Scientific Capacity Building in Disease Endemic Countries for … · 2015-06-05 · Scientific...
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AFRICAN RESEARCH NETWORK FOR NEGLECTED TROPICAL DISEASES (ARNTD) Scientific Capacity Building in Disease Endemic Countries for Sustainable Control of NTDs Pauline Mwinzi, PhD
Transcript of Scientific Capacity Building in Disease Endemic Countries for … · 2015-06-05 · Scientific...
AFRICAN RESEARCH NETWORK FOR NEGLECTED TROPICAL DISEASES
(ARNTD)
Scientific Capacity Building in Disease Endemic Countries for
Sustainable Control of NTDs
Pauline Mwinzi, PhD
• The five foundations all involved in research capacity building in Africa and linked through European Foundation Centre.
• In 2007 NTDs were starting to get attention from governments and international organisations.
• Funding for treatment programmes but dearth of expertise in African countries for research, policy development and implementation was inadequate
• ARNTD: African and European – proposed a capacity building programme for young African scientists
ARNTD: Founded by EFINTD fellows
EFINTD
FELLOWS SUPPORTED UNDER EFINTD 2009‐2014
23 Fellows• 10 senior• 13 junior
12 Sub-Saharan African countries
17 Fellows - Anglophone countries4 Fellows - Francophone countries2 Fellows - Lusophone countries
4 female fellows: 2 East Africa2 Southern Africa
Problems identified by NTD researchers
• Lack of critical mass of researchers in NTD• Lack of mentors for home grown junior scientists
• Efforts at influencing policy is uncoordinated and individualized
• Sub‐optimal use of limited available resources
The State of Research on Infectious diseases of Poverty (IDP) :
Highest burdens, lowest number of researchers• Share of research output
by first author's country (2000‐2009) Region Researchers per
Million
Africa 100
Latin America 300
North Africa 700
Central and Eastern Europe
1600
Kumasi Aug 2013
Hannover Oct 2013g
Formal and informal meetings
…. the need for a structure that facilitates and promotes the growth of research and research capacity in Neglected Tropical Diseases (NTDs) in Africa
The African Research Network for Neglected Tropical Diseases
• Builds on network of EFINTD research fellows• A platform for NTD experts on the African continent
• Empower current and future generation of African researchers to support evidence‐based control and elimination of NTDs
• Build sustainable collaborative network for NTDs between researchers, policy makers and implementers on the African continent
MISSION
To empower current and future generation of African researchers to support evidence‐based control and elimination of NTDs
ARNTD Vision
Physical location in Africa
The ARNTD SecretariatKumasi Collaborative Center for Research in Tropical Medicine KCCRKNUST University Office, PMB Kumasi, GhanaOffice: +233 3220 60351 Ext. 210http://www.arntd.org
MANAGEMENT BOARD
EFINTD FELLOWS
RESEARCHERS, POLICY MAKERS, NTD PROGRAM MANAGERS
EXECUTIVE DIRECTOR
ADVISORY BOARD
ARNTD ORGANOGRAM
Clinical Trials
Elia JohnAlex Debrah Khumbo KaluaElia John Mike Osei Atweneboana Uwem Ekpo Sonou aboubakary Robert Twoyengyere Anthony AblordeyHikabasa Halwindi
Operational Research
Uwem EkpoAnne KazibwePauline Mwinzi Robert Twoyengyere Mike OSei AtweneboanaMathurin KoffiOlaoluwa Akinwale
Social Science
Hikabasa Halwindi Sonou aboubakary Sammy Njenga Anthony Ablordey Eduardo Samo Gudo Uwem Ekpo Mathurin Koffi
Co‐infection studies Mike Osei Atweneboana Pauline MwinziTom Kariuki Sammy NjengaUwem Ekpo
2
Expert Research Teams
Basic Research
Simo Gustave Ayo Olayemi Trudi O’Neil Tom Kariuki Enock Matovu Tendongfor NicholasRichard PhillipsAnthony Ablordey
Current Research Focus Areas for Fellows
Research Fellows
Is there Bilharzia in African Cities?
Snail abundance
0
1 - 50
51 - 100
101 - 200
Airport
River NyamasariaSewage line
Informal area boundary
Road
Snail abundance
0
1 - 50
51 - 100
101 - 200
Airport
River NyamasariaSewage line
Informal area boundary
Road
Total snails
Lake Victoria
Nyamasaria
Nyamasaria
Nyalenda B
Nyalenda A
Kaloleni
Manyatta A
Manyatta B
Obunga
Bandani
Total snails
Lake Victoria
Nyamasaria
Nyamasaria
Nyalenda B
Nyalenda A
Kaloleni
Manyatta A
Manyatta B
Obunga
Bandani
N
EW
S
N
EW
S
Snail abundance
0
1 - 50
51 - 100
101 - 200
Airport
River NyamasariaSewage line
Informal area boundary
Road
Snail abundance
0
1 - 50
51 - 100
101 - 200
Airport
River NyamasariaSewage line
Informal area boundary
Road
Total snails
Lake Victoria
Nyamasaria
Nyamasaria
Nyalenda B
Nyalenda A
Kaloleni
Manyatta A
Manyatta B
Obunga
Bandani
Total snails
Lake Victoria
Nyamasaria
Nyamasaria
Nyalenda B
Nyalenda A
Kaloleni
Manyatta A
Manyatta B
Obunga
Bandani
N
EW
S
N
EW
S
0
5000
10000
15000
20000
25000
Borehole Dam Protectedwell
Unprotectedwell
River Spring
0
1000
2000
3000
4000
5000
6000
Borehole Dam Protectedwell
Unprotectedwell
River Spring
Tota
l col
iform
den
sity
per
100
ml
E. col
icol
iform
den
sity
per
100
ml
A
B
a
a
aa
a
a
a
b
ab
ab b
ab
(7)
(6)
(27)
(3)
(11)
(26)
0
5000
10000
15000
20000
25000
Borehole Dam Protectedwell
Unprotectedwell
River Spring
0
1000
2000
3000
4000
5000
6000
Borehole Dam Protectedwell
Unprotectedwell
River Spring
Tota
l col
iform
den
sity
per
100
ml
E. col
icol
iform
den
sity
per
100
ml
A
B
a
a
aa
a
a
a
b
ab
ab b
ab
(7)
(6)
(27)
(3)
(11)
(26)
Snail vector mapping
Determine faecalcontamination of domestic water sources
Human water contact activities
Mwinzi PN et al PLoS Negl Trop Dis. 2014 Apr 3;8(4):e2784Mwinzi PN et al Parasitology. 2011 Oct;138(12):1569‐77.
Studies in Kisumu, Kenya
• Model predicted prevalence of A. lumbricoides, Hookworm, T. Trichiura & Schistosomiasis
• Environmental predictors of soil transmitted helminth risk such as day land surface temperature and dense vegetation
• Estimates of school-aged children infected and their deworming requirements
Bayesian geospatial model-based estimates of Soil Transmitted Helminths in Nigeria
Ekpo UF et al (2013) Geospatial Health 7(2): 43‐54.Oluwole AS et al (2015) PLoS NTD (under review)
Before antibiotics After antibiotics
Year 2000 2001‐2002 2004 2006‐2008 2009‐2011 2012 to date
Mice data showRS efficacy
Human trial of RS
RS8 recommended by WHO
RS4RC4 vs RS8
EFINTD studyRS2RC6
ALM/WHO studyRS8 vs RC8
R= Rifampicin S=Streptomycin C=Clarithromycin
DFID/MRC study intobiomarkers for shorter treatment
Phillips R et al AAC 2014 58(2):1161‐6.
Development of an oral regimen for treatment of Buruli ulcer
Peer-reviewed articles published by Fellows in 2010-2014
27
42 43
50
61
0
10
20
30
40
50
60
70
2010 2011 2012 2013 2014Num
ber o
f pub
lications
Year
50 publications – EFINTD fellows35 Open Access Journals; 262 citations
Peer-reviewed publications with EFINTD funding
Total of 101 presentations52 international conferences49 local conferences
Acknowledgements
• EFINTD
• EFINTD Coordinator – Prof. Bernhard Fleischer ‐ Bernhard Nocht Institute for Tropical Medicine
• ARNTD ADVISORY BOARD – Prof. Paul Klatser ‐ Royal Tropical Institute– Prof. David Molyneux ‐ Liverpool School of Tropical Medicine – Prof. Michael Parkhouse ‐ Instituto Gulbenkian de Ciencia– Prof. Koussay Dellagi ‐ Intitut de Recherche pour le Développement– Dr. Mwele Malecela, NIMRI
• EFINTD Fellows
Thank You!
The ARNTD SecretariatKumasi Collaborative Center for Research in Tropical Medicine KCCRKNUST University Office, PMB Kumasi, GhanaOffice: +233 3220 60351 Ext. 210Email: [email protected] http://www.arntd.org (Under reconstruction)
