1 KTH School of Information and Communication Technology KTH Royal Institute of Technology.
School of Biotechnology KTH Royal Institute of Technology
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School of BiotechnologyKTH Royal Institute of Technology
Samverkan i blandkultur på Science for Life Laboratory
CSG, 18:e april, 2013
Prof. Stefan Ståhl
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Innehåll
• Samverkan på BIO
• Vad är Proteinatlasen och Science for Life Laboratory
• Utmaningar
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BIO-skolans samverkan
• Vid behov (3-4 ggr/år)
• Ärenden:• T/A-tjänster• Lärartjänster• Tillbud• Bokslut/budget• Arbetsmiljöplan• Flytt av personal
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www.biotech.kth.se
School of Biotechnology
• Industrial Biotechnology (Larsson)
• Gene Technology (Lundeberg)
• Glycoscience (Bulone)
• Protein Technology (Nygren)
• Proteomics & Nanobiotechnology (Uhlén)
• Theoretical Chemistry & Biology (Ågren)
www.biotech.kth.se
Technology-driven research in“Life Science”• Fundamental research• Applied research
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www.biotech.kth.se
School of Biotechnology
• Industrial Biotechnology
• Gene Technology
• Glycoscience
• Protein Technology
• Proteomics & Nanobiotechnology
• Theoretical Chemistry & Biology
www.biotech.kth.se
New materials
Biotech tools
Medical research & diagnostics• Production of pharmaceuticals
(small molecules/proteins)• Targeted diagnostics and therapy• Understanding diseases
Biosustainability
Energy production
Biofuels
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www.biotech.kth.se
School of Biotechnology
• Industrial Biotechnology (Larsson)
• Gene Technology (Lundeberg)
• Glycoscience (Bulone)
• Protein Technology (Nygren)
• Proteomics & Nanobiotechnology (Uhlén)
• Theoretical Chemistry & Biology (Ågren)
www.biotech.kth.se
Dean: Stefan StåhlVice Dean: Amelie Eriksson Karlström18 Professors> 300 Students> 340 Employees> 110 PhD students≈ 30 teachers (faculty)≈ 50 research leaders
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www.biotech.kth.se
BIO-skolans intäkter/kostnader
www.biotech.kth.se
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013b0
50,000
100,000
150,000
200,000
250,000
300,000
350,000
Bioteknologi (tkr)
Intäkter
Kostnader
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www.proteinatlas.org
Mathias Uhlén, KTH
Finansiering: Wallenberg Foundation 2003-15 (900 mkr)
KTH, Uppsala, and Mumbai
> 120 anställda
Antikroppar till alla kroppens proteiner = 20 000 st (10 nya validerade antikroppar per dag)
Offentlig digital “kartbok”
”Den mänskliga proteinatlasen”
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Cell profiling
Proteinernas lokalisering på cellnivå analyseras med konfokalmikroskopi Startade med 3 cellinjer : A-431, U 251 mg, U –
2 os (hud, hjärna och ben) Idag analyseras 15 olika cellinjer
Grönt – HPA antikroppen Blått – Cellkärnan Rött - Cytoskelettet Gult – ER (endoplasmiska nätverket)
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Release av version 11 den 11 mars 2013, 15156 gener (75%) Första utkastet av den mänskliga proteinatlasen 2015 (20,000 gener)
Status och framtid
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Human Protein Atlas
• Löptid 2003-2015
• > 100 anställda (KTH, Uppsala universitet, Mumbai)
• > 20 tekniker på KTH – stor omsättning
• Generellt rekryteringstillstånd
• ~ 15 tekniker/år
HPA en förutsättning för Science for Life Laboratory (Proteinatlasen > 3000 besök per dag)
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Four broad research platforms:
• Genomics
• Proteomics and protein profiling
• Bioimaging and functional biology
• Bioinformatics and systems biology
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Two buildings (14,000 m2)
• Alfa 1-6- Summer 2012
• Gamma 3,4,6(1/2)- Summer 2013
• Gamma 5- Sept/Oct 2013
234
123
654
5
20102011
20122013
Center Director: Mathias Uhlen
Deputy Director: Gunnar von Heijne
Site Director: Fredrik Sterky
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SciLifeLab Stockholm development
Alfa-huset
Gamma-huset
Personnel 2010 2011 2012 2013
Funded by strategic grant 26 40 55 110
Total no of personnel 70 180 350 ~700
Number of research groups 9 18 30 ~50
Bioinformatics personnel 18 80 130 ~170
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Utmaningar
• Flytt av grupper
• Tre universitet – tre kulturer
• Forskarna (KTH, KI, SU) – blandade på lab och i kontorslandskap
• Hur skapas ”vi-känsla”? För SciLifeLab – för hemuniversitet?
• Olika lönenivåer (ex. doktorandstege)KI: 23.6 – 27.1 kkr; KTH: 25.7-30.75 kkr; SU: 23.2 - 26.8 kkr
• Olika arbetstidsavtal
• Friskvårdsersättning – olika regler/nivåer!
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Utmaningar
• Verksamhetsgruppering – samverkansenhet eller inte?
• Arbetsmiljöansvar delegerat till föreståndare (Fredrik Sterky)?
• Ambitionerna sprack! Ej juridiskt stöd?!
• Idag: Forskarna tillhör universitetsavdelningar (personalansvar)Arbetsmiljöavtal under framtagande (Leif Svanblom)Akuta åtgärder ”delegeras” till Fredrik Sterky
• Industrial Biotechnology (Larsson)
• Gene Technology (Lundeberg)
• Glycoscience (Bulone)
• Protein Technology (Nygren)
• Proteomics & Nanobiotechnology (Uhlén)
• Theoretical Chemistry & Biology (Ågren)
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Bra stämning och “vi känsla” på SciLifeLab!
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Infrastructure funding (150 MSEK/year)- National infrastructure - service (instrumentation, personnel)- International infrastructure (participation in international efforts)- Technical development (of national interest)- Scientific leadership, administration, rent, data storage- Training
Drug development funding (40 MSEK/year)- National infrastructure for development of chemical and biological drugs
Strategic research funding SFO (145 MSEK/year)- Larger research projects- New recruitments- Technical development
Finansiering (2013-2015)
Budget Uppsala/Stockholm:67/133 mkr/år
Budget Uppsala/Stockholm:44/101 mkr/år
KTH: 78 mkr/år
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…fortsatt samverkan i blandkultur
• “Nationell fas” inleds under 2013
• KTH fortsatt huvudman
• 335 mkr/år (400 mkr/år fr 2016)
• KTH, KI, SU & UU = SciLifeLab Sweden
• Nationella resurs-plattformar
• Nationell referens-kommitté (SS, KTH-rep)
• Styrelse beslutas av KTHs US (17 april, 2013)Ordf. Göran Sandberg, KAW
Margareta Olsson Birgersson, Roche, näringslivsrepresentant
Sophia Hober, dekanus, KTH
Hans-Gustav Ljungren, dekan forskning, KI
Britt Skogseid, vice-rektor, UU
Hans Adolfsson, Prorektor, SU
Maria Anvret, GU
Gunella Westergren-Thorsson, Dekanus Med Fak, LU
Karl-Eric Magnusson, Linköping (ordf. NRK)
• Stort ansvar för Svenkt forskar-anseende
• Tydlighet & transparens och världsledande forskning!
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…fortsatt samverkan i blandkultur