Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc...
-
Upload
truonghanh -
Category
Documents
-
view
220 -
download
2
Transcript of Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc...
![Page 1: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/1.jpg)
Skeletal and Muscular Systems
• Myth No. 1: A fracture is a milder form of bone injury than a broken bone.
• Myth No. 2: Once bones are fully developed, they stop changing.
• Myth No. 3: Osteoporosis is a painful bone condition.
• Myth No. 4: Vitamin D deficiency causes rickets, a disease of malnourished children.
• Myth No. 5: If you have broken a bone, you'll know it right away.
• Myth No. 6: A broken bone heals stronger than it was before the break.
2
Bone myths
![Page 2: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/2.jpg)
Skeletal System
• The framework for your body • 206 bones • “Os-” bone; • “Osteo-” bone • Two divisions
–Axial: Skull, vertebrae, ribs, sternum –Appendicular; arms and legs.
• Contains both bone tissue and cartilage
![Page 3: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/3.jpg)
5
Osteocytes are bone cells
![Page 4: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/4.jpg)
7
Bone contains:• Minerals – especially calcium which
provides for the hardness of bone • Collagen fibers which provides
strength of bone • If one or the other is missing bones
will be soft or brittle
![Page 5: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/5.jpg)
Bone has an excellent blood supply
Joint• “art-” and “arthr-” mean joint • Ligaments stabilize joints • Cartilage caps the bones at the joint
for a smooth surface
![Page 6: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/6.jpg)
Cartilage
• “chondr-” means cartilage • Healing capability is poorer than
bone • Mostly due to decreased blood
supply.
![Page 7: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/7.jpg)
Skeleton Function
• Framework; muscles attach • Support; allows upright posture • Movement; muscle leverage • Protection; Brain, lungs, heart, etc. • Blood cell production from bone
marrow; red and white blood cells • Storage of minerals & fat; calcium,
phosphate. • Fat in yellow marrow.
![Page 8: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/8.jpg)
Disorders of Skeleton-Osteoporosis
Incidence• Common in the U.S. • Responsible for many
fractures each year • Affect 200 million
women worldwide - 10% aged 60; 66% women aged 90
• Men; 27% for over 50
![Page 9: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/9.jpg)
Cause• Inadequate calcium • Females, older more
commonly • Sedentary lifestyle • Poor diet • Pregnancy giving
calcium to fetus • Menopause leads to
calcium withdrawal from bone
Prevention/Treatment
• Weight-bearing exercise • Calcium in diet • Estrogen replacement
therapy after menopause
• Drugs, such as Fosamax
![Page 10: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/10.jpg)
Arthritis
• Osteoarthritis is the wear and tear arthritis due to joint damage and injuries
Arthritis• Rheumatoid arthritis is an
autoimmune disease in which the immune system attacks the joints in the body leading to their gradual destruction
![Page 11: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/11.jpg)
Sprain• Joint injury that stretches or tears
supportive ligaments • A severe sprain can result in a
dislocation
Fracture• Generally bones heal well with
proper alignment, stabilization, and without infection
![Page 12: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/12.jpg)
Fractures• Hairline or greenstick: young, soft bone in
which the bone bends and partially breaks • Simple • Compound = Open; skin is broken • Comminuted: bone has broken into a
number of pieces.
![Page 13: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/13.jpg)
Muscular System
• “Myo-” means muscle
• Muscle tissue is capable of contraction
Smooth muscle
• Found in the wall of tubular structures such as intestine
•Involuntary • Smooth appearance microscopically • Peristalsis is a wave like contraction
of smooth muscle
![Page 14: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/14.jpg)
![Page 15: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/15.jpg)
Cardiac Muscle
• Heart muscle •Involuntary • Striated, or striped when observed
microscopically
![Page 16: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/16.jpg)
Skeletal Muscle
• Muscle attached to the skeleton • Voluntary • Striated microscopically
![Page 17: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/17.jpg)
Skeletal Muscle• Tendons attach muscle to bone
![Page 18: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/18.jpg)
36
![Page 19: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/19.jpg)
Microscopic Muscle• Myofiber =
muscle cell • Myofibril =
the striated parts of the muscle cell
• Myofilaments = the proteins that make up the myofibrils
![Page 20: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/20.jpg)
Myofilaments
• The two main proteins that comprise the myofilaments are: –Myosin – very thick protein –Actin – very thin protein
![Page 21: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/21.jpg)
Sarcomere• The actin and myosin in the muscle
cells are arranged in small groups called SARCOMERES
• Since contraction occurs at the microscopic level of the sarcomere, the sarcomere is the functional unit of contraction
42
![Page 22: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/22.jpg)
Sliding Filament Theory
• This describes the mechanics of muscle contraction
• The myosin “heads” grab on to the actin protein and pull the actin towards the center of the sarcomere, making the sarcomere shorter.
![Page 23: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/23.jpg)
![Page 24: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/24.jpg)
48
![Page 25: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/25.jpg)
ATP
• ATP is necessary for muscle contraction
• Running out of ATP may lead to muscle fatigue
![Page 26: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/26.jpg)
Motor Neuron
• Skeletal muscle will not contract unless a motor neuron (movement nerve cell) stimulates it to contract
![Page 27: Skeletal and Muscular Systems 2014rowdysites.msudenver.edu/~raoa/rao/bio1000/1000 pdfs/Skel-Musc Sy… · Skeletal and Muscular Systems ... •Mostly due to decreased blood supply.](https://reader033.fdocuments.net/reader033/viewer/2022051800/5ac8f7d17f8b9a7d548ccd86/html5/thumbnails/27.jpg)
Motor Unit
• A motor neuron plus how every many skeletal muscle cells it serves is a motor unit
• A motor unit that has one neuron to one muscle cell allows for very precise movements
• A motor unit that has one neuron to 400 muscle cells does not provide precise control