SUMUKTI SYRUP

PRESENTED BY

DR PRABHAKAR MANU

2ND YEAR PG SCHOLAR

DEPT. OF MANASA ROGA

SDM COLLEGE OF AYURVEDA & HOSPITAL,

HASSAN

CONTENTS

• INTRODUCTION

• INGREDIENTS

• RASPANCHAKA

• SUMUKTI SYP. AS A WHOLE

• DOSES AND ANUPANA

• RESEARCH WORKS DONE

INTRODUCTION

•Popular & Anubhoota Yoga

of SDMCAH, Hassan

•Hepatoprotective in action

•Widely used in De-addiction

program

INGREDIENTS

1. Guduchi

2. Bringaraja

3. Kirata Tiktha

4. Amalaki

5. Hareetaki

6. Vibhitaki

7. Draksha

8. Sugar

9. Mandukaparni

10.Aswagandha

11.Yashtimadhu

12.Katuki

Sl No

Sanskrit name Latin Name Part Used Quantity in gms

1. Aswangandha Withania somnifera

Root 400

2. Hareetaki Terminalia chebula

Fruit 400

3. Vibhitaki Terminalia bellerica

Fruit 400

4. Amalaki Emblica offinalis

Fruit 400

5. Yashtimadhu Glycyrrihiza glabra

Stem, Root 400

6. MandukaparniCentrella asiatica

W P 100

7. Guduchi Tinospora cordifolia

Stem 400

8. Kiratatikhta Swertia chirata

W P 800

9. Katuki Pichrorhiza kurroa

Rhi 800

10.

Draksha Vitis venefera

Fruit 3200

11.

Bringaraja Weddalia calendulaca

W P 400

15 Sodium benzoate

.5%

16 sugar 50kg

Sl No

Sanskrit name Ra Gu Vip Vee

1. Aswangandha Ti, Kas La M S

2. Hareetaki M,A,Kat,Kas,Ti La, Ru M U

3. Vibhitaki Kas La, Ru M U

4. Amalaki M,A,Kat,Kas,Ti La, Ru M S

5. Yashtimadhu M G, Sn M S

6. Mandukaparni M,Kat,Kas,Ti La, Sa M S

7. Guduchi Ti, Kas La M U

8. Kiratatikhta T La, Ru K S

9. Katuki Kat,T La K U

10. Draksha M, Kas G, Sn M S

11. Bringaraja Kat,T Ru, Ti K U

Sanskrit name KARMA

Aswangandha Rasayana, Vatakaphahara, Balya

Hareetaki Deepana,Tridoshahara, RasayanaVibhitaki Kaphapittahara, Bhedaka, Krimihara

Amalaki Rasayana, Tridoshahara, Cakushya,Raktaprasadana

Yashtimadhu Balya, Rakthaprasadana, VP hara

Mandukaparni Balya,Vishahara,Medhya,RasayanaGuduchi Deepana, Rasayana,VPK, Rakthashodaka

Kiratatikta Rakthashodhaka, KP hara

Katuki Pittahara, Deepana, Hrudya

Draksha Bruhmana, VP hara, Vrushya

Bringaraja Balya, K P hara, Rasayana, Vishahara

SUMUKTI SYP. AS A WHOLE

• Rasa- Tiktha, Kashaya

• Guna- Laghu, Ruksha

• Vipaka- Madhura

• Veerya- Sita

• Karma- Tridosha, Balya, Rasayana, Vishagna, Rakthaprasadana, Rakthashodaka, Medhya

DOSE

• 2 – 4 teaspoon twice a day after food

• Anupana - water

RESEARCH WORKS DONE

• A CLINICAL STUDY ON THE EFFICACY OF “SUMUKTI”-AN INDEGINOUS COMPOUND ON MADATYAYA W.S.R TO ALCOHOL DEPENDENCE

By

Dr. UNNIKRISHNAN P. M

Under The Guidance of

DR. SAVITHA H.P, MD(Ayu)

Associate Professor

Department of Manasa Roga

• Effect on subjective parameters

• Effect of sumukti on craving:

• 30 patients shown craving in a mean of 8.13 which is reduced to 2.96 after treatment and 63.59% of improvement

• Effect of sumukti on tolerance:

•Mean score of tolerance was 6.36 before treatment which came down to 1.36 after treatment. It shown 78.61% of improvement

• Effect of sumukti on salience:

• Symptom salience had a mean score of 6.13 before treatment and it came down to 2.16 after treatment. It shown 64.76% of improvement

• Effect of sumukti on loss of control:

• 6.70 was the mean score of symptom loss of control before treatment which came down to 1.9 after completion of one month treatment.

• Effect on objective parameters

• Effect of sumukti on liver function test

• Effect on total bilirubin:

• Before treatment means score of total bilirubin was 1.35 which came down to 0.94 with 30.37% of improvement.

• Effect on direct bilirubin:

• Before treatment mean score of direct bilirubin was 0.85 which came down to 0.58 with 31.76% of improvement.

• Effect on indirect bilirubin:

• Before treatment mean score of indirect bilirubin was 0.50 which came down to 0.36 with 28% of improvement.

• Effect on aspartate aminotransferase [ SGOT]:

• Before treatment mean score of SGOT was 89.95 which came down to 30.06 with 66.58% of improvement.

• Effect of sumukti on persistent use:

• Persistent use showed a mean score of 7.13 before treatment and it came down to 1.73 after completion of treatment. It showed 75.73% of improvement

• Effect of sumukti on withdrawal symptoms:

• In withdrawal symptoms 5.2 was the mean score before treatment which came down to 1.26 after treatment. It showed 75.76% improvement

• Effect on alanine aminotransferase [SGPT]:

• Before treatment mean score of SGPT was 74.74 which came down to 27.01 with 63.86% of improvement.

• Effect on USG abdomen:

• Mean value of USG abdomen was 1.33 before treatment and it came down to 0.00 after treatment.

ACTIVE INGREDIENTS• Comparative study of the antioxidant and reactive

oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis

•  T. chebula, T. belerica and E. officinalis fruits, through their measurement of activities in scavenging of different free radicals including hydroxyl, superoxide, nitric oxide, hydrogen peroxide, peroxynitrite, singlet oxygen, hypochlorous acid, phenol, flavonoid and ascorbic acid content and total antioxidant activity

• Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin

•  Other in vivo and clinical studies have reported beneficial effects of both licorice and glycyrrhizin consumption including anti-ulcer, anti-viral, and hepatoprotective responses.

• Tinosporia cordifolia has hepato protective activity,And has antioxident activity.

POTENT HERBAL HEPATOPROTECTIVE DRUGS-

A REVIEW

SWERTIA CHIRATA

Amarogentin, Gentiopicrin ,Gentianine, Drug also possesses digestive, hepatic (conditions pertaining to the liver), tonic, astringent and appetizer properties and used in cough, dropsy and skin diseases.

Eclipta Alba (Bhringaraj)- The hepatoprotective effect of the ethanol/water (1:1) extract of Eclipta Alba (Asteraceae) was studied at subcellular levels in rats against (CCl4) -induced hepatotoxicity. The loss of hepatic lysomal acid phosphatase and alkaline phosphatase by (CCl4) was significantly restored by Eclipta Alba.

• Picrorhiza kurroa (Kutki)

• The increased levels of serum glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase, lipoprotein-X (LP-X) and bilirubin in the infected animals were marked reduced by different doses of picroliv.

DISPENSARY PACKAGING

Discussion and conclusion

• One of the important yoga acting as Hepatoprotective action

• All ingredients have tikta rasa converted into syrup base with added sugar to avoid patient compliance and to make more palatable

• Majority of ingredients have antioxidant activity

Thank you……….