Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted Imaging
Susceptibility Weighted MRI and Cerebrovascular Disorders
description
Transcript of Susceptibility Weighted MRI and Cerebrovascular Disorders
Susceptibility Weighted MRI and Cerebrovascular Disorders
Fony Y Tsai, Hung-Wen Kao, Yu-Kun Tsui,
Anton H Hasso and Fred Greensite,
UC Irvine Medical Center, Orange, Ca
Method and Materials• All patients underwent MRI with 12 channel head coil in
1.5T(Avanto,Siemens,Erlangen,Germany)and 3T(Trio,Siemens,Erlangen,Germany).
• Parameters of SWI:• 1.5T:TR:49ms,TE40msFlip angle15,bandwidth
80kHz,slice thickness 2mm,64slices in a single slab,matrix size177x256,acquistion time 3min&59s with iPAT factor-2.
• 3T:Tr27ms,TE29ms,Flip angle15,bandwidth 120kHz,slice thickness 2mm,64slices in a single slab, matrix size182x256,acquisition time 3min&22s with iPAT factor-2
• All images obtained in axial plane• The phase,magnitude,SWI and minIP images were
uploaded to PACS system.
Method and Materials• Retrospectively reviewed 903 patients from July 2008 to July
2010.• Among those 595 patients who had varied cerebrovascular
diseases were reported in our previous study excluded• 299 ischemic stroke,7 cardiac arrested with cessation of
cerebral circulation and 2 chronic venous hypertension• Gender ratio: male to female:162 to 146• Age: mean ae of all patients:65.4 and mean female is 69.1 and
mean male age is 62.6. • 118 patients had complete pre and post-treatment CT,MRI
with SWI.• 32 of 118 were excluded from motions and artifacts• 86 stroke patients and 9 others were evaluated in this series.
Result of Stroke Patients• 4 patients: vertebral arterial disease• 7 patients: posterior cerebral arterial occlusion• 11 patients: internal carotid arterial thrombosis• 21 patients: diffused atherosclerosis• 2 patients: anterior cerebral arterial disease• 42 patients: middle cerebral arterial thrombosis• 23 patients had negative on SWI from small infarction
on DWI• 56 patients had early sign of infarction on CT,CT finding
did not accord with SWI• 63 patients had varied degree of abnormal hypointense
vessel on SWI.
Cases Presentations
Case 128/male acute left side weakness,
history of chronic headache without definite etiology
CT,T1&DWI
Flair&contrast
Venous Pressure Gradient It was double SSS>SS Venous hypertension
Case Presentation
Case 252/F acute confusion with stomach Flu,
Suddenly lapsed to coma, upon arrival to UCI from transferring,
unresponsive.
Initial CT
arrival CT
Case Presentation
Case 3 55/M presented with acute left side
weakness history of hypertension and hyperlipdemia
PWI/MTT
SWI
Case Presentation
Case 473/F presented with acute left side
weakness with Aggrenox,history of TIA and hypertension
Initial MRI DWI/Flair
Flair,PWI/MTT
PWI/ dfV
MRA and Cerebral Angiogram
Follow-up MRA &DWI
Follow-up Flair
Case Presentation
Case 543/M presented with expressive aphasia, right homonymous hemianopsia and right side weakness, worse on upper extremity.
Case Presentaion
Case 656/M sudden lost his right eye vision
and left side weakness,History of hypertension and recent
Myocardial Infarction
Summary and Conclusion
• Presence of deoxygenated hyopintense vessels may indicated slow/stasis or thrombosis
• It may be used to detect venous hyperetension,braindeath,and poor prognosis of infarction due to poor intrinsic collaterals
Thank you for attention
Appreciate the opportunity to share our experience