensive Wellness Panel

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The Great Plains Laboratory, Inc.

1call: (913) 341-8949William Shaw, Ph.D., Director | 11813 West 77th Street, Lenexa, KS 66214 | (913) 341-8949 | Fax (913) 341-6207 | www.GPL4U.com

A research-based clinical laboratory offering services worldwide.

Information Guide

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1www.GPL4U.com

William Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry. Before he founded The Great Plains Laboratory, Dr. Shaw worked for the Centers for Disease Control and Prevention, Children’s Mercy Hospital, University of Missouri at Kansas City School of Medicine, and Smith

Kline Laboratories. He is the author of “Biological Treatments for Autism and PDD,” originally published in 1998 and “Autism: Beyond the Basics,” published in 2009. He is also a frequent speaker at conferences worldwide.

Dr. Shaw is the stepfather of a child with autism and has helped thousands of patients and medical practitioners to successfully improve the lives of people with autism, AD(H)D, Alzheimer’s disease, arthritis, bipolar disorder, chronic fatigue, depression, fibromyalgia, immune deficiencies, multiple sclerosis, OCD, Parkinson’s disease, seizure disorders, tic disorders, Tourette syndrome, and other serious conditions.

Dr. Shaw’s research led him to discover the neurological effects that yeast and bacteria metabolites have on the behavior of children with autism. His research soon expanded to fungal metabolites, oxalate production, cholesterol deficiency, and specific mitochondrial markers. All these discoveries, combined with the latest computer technology, allowed Dr. Shaw to develop a very unique Organic Acids Test that measures specific markers from yeast and bacteria.

Our MissionOur mission is to improve health treatment outcomes for chronic illnesses by providing the most accurate, reliable, and comprehensive biomedical analyses available - using the latest technology and proven techniques – and by providing education to patients, families, and health care practitioners.”

Contact Information

About the Director

Hours of Operation:8 a.m. to 5 p.m. Central time USA 1400 (2 p.m.) to 2300 (11 p.m.) Coordinated Universal Time (UTC)

Customer Service:Toll Free: 800-288-0383Local: 913-341-8949Fax: 913-341-6207General Inquiries: [email protected]

Billing / Insurance:Direct Line: [email protected]

■ Free shipping in the U.S.

■ Easy-to-read graphic results

■ Free results consultation

■ Free webinars

■ Friendly customer service

■ Physician referral programs

■ Interpretation guides

■ Physician educational events

■ BioMed Today e-newsletter

Services we offer

The Great Plains Laboratory, Inc. (GPL) is a research-based clinical laboratory that

offers testing for nutritional factors in chronic illnesses worldwide. Our company was

founded in 1996 and is currently serving more than 100 countries. We provide a variety

of metabolic tests that are not routinely available through other laboratories, and have

tested more than 200,000 patients with autism and other related disorders. Our goal

is to help people achieve their maximum potential through quality laboratory testing,

knowledgeable staff, and excellent customer service.

2call: (913) 341-8949

Educational Resources.................................................1

Other Resources ............................................................2

Payment Options ..........................................................3

Getting Started With Our Lab Services.....................4AuthorizationOrder a Test KitSpecimen CollectionShippingResultsCancellation Policy

Frequently Asked Questions ......................................5

Testimonials ..................................................................6

TestsOrganic Acids Test (OAT) .............................................8

IgG Food Allergy Test w/ Candida ............................... 11

Metals Tests................................................................. 13

Gluten / Casein Peptides Test .................................. 15

IgE Food and Inhalant Allergy Tests ....................... 16

Hormone Panels ........................................................ 17

Amino Acids Tests ...................................................... 18

Vitamin D Test ............................................................ 19

Advanced Cholesterol Profile .................................. 20

Immune Deficiency Profile ...................................... 21

Comprehensive Stool Analysis................................ 22

Copper / Zinc Profile ................................................. 23

Comprehensive Fatty Acids Test ............................. 24

GPL3 ............................................................................. 25

GPL4 ............................................................................. 26

OAT + IgG Food Allergy Test w/ Candida Combo . 27

OAT + Amino Acids Urine Test Combo ................... 27

Comprehensive Test Panels ..................................... 28Comprehensive Autism PanelComprehensive Mental Health PanelOther Available Test Panels:Comprehensive AD(H)D PanelComprehensive Wellness Panel

International Support:Customer service support is available in multiple languages: Spanish, German, French, Portuguese, Italian, Japanese, and ChineseDirect Line: 913-754-0461

Table of ContentsOur laboratory offers comprehensive evaluation panels that provide physicians with the right tools for a more effective, individualized treatment. We are equipped with state-of-the-art instrumentation. Our superior technology allows us to develop more unique tests than regular commercial laboratories, while adhering to the strictest quality control and quality assurance guidelines of regulatory agencies.

Lab Certifications

CLIAThe Great Plains Laboratory is fully certified under the federally mandated Clinical Laboratory Improvement Amendments (CLIA). All referral laboratories used by The Great Plains Laboratory are also CLIA certified.

CAPThe Great Plains Laboratory voluntarily participates in all proficiency programs offered by the College of American Pathologists (CAP). The CAP is the world’s largest association composed exclusively of board-certified pathologists and pathologists-in-training and is the worldwide leader in laboratory quality assurance. In this program, our laboratory must constantly demonstrate our ability to successfully identify and quantify unknown specimens.

Internal Quality ControlIn addition to inspections by the state and participation in external proficiency testing programs of the CAP, GPL also has a strong internal quality control program. We have a dedicated staff of scientific professionals whose focus is to monitor the effectiveness of our tests and to ensure the quality and integrity of all laboratory methods. Portions of quality control samples are analyzed with every test batch to ensure laboratory quality. Patient samples are also frequently split to make sure that different technologists perform similar work.

Food and Drug Administration (FDA) ApprovalsThe FDA regulates companies that sell instruments and reagents to clinical testing laboratories. The Great Plains Laboratory uses many FDA-approved instruments and reagents. In some cases, there are no commercially available instruments or reagents. Such tests, termed “home brew” tests, are regulated by the CLIA regulatory agencies. The FDA does not directly regulate clinical laboratories.

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Interpretation GuidesThe Great Plains Laboratory offers a written interpretation with most test results. Any abnormal values that are uncovered in the analysis are considered and expanded upon in the interpretation. The information we provide will help the patient and the practitioner to understand the clinical significance of each abnormal value associated with a particular analyte. The significance of the result depends greatly on the individual value associated with the metabolite. The interpretation will narrow down the possible causes of the abnormality.

Free Consultation with ResultsWe want our clients to receive the maximum value for their laboratory testing which is why we offer free 30-minute consultations to explain the test results in detail. Medical practitioners and patients are better equipped to move forward with the appropriate treatment once they have a clear understanding of the test results. Our staff has been observing trends in test results for over 10 years, and they are glad to provide their experience and expertise to the troubling cases that need more attention.

Educational Events GPL is dedicated to educating both patients and practitioners alike. We frequently host, sponsor, and attend educational events around the world.

Our Annual Physician Educational Workshops provide practitioners with the opportunity to learn more about the latest research and the clinical significance of tests and treatments. We provide useful tools for practitioners to understand the various influences that complicate metabolic pathways and explain the connection in our test results. Using the latest research on specific compounds and metabolites, we bring new insight to the disease process. The practitioner will gain an understanding of the clinical significance of biomedical testing and a clear comprehension of the appropriate treatment.

We are the primary sponsor of the Integrative Medicine for Mental Health (IMMH) Conference. IMMH is an organization that supports a whole-body approach, utilizing multiple fields of medicine and nutritional sciences to help patients obtain mental wellness. The integrative approach includes metabolic testing, nutritional therapies, dietary interventions, and traditional medical treatments. IMMH organizes an annual conference that presents concepts and practical guidelines that can dramatically improve the quality of life of your patients. Practical applications and effective protocols are presented and can be easily applied in a clinical setting.

To find out where GPL is participating in a conference, visit the Upcoming Events page on our website.

Free WebinarsGPL offers webinars presented by physicians and other professionals on a variety of topics, including autism, mental health, and laboratory testing. A wide range of experts on the topic of biomedical treatment and testing conduct educational seminars via webinars. The information is designed to provide useful information about the clinical manifestations that occur in certain disorders. Presenters draw from years of experience to bring you important, helpful information about various situations that can occur in the body to create illness and disease. In additon, a large number of our webinars are archived in our Webinar Library and can be accessed any time.

Find out more on our website www.GPL4U.com.

Educational Resources

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call: (913) 341-8949

BioMed Today Email NewsletterWe provide a free newsletter publication called BioMed Today that includes a featured topic and related articles about new and updated discoveries in the biomedical field, as well as upcoming events, discussions, tips, recent news, and other resources. Sign up for our email updates for information on new and updated tests, conferences, and webinars. Don’t miss out on all that GPL has to offer! Visit www.GPL4U.com and click Email Signup.

Physician Referral DatabaseWe are happy to recommend the names of experienced medical practitioners to patients and parents who need help getting testing or treatment. In areas where there is not a medical practitioner nearby, we can recommend the medical practitioners who provide long-distance phone consultations. The medical practitioners we recommend are familiar with our tests and are qualified to help patients with recommendations, authorizations, and treatment options.

Online Test OrdersPhysicians can order our test kits online through ResultsPlus. This online portal also allows the physician to update account and billing information, send test kits directly to patients, and access the most up-to-date testing information. Find out more on our website under For Clinicians.

Many of the tests we offer are also available through MyMedLab. This is an online test ordering system that provides patients with everything they need to test through The Great Plains Laboratory, including a medical practitioner’s signature and a professional blood draw. To learn more about MyMedLab, visit our website or go to https://greatplains.mymedlab.com.

Other Resources

IMMH Clinician Registry and ResourcesA Clinician Registry is available through www.IMMH.org. The registry provides patients with a list of medical professionals who can assess and treat Mental Health disorders based on an integrative medical approach. Integrative medicine for mental health is a whole body approach utilizing multiple fields of medicine and nutritional sciences. The goal is to help patients regain mental wellness through the use of individualized metabolic testing, nutritional therapies, dietary interventions, along with traditional medical treatments, including medications and psychotherapy. The IMMH Clinician Registry eligibility is exclusive to practitioners who have attended an IMMH Conference.

Find more about the IMMH Clinician Registry and upcoming events on the IMMH website. This website contains other resources such as research articles, webinars, blog posts, and other useful tools for integrative practitioners.

Nutritional SupplementsNew Beginnings Nutritionals provides specialized, high-quality nutritional supplements for adults and children on the autistic spectrum and other chronic health issues. They offer professional-quality products that contain pharmaceutical grade ingredients whenever possible and do not contain harmful or allergenic ingredients. Support for special dietary needs is available through a wide variety of supplements that provide help for, digestion, absorption, nutrient deficiencies, detoxification, immune dysfunction, and yeast and bacteria overgrowth.

Website: www.NBNUS.com, Phone: (913) 754-0458 Address: 7797 Quivira Road, Lenexa, KS 66215 USA

We provide useful tools for practitioners to understand the clinical significance of biomedical testing and a clear comprehension of the appropriate treatment.

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Blue Cross and Blue ShieldThe Great Plains Laboratory is contracted with several Blue Cross and Blue Shield (BCBS) PPO plans.* Acceptable plans are recognized in one of two ways: the member’s BCBS insurance card will display a suitcase logo on the front with the letters PPO inside or will have a map of the United States on it. In addition, The Great Plains Laboratory will file the out-of-network claims for most other BCBS plans.*

*See the insurance section on our website for exceptions to the BCBS in-network program.

TricareWe are a participating provider with Tricare in every region of the United States. Patients should include a copy of the front and back of the insurance card and the member’s Social Security number.

*See the insurance section on our website for exceptions to the Tricare program.

MedicareGPL is contracted with Medicare, and many of our tests are covered by Medicare. See the Advance Beneficiary Notice (ABN) for a list of non-covered tests. All patients who have Medicare must sign and return the ABN with the specimen. This form is included in the test kits (with the Test Requisition Form). We require a copy of the front of the patient’s Medicare card be sent with the specimen.

If the patient is enrolled in a Medicare Advantage Plan, then we require a copy of the front and back of the patient’s Medicare Advantage Card. The Medicare Advantage Card is not the same as a Medicare card. Please contact our Billing Department with any questions concerning coverage.

Out-of-Network Insurance PlansThe Great Plains Laboratory is considered “out-of-network” with some Blue Cross Blue Shield plans, United Healthcare, and Cigna. The laboratory will file out-of-network insurance on behalf of the patient, provided the patient includes a 20% out-of-network prepayment along with the insurance information on the Test Requisition Form. Prepayment is required for all out-of-network claims even when insurance states that full reimbursement will be made. Should the insurance pay for more than the patient balance, a reimbursement check will automatically be mailed to the patient. PPO insurance policies will usually cover our services once the patient’s out-of-network deductible has been met. The patient will be responsible for any co-insurance, co-payments, and any services denied as “not medically necessary.” However, some “out-of-network” insurance policies will pay in full for the tests performed at The Great Plains Laboratory.

Insurance Plans Not FiledWe cannot bill State-Run Medicaid Programs, Humana, Aetna, or HMOs (check the website for HMO exceptions). If the patient subscribes to any of these insurance plans, the patient must pay in full by check or credit card.

Self PayWe offer a prompt-pay discount by paying in full at the time of testing. We accept checks and all major credit cards including: Visa, MasterCard, Discover, American Express, JCB, and Diners Club. We will send a statement of services for you to file with your insurance company.

PayPalGPL accepts payments made through PayPal. Signing up for a PayPal account only takes a few minutes and is an alternative to using checks, credit cards, or wire transfers to pay for your testing.

If you choose to send payment via PayPal, you must complete the “Email to recipient” section within paypal when sending money. Please include the patient’s name, date of birth, and billing address so we can match your payment with the correct account. Send PayPal payments to [email protected].

Insurance Coverage Verification GuideWe provide an Insurance Coverage Verification Guide. This helpful tool includes an insurance overview that patients can use to determine eligibility, restrictions, and requirements. By calling your insurance provider, you can verify your coverage and gather information to determine any out-of-pocket expenses.

For the Insurance Coverage Verification Guide, visit Pricing and Payment Options on our website, or contact Customer Service.

Method of PaymentPayment information must be received by the time the specimen arrives at our laboratory for the specimen to be processed.

For questions, please contact the Billing Department at 913-754-0459 or [email protected].

Payment Options Getting Started With Our Lab Services

4call: (913) 341-8949

AuthorizationOur laboratory requires an authorization from a medical practitioner on all tests performed in the United States. Authorization is not required for patients who reside outside the United States. We do not provide testing for any patient or medical practitioner who resides or practices in New York.

We will gladly refer patients to medical practitioners who use The Great Plains Laboratory tests. These practitioners are more likely to provide authorization or treatment based upon results.

Order a Test KitTest kits can be ordered online, by phone, by fax, or by a medical practitioner. The kits are usually mailed directly to the patient and will include everything the patient needs to collect and submit the specimen. We do not require patients to have the practitioner’s authorization before ordering a test kit. However, a prescription or signed requisition must be returned with the specimen or sent to our lab directly by the practitioner.

A kit order must be signed by a practitioner to be considered authorized. Practitioners can submit signed kit requests to our lab via fax or through our Online Test Requisition Form. A completed copy of the Online Test Requisition Form will be included in the patient test kits for convenience. Faxed authorizations will be kept on file at the lab to be matched with patient specimen upon arrival.

No payment is necessary to order a test kit within the United States. Test kits ordered from within the United States will include a Test Requisition Form; payment, insurance, and privacy forms; instructions; specimen collection components; and a pre-paid FedEx overnight clinical pack.

International

Payment is required for kits ordered from outside the United States. These test kits will include a Test Requisition Form, payment form, instructions, commercial invoice, specimen collection components, and a pre-paid international FedEx priority clinical pack.

Specimen CollectionTest collection instructions are included with all test kits. The urine, stool, hair, and IgG dried blood spot (DBS) specimens can all be collected from home by the patient. Blood kits will need to be taken to a phlebotomist to perform the blood draw. The majority of blood-draw sites will ship the blood for the patient using the test kit provided. Those that do not ship the specimen should return the specimen to the patient for return shipment. Our Customer Service staff is available to answer questions about specimen collection. A list of frequently asked questions for patients is on our website.

ShippingShipping in the United States is free. Patients within the United States will not need to pay FedEx when sending samples to our laboratory. After collecting the sample, please call 1-800-463-3339 (1-800-GoFedEx) for pick up. Remember to mention you have an overnight FedEx billable stamp return.

International

Patients who reside outside the United States are responsible for the cost of shipping test kits both into and out of the laboratory. Shipping charges will vary depending on the country. Patients will need to provide the laboratory with a method of payment upon ordering their test kit. We include a prepaid FedEx International Priority Service bag in our international test kits. The charges for inbound shipping are applied to the patient’s account once the specimen has been received by our laboratory. We have distributors in many countries that can provide our test kits to patients at a reduced cost. Please contact International Support at 913-754-0461 to find out if there is a distributor in your country.

ResultsResults are sent out according to the parameters established by the practitioner on the New Client Form. Our laboratory will automatically mail a copy of results to the patient. The patient can also request that the laboratory send out results via secure email or secure fax after they are completed. Customer Service will make every attempt to accommodate the patient’s request for results. In some cases, the patients will have to obtain results from their medical practitioner.

Cancellation PolicyThe Great Plains Laboratory must be notified by the medical practitioner, patient, or parent/guardian to cancel a test. Cancellations will be honored if requested within 24 hours of receipt of the sample by the laboratory. Because testing processes begin within 24 hours, requests for cancellation beyond this time will not be honored.

Getting Started With Our Lab Services

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Do I need to have a medical practitioner’s approval to get testing performed at The Great Plains Laboratory?A medical practitioner’s approval is necessary if you are a resident of the United States. It is recommended, but not obligatory, for residents of other countries. An approved medical practitioner could be any of those listed in the following question.

What type of medical practitioners can authorize tests?The Great Plains Laboratory recognizes Medical Doctors (MD), Osteopathic Doctors (DO), Chiropractic Physicians (DC), Naturopathic Physicians (ND), Doctors of Philosophy in Psychology, Biochemistry, Toxicology, and Nursing (PhD), Doctors of Oriental Medicine (DOM), Licensed Acupuncturist (Lac), Physicians Assistants (PA), Nurse Practitioners (ARNP), Nurse Midwives (CNM), Certified Nutritionists (CCN), and Registered Dietitians (RD). It is the practitioner’s responsibility to work within the rules and guidelines of the state in which they practice.

How do I find a doctor familiar with GPL’s testing?We have a national database of over 3,000 medical practitioners. Please call Customer Service at 1-800-288-0383 to locate a medical practitioner in your area. Authorization does not have to come from your primary care physician; any licensed health professional can order testing in your state.

Where can I go to get blood drawn? We are contracted with national phlebotomy services which can provide blood draw services for our testing. In addition, many children’s hospitals and national laboratory chains have walk-in phlebotomy clinics that will perform a blood draw using a GPL blood kit. Please call Customer Service for recommended blood-draw facilities in your area. Patients are responsible for any fees associated with a blood draw. Additionally, phlebotomy services can be arranged either at home or an agreed upon site for an added fee. More details regarding blood collection can be found on our website under the for patients section.

When should I expect the test results?All tests have different turn around times. Most test results take 1-3 weeks to be completed. Our standard procedure is to release a faxed copy and mail a hard copy of the test results to the authorizing medical practitioner. a hard copy of the results can be mailed to the patient on their request.

I have already done testing with you. Is my insurance information on file? Yes, your insurance information is on file. However, we request that an updated copy of your insurance card be sent with your sample.

How do I find out if my insurance will cover your tests?Coverage is determined by a number of factors, including the type of procedure, the medical diagnosis, and the insurance policy guidelines. We encourage patients to call their insurance company to find out if tests may be covered. An Insurance Coverage Verification Guide is available on our website to help determine coverage.

It is helpful to provide CPT and ICD-9 codes to the insurance company when calling for pre-approval. The CPT codes are provided by the laboratory and are located on the page associated with the test in this Information Guide and also on our website. The ICD-9 codes are provided by the practitioner.

Can I test my child who is not potty-trained?Yes, we provide pediatric collection tape-on bags to collect the urine from infants or children who are not potty-trained. Please request the pediatric collection bags when ordering tests through Customer Service or online.

Can I perform multiple urine tests using one specimen?Yes, you can perform many of the urine tests with one urine sample. Each test has a specific volume requirement. The urine collection container holds about 70 mL. You will need a special collection jug to perform the timed and 24-hour urine tests, which require at least 40 mLs of urine

Frequently Asked Questions

More Frequently asked Questions are available on our website. Please contact customer service if you have any other questions not listed:

[email protected] | 913-341-8949

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“Great Plains Laboratory provides me with information which has not only changed the lives of my patients and their families for the better but enables me to link otherwise puzzling symptoms with correctable causes far more completely than other labs I have used. It has been extremely interesting and just plain FUN to see patients with “chronic” illnesses improve dramatically or even recover as a result of using information from Great Plains. The reports are easy to read and arrive in a timely manner. Helpful, friendly technical support is readily available when needed. The clinician training courses the Great Plains Lab provides are invaluable too; these are a great way to learn about the science behind the tests, the pathology and treatments, as well as to meet the people you’ll be dealing with at the lab.”

– Deborah Nash, MD

“Your lab has a very appropriate name that suits its mission: ‘Great.’ I would like to thank you for the excellent consultation I received and friendly and knowledgeable customer service assistance. It is especially nice for the clients to receive the service in their native languages! I consider your laboratory not regular, but special, and it’s great to have these non-traditional tests available.”

– Anna

“I would like to thank you from my heart for the way you’ve helped our kids — especially Dr. William Shaw. May God bless him and all of you and give you a thousand years to live for continuing to help our kids to leave this cloudy road of autism and related disorders. Again, a thousand thanks!”

– Mother of a girl with autism in Venezuela

“I just want to express my sincerest gratitude for your research and commitment to helping people. If it were not for your work, I honestly believe that my son would not be talking, socializing, nor making the remarkable progress that he has been making in the past five months since starting the GFCF diet.”

– Email to The Great Plains Laboratory

“As always, it was a great pleasure and comfort to speak with you today (re: dimethylglycine and trimethylglycine). I cannot imagine ourselves without the generous and knowledgeable service you, Dr. Shaw, and all the staff at GPL provide. We are eternally grateful for your support in the amazing and continuing progress our son, Eli, has achieved in the past 3 years -- ever since we first had him tested by GPL (and your help with his GFCF diet). Thank you.”

– Email from a father regarding his child

“I am very happy with the IgG test results from Great Plains. I always say that without this valuable test, I would not be in practice. It has helped so many of my patients! Recently, I had a patient with the most severe case of eczema I had ever seen in my practice. We did the Great Plains IgG testing [and] we saw he was sensitive to the usual gluten, dairy and eggs, and promptly removed these foods. Beef had also come up very elevated, but I had initially ignored that result, thinking that beef is a rather ‘benign’ food. Finally once we removed beef, the eczema cleared completely! So if it were not for this testing, this child would still be suffering.”

– Elaine H., MS, RN, APN

“Thank you so much for all your help! Thank you also for taking the time to talk to me on the phone. Jacob has had an incredible breakthrough! He is in a more receptive mood, with better eye contact, language, etc.! Thank you for helping my son to feel better and his body to work more efficiently! We look forward to taking your test again and seeing where he stands in a few months. ”

– Parents of a child with autism in Burlingame, CA

“I like the work of The Great Plains Laboratory and the book and conferences by Dr. Shaw. I have sent samples of my patients’ for detection of organic acids and morphine peptides in urine and now they are improving greatly with the results you have recommended.”

– Pediatrician from Barcelona, Spain

“I’m sending you this note to express my appreciation to your company and recognize your Customer Service consultants. You need to know that I am a demanding customer with high expectations, and it is not often that I come across companies/individuals that compel me to send a thank you note such as this. Customer Service followed through on every commitment; was prompt, knowledgeable, friendly; and bottom line helped me solve my issues. I didn’t get double talk or company policy talk – the representative took the time to listen to me and worked the problem to resolution.”

– Shane

“We have noticed ... much improvement in hyperactivity, more eye contact, increased vocalization, better sleep pattern, better concentration, and decrease of compulsive behaviors, and self injury. The positive impact of your findings on our son’s life and our family cannot be described in words.”

– A.E., father of a child with autism in Paramus, NJ

Testimonials

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Tests

Organic Acids Test (OAT)

IgG Food Allergy Test w/ Candida

Metals Tests

Gluten / Casein Peptides Test

IgE Food and Inhalant Allergy Tests

Hormone Panels

Amino Acids Tests

Vitamin D Test

Advanced Cholesterol Profile

Immune Deficiency Profile

Comprehensive Stool Analysis

Copper / Zinc Profile

Comprehensive Fatty Acids Test

GPL3 & GPL4 Panels

OAT + IgG Food Allergy Test w/ Candida Combo

OAT + Amino Acids Urine Test Combo

Comprehensive Test Panels

■ C-Reactive Protein Test (hs-CRP) – Serum

■ Celiac Disease Test – Serum

■ Ceruloplasmin Test – Serum

■ Copper Test – Serum

■ Kryptopyrrole Test – Urine

■ Prealbumin Test – Serum

■ Streptococcus Antibodies Profile – Serum

■ Uric Acid Test (24 hr. or Random) – Urine

■ Yeast Culture w/ Sensitivity Test – Stool

■ Zinc Test – Serum

Other Available Test OptionsVisit us online at www.GPL4U.com for details.

Providing Comprehensive Nutritional Analysis and Individualized Treatment Options

8call: (913) 341-8949

General DescriptionThe Organic Acids Test (OAT) provides information about the body’s biochemical balance by measuring metabolic byproducts in urine. The 74 metabolites, including creatinine, detected in the OAT can indicate vitamin and hormone metabolism, energy cycle function, intestinal wall integrity, neurotransmitter metabolites, and muscle function. Specimens from individuals with a chronic illness, allergic condition, or neurological disorder often have one or more abnormal organic acids. Some organic compounds are produced by an overgrowth of gastrointestinal yeast or bacterial species due to impaired immune function, exposure to broad-spectrum antibiotics, or high consumption of simple carbohydrates. The OAT reliably detects the overgrowth of yeast and bacteria species commonly missed by conventional culture methods. These organisms and their metabolites can produce or magnify symptoms of many medical conditions. Identification of yeast or bacterial overgrowth paired with successful treatment increases the chance of recovery.

The Organic Acids Test report includes: markers of nutritional deficiency, intestinal dysbiosis, oxalate metabolism, detoxification, bone disorders, amino acid, neurotransmitter, ketone, and fatty acid metabolism.

The Microbial Organic Acids Test report includes: markers of dysbiosis, inflammation, beneficial and harmful bacteria, Clostridia, Candida, and other yeast and fungal species.

Clinical Usefulness ■ Understand vitamin and hormone metabolism ■ Determine capacity to generate energy ■ Evaluate intestinal wall integrity ■ Assess performance of the central nervous system ■ Evaluate muscle function ■ Reveal excessive levels of gastrointestinal (GI) yeast ■ Reveal excessive levels of GI bacteria ■ Detect nutritional or antioxidant deficiencies ■ Determine problems in fatty acid metabolism ■ Identify oxalate imbalances

RecommendationsDepending on test results, follow-up may include:

■ Dietary modification ■ Probiotic supplementation ■ Nutritional supplementation ■ Oral anti-fungal or anti-bacterial medications ■ Antioxidant therapy ■ Initiation of detoxification protocols ■ Follow-up genetic testing

Specimen Requirements10 mL of first-morning urine before food or drink. Patient must avoid apples, grapes (including raisins), pears, cranberries, and their juices 24 hours prior to specimen collection.

CPT Codes82131 82507 82570 83150 83497 83605 83921*63 83945 84207 84210 84585 84591

Microbial Organic Acids Test(21 components, including creatinine) This test is included in the Organic Acids Test and primarily shows metabolites produced by yeast and bacteria. Additional indicators of yeast and bacterial metablism are also included.

The Microbial Organic Acids Test (MOAT) is ideal for follow-up to the OAT and may be recommended by practitioners looking for a specific abnormality, monitoring certain microbial balances, or assessing treatment efficacy. We strongly recommend the OAT as the initial screening test.

Specimen Requirements10 mL of first-morning urine before food or drink. Patient must avoid apples, grapes (including raisins), pears, cranberries, and their juices 24 hours prior to the specimen collection.

CPT Codes82570 83921*20

U.S. Patent # 5,686,311

Certain uses of the compounds arabinose, citramalic, tartaric, 3-oxoglutaric,

carboxycitric, 3,4-dihydroxyphenylpropionic (DHPPA), and 3-(3-hydroxyphenyl)-3-

hydroxypropionic (HPHPA) acids in their application to autism in the Organic Acids

Test and Microbial Organic Acids Test are protected by USA patent 5,686,311 granted

November 11, 1997.

Organic Acids Test (OAT)

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Metabolic Markers in Urine Reference Population - Females Under Age 13 (mmol/mol creatinine)

Patient

Value

Reference Range

Intestinal Microbial Overgrowth

Yeast and Fungal Markers

3.1≤1 5.3

3.1Citramalic

7.4≤2 30

7.45-Hydroxymethyl-2-furoic

0.50≤3 0.52

0.503-Oxoglutaric

8.6≤4 22

8.6Furan-2,5-dicarboxylic

0.07≤5 3.6

0.07Furancarbonylglycine

9.0≤ H6 3.9

9.0Tartaric

242≤ H7 56

242Arabinose

1.3≤8 34

1.3Carboxycitric

0.08≤9 0.86

0.08Tricarballylic

Malabsorption and Bacterial Markers

0.45≤10 1.1

0.452-Hydroxyphenylacetic

16≤11 30

164-Hydroxyphenylacetic

2.0-12 2.00.09

2.04-Hydroxybenzoic

15≤13 27

154-Hydroxyhippuric

377≤14 717

377Hippuric

6.1≤15 11

6.13-Indoleacetic

39≤ H16 15

39Succinic

148≤17 227

148HPHPA (Clostridia Marker)

63≤18 76

634-Cresol (C. difficile)

0.29≤19 0.73

0.29DHPPA (Beneficial Bacteria)

Testing performed by The Great Plains Laboratory, Inc., Lenexa, Kansas. The Great Plains Laboratory has developed and determined the

performance characteristics of this test. This test has not been evaluated by the U.S. FDA; the FDA does not currently regulate such testing.

Organic Acids Test - Nutritional and Metabolic Profile Page 1 of 9



Patient Name:

Physician:



Patient

Value

Reference Range

Indicators of Detoxification

52-57 637.0

52Pyroglutamic

0.36≤58 0.88

0.36Orotic

3.2≤ H59 1.2

3.22-Hydroxyhippuric

Amino Acid Metabolites

0.63≤60 1.2

0.632-Hydroxyisovaleric

0- L61 2.40.03

0.002-Oxoisovaleric

0≤62 1.1

0.003-Methyl-2-oxovaleric

0.07≤63 0.70

0.072-Hydroxyisocaproic

0.05≤64 0.54

0.052-Oxoisocaproic

0.03≤65 0.30

0.032-Oxo-4-methiolbutyric

0.38≤ H66 0.28

0.38Mandelic

0.11≤67 0.27

0.11Phenyllactic

0.12- L68 2.30.45

0.12Phenylpyruvic

0.06≤69 0.51

0.06Homogentisic

0.59-70 1.10.04

0.594-Hydroxyphenyllactic

2.8≤71 8.1

2.8N-Acetylaspartic

1.7≤72 12

1.7Malonic

1.6- H73 0.950.07

1.63-Methylglutaric

18≤ H74 11

183-Hydroxyglutaric

1.7≤75 6.4

1.73-Methylglutaconic

Bone Metabolites

2 761-76 7 3001 000

2761Phosphoric




Patient Name:

Physician:



Patient

Value

Reference Range

Ketone and Fatty Acid Oxidation

2.4≤41 4.1

2.43-Hydroxybutyric

1.2≤42 10

1.2Acetoacetic

0.55≤43 3.4

0.554-Hydroxybutyric

3.8≤44 4.6

3.8Ethylmalonic

4.4≤ H45 4.3

4.4Methylsuccinic

5.5≤46 9.7

5.5Adipic

4.1≤47 9.5

4.1Suberic

0.08≤48 0.37

0.08Sebacic

Nutritional Markers

Vitamin B12

3.0≤49 6.2

3.0Methylmalonic ä

Vitamin B6

2.7≤50 59

2.7Pyridoxic (B6)

Vitamin B5

13≤51 26

13Pantothenic (B5)

Vitamin B2 (Riboflavin)

0.35≤52 1.1

0.35Glutaric ä

Vitamin C

0.82- L53 20010

0.82Ascorbic

Vitamin Q10 (CoQ10)

55≤54 101

553-Hydroxy-3-methylglutaric ä

Glutathione Precursor and Chelating Agent

0.09≤55 0.41

0.09N-Acetylcysteine (NAC)

Biotin (Vitamin H)

4.9≤56 5.5

4.9Methylcitric ä

ä A high value for this marker may indicate a deficiency of this vitamin.


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Contact us on the wide variety

of insurance options available! email: customerservice@gp14ucom

Phone: {9131141-8449 Fain (913)341•6207 ww.GPL4Lf COm

The OATassists fn evaluating:

• Krebs Cycle atenonnialftles

* Neurotransmitter levels

'Nutritional deficlencles

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Fatty acid metabolism • Okalate levels

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The Clinical Significance of the Organic Acids Test

the °Tank Arias Test OM offers an accurate metabolic snaeshcrt of what is ryoing on in the brxly

not offering the most complete and accurate evaluation of intestinal Yeast and bacteria, it.1150 prqvides in fOrmation on importzrd neurotransmitters nutritional markers, glutathiorve

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oxalate metabolism, and much mom The test offers

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markets that can be very useful for discovering underlying ca uses of chronic illness.

Patientsand physicians moon that treating Yeast dna bacterial abnormalities rechiCeSfbri9ue, increases alertness and energy, improves sleep normalizes bowel function,

and radix% hyperactivity and abdominal pain.

Clinical Significance of the OrpanicArids rest

10call: (913) 341-8949

Report AnalysisGlycolysis: Elevations may result from infection, exercise, or B vitamin deficiency. Very high levels may result from genetic metabolic disorders.

Krebs cycle: Abnormalities may result from nutrient deficiencies, microbial overgrowth, or glutathione (GSH) synthesis deficiency.

2-oxoglutaric: Regeneration of amino acids to remove excess ammonia may result in low levels.

Neurotransmitters: Metabolites of dopamine, norepinephrine, adrenaline, and serotonin are measured. Abnormalities may result from stress or poor detoxification, toxic metal exposure, and rarely, specific tumors. Low levels may be associated with mood disorders or depression.

Pyrimidines: Slight elevations may occur from folic acid deficiency. Significant elevations can indicate possible genetic disorders.

Fatty acids: Elevations can result from ketogenic diets or fasting, intake of medium-chain triglycerides, carnitine deficiency, diabetes, or genetic disorders.

Toxic indicators: Abnormalities can result from a deficiency of glutathione, poor ammonia detoxification, or the ingestion of aspartame, or salicylates.

Vitamin indicators: Abnormalities involving B12, B6, B5, B2, CoQ10, absorbic acid, biotin, and ascorbic acid are measured.

Amino acids: High elevations are associated with possible genetic errors in metabolism. These markers are deaminated by-products of amino acids themselves. Low levels do not indicate inadequate protein intake.

Slight elevations of valeric acid analogs may indicate a greater requirement for thiamine (B1).

3-Methylglutaric or 3-methylglutaconic Acid: Elevated levels indicate reduced capacity to metabolize leucine. Small elevations may accompany impairment of mitochondrial function.

3-Hydroxyglutaric Acid: Elevations indicate deficiency in the enzyme involved in the breakdown of lysine hydroxylysine and tryptophan.

Phosphate: Low phosphate is primarily associated with vitamin D deficiency. Individuals consuming a low grain diet may have lower phosphoric acid compared to those on a conventional “Western Diet.” More rarely, hypoparathyroidism may be involved.



Patient Name:

Physician:



Patient

Value

Reference Range

Indicators of Detoxification

52-57 637.0

52Pyroglutamic

0.36≤58 0.88

0.36Orotic

3.2≤ H59 1.2

3.22-Hydroxyhippuric

Amino Acid Metabolites

0.63≤60 1.2

0.632-Hydroxyisovaleric

0- L61 2.40.03

0.002-Oxoisovaleric

0≤62 1.1

0.003-Methyl-2-oxovaleric

0.07≤63 0.70

0.072-Hydroxyisocaproic

0.05≤64 0.54

0.052-Oxoisocaproic

0.03≤65 0.30

0.032-Oxo-4-methiolbutyric

0.38≤ H66 0.28

0.38Mandelic

0.11≤67 0.27

0.11Phenyllactic

0.12- L68 2.30.45

0.12Phenylpyruvic

0.06≤69 0.51

0.06Homogentisic

0.59-70 1.10.04

0.594-Hydroxyphenyllactic

2.8≤71 8.1

2.8N-Acetylaspartic

1.7≤72 12

1.7Malonic

1.6- H73 0.950.07

1.63-Methylglutaric

18≤ H74 11

183-Hydroxyglutaric

1.7≤75 6.4

1.73-Methylglutaconic

Bone Metabolites

2 761-76 7 3001 000

2761Phosphoric


A booklet explaining the complete clinical significance of each metabolite included in the Organic Acids Test is freely available to all physicians.

Organic Acids Test (OAT)...continued



Patient Name:

Physician:



Patient

Value

Reference Range

Ketone and Fatty Acid Oxidation

2.4≤41 4.1

2.43-Hydroxybutyric

1.2≤42 10

1.2Acetoacetic

0.55≤43 3.4

0.554-Hydroxybutyric

3.8≤44 4.6

3.8Ethylmalonic

4.4≤ H45 4.3

4.4Methylsuccinic

5.5≤46 9.7

5.5Adipic

4.1≤47 9.5

4.1Suberic

0.08≤48 0.37

0.08Sebacic

Nutritional Markers

Vitamin B12

3.0≤49 6.2

3.0Methylmalonic ä

Vitamin B6

2.7≤50 59

2.7Pyridoxic (B6)

Vitamin B5

13≤51 26

13Pantothenic (B5)

Vitamin B2 (Riboflavin)

0.35≤52 1.1

0.35Glutaric ä

Vitamin C

0.82- L53 20010

0.82Ascorbic

Vitamin Q10 (CoQ10)

55≤54 101

553-Hydroxy-3-methylglutaric ä

Glutathione Precursor and Chelating Agent

0.09≤55 0.41

0.09N-Acetylcysteine (NAC)

Biotin (Vitamin H)

4.9≤56 5.5

4.9Methylcitric ä

ä A high value for this marker may indicate a deficiency of this vitamin.




Patient Name:

Physician:


2.3

7.4H

3.3 H

63 148

8.2

4.3

1.9

0.29


0

. . . . . . . . . . . . 11

www.GPL4U.com

General DescriptionElevated levels of IgG (Immunoglobulin G) antibodies are associated with a wide variety of illnesses. Symptoms ranging from headache and nausea to seizure and hyperactivity may occur hours or even days after the offending food has been ingested. The degree and severity of symptoms vary due to the individual’s genetic makeup. The complete elimination of IgG positive foods may result in important improvements in symptoms of irritable bowel syndrome, autism, AD(H)D, cystic fibrosis, rheumatoid arthritis, and epilepsy, as demonstrated in numerous clinical studies. The 94 foods tested increase the identification of various offending foods.

The standard IgG Food Allergy Test includes the foods most common in Western diets, while the IgG Asian Food Allergy panel is designed for individuals who commonly eat Asian cuisine. Asian foods tested include mango, sunflower seeds, miso (soybean paste), green tea, and a variety of seafood. This test replaces some vegetables in the general IgG Food Allergy Test with more common Asian vegetables, such as the shiitake mushroom, and adds a new “spices” food category. The Asian panel also analyzes twice as many seafood items than the general test, ranging from oysters and clams to Pacific saury.

Clinical Usefulness ■ Promote non-invasive, food-based therapy ■ Eliminate allergy triggers ■ Reduce the burden on the immune system ■ Reduce gut inflammation ■ Reduce food cravings ■ Improve assimilation of nutrients ■ Reduce food mediated behaviors


■ Elimination of offending foods ■ Immune system support ■ Gut restoration ■ Implementation of a food rotation diet (included in report) ■ Supplementation

Specimen RequirementsSerum: 1 mL of serum in a gold-topped SST or in a royal blue-topped no-additive tube.

- or -

Dried Blood Spot (DBS): Five full circles of blood on the protein saver card.

CPT Codes86001*93 86628 86671*2 No Medicare Coverage


Physician Name:Requisition #:

Patient Name: Date of Collection:

Time of Collection:Patient Age:

Sex: Print Date:

Comprehensive IgG Food Allergy Test + C. albicans, S. cerevisiae (94)

Reactivity Summary

High

Egg White Egg Yolk Candida Albicans

Milk Yeast, Bakers * Yeast, Brewers *

Whey Yogurt Casein

Cheese Beef Goat Cheese

Lemon Strawberry Sorghum

Moderate

Cranberry Wheat Mozzarella Cheese

Wheat Gluten Celery Kidney Bean

Grapefruit Lettuce Gliadin

Garlic Rye Millet

Peanut Barley Corn

Cocoa

Low

Pinto Bean Green Bean Lamb

Buckwheat Honey Mushroom

Chicken Salmon Sesame

Onion Tomato Pistachio

Watermelon Apple Pear

Pineapple Pecan Broccoli

Blueberry Carrot Cane Sugar

Banana Radish Potato

Eggplant Turkey Orange

Green Pepper Flax Spinach

Cabbage Cashews Oat

Grape Pumpkin Beet

Nuts and Seeds Continued

Sunflower 1.67

Walnut 1.62

Vegetables

Asparagus 1.98

Avocado 1.92

Broccoli 2.50

Beet 2.01

Cabbage 2.16

Carrot 2.44

Celery 4.28

Eggplant 2.26

Garlic 3.92

Green Pepper 2.24

Lettuce 4.07

Onion 2.84

Potato 2.37

Pumpkin 2.04

Radish 2.38

Spinach 2.17

Sweet Potato 1.59

Tomato 2.69

Miscellaneous

Candida Albicans 12.84

Cane Sugar 2.43

Cocoa 3.57

Coffee 1.98

Honey 3.13

Mushroom 3.06

Yeast, Bakers * 8.62

Yeast, Brewers * 8.40

Not Significant

Moderate

High

1.00-1.99

2.00-3.49

3.50-4.99

>=5

*Saccharomyces cerevisiae

Low

Testing performed by The Great Plains Laboratory, Inc., Lenexa, Kansas. The Great Plains Laboratory has developed and determined

the performance characteristics of this test. This test has not been evaluated by the U.S. Food and Drug Administration.

■ Almond ■ Apple ■ Apricot ■ Asparagus ■ Avocado ■ Baker's Yeast (Saccharomyces cerevisiae)

■ Banana ■ Barley ■ Beef ■ Beet ■ Blueberry ■ Brewer's Yeast (Saccharomyces cerevisiae)

■ Broccoli

■ Buckwheat ■ Succinic ■ Cabbage ■ Candida albicans ■ Cane Sugar ■ Carrot ■ Cashews ■ Casein ■ Celery ■ Cheese ■ Chicken ■ Cocoa ■ Coconut ■ Cod fish ■ Coffee ■ Corn ■ Crab

■ Cranberry ■ Eggplant ■ Egg White ■ Egg Yolk ■ Flax ■ Garbanzo Beans ■ Garlic ■ Gliadin ■ Goat's Milk Cheese ■ Grape ■ Grapefruit ■ Green Bean ■ Green Pepper ■ Halibut ■ Hazelnut ■ Honey ■ Kidney Bean

■ Lamb ■ Lemon ■ Lentil ■ Lettuce ■ Lima bean ■ Lobster ■ Milk ■ Millet ■ Orotic ■ Oat ■ Onion ■ Orange ■ Papaya ■ Pea ■ Peach ■ Peanut ■ Pear

■ Pecan ■ Pineapple ■ Pinto Bean ■ Pistachio ■ Plum (Prune) ■ Pork ■ Potato ■ Pumpkin ■ Radish ■ Rice ■ Rye ■ Salmon ■ Sardine ■ Sesame ■ Shrimp ■ Sorghum ■ Soybean

■ Spinach ■ Strawberry ■ Sunflower ■ Sweet Potato ■ Tomato ■ Tuna ■ Turkey ■ Wheat Gluten ■ Walnut ■ Watermelon ■ Wheat ■ Whey ■ Yogurt

Analyte List (93 Foods)


William Shaw, Ph.D Director 11813 W. 77th Street, Lenexa, KS 66214

(913) 341-8949 Fax (9 I 3) 34 I -6207

1

12call: (913) 341-8949

Physician Name:

Requisition #:

Patient Name:Date of Collection:

Time of Collection:

Patient Age:

Sex:Print Date:


Reactivity SummaryHigh

Egg White Egg Yolk Candida AlbicansMilk Yeast, Bakers * Yeast, Brewers *Whey Yogurt CaseinCheese Beef Goat CheeseLemon Strawberry Sorghum

Moderate

Cranberry Wheat Mozzarella CheeseWheat Gluten Celery Kidney BeanGrapefruit Lettuce GliadinGarlic Rye MilletPeanut Barley CornCocoa

Low

Pinto Bean Green Bean LambBuckwheat Honey MushroomChicken Salmon SesameOnion Tomato PistachioWatermelon Apple PearPineapple Pecan BroccoliBlueberry Carrot Cane SugarBanana Radish PotatoEggplant Turkey OrangeGreen Pepper Flax SpinachCabbage Cashews OatGrape Pumpkin Beet

Nuts and Seeds ContinuedSunflower

1.67Walnut

1.62Vegetables

Asparagus 1.98

Avocado 1.92

Broccoli 2.50

Beet 2.01

Cabbage 2.16

Carrot 2.44

Celery 4.28

Eggplant 2.26

Garlic 3.92

Green Pepper 2.24

Lettuce 4.07

Onion 2.84

Potato 2.37

Pumpkin 2.04

Radish 2.38

Spinach 2.17

Sweet Potato 1.59

Tomato 2.69

Miscellaneous

Candida Albicans 12.84

Cane Sugar 2.43

Cocoa 3.57

Coffee 1.98

Honey 3.13

Mushroom 3.06

Yeast, Bakers * 8.62

Yeast, Brewers * 8.40

Not Significant

Moderate

High

1.00-1.99

2.00-3.49

3.50-4.99

>=5

*Saccharomyces cerevisiae

Low

Testing performed by The Great Plains Laboratory, Inc., Lenexa, Kansas. The Great Plains Laboratory has developed and determined the performance characteristics of this test. This test has not been evaluated by the U.S. Food and Drug Administration.




Sex: Print Date:


Dairy

Casein 7.15

Cheese 7.05

Goat Cheese 5.91

Milk 9.39

Mozzarella Cheese 4.65

Whey 8.13

Yogurt 7.27

Legumes - Beans and Peas

Garbanzo Bean 1.96

Green Bean 3.34

Kidney Bean 4.19

Lentil 1.28

Lima Bean 1.22

Pea 1.36

Pinto Bean 3.46

Soybean 1.69

Fruit

Apple 2.60

Apricot 1.81

Banana 2.39

Blueberry 2.45

Coconut 1.96

Cranberry 4.90

Grape 2.06

Grapefruit 4.16

Lemon 5.40

Orange 2.25

Papaya 1.78

Peach 1.67

Pear 2.60

Pineapple 2.59

Plum (Prune) 1.69

Strawberry 5.33

Watermelon 2.66

Grains

Barley 3.61

Buckwheat 3.24

Corn 3.60

Gliadin 3.95

Millet 3.84

Oat 2.11

Rice 1.70

Rye 3.88

Sorghum 5.09

Wheat Gluten 4.34

Wheat 4.72

Fish

Cod Fish 1.79

Crab 0.99

Halibut 1.85

Lobster 1.49

Salmon 2.89

Sardine 1.30

Shrimp 0.99

Tuna 1.98

Meat/Fowl

Beef 6.39

Chicken 3.05

Egg White 13.63

Egg Yolk 12.91

Lamb 3.25

Pork 1.68

Turkey 2.26

Nuts and Seeds

Almond 1.86

Cashews 2.12

Flax 2.18

Hazelnut 1.45

Peanut 3.77

Pecan 2.56

Pistachio 2.66

Sesame 2.85



LAM PATIENT SEX: AGE: CLIENT#:

TOXIC ELEMENTS

RESULT g/g

REFERENCE RANGE 1

Aluminum 33 Antimony 0.091 < 0 . OM Arsenic 0.036 Beryllium < 0.01 Bismuth 0.009 Cadmium 0.021 Lead 1.6 Mercury 1.6 Platinum < 0.003 Thallium < 0.001 Thorium < 0.001 Uranium 0.091 Nickel 0.24 Silver 0.26 Tin 0.37 Titanium 0.92 Total Toxic Representation

IIMMI.

_ ELEMEli Calcium Magnesium Sodium Potassium Copper Zinc Manganese Chromium

I=

Vanadium Molybdenum Boron Iodine Lithium Phosphorus Selenium Strontium Sulfur Barium Cobalt Iron Germanium Rubidium Zirconium

■ COMMENTS Date Collect( Date Receive Date Comple

Methodology

The Great 662'

13www.GPL4U.com

µµµµ < 8.0

< 0.080 < 0.020 < 0.13 < 0.15 < 1.0 < 0.40 < 0.005 < 0.010 < 0.005 < 0.060 < 0.40 < 0.20 < 0.30 < 1.0

µµµµ 125- 370 12- 30 12- 90 12- 40 8.0- 16 100- 190 0.20- 0.55 0.26- 0.500.030- 0.100.050- 0.13 0.60- 4.0 0.25- 1.30.007- 0.023 160- 250 0.95- 1.7 0.16- 1.045500- 53000 0.16- 0.800.013- 0.035 8.0- 190.045- 0.0650.016- 0.180.040- 1.0

4- 300.8- 80.5- 10 4- 20

V06.99 > 800


Hair Metals Test General DescriptionHeavy metals toxicity, caused by increasing levels of environmental pollution and use of chemicals in industry, is a growing threat to the health and development of children. High levels of toxic metals deposited in body tissues, and subsequently the brain, may cause significant developmental and neurological damage.

A Metals Hair Test is ideal for checking current exposure to toxic metals. For example, a study in Poland found a high correlation between hair and brain mercury. Hair provides important information that can assist practitioners with an early diagnosis of physiological disorders associated with aberrations in essential and toxic element metabolism.

The U.S. Environmental Protection Agency stated in a recent report that “... if hair samples are properly collected and cleaned, and analyzed by the best analytic methods, using standards and blanks as required, in a clean and reliable laboratory by experienced personnel, the data are reliable” (U.S.E.P.A. 600/4-79-049).

The Center for Disease Control acknowledges that hair mercury levels provide a valuable maternal and infant marker for exposure to neurotoxic methylmercury from fish.

Clinical Usefulness ■ Determine if metal toxicity is contributing to a disorder ■ Determine if a deficiency in minerals is inhibiting metabolic processes


■ Identification of the source of contamination ■ Elimination of heavy metals from the environment ■ Elimination of heavy metals from the body ■ Mineral supplementation ■ Administration of supplements that support detoxification

Specimen Requirements1 gram of hair.

CPT CodesHair: 82108 82300 82525 83018*28 83655 83735 83785 83825 83885 84100 84255 84630

No Medicare Coverage

Metals Tests

Report Analysis - Hair Metals TestToxic element representation

The greater the elevation of the toxic metals found in the test, the greater the risk for damage. High accumulation of heavy metals can cause or contribute to chronic illness. Test results will help identify the source of the exposure.

Aluminum, Antimony, Arsenic, Beryllium, Bismuth, Cadmium, Lead, Mercury, Platinum, Thallium, Thorium, Uranium, Nickel, Silver, Tin, Titanium

Essential element representation

Nutritional mineral assessment in hair can identify the disruption of transport due to heavy metals accumulation. Dietary deficiency in essential minerals (metals) can seriously inhibit neurotransmission and the body’s ability to eliminate harmful toxins.

Calcium, Magnesium, Sodium, Potassium, Copper, Zinc, Manganese, Chromium, Vanadium, Molybdenum, Boron, Iodine, Lithium, Phosphorus, Selenium, Strontium, Sulfur, Barium, Cobalt, Iron, Germanium, Rubidium, Zirconium; Ratios: Calcium/Magnesium, Sodium/Potassium, Zinc/Copper, Zinc/Cadmium, Calcium/Phosphorus

Na/K 0.5 Zn/Cu 8.18

84th 97.5th

68th

III

I

95th

ED

PERCENTILE

11

I=1

IINO

MI

•

ELEMENTS RATIOS EXPECTED

RANGE

Ca/Mg 6.63 Ca/P 2.48

Zn/Cd > 999

III

MI

• MI

MI

ill

ii

L

■

I S

PERCENTILE

14 • Tel: 913.341.8949 • Fax: 913.341.6207

14call: (913) 341-8949

µµµµ < 8.0

< 0.080 < 0.020 < 0.13 < 0.15 < 1.0 < 0.40 < 0.005 < 0.010 < 0.005 < 0.060 < 0.40 < 0.20 < 0.30 < 1.0

µµµµ 125- 370 12- 30 12- 90 12- 40 8.0- 16 100- 190 0.20- 0.55 0.26- 0.500.030- 0.100.050- 0.13 0.60- 4.0 0.25- 1.30.007- 0.023 160- 250 0.95- 1.7 0.16- 1.045500- 53000 0.16- 0.800.013- 0.035 8.0- 190.045- 0.0650.016- 0.180.040- 1.0

4- 300.8- 80.5- 10 4- 20

V06.99 > 800


Additional Metals TestsBlood is routinely checked for metals toxicity; however, blood only reflects very acute and extreme poisoning by metals. Acute metals poisoning is rare. A chronic, low-level exposure to toxic metals, which can result in significant retention in the body, is more common. This can be associated with a vast array of adverse health effects and chronic disease. Cellular damage can occur at much lower levels than what is expressed in blood. We recommend blood only for checking levels of essential minerals and acute exposure to heavy metals.

Urine testing is recommended to check how well toxic metals are being eliminated after consuming a chelating (metal removing) agent. Analysis of the toxic metals concentrations in urine after the administration of a metal detoxifying agent is an objective way to evaluate the accumulation of toxic metals in body tissues.

Fecal testing is recommended for the determination of actual exposure to metals as opposed to the accumulation of metals in the body. Analysis of elements in feces provides indirect information about the potential for toxic metals burden. For many toxic metals, fecal (biliary) excretion is the primary natural route of elimination from the body. Thus, the representation of metals in fecal matter is a reflection of the metals ingested in the diet or excreted into the intestine.

Specimen RequirementsWhole Blood: 7 mL of whole blood drawn in a royal blue-topped potassium EDTA tube.

Red Blood Cell: 4 mL of packed cells in a royal blue-topped potassium EDTA tube.

Urine: 50 mL of urine.

Fecal: 35 mL of stool collected in the red-topped vial (with ultra-pure water). Do not overfill the specimen.

CPT CodesWhole Blood: 82310 82495 82525 83018*7 83655 83735 83825 84132 84255 84285 84295 84630

Red Blood Cell: 82175 82300 82310 82495 82525 83015 83018*4 83655 83735 83785 83825 84100 84132 84255 84630

Urine: 82108 82175 82300 82495 82525 82570 83018 83540 83655 83735 83785 83825 83885 84100 84133 84255 84300 84630

Fecal: 82175 82300 82525 83015 83655 83825 83885

No Medicare Coverage (for all metals tests)

Report Analysis - Additional Tests for Metals

Whole Blood

Essential: Calcium, Copper, Lithium, Magnesium, Manganese, Molybdenum, Selenium, Strontium, Zinc Toxic: Arsenic, Barium, Cadmium, Cobalt, Lead, Mercury, Nickel, Platinum, Silver, Thallium, Uranium

Red Blood Cell

Essential: Boron, Chromium, Calcium, Copper, Iron, Magnesium, Manganese, Molybdenum, Phosphorus, Potassium, Selenium, Vanadium, Zinc

Toxic: Arsenic, Cadmium, Lead, Mercury, Thallium

Urine

Essential: Boron, Calcium, Chromium, Cobalt, Copper, Iron, Magnesium, Manganese, Molybdenum, Phosphorus, Potassium, Selenium, Sodium, Strontium, Sulfur, Vanadium, Zinc

Toxic: Aluminum, Antimony, Arsenic, Barium, Beryllium, Bismuth, Cadmium, Cesium, Gadolinium, Lead, Mercury, Nickel, Palladium, Platinum, Tellurium, Thallium, Thorium, Tin, Titanium, Tungsten, Uranium

Fecal

Toxic: Antimony, Arsenic, Beryllium, Bismuth, Cadmium, Copper, Lead, Mercury, Nickel, Platinum, Thallium, Tungsten, Uranium

Metals Tests

If either of the peptide results is abnormal, a gluten-free and caselbfree diet should be considered for the person who wee tested. H both peptide results are normal, further testing with IgG food allergy tests should be done before adopting a diet containing gluten and/or casein. If both peptide and IgG food allergy tests are norms!, then the person can probably tolerate gluten and casein but a one-month elimination diet trial without these foods might still be useful.

Children on gluten and/or casein free diets may have normal values of the peptides In urine. Children with high values may benefit from gluten/casein free diets and/or peptides. supplementation. Children with normal papa& values may still have wheat and/or milk anemias that can be debated by allergy tests.

People on e diet containing soy proteins or who areconsuming soy "milk. may also have high peptides in their urine. Soy proteins are used as emulsifier., extenders, binders and stabilizers in meat, poultry, snack foods, sabage, frozen spaghetti, and whipped toppings. Textured vegetable protein (TVP) is soy based and many meat substitutes are soy-based. We have found that individuals on soy may have high values for gliadorphin and/or casomorphin presumably baccause of papacies from soy that are similar or identical 10 those in gluten or casein (Zhang Xi, Wang HY, Fu ZQ, WuX11, XuGL Bloactive small peptides from soybean protein. Ann N Y Aced Sal 1998 Dee 13; M. 640-5).

Individusis on peptidases such as Serenade or Enzymade may have high peptide values in the urine. This does not mean that thees products are harmful in any way. We cannot rule out the possibility that one of the components of fhbe products could be interfering in the tests for gliadorphin and/or casomorphin.

This bat was developed and its performance characteristics determined by The Great Plains Laboratory. It has not been cleared or approved by the U.S. Food and Drug Administration.

The FDA has determined that such clearance or approval is not necessary. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 CCUAI as qualified to perform high-complexity clinical tasting.

Peptide (P) Creatinine (C) Relative Ratio Relative Ratio Normal (P/C)

40.58 2.13

4.8 82 0.06 40.58

ng/mi mg/di

175.4 82

Papacies

Casomorphin (Milk)

Gliadorphin (Wheat)

- f The Great Plains Laboratory, Inc. -•• ••••1.

WII1larn Shaw..6..T .121rector

Requisition is

Patient Name:

Patient Age:

Sow

11413164a 77th %vas Lone6a. KS 64214 (413) 341.0949 Fax (413) 341.6207

Physician Name:

Date of Collection:

Time of Collection:

Print Date:

Peptides

15www.GPL4U.com

General DescriptionPeptides are incompletely degraded pieces of protein. The peptides from gluten and casein are important because they can react with opiate receptors in the brain, mimicking the effects of opiate drugs like heroin and morphine. These compounds, called neuropeptides, have been shown to react with areas of the brain such as the temporal lobes, which are involved in speech and auditory integration. Neuropeptides also reduce one’s ability to feel pain and influence cognitive function.

Many people with food allergies to milk and wheat also experience the opiate-like effect of gluten and casein neuropeptides. Others experience this effect in the absence of milk and wheat allergies. Thus, it is wise to complete both peptide and food allergy testing.

Clinical Usefulness ■ Determine whether cognitive or behavioral abnormalities may be due to the presence of opiate peptides

■ Identify the factors that may be contributing to digestive issues ■ Determine if wheat and dairy products are properly digested ■ Predict the success of a gluten- and casein-free diet


■ Restriction of gluten and casein from the diet ■ Administration of digestive enzymes ■ Nutritional counseling ■ Calcium supplementation

Specimen Requirements10 mL of first-morning urine before food and drink. The patient must discontinue soy proteins one week prior to collection of specimen (soy bean oil and soy lecithin are considered acceptable).

CPT Codes82570 83519*2


Report Analysis

Gliadorphin (or gluteomorphin) is a peptide derived from the wheat protein gluten. Other related grains such as rye, barley, and oats also contain the sequence of amino acids found in gluten.

Casomorphin is a peptide derived from the milk protein casein. Casein is one of the major proteins in the milk of all mammals, including cows, goats, and humans.

The composition of casomorphin and gliadorphin are very similar. Both casomorphin and gliadorphin contain a sequence of seven amino acids, including the sequence tyrosine and proline at the N-terminus, and proline at positions 4 and 6. These incompletely digested peptides are structurally similar to the opiate receptors in the brain. Once absorbed, they can alter behavior and other physiological reactions.

Individuals consuming large amounts of soy may have high values of casomorphin and gliadorphin in the urine presumably because the peptides from soy are structurally similar or identical to those in gluten and casein.


16call: (913) 341-8949

General DescriptionType one, or “classic,” allergy causes redness, swelling, and heat in the body as a result of the elevated blood levels of Immunoglobulin E (IgE). Contrary to popular belief, the symptoms produced by IgE can be subtle and similar to those seen in other conditions. This potential confusion makes diagnostic testing very important in recognizing the offending source. The Advanced IgE Tests increase the chance that a patient may identify numerous offending foods and/or inhalants, including Thimerosal and Candida.

Clinical Usefulness ■ Promote non-invasive, food-based therapy ■ Eliminate allergy triggers ■ Reduce the burden on the immune system ■ Reduce inflammation ■ Reduce food cravings ■ Improve assimilation of nutrients


■ Elimination of the offending foods ■ Elimination of the offending inhalants ■ Immune system support ■ Gut restoration ■ Implementation of a rotation diet ■ Supplementation ■ Administration of antihistamines ■ Use of air purifiers

Specimen RequirementsIgE Food Allergy Tests:5 mL (Basic) or 8 mL (Advanced) of serum in a gold-topped SST or royal blue-topped no-additive tube. The elimination of a food will reduce the ability for our laboratory to detect antibodies (allergies) to that food.

IgE Inhalant Allergy Tests:5 mL (Basic) or 8 mL (Advanced) of serum in a gold-topped SST or royal blue-topped no-additive tube.

CPT CodesIgE Food Allergy Tests: 86003*25 86003*93IgE Inhalant Allergy Tests: 86003*36 86003*69No Medicare Coverage

Report Analysis

IgE Food Allergy Advanced TestAlmond, Apple, Apricot, Asparagus, Avocado, Banana, Barley, Beef, Beet, Blueberry, Broccoli, Buckwheat, Cabbage, Cane Sugar, Carrot, Casein, Cashews, Celery, Cheese, Chicken, Coconut, Cod Fish, Cocoa, Coffee, Corn, Crab, Cranberry, Eggplant, Egg White, Egg Yolk, Flax, Garbanzo Bean, Garlic, Gluten, Goat’s Milk Cheese, Grape, Grapefruit, Green Bean, Green Pepper, Halibut, Hazelnut, Honey, Kidney Bean, Lamb, Lemon, Lentil, Lettuce, Lima Bean, Lobster, Mango, Milk, Millet, Mushroom, Oat, Onion, Orange, Papaya, Pea, Peach, Peanut, Pear, Pecan, Pineapple, Pinto Bean, Pistachio, Plum, Pork, Potato, Pumpkin, Radish, Raisin, Rice, Rye, Salmon, Sardine, Sesame, Shrimp, Soybean, Spinach, Strawberry, Sunflower, Sweet Potato, Tomato, Turkey, Tuna, Walnut, Watermelon, Wheat, Whey, Yogurt, Yeast (Bakers), Yeast (Brewers), Zucchini

IgE Inhalant Allergy Advanced TestAcacia, Alder (Smooth), Alternaria, Ash (White), Aspergillus, Bahia Grass, Bermuda Grass, Bluegrass (Kentucky), Box Elder (Maple), Brome Grass, Candida, Cat, Cedar (Mountain), Cladosporium, Cocklebur, Cockroach, Corn (Cultivated), Cottonwood Tree, Cypress (Bald), Dockweed (Yellow), Dog, Elm (American and Fall Blooming), Ferret, Fescue (Meadow), Gerbil, Goldenrod, Hickory (White), House Dust, Iodine Bush, Johnson Grass, Lamb’s Quarters, Maple (Red), Marsh Elder (Rough), Mexican Tea, Mite (D. Farinae), Mouse, Mulberry (Red and White), Nettle, Oak (Live, White, and Red), Oats, (Cultivated), Oat Grass Tall, Pecan Tree, Penicillium, Pigweed (Spiny and Rough), Plantain (English), Poplar (White), Privet, Rabbit, Ragweed (Giant and Short), Rye (Cultivated), Rye Grass (Perennial), Salt Cedar, Salt Grass, Sheep Sorrel, Sweet Gum, Sycamore, Thimerosal, Timothy Grass, Tree of Heaven, Walnut (Black), Western Water Hemp, Wheat (Cultivated), Willow (Black)

* Smaller panels are also available for 25 foods and 36 inhalants

IgE Food and Inhalant Allergy Tests

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The Great Plains

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17www.GPL4U.com

General DescriptionHormones are essential for our overall well-being. Sex hormones and the adrenal (stress) hormones are subject to change due to age, environmental stress, and other factors. DHEA and cortisol are the main adrenal stress hormones. The primary sex hormones are the three main estrogens (Estrone, Estradiol, and Estriol) and testosterone. We frequently think of estrogen as being a female hormone and testosterone as being a male hormone, but men and women make both, plus several more that must be in balance for optimum health.

An imbalance of any hormone can throw physical and mental health out of balance, causing aggravating and even serious health problems. For decades Western medicine has prescribed Hormone Replacement Therapy as a “one size fits all” approach. However, hormones are like fingerprints, and in order to achieve optimum health, people should be aware of their specific imbalances.

Being able to identify a hormonal imbalance is essential to designing an effective treatment plan. If a patient is seeking bio-identical hormone replacement therapy (BHRT) or a topical hormone therapy, free hormone levels should be assessed first before proceeding with a particular therapy.

Clinical Usefulness ■ Determine if there are hormonal imbalances ■ Determine if there is estrogen dominance ■ Monitor exogenous hormone therapies ■ Assess disruption of optimum diurnal cortisol patterns


■ Adjustments in hormone therapy ■ Lifestyle changes ■ Symptom relief therapy

Specimen RequirementsSaliva: 3/4 Saliva Tube full x4

CPT CodesComprehensive Plus Panel:

82679 82670 82677 84144 84402 82626 82530*4

Comprehensive Panel:

82670 84144 84402 82626 82530*4

Short Comprehensive Panel:

82670 84144 84402 82626 82530*2

Report Analysis Short Comprehensive Panel (for men + women):

Comprehensive Panel (for men + women):

■ Add 4x cortisol

Comprehensive Plus Panel (for women only):

■ Add: Estrone, Estriol

■ Estradiol (estrogen) ■ Progesterone ■ Testosterone

■ DHEA ■ Cortisol (2x a day)

Report Number:-SMP01

Provider:Labrix Clinical Services, Inc16255 SE 130th AveClackamas, OR 97015 Ordering Provider:

Patient Info:Amber Sample H

Age:28 FGender:

Menopausal Status:

[email protected] A St.Suite BPortland, OR 97123

Sample Collection Date/TimeMorning 06/25/2012 0530Noon 06/25/2012 1130Evening 06/25/2012 1745Night 06/25/2012 2200 Samples Arrived 06/26/2012Results Reported 06/28/2012

Saliva Hormone Test Result Units L WR H Reference RangeEstrone (E1) 6.00 pg/ml 7.2-40.6 pre menopausal

Estradiol (E2) 6.48 pg/ml 1.5-10.8 supplementation

Estriol (E3) 30.00 pg/ml <30.0 female, non-pregnant

EQ (E3 / (E1 + E2))Progesterone (Pg) 200.00 pg/ml 127.0-446.0 pre menopausal (luteal)

Ratio of Pg/E2Testosterone 56.00 pg/ml 6.1-49.0 female

DHEA 252.60 pg/ml 106.0-300.0 female

Cortisol Morning 41.00 nmol/L 5.1-40.2; optimal range: 18-35*

Cortisol Noon 15.00 nmol/L 2.1-15.7; optimal range: 6-12*

Cortisol Evening 2.00 nmol/L 1.8-12; optimal range: 4-8*

Cortisol Night 0.80 nmol/L 0.9-9.2; optimal range: 2-6*

Adrenal Phase:

Hormone Interpretations:

Estrone and estradiol are within the reference ranges, however the Estrogen Quotient (EQ) is suboptimal.Estriol is less potent than the other estrogens and when present in sufficient quantities (as indicated by anoptimal EQ) it plays an antagonistic role, and may govern the proliferative effects of estrone and estradiol.Although estriol level is above the reference range (likely do to individual variance), estriol supplementationis a consideration to optimize this quotient and reduce associated risks. * References available uponrequest.Progesterone to estradiol (Pg/E2) ratio and reported symptoms are consistent with estrogen dominance.Supplementation with topical progesterone to correct this relative deficiency is a consideration.DHEA level is consistent with stress response or supplementation (not reported), although metabolicsyndrome cannot be ruled out. Serum vitamin D, fasting glucose and insulin testing may be warranted.Adrenal gland function appears reasonably adequate. Query thyroid insufficiency (perhaps related to iodinedeficiency).

Notes:L=Low(below range) WR=Within Range (within range) H=High (above range)DHEA, Testosterone, Estrone and Estriol results are for investigational use only.*Apply only when all four cortisols are measured. Clinical interpreations may override these generalized optimal ref. ranges.**The Pg/E2 ratio is an optimal range established based on clinical observation. Progesterone supplementation is generallyrequired to achieve this level in men and postmenopausal women.

The Great Plains Laboratory Inc | Analyzed by Labrix Clinical Services, Inc. ADDRESS: 16255 SE 130th Avenue | Clackamas, OR 97015

Report Number:-S0052

Provider:The Great Plains Laboratory Inc11813 West 77th StreetLenexa, KS 66214 USA

Patient Info:Aurora Sample

Age:52 FGender:

Menopausal Status:Post-Menopause

Sample Collection Date/TimeMorningNoonEveningNight Samples Arrived 06/15/2012Results Reported 06/18/2012

Saliva Hormone Test Result Units L WR H Reference RangeEstrone (E1) pg/mlEstradiol (E2) 1.00 pg/ml 1.0-3.2 post menopausal (1.5-10.8 supplementation)

Estriol (E3) pg/mlEQ (E3 / (E1 + E2))Progesterone (Pg) 47.00 pg/ml 18.0-126.0 post menopausal (500-3000 supplementation)

Ratio of Pg/E2 47.00 200-600 post menopausal (Pg supplementation)**

Testosterone 11.90 pg/ml 6.1-49.0 female (30.0-60.0 supplementation)

DHEA 78.40 pg/ml 106.0-300.0 female

Cortisol Morning 12.10 nmol/L 5.1-40.2; optimal range: 18-35*

Cortisol Noon nmol/LCortisol Evening 11.30 nmol/L 1.8-12; optimal range: 4-8*

Cortisol Night nmol/L

Hormone Interpretations:

Notes:L=Low(below range) WR=Within Range (within range) H=High (above range)DHEA, Testosterone, Estrone and Estriol results are for investigational use only.*Apply only when all four cortisols are measured. Clinical interpreations may override these generalized optimal ref. ranges.**The Pg/E2 ratio is an optimal range established based on clinical observation. Progesterone supplementation is generallyrequired to achieve this level in men and postmenopausal women.


Provider:Just Hormones232323 SW Hormone St.Mesa, AZ 85215

Report Number: 09-999

Age: 46 Gender: M

Patient Info: David Sample

Menopausal Status: None

87654 NE Balanced StreetSuffern, NJ 10901Phone: Not available

Samples Date/TimeMorning 11/07/2005 0800Noon 11/07/2005 1230Evening 11/07/2005 1820Night 11/07/2005 2350 Date Samples 11/10/2005Date Results 11/11/2005

Saliva Hormone Test Result Units L WR H Reference RangeEstradiol [E2] <1.0 pg/ml X (1) 1.0-3.2 post-menopausal; (2) 1.0-10.8 pre-menopausal; (3) 1.5-10.0 replacement therapy; (4) <2.5 males

Progesterone 35.9 pg/ml X (1) 18-51 post-menopausal; (2) 127-446 pre-menopausal-luteal; (3) 500-3000 supplementation; (4) <94 males

Ratio of Pg/E2 35.9 X (1) 200-600 females; (2) 200-300 males;

Testosterone 46.1 pg/ml X (1) 30.1-142.5 males; (2) 4.5-49 females; (3) 30-60 therapy females; (4) 250-350 therapy males;

DHEA 61.3 pg/ml X (1) 137-336 males; (2) 106-300 females;

Cortisol Morning 4.0 nmo/L X (1) 5.1-40.2; Optimal Range: 18-35*

Cortisol Noon 4.7 nmo/L X (1) 2.1-15.7; Optimal Range: 6-12*

Cortisol Evening 1.5 nmo/L X (1) 1.8-12; Optimal Range: 4-8*

Cortisol Night <0.3 nmo/L X (1) 0.9-9.2; Optimal Range: 2-6*

Interpretations:

• The low Pg/E2 ratio is consistent with estrogen dominance, which increases the risk of prostate gland enlargement and cancer. Supplementation with topical progesterone to correct this relative

with metabolic syndrome (insulin resistance). Fasting blood sugar and insulin levels may be warranted. Boosting the testosterone level is a consideration.

• DHEA level is consistent with the expected decline with age (adrenopause). The low DHEA level may warrant supplementation for optimal well-being. Note: Supplementation with DHEA may increase testosterone and/or estradiol levels.

• Diurnal cortisol pattern and reported symptoms are consistent with established (Phase 3) adrenal ruled out.

Cortisol Graph

0

10

20

30

40

50

MORNINGNOON

EVENINGNIGHT

(nm

o/L)

* Apply only when all four cortisols are measured. Clinical interpretations may override these generalized optimal reference ranges.

*DHEA, Testosterone and Estriol results are for investigational use only L=Low (below reference range) WR=Within Range (within reference range) H= High (above reference range)


Hormone Panels

LABE PATIENT: SIX: Male AGE: 17 CLIENTS:

MMMMMMMMr

97.601 SPECIMEN MARKERS

Creatinine

RESULT

32

REFERENCE

in:08L 2.r ,s.

PE LE S4°1

ChLaraimiGlutenzle 38 LI.

Ammon:44.M 19800

SPECIMEN VALIDITY INDEX I.

ESSENTIAL AMINO ACIDS

RESULT m..0.

ESSENTIAL / CONDITIONALLY

RANGE REFERENCE I.E

INDISPENSABLE AMINO ACIDS

Le 1e PE so

Se 97.5. Methicmine Lyttine

6.6

200 Thremine 120 Lo

Lm in 37 IL

Isoleucine 13 Velure 10 11.0121.minc 40 IL

TOP:NM 27 Teeine 1200

Cr... 66 AGIN. 23 Lo

HislitlDe 1080

NONESSENTIAL AMINO ACIDS

Alminc

RESULT ...........

230

REFERENCE RANGE

NONE88ENTUILAMINO

2.5. ir

ACIDS PERCENTILE

Wrl NA L.

97.5.

Pup.. 20 Saperegim 130

GINLmine 250 0190899 6.6 Cy./ 83 Glycke 920

86 Seth. 340 Pon. 5 IL

The Greet Plaine Laboratory, Inc. • 11813 W. 77 Street, Lenexa KS, 66214 • Tel: 913.341.8945 • Fax: 513.341.6207

18call: (913) 341-8949

General DescriptionThe Amino Acids Urine and Plasma Tests can be utilized by the medical practitioner for different purposes. Urinary amino acids are discarded by the body as excess or “waste,” while amino acids present in plasma indicate availability for building structural, transport, and storage proteins. Amino acids also play a role in neurotransmitter functioning, cholesterol and carbohydrate metabolism, and detoxification processes.

Clinical Usefulness ■ Determine the availability of essential/conditionally indispensable amino acids

■ Evaluate urea cycle metabolites ■ Assess the efficiency of B6, B12, and folate-dependent enzymes ■ Identify the level of magnesium-dependent markers ■ Measure nonessential amino acids levels ■ Evaluate protein digestion and absorption


■ Dietary modification ■ Modification of vitamin and antioxidant intake ■ Magnesium supplementation ■ Probiotic supplementation ■ Digestive enzyme supplementation ■ Follow-up tests for metabolic syndromes

Specimen RequirementsUrine: 25 mL of first-morning urine before food or drink. The patient should discontinue amino acid supplementation prior to collection.

- or -

Plasma: 7 mL of whole blood in a lavender-topped EDTA tube. Specimen must be returned within 24 hours of the collection. This test is only available in the US.

CPT Codes82139*1 82140 82492 84540

45- 225

5- 160

9000- 39000 µM

µµµµ

7- 35

35- 500

60- 230

18- 70

8- 35

12- 50

25- 75

20- 75

170- 1200

20- 57

8- 50

270- 1150

µµµµ

100- 500

20- 70

50- 225

180- 530

5- 45

20- 90

400- 1800

30- 150

130- 400

1- 45


Report AnalysisEssential/conditionally indispensable amino acids reflect dietary intake.

Nonessential amino acids reflect assimilation of proteins and usage by the body.

Gastrointestinal markers determine the availability of proteins involved in the assimilation of nutrients.

Magnesium-dependent markers indicate the synthesis of amino acids that require magnesium.

B6, B12, and folate dependent markers indicate the metabolism of amino acids that require these co-factors.

Detoxification markers indicate the availability of amino acids involved with trans-sulfuration pathway.

Neurological markers indicate the availability of the amino acids needed for the synthesis of neurotransmitters.

Urea cycle metabolites indicate the availability of amino acids needed for ammonia detoxification.

Amino Acids Tests


Wiliam sna re PhiD.. Director

rmemitiffon osi

Pagaol Name:

Patient Age:

Sac

I 18 I3West nth Street Lenexa. ff5 66214 1913) 1414949 Fax 14131341.6207

Physic!. Nam,

Dale of Coilecbon:

Mete of Cofieoffon:

,Vint MA 4:

Vitamin A 25 OH

metabolic Marker

Relimente Range- nufint. PAM,. Vett* - notch

25-Hydrant 02 c 4.0

25-Hydro:rt. 03

2g0

20-Mytelimi D FOtat ID2+D0)

25 - 80

29.0

410 non's_ severe deficisnoy.

10-24 agrthi mild to moderate deficiervoie.

25-80 agfrni optimum leveler'

81-150 motmL toxicity possibia**

e1511rmfml_ toxlo levels *""*

Could be amocithed with osteornalacia or rickets

May be aslotheted with inbrethed rob en ostoopoomet or SecOndery nypaNimativoidam

Oblinum levels in die normal mombilion

80ntent la the lowest reported level associated wilt toxicity in paterasiantrout Mary hyperparathmoidisan who have limiest renal luntim

MOM patieols with Imlay have lavals >150nollint. Patients with mnial Mime mn have very high 2.5-0M-WO teweiS senthil any SIM 0010xMly, 00 renal Oenvenntin tO the adive hannarie 1, 25-0M-VI0 i9 impaled Or sliest

These veteran. ranges represent chino& decision values that apply to Mee and barman of MI ages, rather than populatian-based reference vetoes. Populatian Magma ranges far 25-01-1-14ID vary widely depentrig on ethnic background, age, geographic location of the studied populations, and the sartiOnthseason. Population-based newel correlate goody with serum 25-OH-VW ooncontratimm that are uncoated with biologically arid Or:sally relevant OlImso C effects and are Therefore of Imbed clnicol value

19www.GPL4U.com

General DescriptionVitamin D is a generic term that includes several metabolically related sterol substances that have hormonal activity. The metabolite 25-hydroxyvitamin D is the major circulating form of vitamin D in the body and the best indicator of a patient’s status due to its long half-life (2-3 weeks). The major biologic function of vitamin D is to maintain normal blood levels of calcium and phosphorus involved in bone mineralization. Vitamin D also controls more than 1,000 genes, including those responsible for the regulation of cellular proliferation, differentiation, apoptosis, and angiogenesis. The immune-modulating effects of vitamin D are profound as evidenced by the many conditions associated with vitamin D deficiency.

Clinical Usefulness ■ Determine if dietary vitamin D is sufficient ■ Determine if sun exposure is adequate ■ Determine if supplementation is reaching toxic levels ■ Assess the likelihood of malabsorption, liver disease, and nephrotic syndrome


■ Addition of vitamin D supplementation ■ Increased sun exposure ■ Discontinuation of supplementation ■ Dietary modifications ■ Additional testing

Specimen RequirementsSerum: 2 mL of serum in a gold-topped SST.

- or -

Dried Blood Spot (DBS): Five full circles of dried blood on the protein saver card.

CPT Codes82306 82542


Report AnalysisVitamin D

Two forms of vitamin D (25-OH-VitD2 and 25-OH-VitD3) are measured in this analysis. Vitamin D is obtained from foods of animal origin and from ultraviolet light-stimulated conversion of 7-dehydrocholesterol in the skin. Small amounts of vitamin D are obtained from foods of plant origin. Vitamin D is used to fortify various foods and is available in over-the-counter supplements.

Desirable values are 25-80 ng/mL. Mild to moderate deficiency values are 10-24 ng/mL. Values below 10 ng/mL indicate severe deficiency, and values over 80 ng/mL indicate possible toxicity.

Vitamin D Test

Patient ID #

Date Reported Patient Name

Date of collection Patient age

Time of collection Physician name

Patient Sex

Total Cholesterol

Cholesterol Result mg/dL 124

Reference Range

Result

Reference ranges for normal people.

Age -years Males Males Females Females 5 percentile 95 percentile 5 percentile 95 percentile

0-4 114 203 112 200 5-9 121 203 126 205 10-14 119 202 124 201 15-19 113 197 119 200 20-24 124 218 122 216 25-29 133 244 128 222 30-34 138 254 130 230 35-39 146 270 140 242 40-44 151 268 147 252 45-49 158 276 152 265 50-54 158 277 162 285 55-59 156 276 172 300 60-64 159 276 172 297 65-69 158 274 171 303 >70 144 265 173 280

Source: Lipid Research Clinics Population Studies Data Book, NM publication no. 80-1527

20call: (913) 341-8949

General DescriptionThe concept of “good” and “bad” cholesterol depends highly on the circumstances of the individual person. Although very high blood serum cholesterol values are associated with heart disease, low values (below 160 mg/dl) are associated with increased violent behavior, suicide, depression, anxiety, bipolar disease, Parkinson’s disease, and increased mortality from cancer. Low cholesterol values are also associated with manganese deficiency, Celiac disease, hyperthyroidism, liver disease, malabsorption, and malnutrition.

Clinical Usefulness ■ Determine whether a cholesterol deficiency is present ■ Determine if cholesterol is elevated ■ Identify the presence of abnormalities in cholesterol transport ■ Determine if the body is eliminating homocysteine ■ Identify risk factors for vascular and neurological disease ■ Assess risk of having a premature baby


■ Dietary modification ■ Supplementation ■ Follow-up/confirmational testing

Specimen Requirements2 mL of serum in a gold-topped SST or in a royal blue-topped no-additive tube.

CPT Codes82172*2 82465 83090 83695 83718


William Shaw, Ph.D Director 11813 W. 77th Street, Lenexa, KS 66214 (913) 341-8949 Fax (913) 341-6207

Report AnalysisTotal cholesterol: Total cholesterol measures all types of cholesterol.

Apolipoprotein A-I (Apo A-I): The main protein component of HDL (high density lipoprotein).

Apolipoprotein B (Apo B): The main protein component of LDL (low density lipoprotein).

Lipoprotein (a) (Lp (a)): Consists of two components: LDL and a glycoprotein, linked by a disulfide bridge.

Homocysteine (Hcy): A sulfur-containing amino acid that can be converted to methionine by methionine synthetase or homocysteine methyltransferase. High homocysteine is a risk factor for cardiovascular diseases.

Each result is reported as low, intermediate, or high according to the ranges established.

Reference chart: Values are deemed significant according to the age and sex of the patient. A comprehensive chart is included with the test results.


ID Number

Date Reported Patient Name

Date of collection Patient Age

Time of collection Physician name

Patient Sex

IMMUNE DEFICIENCY PANEL

Immunoglobullne Reference IgG Subclasses Reference Ranges

mgldl Ranges

IgG 694 667 to 1454 I9G-1 505 342 to 1150

IPA 64 L 77 to 219 I9G-2 130 100 to 455

IgM 94 49 to 261 IgG-3 24 26 to 125

IUhnl 190-4 7 4 to 136 IgE 225 H 2.4 to 52

Metals Ug/ml

Imo' 0.60 L 0.66 to

A patient with an IgE value greater than 751U/m1 la likely to have significant IgE allergies and shoukl be further evaluated to determine specific IgE allergies as well as IgG allergies.

If a patient has an IgE value of less then 10 !Wm!, IgE allergies are unlikely but the patient may all have significant IgG allergies.

Patients with IgE between 10-751U/m1 may have intermediate values of IgE mediated allergies and might also have 19G allergies.

21www.GPL4U.com

General DescriptionIndividuals with recurrent infections, otitis media, asthma, and certain genetic disorders may have an immune deficiency or imbalance contributing to their disorder. Immunodeficiency predisposes an individual to intestinal yeast overgrowth, opportunistic infection, and poor health. An overactive immune system is a major contributor to severe environmental allergies and may contribute to the development of autoimmune diseases such as rheumatoid arthritis and lupus.

Clinical Usefulness ■ Assess the adequacy of immunoglobulin levels ■ Determine whether high levels of immunoglobulin are present ■ Assess the adequacy of zinc levels ■ Assess the potential for allergies ■ Determine whether the individual is at risk for infection


■ Follow-up allergy testing in those with high levels of IgG or IgE

■ Supplementation with zinc and selenium ■ Supplementation with lactoferrin and colostrum ■ IV administration of gamma globulin and IgG ■ Administration of Transfer Factor ■ Supplementation with L-Glutathione, coenzyme Q10, and N-acetylcysteine

Specimen Requirements3 mL of serum collected in a royal blue-topped no-additive tube.

CPT Codes82784 82785 82787*4 84630


William Shaw, Ph.D Director 11813 W. 77th Street, Lenexa, KS 66214 (913) 341-8949 Fax (913) 341-6207

Report AnalysisIgM is the first response to infection or immunization. The presence of high levels of IgM antibodies indicates a recent infection. IgM antibodies diminish a few months after infection.

IgG antibodies are produced by the B-lymphocytes when the body is attacked by the same microorganism in a subsequent invasion.

IgE triggers histaminic allergy reactions (hives, sneezing, reddened skin, etc.). IgE also protects the body from parasites. Elevated serum IgE is associated with a history of excessive allergies.

IgA protects the nasal and intestinal lining from microorganisms. Blood levels of IgA may indicate genetic ability to produce sufficient amounts of IgA. Secretory IgA (sIgA) is measured in stool samples and may vary widely depending on the conditions in the bowel.


22call: (913) 341-8949

General DescriptionThe Comprehensive Stool Analysis detects the presence of pathogenic microorganisms such as yeast, parasites, and bacteria that contribute to chronic illness and neurological dysfunction. It provides helpful information about prescription and natural products effective against specific microorganism strains detected in the sample. The test also evaluates beneficial bacteria levels, intestinal immune function, overall intestinal health (occult blood, short chain fatty acids, pH, and mucus), and inflammatory markers.

Clinical Usefulness ■ Parameters for digestion and absorption ■ Cultures for bacteria ■ Cultures for yeast ■ Parasite testing ■ Sensitivity panels ■ Inflammatory markers ■ Stool metabolic markers ■ Infectious pathogens


■ Antifungal agents ■ Antibiotic agents ■ Antiparasitic agents ■ Probiotics ■ Digestive enzymes ■ Follow-up/confirmational tests ■ Nutritional supplements

Specimen RequirementsThe sample must be collected on two separate days (at least 12 hours apart). The specimen must be received within 10 days of the first collection, but it is preferred within five days of collection. It is recommended to discontinue use of any antibiotic and antifungal products two weeks before sample collection. The patient must also discontinue digestive enzymes, antacids, iron supplements, vitamin C over 250 mg, aspirin, anti-inflammatories, and large amounts of meat 48 hours prior to the collection of the specimen.

CPT Codes82272† 82492† 82656 83516† 83631 83986 85549† 87045 87046 87102 87177*2 87209*2 87328 87329 89125 89160† †No Medicare Coverage

Report AnalysisBacterial culture

73 possible species of imbalanced and dysbiotic bacteria, 6 species of beneficial bacteria.

Yeast (mycology) culture

48 possible yeast and fungal species.

Parasite isolation

22 possible parasites, markers of digestion and absorption. Findings can indicate if an individual has pancreatic insufficiency and provide information regarding macronutrient absorption.

Inflammatory markers

Findings can indicate whether the individual has moderate or high inflammation in the gut lining. These markers are helpful in diagnosing irritable bowel syndrome as well as transient inflammation due to acute illness.

Immunology

Secretory Immunoglobulin A (sIgA) is the primary antibody of the GI tract. This is the primary defense in our assimilation of food particles versus pathogens. Low levels can predispose a person to infections and bowel disease.

Short chain fatty acids

Short chain fatty acids result from the fermentation of dietary fiber by beneficial bacteria. These fats play an important role in the health of the GI tract as well as protecting against disease.

Intestinal health markers

These markers can be elevated in infection, cancer, and colitis.

Yeast

The microscopic examination of yeast identifies the visible presence of yeast cells.

Yeast sensitivity to:

Fluconazole, Itraconazole, Ketoconazole, Nystatin, Berberine, Caprylic Acid, Goldenseal, Oregano, Tanalbit, Undecylenic Acid, Uva Ursi

Bacterial sensitivity to:

Amoxicillin, Ampicillin, Augmentin, Ciprofloxacin, Trimeth-sulfa, Berberine, Black Walnut, Caprylic Acid, Cats Claw, Citrus Seed Extract, Goldenseal, Oregano, Uva Ursi

For Staphylococcus aureus:

Benzypenicillin, Oxacillin, Tetracycline, Trimeth-sulfa, Vancomycin, Berberine, Black Walnut, Caprylic Acid, Cats Claw, Citrus Seed Extract, Goldenseal, Oregano, Uva Ursi


--..'01 The Great Plains Laboratory, Inc. /111 Willurn spew, RI Dime cru 11813 Wen 7741 Scroo4Lenc..155- 44714 X9131341.8949

Fax 49131 3414207

Requisition th

Physician Name:

Patient Name:

Date of Collection:

Patient Arc

Thee of Collection:

Sex:

Print Date:

Copper Zinc Profile Reference !Mental

Compound

Reference Range Unite Patient Value

Low Normal High

CeruloplasmIn 1.5 - 4.5 umoVL 2.2

CeruloplasmIn-Copper 9.0 - 27.0 umoVL 132

'Copper Serum 12.0 - 23.0 umoin. 21.1

*Zinc Serum 10.0 - 17.0 umoVL 13.4

NonCeruloplaemln-Copper 2.3 6.3 um°111- 7.8 H

CopperfZinc 0.8 - 2.0 Ratio 1.6

'Teat. performed by Mayo Reference Laboratories, Rochester, Minnesota

I -4

I —4

High nonceruloplasmin or "free" copper High nonceruloplasmin or "free" copper is associated with Wilson's disease, a genetic disease due to a defective ATPase dependent copper transport protein, Menkes steely hair disorder, autistic spectrum disorders, extrahepatic biliary atresia, copper poisoning, chronic liver disease, primary biliary cirrhosis, Aagenes syndrome, and arterioductular hypoplasia syndrome.

23www.GPL4U.com

General DescriptionThe Copper/Zinc Profile is an excellent way to assess immune status and the nutritional intake and/or absorption of zinc and copper. Zinc is an essential trace element required for the activity of more than 300 enzymes. It is necessary for proper functioning of the immune system and is involved in most major metabolic pathways. Zinc has an inverse relationship with copper in the body. As zinc status decreases, copper status increases, and vice versa. Adequate copper levels are essential for the growth of new blood vessels, wound healing, and recovery from heart attacks and strokes. When levels are only slightly above normal physiological amounts, copper can be toxic. Any mild abnormality or impairment of liver function can lead to copper excess.

Clinical Usefulness ■ Assessment of zinc status ■ Assessment of copper status and toxicity ■ Assessment of immune status


■ Zinc supplementation ■ Copper supplementation ■ Dietary modification ■ Molybdenum salt supplementation ■ Administration of penicillamine to reduce copper excess

Specimen Requirements3 mL of serum drawn into a royal blue-topped no-additive tube.

CPT Codes82390 82525 84630

Report AnalysisZinc: General signs of zinc deficiency are sleep disturbances, diarrhea, poor appetite, unhealthy skin, behavioral problems, inability to heal wounds, and chronic infections.

Copper: Even modest variations in intake and retention can cause copper to build up to toxic levels in some sensitive individuals. Low copper can cause anemia, poor immune function, poor growth, reduced skin and hair pigmentation, and poor formation of the catecholamine neurotransmitters.

Ceruloplasmin: Copper is transported through the body by means of a protein called ceruloplasmin. The availability of this protein in the body is used to predict the potential for toxic copper accumulation.

Copper/zinc ratio: This ratio elucidates the crucial balance between the two metals.


The Great Plains Laboratory, Inc. William Shaw, Ph an Director 11811 Weir 77(8 Saner, Lenexa, KS 66211 1912) 34 I -8919 Fax (911} 141-6207

24call: (913) 341-8949

General DescriptionThis comprehensive test profiles mitochondrial and peroxisomal fatty acid metabolism and the patient’s nutritional status. The report includes 30 markers and total levels of saturated, monounsaturated, polyunsaturated, omega-3, and omega-6 fatty acids. Essential fats play an important role in regulating inflammation, forming cell membranes, and in the optimal function of the brain, nerves, eyes, skin, connective tissue, and blood vessels.

Clinical Usefulness ■ Monitoring treatment of essential fatty acid deficiency ■ Monitoring the response to provocative tests, such as fasting or loading tests


■ Flaxseed oil as source of ALA from which EPA and DHA are synthesized

■ Fish oil or cod liver oil as direct sources of EPA and DHA ■ Evening primrose oil, borage oil, or black currant oil as sources of GLA if insufficiently synthesized

■ Hemp oil as source of both ALA and GLA

Specimen Requirements2 mL of serum in a gold-topped or blue-topped tube. This test requires an overnight fast, and the patient must avoid alcohol for 24 hours prior to sample collection. The sample must be immediately frozen and shipped with frozen gel pack. This test is only available in the U.S. and Canada.

CPT Code82544*30 No Medicare Coverage

Sex:

Patient Age:

Patient Name:

Requisition #:

Print Date:

Time of Collection:

Date of Collection:

Physician Name:

Comprehensive Fatty Acids Panel - Serum

Common Name Lipid Name Reference Range Patient Result Units

HighReference RangeLow

Omega-3 Polyunsaturated Series

umol/LC18:3 (n-3)alpha-Linolenic Acid (ALA) 1 - 12020 76

umol/LC20:5 (n-3)Eicosapentaenoic Acid (EPA) 2 - 908 30

umol/LC22:5 (n-3)Docosapentaenoic Acid (DPA) 3 - 27030 35

umol/LC22:6 (n-3)Docosahexanoic Acid (DHA) 4 - 16030 119

Omega-6 Polyunsaturated Series

umol/LC18:2 (n-6)Linoleic Acid (LA) 5 - 35001600 3181

umol/LC18:3 (n-6)gamma-Linolenic Acid (GLA) 6 - 1309 32

umol/LC20:3 (n-6)dihomo-gamma-Linolenic Acid (DGLA) 7 - 22060 60

umol/LC20:4 (n-6)Arachidonic Acid (ARA) 8 - 1030350 648

umol/LC22:5 (n-6)Docosapentaenoic Acid (DPA) 9 L - 5010 5

umol/LC22:4 (n-6)Docosatetraenoic Acid 10 L - 4010 9

Page 1 of 5


GPL-t

The Great Plains Laboratory. Ono.

•••.% The Great Plains Laboratory, Inc.

L

1

25www.GPL4U.com

General DescriptionThis panel provides a thorough assessment of the patient’s overall health regarding to their metabolism, vitamin and mineral levels, food allergies, and metal toxicity. Testing for organic acids, IgGs, food allergies, and metals is crucial to detect any deficiencies within the body. With the GPL3 panel, no blood draw is required. Included in the GPL3 is the Organic Acids Test, IgG Food Allergy Test (Dried Blood Spot), and Metals Hair Test.

Specimen RequirementsUrine: 10mL of first morning urine before food or drink. Patient must avoid apples, grapes (including raisins), pears, cranberries, and their juices 24 hours prior to specimen collection.

Dried Blood Spot (DBS): Five full circles of blood on the protein saver card.

Hair: 1 gram of hair

■ Detect nutritional or antioxidant deficiencies ■ Understand vitamin and hormone metabolism ■ Assess performance or antioxidant deficiencies ■ Reveal excessive levels of gastrointestinal (GI) yeast and bacteria ■ Promote noninvasive, food-based therapy ■ Reduce the burden on the immune system

■ Reduce gut inflammation ■ Determine if a deficiency in minerals is inhibiting metabolic processes

■ Determine if dietary vitamin D is sufficient* ■ Assess the likelihood of malabsorption, liver disease, and nephritic syndrome*

* only applicable to the GPL4

The GPL3 profile includes the following valuable tests: ■ Organic Acids Test - 74 markers ■ IgG Food Allergy Test - 93 markers plus Candida ■ Metals Hair Test - 50 markers

CPT Codes82108 82131 82300 82507 82525 82570 83018*28 83150 83497 83605 83655 83735 83785 83825 83885 83921*63 83945 84100 84207 84210 84255 84585 84591 84630 86001*93 86628 86671*2 No Medicare Coverage

µµµµ < 8.0

< 0.080 < 0.020 < 2.0 < 0.15 < 1.0 < 0.40 < 0.005 < 0.010 < 0.005 < 0.060 < 0.40 < 0.20 < 0.30 < 1.0

µµµµ 125- 370 12- 30 12- 90 12- 40 8.0- 16 100- 190 0.20- 0.55 0.26- 0.500.030- 0.100.050- 0.13 0.60- 4.0 0.25- 1.30.007- 0.023 160- 250 0.95- 1.7 0.16- 1.045500- 53000 0.16- 0.800.013- 0.035 8.0- 190.045- 0.0650.016- 0.180.040- 1.0

4- 300.8- 80.5- 10 4- 20

V06.99 > 800

LAB#: PATIENT: ID: SEX: AGE: 273466Requisition #:

Patient Name:

Physician:



F

4


Time of Collection:

Print Date:


Patient

Value

Reference Range



3.1≤1 5.3

3.1Citramalic

7.4≤2 30


0.50≤3 0.52

0.503-Oxoglutaric

8.6≤4 22


0.07≤5 3.6


9.0≤ H6 3.9

9.0Tartaric

242≤ H7 56

242Arabinose

1.3≤8 34

1.3Carboxycitric

0.08≤9 0.86

0.08Tricarballylic


0.45≤10 1.1


16≤11 30


2.0-12 2.00.09

2.04-Hydroxybenzoic

15≤13 27

154-Hydroxyhippuric

377≤14 717

377Hippuric

6.1≤15 11

6.13-Indoleacetic

39≤ H16 15

39Succinic

148≤17 227


63≤18 76


0.29≤19 0.73








Sex: Print Date:


Dairy

Casein 7.15

Cheese 7.05

Goat Cheese 5.91

Milk 9.39


Whey 8.13

Yogurt 7.27


Garbanzo Bean 1.96

Green Bean 3.34

Kidney Bean 4.19

Lentil 1.28

Lima Bean 1.22

Pea 1.36

Pinto Bean 3.46

Soybean 1.69

Fruit

Apple 2.60

Apricot 1.81

Banana 2.39

Blueberry 2.45

Coconut 1.96

Cranberry 4.90

Grape 2.06

Grapefruit 4.16

Lemon 5.40

Orange 2.25

Papaya 1.78

Peach 1.67

Pear 2.60

Pineapple 2.59

Plum (Prune) 1.69

Strawberry 5.33

Watermelon 2.66

Grains

Barley 3.61

Buckwheat 3.24

Corn 3.60

Gliadin 3.95

Millet 3.84

Oat 2.11

Rice 1.70

Rye 3.88

Sorghum 5.09

Wheat Gluten 4.34

Wheat 4.72

Fish

Cod Fish 1.79

Crab 0.99

Halibut 1.85

Lobster 1.49

Salmon 2.89

Sardine 1.30

Shrimp 0.99

Tuna 1.98

Meat/Fowl

Beef 6.39

Chicken 3.05

Egg White 13.63

Egg Yolk 12.91

Lamb 3.25

Pork 1.68

Turkey 2.26

Nuts and Seeds

Almond 1.86

Cashews 2.12

Flax 2.18

Hazelnut 1.45

Peanut 3.77

Pecan 2.56

Pistachio 2.66

Sesame 2.85



Organic Acids Test IgG Food Allergy Test Metals Hair Test

Clinical Usefulness of the GPL3 & GPL4

'+‘.1/ The ilreai Plain. Labe/alone. inn. T. Gr.11 P12412

CH

GPL-

26call: (913) 341-8949

General DescriptionThe GPL4 panel provides a comprehensive assessment of an individual’s metabolism and is targeted to find any irregularities that are directly related to numerous conditions. This Panel provides a comprehensive assessment of the individual’s metabolism to assess microbial dysbiosis, and also provides vitamin levels and indicators of possible genetic problems. Included in the panel: Organic Acids Test, IgG Food Allergy Test, Red Blood Cell Metals or Metals Hair (your choice), and Vitamin D Test. With the GPL4 panel, a no blood draw option is also available.

Specimen RequirementsUrine: 10mL of first morning urine before food or drink. Patient must avoid apples, grapes (including raisins), pears, cranberries, and their juices 24 hours prior to specimen collection.

Depending on test results, follow-up may include:

■ Dietary modifications ■ Probiotic and/or nutritional supplementation ■ Antioxidant therapy ■ Elimination of offending foods

■ Immune system support ■ Gut restoration ■ Identification of the source of contamination ■ Elimination of heavy metals from the body and environment ■ Mineral supplementation

This extensive profile covers over 150 biomarkers, each carefully explained and addressed in the following tests:

CPT Codes - DBS82108 82131 82300 82306 82507 82525 82542 82570 83018*28 83150 83497 83605 83655 83735 83785 83825 83885 83921*63 83945 84100 84207 84210 84255 84585 84591 84630 86001*93 86628 86671*2 No Medicare Coverage

CPT Codes - Serum82131 82175 82300 82306 82310 82495 82507 82525 82542 82570 83015 83018*4 83150 83497 83605 83655 83735 83785 83825 83921*63 83945 84100 84132 84207 84210 84255 84585 84591 84630 86001*93 86628 86671*2 No Medicare Coverage

Organic Acids Test IgG Food Allergy Test Metals Hair / Metals RBC Test Vitamin D

µµµµ < 8.0

< 0.080 < 0.020 < 2.0 < 0.15 < 1.0 < 0.40 < 0.005 < 0.010 < 0.005 < 0.060 < 0.40 < 0.20 < 0.30 < 1.0

µµµµ 125- 370 12- 30 12- 90 12- 40 8.0- 16 100- 190 0.20- 0.55 0.26- 0.500.030- 0.100.050- 0.13 0.60- 4.0 0.25- 1.30.007- 0.023 160- 250 0.95- 1.7 0.16- 1.045500- 53000 0.16- 0.800.013- 0.035 8.0- 190.045- 0.0650.016- 0.180.040- 1.0

4- 300.8- 80.5- 10 4- 20

V06.99 > 800

LAB#: PATIENT: ID: SEX: AGE:

RED BLOOD CELL ELEMENTS

NUTRIENT ELEMENTSRESULT REFERENCE PERCENTILE

ELEMENTS µµµµg/g RANGE 2.5th 16th 50th 84th 97.5th

Calcium 17 8- 31

Magnesium 42 36- 64

Potassium mEq/L 79 65- 95

Phosphorus 515 480- 745

Copper 0.60 0.52- 0.89

Zinc 13.3 8- 14.5

Iron 802 745- 1050

Manganese 0.013 0.007- 0.030

Chromium 0.0006 0.0003-0.0060

Selenium 0.22 0.19- 0.38

Boron 0.023 0.01- 0.110

Vanadium 0.0002 0.0001-0.0020

Molybdenum < 0.0005 0.0005-0.0020

POTENTIALLY TOXIC ELEMENTSTOXIC RESULT REFERENCE PERCENTILE

ELEMENTS µµµµg/g RANGE 95th 99th

Arsenic 0.004 < 0.010

Cadmium 0.001 < 0.005

Lead 0.017 < 0.090

Mercury 0.001 < 0.010

Thallium < 0.0001 < 0.0005

SPECIMEN DATAComments: Date Collected: Methodology:Date Received: µg/g = ppmDate Completed: V10.01

©DOCTOR’S DATA, INC. ADDRESS: 3755 Illinois Avenue, St. Charles, IL 60174-2420 CLIA ID NO: 14D0646470 MEDICARE PROVIDER NO: 148453

LAB#: PATIENT: ID: SEX: AGE:


Patient Name:

Physician:



F

4


Time of Collection:

Print Date:


Patient

Value

Reference Range



3.1≤1 5.3

3.1Citramalic

7.4≤2 30


0.50≤3 0.52

0.503-Oxoglutaric

8.6≤4 22


0.07≤5 3.6


9.0≤ H6 3.9

9.0Tartaric

242≤ H7 56

242Arabinose

1.3≤8 34

1.3Carboxycitric

0.08≤9 0.86

0.08Tricarballylic


0.45≤10 1.1


16≤11 30


2.0-12 2.00.09

2.04-Hydroxybenzoic

15≤13 27

154-Hydroxyhippuric

377≤14 717

377Hippuric

6.1≤15 11

6.13-Indoleacetic

39≤ H16 15

39Succinic

148≤17 227


63≤18 76


0.29≤19 0.73








Sex: Print Date:


Dairy

Casein 7.15

Cheese 7.05

Goat Cheese 5.91

Milk 9.39


Whey 8.13

Yogurt 7.27


Garbanzo Bean 1.96

Green Bean 3.34

Kidney Bean 4.19

Lentil 1.28

Lima Bean 1.22

Pea 1.36

Pinto Bean 3.46

Soybean 1.69

Fruit

Apple 2.60

Apricot 1.81

Banana 2.39

Blueberry 2.45

Coconut 1.96

Cranberry 4.90

Grape 2.06

Grapefruit 4.16

Lemon 5.40

Orange 2.25

Papaya 1.78

Peach 1.67

Pear 2.60

Pineapple 2.59

Plum (Prune) 1.69

Strawberry 5.33

Watermelon 2.66

Grains

Barley 3.61

Buckwheat 3.24

Corn 3.60

Gliadin 3.95

Millet 3.84

Oat 2.11

Rice 1.70

Rye 3.88

Sorghum 5.09

Wheat Gluten 4.34

Wheat 4.72

Fish

Cod Fish 1.79

Crab 0.99

Halibut 1.85

Lobster 1.49

Salmon 2.89

Sardine 1.30

Shrimp 0.99

Tuna 1.98

Meat/Fowl

Beef 6.39

Chicken 3.05

Egg White 13.63

Egg Yolk 12.91

Lamb 3.25

Pork 1.68

Turkey 2.26

Nuts and Seeds

Almond 1.86

Cashews 2.12

Flax 2.18

Hazelnut 1.45

Peanut 3.77

Pecan 2.56

Pistachio 2.66

Sesame 2.85



Recommendations

GPL4 Serum ■ Organic Acids Test - 74 markers ■ IgG Food Allergy Test - 93 markers plus Candida ■ Metals RBC Test - 18 markers ■ Vitamin D - 2 markers

GPL4 DBS ■ Organic Acids Test - 74 markers ■ IgG Food Allergy Test - 93 markers plus Candida ■ Metals Hair Test - 39 markers ■ Vitamin D - 2 markers

- or -

GPL4 Serum:

Serum: 2 mL of serum in a gold-topped SST or royal blue-topped no-additive tube.

Red Blood Cell: 4mL of packed cells in a royal blue topped potassium RDTA tube.

GPL4 DBS:

Hair: 1 gram of hair

Dried Blood Spot (DBS): Two protein saver cards filled with five full circles of blood.

0 27www.GPL4U.com

General DescriptionA combination of our most popular tests, the Organic Acids Test (OAT) and the IgG Food Allergy Test w/ Candida, is a powerful diagnostic tool. Together, these tests help physicians evaluate their patients’ “state of the gut” and reveals how abnormal results may be contributing to chronic health issues. This combo is an excellent value if your insurance company does not typically reimburse for the standalone IgG Food Allergy Test. Visit the Insurance Benefits section on the OAT + IgG Combo webpage for more details.

Clinical Usefulness ■ The combined tests increase the likelihood of identifying significant factors impairing health.

■ Results indicate the extent of yeast and bacteria overgrowth in the GI tract and provide insight on nutritional status, Clostridia infection, and fatty acids and energy metabolism.

■ The test reveals food sensitivities, that when removed from the diet often mitigate patients’ symptoms.


■ Dietary modification ■ Nutritional and/or probiotic supplementation ■ Follow-up/confirmational testing ■ Elimination of offending foods/implemention of a rotation diet ■ Immune system support

Specimen RequirementsUrine: 10 mL of first-morning urine before food or drink. Patient must avoid apples, grapes (including raisins), pears, cranberries, and their juices 24 hours prior to specimen collection.

Serum: 1 mL of serum in a gold-topped SST or in a royal blue-topped no-additive tube.

Dried Blood Spot (DBS): Five full circles of dried blood on the protein saver card.

CPT Codes86001*93 86628 86671 82131 82507 82570 83150 83497 83605 83921*65 83945 84207 84210 84585 84591 No Medicare Coverage

General DescriptionThe Great Plains Laboratory offers the OAT and Amino Acids Urine Test as a combo. The OAT and Amino Acids Test quantifies different markers for assessing GI function, detoxification capacity, and certain nutritional deficiencies. Together they provide a more in-depth evaluation of overall nutritional status and digestive sufficiency. This combo is an excellent value if your insurance company does not typically reimburse for the standalone Amino Acids Urine Test. Visit the Insurance Benefits section on the OAT + Amino Acids Combo webpage for more details.

Clinical Usefulness ■ More complete insight into overall nutritional status ■ More complete evaluation of GI function and intestinal dysbiosis ■ More complete assessment of detoxification capacity ■ Indication of potential harmful genetic variations ■ Stronger clinical assessment of complex patients ■ Assistance in building a treatment plan


■ Treatment for intestinal dysbiosis ■ Nutritional and supplement support ■ Detoxification ■ Genetic testing

Specimen Requirements35 mL of first-morning urine before food or drink. Patient must avoid apples, grapes (including raisins), pears, cranberries, and their juices 24 hours prior to specimen collection. The patient should also discontinue amino acid supplementation prior to collection.

CPT Code82139*1 82140 82492 84540 82131 82507 82570 83150 83497 83605 83921*65 83945 84207 84210 84585 84591

OAT + IgG Food Allergy Test w/ Candida Combo

OAT + Amino Acids Urine Test Combo

28call: (913) 341-8949

Comprehensive Autism Panel

Comprehensive Mental Health Panel

Comprehensive AD(H)D Panel

Comprehensive Wellness Panel




Ferritin Test




Metals Hair Test

Streptococcus Antibodies Profile

Vitamin D Test

Organic Acids Test


Amino Acids Urine Test




Ferritin Test



Metals Hair Test

Organic Acids Test

Streptococcus Antibodies Profile

Vitamin D Test


Amino Acids Plasma Test






Metals Hair Test

Organic Acids Test

Vitamin D Test


Amino Acids Plasma Test



Ferritin Test



Metals Hair Test

Organic Acids Test

Vitamin D Test

Routine lab work often falls short of uncovering the subtle abnormalities which can have a profound effect on health. Unless properly addressed, this vicious cycle will continue to inhibit the various chemical pathways necessary for proper neurological and immune function. The resulting complications will contribute to, and may even cause, the symptoms of the patient.

A biomedical approach to treatment is a search for the underlying physiological imbalances contributing to the symptoms of a patient’s disorder. Treatments are designed to restore the body to balance and optimize function through nutritional support, diet, detoxification, and reduction of environmental influences. Laboratory testing and environmental assessments can help to identify causal factors and to focus treatment.

Other Available Test Panels: ■ Comprehensive Fibromyalgia & CFS Panel ■ Comprehensive Tourette’s & Tics Panel ■ Basic Wellness Panel ■ Basic AD(H)D Panel

■ Basic Tourette’s & Tics Panel ■ Basic Fibromyalgia & CFS Panel ■ Basic Mental Health Panel

Visit us online at www.GPL4U.com for more information about comprehensive testing.

Comprehensive Test Panels

How A Comprehensive Approach Will Benefit Your Health:

"'"•/1\


rillCO

Information Guide

The most accurate, reliable, and comprehensive biomedical analysis. The Great Plains Laboratory, Inc. is a world leader in providing testing for nutritional factors in chronic illnesses such as autism, fibromyalgia, and AD(H)D.

We offer a variety of metabolic tests such as immune deficiency evaluations, amino acid tests, essential fatty acid tests, organic acids testing, metal toxicity, and food allergies tests. Our vision is to have no borders when it comes to improving people’s quality of life.

William Shaw, Ph.D., Director | 11813 West 77th Street, Lenexa, KS 66214 | (913) 341-8949 | Fax (913) 341-6207 | www.GPL4U.com

Rev. 02/17/2014

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