SEMESTER -2 sem.€¦ · DR.VEENA M. MAHAJAN. DNA DAMAGE AND REPAIRE CONTENT ... 1.Excision repair...
Transcript of SEMESTER -2 sem.€¦ · DR.VEENA M. MAHAJAN. DNA DAMAGE AND REPAIRE CONTENT ... 1.Excision repair...
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J. M. PATEL ART COMMERCE AND
SCIENCE COLLEGE
SEMESTER -2nd sem.
PRESENTED BY
DR.VEENA M. MAHAJAN
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DNA DAMAGE AND
REPAIRE
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CONTENT
Introduction
Types of DNA Damage
Types of mutation
DNA repair mechanism
Excision Repair
Mismatch Repair
Recombination repair
Double strand DNA break repair
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WHAT IS DNA
A nucleic acid that carries the
genetic in formation in cell &some
viruses consisting a two long chain of
nucleotide twisted in double helix
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DNA DAMAGES
Types of damages
Mutation
Types of mutation
1. point mutation
transition and transversion
2. frameshift mutation
addition and deletion
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1. POINT MUTATION
TRANSVERSION AND TRANSITION
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2.FREAMSHIFT MUTATION
Addition and deletion causing shift
1.mutation in single stranded break :-ex. peroxide
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2.DOUBLE STRAND BREAK (DS BREAK)
T-T dimmer mutation :-
Repair enzyme
photolygase in this dimmer.
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•INTERCALATION
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AFFECT OF DYES IN MUTATION
Acridine dyes : yellow, orange , red
Ethidium bromide :it’s a aromatic &
flourscent compound
Acriflovin :It is antiseptic & orange,
brown in colour
Proflavin : used urinary antiseptic
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•CROSSLINKING MUTATION
like mitomycin C
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•APURINATION & APYRIMIDINATION
BREAKAGE OF N-GLYCOSYLIC BOND IN BASE
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DNA REPAIR MECHANISM
1.Excision repair
it consist of a two repair process
DNA glycosylase
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NUCLEOTIDE EXCISION REPAIR
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2.MISMATCH REPAIR
It consist two types of repair
mechanism
Recombination repair
Double strand DNA break
mechanism
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1. RECOMBINATION REPAIR
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BREAK DNA DOUBLE STRAND
REPAIR
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THANK YOU