Siamak Tabibzadeh MD Laguna Beach Rotary Club, 31106 South Coast Highway, 31106 South Coast Highway,...

Siamak Tabibzadeh Siamak Tabibzadeh MDMD

Laguna Beach Rotary Club,Laguna Beach Rotary Club, 31106 South Coast Highway,31106 South Coast Highway,

Laguna Beach, California 92651Laguna Beach, California 92651

July 13, 2012July 13, 2012




July 13, 2012July 13, 2012

Professor,Professor,Department of Oncologic RadiologyDepartment of Oncologic Radiology

University of California, University of California, Irvine, CaliforniaIrvine, California



Aging & Healthy livingAging & Healthy living




July 13, 2012July 13, 2012




July 13, 2012July 13, 2012





President, President,

Frontiers in Bioscience Research Frontiers in Bioscience Research Institute in Aging and CancerInstitute in Aging and Cancer

Irvine, CaliforniaIrvine, California

President, President,

Frontiers in Bioscience Research Frontiers in Bioscience Research Institute in Aging and CancerInstitute in Aging and Cancer

Irvine, CaliforniaIrvine, California

Formation of our universeFormation of our universe

First there was nothingFirst there was nothing

Big bangBig bang

History of our universeHistory of our universe

Formation of atomsFormation of atoms

CoolingCooling Formation of HFormation of H

Major atoms that form lifeMajor atoms that form life

H: Hydrogen

C: Carbon

O: Oxygen

N: Nitrogen

H: Hydrogen

C: Carbon

O: Oxygen

N: Nitrogen

Formation of milky way galaxyFormation of milky way galaxy

Formation of milky way galaxyFormation of milky way galaxy Formation of earthFormation of earth

Comets bring water to earthComets bring water to earth

Collapsing under gravityCollapsing under gravity

Formation of sunFormation of sun

Earth formedEarth formed

Life formedLife formed

Fossilized life formsFossilized life forms

First photosynthesisFirst photosynthesis

Oxygen accumulatesOxygen accumulates

Single cell formsSingle cell forms

Time (Billions of years)Time (Billions of years)

Formation of life on earthFormation of life on earth

Formation of protocellFormation of protocell

Formation of protocell Protocell

Protocells are simple yet are immortalProtocells are simple yet are immortal

Infinite cycles of cell growth and division

Blissful matrimony leads to evolutionBlissful matrimony leads to evolution

Parasitism at the heart of boosting cell energy and mortalityParasitism at the heart of boosting cell energy and mortality

Blissful matrimony leads to evolutionBlissful matrimony leads to evolution

Generation of energyGeneration of energy

Movement a direct result of evolutionMovement a direct result of evolution

Cell with flagellum Cell with flagellum

Sperm

Evolution of flagellumStructure of flagellum

Time (Millions of years)

First intervertabrates

Cambian explosion of life begins

First fish

First land plants and animals

First amphibians

First mammals

Permian extinction

First flowering plants and insects

First primates

First hominids

Divergent species form by evolutionDivergent species form by evolution

Darwin uncovers evolutionDarwin uncovers evolutionDarwin’s handwritten note Tree of life

Evolution is seen in blueprint of lifeEvolution is seen in blueprint of life

Tree of life Tree of life

The dark side of generation of energyThe dark side of generation of energy

Generation of toxic by-productsGeneration of toxic by-products Aging

Monocellular organisms are immortalMonocellular organisms are immortal

Amoeba

Some cells in humans are immortalSome cells in humans are immortal

Cancer cellsCancer cells

Stem cellsStem cells

Causes of agingCauses of aging

Damage to stem cellsDamage to stem cells

Stem cell basis of agingStem cell basis of aging

Causes of agingCauses of aging

Inflamm-agingInflamm-aging

Inflammatory basis of agingInflammatory basis of aging

Causes of agingCauses of agingInflammatory basis of agingInflammatory basis of aging

Willow barkWillow bark

Acetylesalicyclic acidAcetylesalicyclic acid

Reduce inflammation by aspirinReduce inflammation by aspirin

Discovered ~6000 years agoHippocrates described the preparation of it in 460 BC from willow barkCharles Frederic Gerhardt prepare acetylsalicylic acid in 1853.

How to decelerate agingHow to decelerate aging

Avoid stressAvoid stress


Avoid alcohol and cigaretteAvoid alcohol and cigaretteAvoid red meatAvoid red meatAvoid saltAvoid sugar

Glucose

Avoid fatty food and consumption of oilAvoid fatty food and consumption of oil


Exercise dailyExercise daily

5 Minute sun * 1000 IU Vitamin D daily5 Minute sun * 1000 IU Vitamin D daily



Consume 10 cups of water per dayConsume 10 cups of water per day


Have a balanced dietHave a balanced diet

Restrict calorieRestrict calorie

Have multiple mealsHave multiple meals

Avoid obesityAvoid obesity

Consume legumes and nutsConsume legumes and nuts



Tamarind

Consume sour or un-ripened fruitsConsume sour or un-ripened fruitsAvoid sweet fruitsAvoid sweet fruits


Consume vegetablesConsume vegetables

CapsaicinCapsaicin


Consume glass of wine with resveratrolConsume glass of wine with resveratrol

Horseradish

Wasabe Wasabe

Broccoli

CauliflowerArugula

Garlic

Rhubarb


Consume vegetables

General

1. Reduce calorie intake. Reduction of calorie intake per day has been shown in many species to increase longevity

2. Have multiple meals (~6-10) per day comprised of smaller portions to avoid fluctuation of insulin. Insulin inhibits gene signaling that improve repair.

3. Do not allow yourself to get fat. Increase body mass increases the work of stem cells

4. Have a balanced diet comprised of fibers, minerals, vitamins, and protein

5. Reduce stress in your life. Stress shorten lifespan

7. Smile frequently. Smiling reduces stress

8. Rest and have regular sleep that allows you to have a fresh feeling the next day

9. Take vacations and relax with music, good conversation, or a hobby each day

10. Choose a job that you love to reduce your stress during the day

11. If possible do not commute to reduce stress due to driving

12. Exercise frequently (short periods of 2-3 times daily and one to two times per week of exercise that increases the heart rate). Exercise, increases blood flow, and increases the endorphins in the brain allowing you to become happy and relaxed


Foods the avoid

1.Sugar. Glucose turns on insulin pathway and inhibits the repair pathways. Glucose whether in natural (honey, grapes, raisin) or artificial (sugar, or sugar cubes) products exert the same effects

2.Fat. All food that you eat has fat. Do not add fat to your food (do not fry, do not add cheese)

3.Salt. Excess salt leads to vasoconstriction and over time leads to hypertension. Use seasoning, lemon juice or pepper to add taste to your food

4.Red meat. Myoglobin which gives red color to red meat has an iron core. Iron causes cell damage.

5.Animal meat. Animal meats particularly when barbecued lead to aging and cancer

6.Avoid sweet fruits


Foods to consume

1.Have 3-6 cups of water (warm) in the morning. This increases the loss of waste products from your body and dilutes them in the blood

2.Try to use 10 cups of water per day

3.Get sunlight of about 5 minutes per day to receive the required vitamin D. Have your vitamin D measured in your blood and if low, add 1000 to 2000 IU of vitamin D to your diet

4.Include yogurt in your diet

5.Use proteins of plant origin (lentil, bean, pea, tofu)

6.Include legumes in your diet (almond, hazel nut)

7.Include unripened or sour fruits in your diet

8.Include turmeric in your die. Turmeric is anti-oxidant and reduces damage to cells which results from food consumption

9.Include vegetables in your diet. Vegetables add fiber, vitamins and minerals to your diet.

10.Include hot peppers in your diet. The capsaicin in hot peppers is anti-inflammatory and also cause euphoria

11.Include Wasabi, Horseradish, Rhubarb, Cauliflower in your diet

12.Take two cloves of crushed garlic and one tablespoonful of ultra virgin olive oil with one to two tablespoonful of yogurt (mix together) with your lunch and your dinner


Medicine

1.Resveratrol is anti-oxidant and has been shown to increase longevity in many different species. Glucoronides in the red wine increase the absorption of resveratrol significantly from the gastrointestinal tract. The dose for humans has not been determined but approximate dose is at least 25-500 mg.

2. Aspirin is anti-inflammatory (>1000 mg daily) and has been shown to reverse (at 3-4 grams per day) the diabetic hyperglycemia and to lower cholesterol in the blood. To avoid gastrointestinal impact of the acidic nature of this drug, aspirin might be used as salsalate.

3. Vitamin D; 1000-2000 IU units per day


AcknowledgementAcknowledgementChris Wiley, PhD

Research Scientist

Chris does cutting edge research on aging. His work shows

pathways that lead to generation of senescent cells that contribute

to overall aging

Chris Rollins, MS

Research Associate

Chris is investigating the hypothesis that cancer cells are

generated by massive cell damage

Casey Raasumaa, MS

Research Associate

Casey investigating new pathways that lead to increase in healthspan

and lifespan. She also provides administrative background to make FBS a cutting-edge research center

Daniel Tabibzadeh, BS

Development Manager

Daniel creates and maintains the Frontiers in Bioscience Journal

and Research Institute WebSites

www.frontbiosci.org www.frontbiosci.org/ri

Siamak Tabibzadeh MD Laguna Beach Rotary Club, 31106 South Coast Highway, 31106 South Coast Highway,...

Documents

Transcript of Siamak Tabibzadeh MD Laguna Beach Rotary Club, 31106 South Coast Highway, 31106 South Coast Highway,...