DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision...

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Transcript of DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision...

Page 1: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

DNA Repair

Page 2: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

Cell Cycle Checkpoint activation

DNA Repair:

Base Excision Repair

Nucleotide excision repair

Mismatch repair

DSB repair

SENESCENCE/

APOPTOSIS

CANCER

Page 3: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

Source of Damage

Endogenous: Replication Errors Reactive Oxygen Species

Exogenous: UV radiation, IR.. Mutagenic chemicals

Page 4: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

Type of Damage- Endogenous

Oxidation of bases Methylation of bases Hydrolysis of bases Mismatch of bases

Damage mostly on DNA bases, causing point mutations:

Page 5: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

Type of Damage- Exogenous

UV light- pyrimidine dimers IR- Breaks in DNA strands Chemicals (found in smoke, soot and tar)-

diversity of DNA damages including crosslinking of DNA.

Damage mostly on helix structure:

Page 6: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.
Page 7: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

DNA MutationDNA Damage ≠

Page 8: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

The cellular DNA damage response

Transducers

Mediators

Sensors

EffectorsCell cycle arrest

DNA repair ApoptosisDNA repair

DNA damage

Page 9: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

DNA Repair Mechanisms

Page 10: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

DNA Mismatch repair

Page 11: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.
Page 12: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.
Page 13: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.
Page 14: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

Base Excision Repair

Page 15: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

Nucleotide excision repair

Page 16: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

Nucleotide Excision Repair in Eukaryotes

Page 17: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

Xeroderma Pigmentosum


Base Excision Repair Mechanism of DNA PPT by Easybiologyclass

Base Excision Repair Mechanism of DNA PPT by Easybiologyclass

DNA Repair in Drosophila: Mutagens, Models, and Missing Genes · Drosophila appear to utilize other major repair pathways as well, such as base excision repair, nucleotide excision

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Excision Repair Pathways - Cold Spring Harbor Laboratorydnareplication.cshl.edu/content/free/chapters/08_friedberg.pdf · DNA Excision Repair Pathways Errol C. Friedberg ... 3--LP_LP-LP-LPLP1P-5'

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Mechanisms of DNA Repair by Photolyase and Excision …Mechanisms of DNA Repair by Photolyase and Excision Nuclease Aziz Sancar Department of Biochemistry and Biophysics. University

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Tautomerization-dependent recognition and excision of ...2016/06/01  · Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Chenxu Zhua,1,

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DNA damage and repair summary 1.Defects in repair cause disease 2.Common types of DNA damage 3.DNA repair pathways Direct enzymatic repair Base excision.

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Shining a Light on Base Excision DNA Repair - August 6-7, 2020€¦ · Shining a Light on Base Excision DNA Repair A Symposium in Honor of Samuel Wilson, M.D. August 6 – 7, 2020

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ANNEX F DNA repair and mutagenesis · 4 ANNEX F: DNA REPAIR AND MUTAGENESIS a Base excision enzyme-sensitive sites [P31] or antibody detection of thymine glycol [L60]. Therefore,

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RECOMBINATIONAL DNA REPAIR OF D EPLICATION F … · 2005-06-16 · repair can take its place with excision repair, mismatch repair, base excision re-pair, and direct repair [such

RECOMBINATIONAL DNA REPAIR OF D EPLICATION F … · 2005-06-16 · repair can take its place with excision repair, mismatch repair, base excision re-pair, and direct repair [such

Spermatogenesis, DNA damage and DNA repair mechanisms …...In the male germline cells, DNA repair mechanisms include nucleotide excision repair, base excision repair, DNA mismatch

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DNA Repair Nucleotide Excision Repair XP and CS BiS222 By Jooyoung Chang 장주영 Class #01 / Stu. #20091259.

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