Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important?...
-
date post
20-Dec-2015 -
Category
Documents
-
view
222 -
download
7
Transcript of Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important?...
![Page 1: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/1.jpg)
Starter Questions:
1. What did you think of this paper? Did you find it interesting? Is it important?
2. What tissues does influenza infect? What immune mechanisms are important at this site of infection?
3. This group hypothesized that increased innate immune responses might harm thehost and help the pathogen (influenza).Did this hypothesis surprise you? Why or why not?
![Page 2: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/2.jpg)
Background
• 1918 influenza extremely pathogenic, killing ~50 million people world wide.
• H1N1 subtype…but other H1N1 subtypes are not so deadly…
• Previously shown that infection with virus containing the 1918 H1 and N1 resulted in massive macrophage and neutrophil infiltration…the cause of increased pathogenicity?
What do you guys think of this hypothesis?
![Page 3: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/3.jpg)
• Hemagglutinin: receptor required for viral entry, binds to sialic acid reisdues on host cells.
• Neuraminidase: aids in viral release from host cells by cleaving sialic residues from surface of host cells.
![Page 4: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/4.jpg)
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Influenza infectious cycle
![Page 5: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/5.jpg)
Influenza strains used
Why did they decide to use the Tx/91 and 1918HA/NA:Tx/91 viruses for this paper?
![Page 6: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/6.jpg)
rescued Tx/91
HA/NA:Tx/91
Tx/91
Fig. 1
Lung titers
![Page 7: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/7.jpg)
Fig. 2
TX/91
1918 HA/NA:TX/91
![Page 8: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/8.jpg)
![Page 9: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/9.jpg)
Fig. 3
![Page 10: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/10.jpg)
Fig. 4
ctrl antibody
Neutrophil antibody
Neutrophil antibody+clodronate liposomes
clodronate liposomes
PBS liposomes
Lung titers
Brain titers
![Page 11: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/11.jpg)
Fig. 5
![Page 12: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/12.jpg)
1918 influenza increases certain innate immune inflammatory responses and decreases type-I Interferon responses in infected monkeys.
![Page 13: Starter Questions: 1.What did you think of this paper? Did you find it interesting? Is it important? 2.What tissues does influenza infect? What immune.](https://reader030.fdocuments.net/reader030/viewer/2022032704/56649d4a5503460f94a27c17/html5/thumbnails/13.jpg)