Supplementary Data Set 1. Regional association plots of ... · PPIC PRDM6 CEP120 CSNK1G3 122.2...
9
1 0 2 4 6 8 10 - log 10 (p−value) 0 20 40 60 80 100 Recombination rate (cM/Mb) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● rs2076463 0.2 0.4 0.6 0.8 r 2 5 genes omitted SLC9A1 WDTC1 TMEM222 LOC644961 SYTL1 GPR3 AHDC1 FGR IFI6 FAM76A STX12 PPP1R8 SCARNA1 THEMIS2 RPA2 XKR8 EYA3 27.6 27.8 28 28.2 28.4 Position on chr1 (Mb) Brain_AC Brain_CG Brain_HM Brain_ITL Brain_MFL Brain_SN CD19+ Cells Pancreatic Islets Supplementary Data Set 1. Regional association plots of newly identified loci. 0 2 4 6 8 10 - log 10 (p−value) 0 20 40 60 80 100 Recombination rate (cM/Mb) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● rs860295 0.2 0.4 0.6 0.8 r 2 14 genes omitted PKLR FDPS RUSC1−AS1 RUSC1 ASH1L−AS1 MSTO1 MSTO2P YY1AP1 DAP3 GON4L SYT11 RIT1 KIAA0907 SNORA80E SSR2 MIR7851 RAB25 MEX3A LMNA SLC25A44 PMF1 BGLAP PAQR6 155.4 155.6 155.8 156 156.2 Position on chr1 (Mb) Brain_AC Brain_CG Brain_HM Brain_ITL Brain_MFL Brain_SN CD19+ Cells Pancreatic Islets 0 2 4 6 8 10 - log 10 (p−value) 0 20 40 60 80 100 Recombination rate (cM/Mb) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● rs491055 0.2 0.4 0.6 0.8 r 2 BRINP3 LINC01351 LOC440704 190 190.2 190.4 190.6 190.8 Position on chr1 (Mb) Brain_AC Brain_CG Brain_HM Brain_ITL Brain_MFL Brain_SN CD19+ Cells Pancreatic Islets 0 2 4 6 8 10 - log 10 (p−value) 0 20 40 60 80 100 Recombination rate (cM/Mb) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● rs6734118 0.2 0.4 0.6 0.8 r 2 1 gene omitted STRN HEATR5B GPATCH11 EIF2AK2 SULT6B1 CEBPZOS NDUFAF7 PRKD3 QPCT CDC42EP3 LINC00211 37.2 37.4 37.6 37.8 38 Position on chr2 (Mb) Brain_AC Brain_CG Brain_HM Brain_ITL Brain_MFL Brain_SN CD19+ Cells Pancreatic Islets 0 2 4 6 8 10 - log 10 (p−value) 0 20 40 60 80 100 Recombination rate (cM/Mb) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● rs10174398 0.2 0.4 0.6 0.8 r 2 NRXN1 50.8 51 51.2 51.4 51.6 Position on chr2 (Mb) Brain_AC Brain_CG Brain_HM Brain_ITL Brain_MFL Brain_SN Pancreatic Islets 0 2 4 6 8 10 - log 10 (p−value) 0 20 40 60 80 100 Recombination rate (cM/Mb) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 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● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● rs77489951 0.2 0.4 0.6 0.8 r 2 RMDN2−AS1 RMDN2 CYP1B1 CYP1B1−AS1 ATL2 LOC101929596 HNRNPLL GALM SRSF7 GEMIN6 DHX57 MORN2 ARHGEF33 LOC375196 SOS1 38.4 38.6 38.8 39 39.2 Position on chr2 (Mb) Brain_AC Brain_CG Brain_HM Brain_ITL Brain_MFL Brain_SN CD19+ Cells Pancreatic Islets Nature Genetics: doi:10.1038/ng.3951
Transcript of Supplementary Data Set 1. Regional association plots of ... · PPIC PRDM6 CEP120 CSNK1G3 122.2...
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rs2076463
0.2
0.4
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0.8
r2
5 genesomitted
SLC9A1
WDTC1
TMEM222
LOC644961
SYTL1
MAP3K6
FCN3
CD164L2
GPR3
AHDC1
FGR
IFI6
FAM76A
STX12
PPP1R8
SCARNA1
THEMIS2
RPA2
SMPDL3B
XKR8
EYA3
27.6 27.8 28 28.2 28.4Position on chr1 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Supplementary Data Set 1. Regional association plots of newly identified loci.
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rs860295
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r2
14 genesomitted
PKLR
FDPS
RUSC1−AS1
RUSC1
ASH1L
MIR555
POU5F1P4
ASH1L−AS1
MSTO1
MSTO2P
YY1AP1
DAP3
GON4L
SYT11
RIT1
KIAA0907
SNORA80E
SCARNA4
RXFP4
ARHGEF2
SSR2
MIR7851
RAB25
MEX3A
LMNA
SEMA4A
SLC25A44
PMF1
PMF1−BGLAP
BGLAP
PAQR6
SMG5
155.4 155.6 155.8 156 156.2Position on chr1 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●●●●●●●●●●rs491055
0.2
0.4
0.6
0.8
r2
BRINP3
LINC01351
LOC440704
190 190.2 190.4 190.6 190.8Position on chr1 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)●●●●●
●●●●●●●
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●
●
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rs6734118
0.2
0.4
0.6
0.8
r2
1 geneomitted
STRN
HEATR5B
GPATCH11
EIF2AK2
SULT6B1
CEBPZOS
CEBPZ
NDUFAF7
PRKD3
QPCT CDC42EP3
LINC00211
37.2 37.4 37.6 37.8 38Position on chr2 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●
●
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rs10174398
0.2
0.4
0.6
0.8
r2
NRXN1
50.8 51 51.2 51.4 51.6Position on chr2 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●
●
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●rs77489951
0.2
0.4
0.6
0.8
r2
RMDN2−AS1
RMDN2
CYP1B1
CYP1B1−AS1
ATL2 LOC101929596
HNRNPLL
GALM
SRSF7
GEMIN6
DHX57
MORN2
ARHGEF33
LOC375196
SOS1
38.4 38.6 38.8 39 39.2Position on chr2 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
2
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●
●
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●
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●●rs10208649
0.2
0.4
0.6
0.8
r2
1 geneomitted
ASB3
GPR75−ASB3
CHAC2
ERLEC1
MIR3682
GPR75
PSME4
ACYP2
TSPYL6
C2orf73
53.8 54 54.2 54.4 54.6Position on chr2 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
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bination rate (cM/M
b)
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●rs2390669
0.2
0.4
0.6
0.8
r2
B3GALT1 STK39 CERS6
MIR4774
168.6 168.8 169 169.2 169.4Position on chr2 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs2574704
0.2
0.4
0.6
0.8
r2
HRH1 ATG7
VGLL4
TAMM41 SYN2
11.2 11.4 11.6 11.8 12Position on chr3 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)●
●
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0.2
0.4
0.6
0.8
r2
3 genesomitted
ULK4 TRAK1
CCK
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SEC22C
SS18L2
NKTR
ZBTB47
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CCDC13
CCDC13−AS1
41.8 42 42.2 42.4 42.6Position on chr3 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs1035491
0.2
0.4
0.6
0.8
r2
1 geneomitted
RNF180 RGS7BP FAM159B
SREK1IP1
CWC27
ADAMTS6
63.6 63.8 64 64.2 64.4Position on chr5 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
5
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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rs1846974
0.2
0.4
0.6
0.8
r2
TMEM161B
TMEM161B−AS1
LOC102546226 LINC00461
MIR9−2
MEF2C
MEF2C−AS1
87.6 87.8 88 88.2 88.4Position on chr5 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
3
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●
●
●
●
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●●●●rs329120
0.2
0.4
0.6
0.8
r2
1 geneomitted
TCF7
SKP1
PPP2CA
MIR3661
CDKL3
UBE2B
CDKN2AIPNL
LOC102546229
LOC101927934
JADE2
SAR1B
SEC24A
CAMLG
DDX46
C5orf24
TXNDC15
PCBD2
MIR4461
CATSPER3133.4 133.6 133.8 134 134.2
Position on chr5 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●
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●rs4308481
0.2
0.4
0.6
0.8
r2
SNX2
SNX24
PPIC PRDM6 CEP120 CSNK1G3
122.2 122.4 122.6 122.8 123Position on chr5 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
5
10
15
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs183975233
0.2
0.4
0.6
0.8
r2
24 genesomitted
SKIV2L
DXO
STK19
C4A
C4B
C4B_2
CYP21A2
ATF6B
FKBPL
PRRT1
LOC100507547
PPT2
PPT2−EGFL8
EGFL8
C6orf10
HCG23
BTNL2
HLA−DRA
HLA−DRB5
HLA−DRB6
HLA−DRB1
HLA−DQA1
HLA−DQB1
HLA−DQA2
HLA−DQB2
HLA−DOB
TAP2
PSMB8
PSMB8−AS1
TAP1
HLA−DMB
HLA−DMA
BRD2
32 32.2 32.4 32.6 32.8Position on chr6 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs9397585
0.2
0.4
0.6
0.8
r2
SYNE1
MYCT1
VIP FBXO5
MTRF1L
RGS17
153 153.2 153.4 153.6 153.8Position on chr6 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs148546399
0.2
0.4
0.6
0.8
r2
PTP4A1
PHF3
EYS
64.4 64.6 64.8 65 65.2Position on chr6 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
12
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●
●●●●
●
●●
●
●●
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●
●
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●
●
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●●●●●●●●●●
●● ●●rs6947395
0.2
0.4
0.6
0.8
r2
LOC100507468
AUTS2
69 69.2 69.4 69.6 69.8Position on chr7 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
4
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●
●
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●
●
●rs143665886
0.2
0.4
0.6
0.8
r2
TFEC TES
115 115.2 115.4 115.6 115.8Position on chr7 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●
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rs108682150.2
0.4
0.6
0.8
r2
SLC28A3 NTRK2
86.8 87 87.2 87.4 87.6Position on chr9 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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rs77636220
0.2
0.4
0.6
0.8
r2
YTHDF3−AS1
YTHDF3
LINC01289
64.2 64.4 64.6 64.8 65Position on chr8 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●
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●rs4366055
0.2
0.4
0.6
0.8
r2
CDH17
GEM
RAD54B
FSBP
KIAA1429
LOC100288748
ESRP1
DPY19L4
INTS8
CCNE2
TP53INP1
95.2 95.4 95.6 95.8 96Position on chr8 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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rs3932549
0.2
0.4
0.6
0.8
r2
1 geneomitted
MIR4291
BARX1
PTPDC1
MIRLET7A1
MIRLET7F1
MIRLET7DHG
MIRLET7D
ZNF169
NUTM2F
LOC100132077
HIATL1
LOC101928099
FBP2
FBP1
C9orf3
MIR2278
96.6 96.8 97 97.2 97.4Position on chr9 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
5
10
15
20
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
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rs7020996
0.2
0.4
0.6
0.8
r2
MTAP C9orf53
CDKN2A
CDKN2B−AS1
CDKN2B
DMRTA1
21.8 22 22.2 22.4 22.6Position on chr9 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
5
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●
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●rs5015933
0.2
0.4
0.6
0.8
r2
ARPC5L
GOLGA1
SCAI
PPP6C
RABEPK
HSPA5
GAPVD1 MAPKAP1 PBX3
127.8 128 128.2 128.4 128.6Position on chr9 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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rs10795945
0.2
0.4
0.6
0.8
r2
ECHDC3
PROSER2
PROSER2−AS1
UPF2
DHTKD1
SEC61A2
NUDT5
CDC123
CAMK1D
MIR4480
12 12.2 12.4 12.6 12.8Position on chr10 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs7912454
0.2
0.4
0.6
0.8
r2
1 geneomitted
MRC1
TMEM236
MIR511−1
SLC39A12
LOC100129213
CACNB2
NSUN6
ARL5B
18.2 18.4 18.6 18.8 19Position on chr10 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
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0
20
40
60
80
100
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●rs80117551
0.2
0.4
0.6
0.8
r2
CTNNA3 DNAJC12
SIRT1
HERC4 MYPN
ATOH7
PBLD
HNRNPH3
RUFY2
DNA2
SLC25A16
TET1
69.4 69.6 69.8 70 70.2Position on chr10 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
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0
20
40
60
80
100
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bination rate (cM/M
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rs1832886
0.2
0.4
0.6
0.8
r2
CPEB3
MARCH5
MARK2P9
IDE
KIF11
HHEX
EXOC6
CYP26C1
CYP26A1
94 94.2 94.4 94.6 94.8Position on chr10 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs12569457
0.2
0.4
0.6
0.8
r2
5 genesomitted
LCOR
C10orf12
SLIT1
LOC100505540
ARHGAP19−SLIT1
ARHGAP19
FRAT1
FRAT2
RRP12
PGAM1
EXOSC1
ZDHHC16
MMS19
UBTD1
ANKRD2
HOGA1
C10orf62
MIR5692C2
MORN4
PI4K2A
AVPI1
MARVELD1
ZFYVE27
SFRP5
LINC00866
98.6 98.8 99 99.2 99.4Position on chr10 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
6
0
2
4
6
8
10
12
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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rs1907240
0.2
0.4
0.6
0.8
r2
MIR5694
WDR11−AS1
WDR11
FGFR2
122.4 122.6 122.8 123 123.2Position on chr10 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
12
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
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●●●●
●●●●●●●●rs1568079
0.2
0.4
0.6
0.8
r2
IKZF5
ACADSB
HMX3
HMX2
BUB3
GPR26 CPXM2
124.8 125 125.2 125.4 125.6Position on chr10 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
12
14
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
●
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●●rs75766425
0.2
0.4
0.6
0.8
r2
FRMD6−AS2
FRMD6
FRMD6−AS1
GNG2
C14orf166
NID2 PTGDR
PTGER2
TXNDC16
52.2 52.4 52.6 52.8 53Position on chr14 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
12
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●●rs80234489
0.2
0.4
0.6
0.8
r2
LINC00941
TSPAN11
DDX11−AS1
DDX11
FAM60A
FLJ13224
DENND5B
DENND5B−AS1
METTL20
AMN1
31 31.2 31.4 31.6 31.8Position on chr12 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
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rs729050
0.2
0.4
0.6
0.8
r2
3 genesomitted
MOAP1
TMEM251
C14orf142
UBR7
BTBD7
UNC79
COX8C PRIMA1
FAM181A−AS1
FAM181A
ASB2
LINC00521
OTUB2
DDX24
IFI27L1
IFI27
IFI27L293.8 94 94.2 94.4 94.6
Position on chr14 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets 0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs2593235
0.2
0.4
0.6
0.8
r2
LOC145783
TCF12
LINC00926
LOC101928611
CGNL1
MYZAP
GCOM1
POLR2M
57.2 57.4 57.6 57.8 58Position on chr15 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
4
7
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs72749754
0.2
0.4
0.6
0.8
r2
VPS13C
C2CD4A
C2CD4B MIR8067
MIR6085
62 62.2 62.4 62.6 62.8Position on chr15 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs180950758
0.2
0.4
0.6
0.8
r2
SLC6A4
BLMH
TMIGD1
CPD
GOSR1
TBC1D29
LRRC37BP1
SH3GL1P2
SUZ12P1
CRLF3
ATAD5
TEFM
ADAP2
RNF135
DPRXP4
MIR4733
NF1
28.6 28.8 29 29.2 29.4Position on chr17 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●●rs4788694
0.2
0.4
0.6
0.8
r2
ZFHX3
HCCAT5
C16orf47 LOC100506172
72.6 72.8 73 73.2 73.4Position on chr16 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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rs4790981
0.2
0.4
0.6
0.8
r2
1 geneomitted
PITPNC1
NOL11
SNORA38B
BPTF
C17orf58
KPNA2
LINC00674
LOC440461
AMZ2
ARSG
SLC16A6
PRKAR1A
WIPI1
MIR63565.6 65.8 66 66.2 66.4
Position on chr17 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs16978956
0.2
0.4
0.6
0.8
r2
1 geneomitted
SNX5
SNORD17
MGME1
OVOL2
PET117
CSRP2BP
ZNF133
LINC00851
DZANK1
POLR3F
MIR3192
RBBP9
SEC23B
LINC00493
DTD1
LOC101929526
LINC00652
LOC100270804
17.8 18 18.2 18.4 18.6Position on chr20 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
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●rs2247627
0.2
0.4
0.6
0.8
r2
LOC101927796
LOC102723578
CBLN4
53.8 54 54.2 54.4 54.6Position on chr20 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
●●
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
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●
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●●
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●rs6089584
0.2
0.4
0.6
0.8
r2
4 genesomitted
CDH4
MIR1257
TAF4 LSM14B
PSMA7
SS18L1
MTG2
HRH3
OSBPL2
ADRM1
LAMA5
MIR4758
LOC101928158
RPS21
CABLES2
RBBP8NL
GATA5
60.2 60.4 60.6 60.8 61Position on chr20 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
8
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
●
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●
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●
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● ●●●●●●●●●●●●●
●●●●●●●
●rs6529684
0.2
0.4
0.6
0.8
r2
1 geneomitted
GPR173
TSPYL2
KANTR
KDM5C
MIR6895
MIR6894
IQSEC2
SMC1A
MIR6857
RIBC1
HSD17B10
HUWE1
MIR98
MIRLET7F2
PHF8
53.2 53.4 53.6 53.8 54Position on chrX (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
5
10
15
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
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●
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●
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● ●●●●
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●●
●rs3121672
0.2
0.4
0.6
0.8
r2
WDR44
MIR1277
DOCK11 IL13RA1
ZCCHC12
LINC01285
LONRF3
KIAA1210
PGRMC1
117.6 117.8 118 118.2 118.4Position on chrX (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●
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●
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●●●●rs1379871
0.2
0.4
0.6
0.8
r2
DMD
31.4 31.6 31.8 32 32.2Position on chrX (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNPancreatic Islets
0
2
4
6
8
10
12
14
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
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rs139913
0.2
0.4
0.6
0.8
r2
ENTHD1
GRAP2
FAM83F
LOC100130899
TNRC6B
ADSL
SGSM3
MKL1
LOC101927257 MCHR1
SLC25A17
MIR4766
40.4 40.6 40.8 41 41.2Position on chr22 (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●
●
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●rs1190736
0.2
0.4
0.6
0.8
r2
VGLL1
MIR934
LINC00892
CD40LG
ARHGEF6 RBMX
SNORD61
GPR101
135.8 136 136.2 136.4 136.6Position on chrX (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
9
0
2
4
6
8
10
−lo
g 10(
p−va
lue)
0
20
40
60
80
100
Recom
bination rate (cM/M
b)
●●●●●●●●●●●●●●●●●● ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
● ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
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●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
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●
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●
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●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
●
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●
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●rs5945324
0.2
0.4
0.6
0.8
r2
5 genesomitted
MAGEA1 ZNF275
ZFP92
TREX2
HAUS7
BGN
ATP2B3
FAM58A
DUSP9
PNCK
SLC6A8
BCAP31
ABCD1
PLXNB3
SRPK3
IDH3G
SSR4
PDZD4
L1CAM
AVPR2
ARHGAP4
NAA10
RENBP
HCFC1
HCFC1−AS1
TMEM187
MIR3202−1
IRAK1
MIR718
MECP2
152.4 152.6 152.8 153 153.2Position on chrX (Mb)
Brain_ACBrain_CGBrain_HMBrain_ITLBrain_MFLBrain_SNCD19+ CellsPancreatic Islets
Nature Genetics: doi:10.1038/ng.3951
